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1 Published Ahead of Print on May 24, 2018, as doi: /haematol Copyright 2018 Ferrata Storti Foundation. Reducing mortality in newly diagnosed standard-risk acute promyelocytic leukemia in elderly treated with arsenic trioxide requires major reduction of chemotherapy: a report by the French Belgian Swiss APL group by Ramy Rahmé, Lionel Ades, Xavier Thomas, Agnès Guerci-Bresler, Arnaud Pigneux, Norbert Vey, Emmanuel Raffoux, Sylvie Castaigne, Olivier Spertini, Sebastian Wittnebel, Jean Pierre Marolleau, Gandhi Damaj, Dominique Bordessoule, Julie Lejeune, Sylvie Chevret, and Pierre Fenaux Haematologica 2018 [Epub ahead of print] Citation: Ramy Rahmé, Lionel Ades, Xavier Thomas, Agnès Guerci-Bresler, Arnaud Pigneux, Norbert Vey, Emmanuel Raffoux, Sylvie Castaigne, Olivier Spertini, Sebastian Wittnebel, Jean Pierre Marolleau, Gandhi Damaj, Dominique Bordessoule, Julie Lejeune, Sylvie Chevret, and Pierre Fenaux. Reducing mortality in newly diagnosed standard-risk acute promyelocytic leukemia in elderly treated with arsenic trioxide requires major reduction of chemotherapy: a report by the French Belgian Swiss APL group. Haematologica. 2018; 103:xxx doi: /haematol Publisher's Disclaimer. E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts that have completed a regular peer review and have been accepted for publication. E-publishing of this PDF file has been approved by the authors. After having E-published Ahead of Print, manuscripts will then undergo technical and English editing, typesetting, proof correction and be presented for the authors' final approval; the final version of the manuscript will then appear in print on a regular issue of the journal. All legal disclaimers that apply to the journal also pertain to this production process.

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3 Š Ž Ž ƒ ƒ ˆ ˆƒ Ž Ž ƒ Šƒ ƒ œ Š Ž ˆ ƒ Š Š Š ˆˆ ƒ ˆˆ ˆ ƒžž ƒ ƒ ƒ Š ƒ ˆˆ ˆ ƒ š 1 Š ƒ ˆƒ ƒ Š ƒ Ž ƒ Š Š ƒ Šƒ Š ƒ ƒ ˆ Ž ƒ ƒ Š Žƒ ƒ 1 3 Ž Ž ƒ ˆƒ ƒ Ž Šƒ ˆ ƒ ƒ Š ƒ Ž Š Ž Ž Ž Žƒ ƒ Žƒ ƒ Šƒ ƒ ƒ Šƒ Š Š Š Š Š ƒ Ž ƒ Šƒ Ž ƒ Š ˆ ˆ Š Ž Ž Ž ƒ ˆ ƒ ƒ Ž Šƒ ƒ ƒ Ž Š Ž ƒž Š Š Š Ž ƒ ˆŽ Ž ˆ Ž Ž ƒ Ž ƒž ƒž 4,5 ƒ ˆ Š Ž Ž Š ƒž ƒ ƒ Ž ƒ Š ˆ Žƒ Žƒ Ž Š Š ƒ Š ƒ ƒ 6 Ž Š ƒž Š ƒ ƒ Ž Šƒ ƒ ƒ Š Žƒ ˆ Žƒ ˆ ƒž ƒ ƒžž ƒž ƒ ƒ Ž 7 Š ƒ Š ƒ ƒ Šƒ Ž Š ƒ Ž ƒž ƒž 7 ˆ ƒ Ž ƒ Ž Šƒ Š Šƒ ƒ ƒ ƒ Š ƒ ƒ Ž ƒ ƒ ˆˆ ƒ Žƒ ƒž Š Ž Ž Ž 8 10 Š ƒ ƒ ƒž ƒ ƒ Š ƒ Ž Ž ƒ Š ƒž ƒ Š ˆ ƒ Ž ˆ ƒ Š ƒ Š ƒ ŽŽ ƒ Ž ˆ ˆ Ž ƒ ˆ ƒžž Š Ž Ž Ž Š Ž Ž ƒ Š Žƒ ˆ Ž Ž ƒ Š ˆ Ž ƒ Šƒ Ž Š 10,11 Š Š Ž ˆ ƒž Š ƒ ƒ ƒ ƒ Ž Šƒ ƒ Ž ƒ ƒ Š Ž ˆ ƒ Ž Žƒ Ž ƒ ƒ ƒ Š Ž Ž ˆ ƒž Š Ž Š Ž Ž ƒ ƒ ƒˆ ˆ ƒ ƒ Š ƒ Š Žƒ ƒ ƒ ƒ ƒ ƒ ˆ Ž ƒ Š ƒ ˆ ƒ Š ƒ ƒ Ž ƒ Š ƒ Š Ž ƒ ƒ ƒ Š ƒ ƒ ƒ ƒ Š ƒ ƒ Š šƒ Ž ƒ Ž Š Š ˆ ƒ ƒˆ Ž ˆ ƒ ƒ ƒž ƒ ŽŽŠ Š ˆ Š ƒ Š Šƒ ƒ Š Š Ž Žƒ ƒ Ž ƒ ƒ ƒ ˆ ƒ Š ˆ Ž ƒ Ž Š ƒ ƒ ˆ ƒ Š Žƒ ƒž ˆˆ ˆ Š ƒ ƒ ƒ ˆŠ ƒž œƒ ƒ

