Sequence-Defined Polymers via Orthogonal Allyl Acrylamide Building Blocks
|
|
- Polly Merritt
- 5 years ago
- Views:
Transcription
1 Sequence-Defined Polymers via Orthogonal Allyl Acrylamide Building Blocks Mintu Porel and Christopher A. Alabi* School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States Table of content Content Page number Materials and Methods... S2 Monomer synthesis S3-S4 Synthesis of polymer with fluorous support.. S4-S5 Figure S1: Phosphine catalyzed Michael addition kinetics.. S6-S7 Figure S2: Thiol-ene reaction kinetics S8 Figure S3: 1 H NMR spectra of fluorous Boc protected allyl amine. S9 Figure S4: Synthetic scheme of test oligomer.. S10 Figure S5: 1 H NMR spectra of test oligomer synthesis.... S11 Figure S6: 1 H NMR spectra: testing stoichiometry of the thiol-ene reaction... S12-S13 Figure S7: Testing Michael addition kinetics with fluorous substrate.. S14 Figure S8: Stepwise LCMS of test oligomer synthesis..... S15 Figure S9-S14: Stepwise 1 H NMR spectra of ISO1 synthesis.. S16-S21 Figure S15: Stepwise LCMS of ISO1 synthesis... S22 Figure S16: 1 H NMR spectra of ISO1 and ISO2 before and after cleavage. Figure S17: HPLC trace of purified ISO1 and ISO2... S23 S24 Figure S18: Tandem mass spectrum of ISO1... S25 Table S1: Table of calculated and observed m/z of the fragments of ISO1. S25 Figure S19: Tandem mass spectrum of ISO2... S26 Table S2: Table of calculated and observed m/z of the fragments of ISO2. S26 Figure S20: 1 H NMR spectra of 16-mer polymer. S27 Figure S21: Tandem mass spectrum of 16-mer polymer.. S28 Table S3: Table of calculated and observed m/z of the fragments of 16-mer... S29 Figure S22-S29: 1 H NMR spectra of monomers... Figure S30-S35: Assigned 1 H NMR spectra of test oligomers (A-F)... S30-S37 S38-S43 S1
2 Materials and Methods General chemicals were purchased from Sigma Aldrich. Precursors (amines and halides) for the monomer synthesis were purchased from Aldrich and Alfa Aesar. Fluorous BOC-ON (C 9 F 19 BOC-ON) and pre-packed fluorous silica cartridges were purchased from Boron Specialties. UV irradiation for the thiol-ene reaction was performed with a BlueWave 75 UV curing spot lamp (Dymax Corporation). 1 H NMR spectra were recorded on INOVA 400 spectrometers. NMR data was analyzed by MestReNova (version 8.1.1). 1 H NMR chemical shifts are reported in units of ppm relative to tetramethylsilane. NMR data are presented in the following order: chemical shift, peak multiplicity (s = singlet, d = doublet, t = triplet, m = multiplet, dd = doublet of doublet, dt = doublet of triplet), proton number, coupling constant. LCMS experiments were carried out on a Shimadzu HPLC LC20-AD and Thermo Scientific LCQ Fleet with a Sprite TARGA C18 column ( mm, 5 µm, Higgins Analytical, Inc.) monitoring at 215 and 260 nm with positive mode for mass detection. Solvents for LCMS were water with 0.1% acetic acid (solvent A) and acetonitrile with 0.1% acetic acid (solvent B). Compounds were eluted at a flow rate of 0.3 ml/min with 0% solvent B for 2 min, followed by a linear gradient of 0% to 10% solvent B over 2 min, followed by a linear gradient of 10% to 100% solvent B over 5 min, and finally 100% solvent B for 1 min before equilibrating the column back to 0% solvent B over 1 min. MALDI-TOF mass spectrometry was performed on a Waters MALDI micro MX MALDI-TOF mass spectrometer using positive ionization and a linear detector. MALDI samples were prepared by depositing the analyte dissolved in methanol and an alpha-cyano-4-hydroxycinnamic acid matrix onto a stainless steel sample plate. The plate was air dried before loading it into the instrument. HPLC purification was performed on a 1100 Series Agilent HPLC system equipped with a UV diode array detector and a 1100 Infinity analytical scale fraction collector using reverse phase C18 column (4.6 x 150 mm, 5 µm). The column compartment was kept at 25 C during fractionation. Solvents for HPLC were water with 0.1% trifluoroacetic acid (solvent A) and acetonitrile with 0.1% trifluoroacetic acid (solvent B). Compounds were eluted at a flow rate of 1 ml/min with 5% solvent B, followed by a linear gradient of 5% to 100% solvent B over 30 min, and finally 100% solvent B for 5 min before equilibrating the column back to 5% solvent B over 1 min. Polymers were collected based on their absorption at 254 nm. The fractionated polymer was transferred to a vial, dried and stored until further analysis. S2
3 Monomers used in the current study: O N O N O N O N N 2a 2b 2c 2d O N H O N O N O N OH 2e 2f 2g 2h 1. Synthesis of Allyl-N-alkyl/aryl-amines Method A (monomer 2b, 2d and 2g): Br R NH 2 K 2 CO 3 HN R Primary amine derivatives were mixed with 1.2 equivalents of K 2 CO 3 in a round bottom flask and 0.2 equivalent of allyl bromide was added dropwise over a period of 30 min at room temperature and stirred overnight. The reaction mixture was then filtered through celite and washed with CH 2 Cl 2. The filtrate was then concentrated at reduced pressure. Excess primary amine was evaporated under high vacuum. The reaction mixture containing the secondary amine (desired product) and tertiary amine (side product) was used without purification for the subsequent reaction with acryloyl chloride. Method B (monomer 2f and 2h): Allyl amine was mixed with 1.2 equivalents of K 2 CO 3 in a round bottom flask and 0.2 equivalent of alkyl/aryl bromide was added dropwise over a period of 30 min at room temperature and S3
4 stirred overnight. The reaction mixture was then filtered through celite and washed with CH 2 Cl 2. The filtrate was then concentrated at reduced pressure. Allyl amine was evaporated under high vacuum. That reaction mixture containing the secondary amine (desired product) and tertiary amine (side product) was used without purification for the subsequent reaction with acryloyl chloride. Method C (monomer 2c): A solution of allylamine in isopropanol was stirred and treated portion wise with 0.3 equivalent 2-dimethylaminoethyl chloride hydrochloride, followed by 1.2 equivalent of K 2 CO 3. The mixture was allowed to stir at room temperature for one hour, then refluxed for two hours, cooled and diluted with 20 ml of a 6.25 M sodium hydroxide solution. The product was extracted with diethyl ether and dried over sodium sulfate. After evaporation of solvent, the residue was distilled to give the pure product (b.p. 50 C at 15 torr). 2. Synthesis of allyl-n-alkyl/aryl-acrylamide Allyl-N-alkyl/aryl-amines and one equivalent of triethylamine were dissolved in CH 2 Cl 2. The reaction mixture was cooled to 0 C, while being stirred. One equivalent of acryloyl chloride (diluted in 5 ml of CH 2 Cl 2 ) was added drop wise to the reaction mixture over a period of 1 h at 0 C. The reaction mixture was stirred at 0 C for 1 h and at room temperature for 1 h. The reaction mixture was washed twice with water and once with brine solution. The organic layer was then dried over anhydrous Na 2 SO 4, filtered, and concentrated at reduced pressure. The crude reaction mixture was purified by silica gel column chromatography. The product was eluted with 5% MeOH in CH 2 Cl 2. Purity was confirmed by 1 H NMR and LCMS. General method for Fluorous solid-phase extraction (FSPE) The fluorous organic mixture to be separated was loaded onto a 2 g pre-packed fluorous solidphase extraction (FSPE) cartridge. A fluorophobic wash (20% water in methanol) was used to elute all the non-fluorous molecules leaving the fluorous molecules retained on the fluorous silica gel. A fluorophilic wash (100% methanol) was then used to elute the fluorous molecules S4
5 from the fluorous stationary phase. For a 50 mg (~ 0.08mmol) loading of crude mixture onto a 2 g pre-packed FSPE cartridge, two 10 ml fluorophobic washes were used to remove the nonfluorous compounds and one 10 ml fluorophilic wash was used to elute the desired fluorous compound. 