4 ƒž ƒ ˆ ƒ ˆ ƒ Ž š Ž Ž ƒ ƒ Š ƒ ƒž ˆ ƒ Š ƒ ƒ ƒ Žƒ Š 12 ƒ Š ƒ Š Ž ƒ ƒˆ Š ˆ ƒžšƒœƒ ƒ Žƒ ƒ ˆ ƒ Š ˆ Š Žƒ ƒ Š ƒ Ž Š ƒ 13 Š ƒ Š ƒ ƒ Ž ƒ ƒ Š Š Ž ƒ Š ˆ ƒ ˆ ƒ ƒ ƒ ˆ Š Ž ƒ ƒ ƒ ƒ Š ƒž ƒ Ž ˆ ˆ Š ƒ Šƒ ƒ Š ˆ ƒ ƒ ˆ Š Šƒ ƒ Š ˆ ƒ ƒ Š Š ƒ Š ƒž ˆ ŽŽ Š Š ˆ ƒ ƒ ƒ ƒ Š ƒžž Š ƒ Žƒ ˆ Š ƒ Žƒ ˆ ƒ Ž ƒ ƒ ƒ œ ƒ ƒ Š Šƒ ƒ Ž ƒƒ Šƒ ƒ Ž ƒ Šˆ Ž ƒ ˆƒ Ž ˆ Š ƒ Š ƒ ƒ Ž ƒ Ž Žƒ ƒ ƒž ƒ Š ƒ Žƒ Š ƒ ƒ ƒ Ž Š ˆ Š Ž ƒ ƒžž ƒ ƒ Š ƒ ƒž ƒž ƒ Ž Žƒ ƒ Š ƒ Š ƒ Š ƒ ˆ Ž Š Š ƒžƒ Š Š ƒ Ž ƒ ƒ ƒ Š Ž ƒˆ Ž ˆ Š ƒ Š ƒ ˆ ƒ Š ˆ ƒ ƒˆ ƒ Ž ˆ ƒ ƒˆ ƒž ƒ ˆ ƒ ƒ ƒ ƒˆ Š ƒ ƒ Š ƒžž Žƒ ƒ ƒ Ž ˆ ƒ ƒˆ Š ƒ Š Ž ƒ Žƒ Ž ƒ ƒ Š ƒžž Žƒ ƒ ƒ Ž ˆ ƒ ƒˆ Š ƒ Š Ž ƒ Ž ˆ ƒ ƒ Ž Š Ž ƒ Žƒ Ž Žƒˆ Š ˆ Ž ƒ ƒ ƒ ƒ Š ƒž ƒ ƒ Š ƒ Ž ƒ Ž Š Ž Š Ž ƒ ŠƒŽ ƒ ƒ ƒ Š Ž Š ˆ Šƒ ƒ ƒ ˆ Š ˆ Ž ƒ ˆ Ž Ž ƒžž ˆ Š Š ƒ ƒ Š Žƒ ƒ ƒ ƒ ˆ ƒ ƒž Š ƒ ˆ Šƒ ƒ ƒžž Ž ƒ ˆ ƒ Š Ž ƒ Ž ƒ Ž ƒ ƒ Ž ƒ Ž ˆ ƒ Ž ƒ Š ƒ ˆ ƒ Š ƒ ƒ Š ƒž Š Ž Ž ƒ Ž ˆƒ š š Š ƒ ˆ Ž ƒ Ž ˆˆ Š Š ƒž Šƒ ƒž ƒ ˆ ƒ Š ƒ ˆ Š Ž Š ƒ ˆ ƒ Š ƒ ˆ

5 Ž ƒ Š Š ˆ ƒ œ ƒž Š ˆ Ž ƒ Ž Ž Ž ƒ Ž ƒ Š ƒ Ž ƒ Š ƒ ƒ š ƒ Š ˆ Ž ƒ Ž ƒ ˆ š šƒ ˆ ƒ Š Ž Šƒ ƒ ƒ š ƒ ƒ ˆ ƒ Š Žƒ Ž Š ƒžž Š ƒž Ž Ž ƒ ˆ 14 Ž ƒ ƒ Ž Š ˆ Š ƒ Š ƒž ƒ ƒ ƒž Šƒ Š ƒ ˆ Š ƒ Š ˆ ƒ Š Š ƒ Žƒ Ž ƒ Ž Šƒ ƒ Šƒ ŽŽ Š ƒž Š Š Ž ƒž ƒ ˆ Ž Ž ƒ 10 ƒ ƒ Ž Šƒ ƒ Ž ƒ Š ƒž ˆ ƒ ƒ ƒž ƒ ƒ ƒžž ƒ ƒ Š Š Šƒ ƒ ˆ ƒ ƒ ˆˆƒ Ž ƒ Ž ƒ Š ƒ ƒ Š Ž ˆ Š ƒ ƒ Ž ƒ ƒ Šƒ Ž ƒžž ˆ Ž Š ƒž ƒ ƒ Š ƒžž ˆƒ ƒž Ž ƒ Š Ž Ž ƒžž ƒ Ž ƒ ƒ ƒ Žƒ ƒ ƒ Ž ƒž ƒ Š Š Žƒ ˆ d ^ D ' d D^ D > E ddde ddd e deed deed d > ^ Z > W> dddd dz W> :, dddd ee e dde dde d ^ D D W Z Z dddd ddd dd ddde ddde d > ^ Z > ^ > Z > dddd dd e ddde dddd d Z Z d y Z W> & dee > dddd de dd dddd dddd e > ^ ^ K > dddd de d ddd ddd e > ^ Z / Z W > ' : K ddde dd de dedd dedd e > & ' s D Z E :D dddd dee d ddd ddd e W h ' > / K t Z d t Z E, Z W > & Z Z / ' W>ddde d : K ddde dd e edd edd dd < Z E,, Z< D>de

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