3. Synthesis of fluorous Boc protected allyl amine C 9 F 19 O O O CN + H 2 N Et 3 N, THF RT, 2h C 9 F 19 O O N H Allyl amine (6.9 mg, 0.12 mmol) and triethylamine (20 mg, 0.2 mmol) were added to a solution of 94.7 mg (0.13 mmol) of 2-[2-(1H,1H,2H,2H-Perfluoro-9-methyldecyl) isopropoxycarbonyloxyimino]-2-phenylacetonitrile (fluorous BOC-ON) in 10 ml THF. The reaction mixture was stirred at room temperature for 2 h. Thereafter the reaction mixture was concentrated to ~0.3 ml under reduced pressure and purified by FSPE. Methanol was evaporated under reduced pressure to yield the fluorous Boc protected allyl amine as a white solid product. Purity of the product was confirmed by 1 H NMR. 1 H NMR (400 MHz, CDCl 3 ): δ 1.47 (s, 6H), 1.97 (m, 2H), 2.10 (m, 2H), 3.73 (s, 2H), 4.66 (m, 1H) and 5.11 (m, 2H), 5.82 (m, 1H). General method for Thiol-ene reaction 1,3-Propanedithiol (0.4 mmol) and 2,2-dimethoxy-2-phenylacetophenone (DMPA, 5 mol % of 1,3-propanedithiol) were added to a solution of corresponding fluorous-olefin (0.08 mmol) in methanol (300 µl). The reaction mixture was subjected to UV irradiation for 90 s at 20 mw/cm 2. The product (fluorous-thiol) was purified by FSPE. General method for Michael addition Allyl-N-alkyl/aryl-acrylamides monomer (0.16 mmol) and dimethyl phenyl phosphine (Me 2 PhP, 5 mol% of monomer) were added to corresponding fluorous-thiol (0.08 mmol) in methanol (300 µl) and stirred for 5 min at room temperature. The product was purified by FSPE. General method for fluorous Boc deprotection The fluorous Boc protected polymer was dissolved in a 50% TFA/CH 2 Cl 2 solution and stirred for 2.5 hours. The resulting mixture was purified by FSPE. In this case, the organic solution that elutes with the fluorophobic wash (20% water in methanol) is the desired product. The eluted product was dried under reduced pressure. Typical polymer concentration for the deprotection is 50 mm. S5
6 Kinetics experiment of Michael addition 1 H NMR spectra of a mixture of N-methyl allyl acrylamide (0.1 mmol) and Me 2 PhP (5 mol% of N-methyl allyl acrylamide) in CD 3 OH (600 µl) was recorded and taken as the 0 min time point. 1,3-propanedithiol (0.2 mmol) was added to this solution, mixed quickly and a 1 H NMR spectrum was recorded every minute. The addition, mixing and recording of the first 1 H NMR was complete within one minute. The progress of the Michael addition was monitored via disappearance of acryloyl olefin proton signal at 6.74 ppm. The percentage of consumed starting material was determined by integration of the 1 H NMR chemical shift at 6.74 ppm relative to that at 2.24 ppm (methyl proton signal from the Me 2 PhP catalyst in the reaction mixture as determined via integration of spectra B (i), see below), which remained constant throughout the reaction. The allyl olefin chemical shift at 5.2 ppm remained constant throughout the reaction indicating that there was no di-addition. S6
7 Figure S1 (A) 1 H NMR spectra (400 MHz, CD 3 OH) of (A) Michael addition reaction mixture mentioned above at different time intervals, (B) (i) Mixture of 2a and Me 2 PhP, (ii) Me 2 PhP (in CD3OD) and (iii) 2a (in CD 3 OD) and (C) kinetic plot of the reaction progress. S7
8 Kinetics experiment of thiol-ene reaction The starting material N-allyl-N-methyl-3-(octylthio)-acrylamide (AMOA) was synthesized by mixing 1-octane thiol and N-methyl allyl acrylamide in presence of 5 mol% propyl amine as catalyst for 24 hours. After removal of propylamine, the reaction was deemed quantitative via 1 H NMR. 1,3-Propanedithiol (0.1 mmol) and DMPA (5 mol% of 1,3-propanedithiol) were added to a solution of AMOA (0.08 mmol) in methanol (300 µl). The reaction mixture was split equally into five vials and each was UV irradiated for 15, 30, 45, 60 and 90s respectively at 20 mw/cm 2. 1 H NMR spectra of the five reaction mixtures were recorded. 1 H NMR of AMOA was used as the 0 s time point. The reaction progress was monitored via integration of the 1 H NMR signals at 5.14 ppm (olefin proton) relative to that at 0.77 ppm. The latter represents the methyl proton of the octyl group, which remained constant throughout the reaction. Figure S2 (i) Partial 1 H NMR spectra (400 MHz, CDCl 3 ) of the thiol-ene reaction mixture mentioned above at different time intervals and (ii) kinetic plot of the reaction progress. S8
9 Figure S3 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) fluorous BOC-ON and (ii) BOC protected fluorous allyl amine; * represents the residual proton signal of CDCl 3. S9
10 Figure S4 Synthesis of the test oligomer using N-allyl-N-methylacrylamide and 1,3- propanedithiol S10
11 Figure S5 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) A, (ii) B, (iii) C, (iv) D, (v) E and (vi) F; * and represent the residual proton signals of CDCl 3 and MeOH respectively. Spectral assignments for compounds A-F are provided in Figure S30-S35. S11
12 (A) S12
13 Figure S6 (A) 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) A; product from the reaction mixture of A and 1,3-propanedithiol at a ratio of (ii) 1:5; (iii) 1:2; (iv) 1:1; (v) 1:0.5 and (vi) 0:1, i.e. only 1,3-propanedithiol. The reaction was performed in the presence of 5 mol% DMPA (w.r.t BOC protected fluorous allylamine), hν = 20 mw/cm 2, 90 sec; The blue and red dots represent olefin and thiol proton signals respectively. The reaction did not go to 100% conversion even after addition of 2 eq of dithiol, but was complete in presence of 5 eq dithiol. *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and MeOH respectively. (B) Expanded region of 1 H NMR spectra of a reaction mixture of A and 1,3-propanedithiol at a ratio of (i) 1:5; (ii) 1:0.5 and (iii) 0:1, i.e. only 1,3-propanedithiol. The proton signals of 1,3-propanedithiol undergo a slight chemical shift upon conjugation with the fluorous tag (see a, b, and c). Hence, the spectrum in B(ii) suggests that the thiol signal at 1.33 ppm is only from mono-addition product. S13
14 Figure S7 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) B; reaction mixture of B with 2 equivalent N-allyl-N-methylacrylamide in presence of 5 mol% of Me 2 PhP after reaction for (ii) 180 s and (iii) 300 s. Blue dots and red dots represent olefin proton signals and thiol proton signals respectively. The presence of the thiol proton signal after 180 s indicates that reaction was not complete, whereas disappearance of thiol signals after 300 s reactions confirms completion of the reaction. S14
15 Figure S8 LCMS of (i) B, calculated for (M+H) , observed ; (ii) C, calculated for (M+H) , observed ; (iii) D, calculated for (M+H) , observed ; (iv) E, calculated for (M+H) , observed ; (v) F, calculated for (M+H) , observed S15
16 Figure S9 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) A, (ii) G and (iii) H; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and MeOH respectively. S16
17 Figure S10 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) I and (ii) J; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and MeOH respectively. S17
18 Figure S11 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) K and (ii) L; * represents the residual proton signals of CDCl 3. S18
19 Figure S12 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) M and (ii) N; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and MeOH respectively. S19
20 Figure S13 1 H NMR spectra (400 MHz, CDCl 3 ) of (i) O and (ii) P; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and MeOH respectively. S20
21 Figure S14 1 H NMR spectra (400 MHz, CDCl 3 ) of (A) (i) Q, and (ii) R with assigned proton signals. The alkyl region could not be accurately assigned due to large number of overlapping proton signals. (B) (i) TFA: H 2 O = 1:1; (ii) TFA: H 2 O = 1:0.5 and (iii) TFA. The 1 H NMR spectra in B suggests that the proton signal of TFA is shifted up field upon hydration, indicating that the proton signal at 5.8 ppm of A(ii) is due to hydrated TFA and protonated amines. * and represent the residual proton signals of CDCl 3, and MeOH respectively. S21
22 Figure S15 LCMS of (i) H, calculated for (M+H) , observed ; (ii) J, calculated for (M+H) , observed ; (iii) L, calculated for (M+H) , observed , (M+2H) ; (iv) N, calculated for (M+H) , observed , (M+2H) ; (v) P, calculated for (M+H) , observed , (M+2H) S22
23 Figure S16 1 H NMR spectra (400 MHz, CDCl 3 ) of (A) before cleavage of (i) ISO2 and (ii) ISO1 and (B) after cleavage of (i) ISO2 and (ii) ISO1 with assigned proton signals. The alkyl region could not be assigned due to large number of overlapping proton signals; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and MeOH respectively. S23
24 Figure S17 HPLC trace of purified (i) ISO1 (retention time = 17.8 min) and (ii) ISO2 (retention time = 17.1 min); * represents the product signal and represents residual loading solvent signals (these peaks show up in a blank run). S24
25 M 1 M2 M 3 M 4 M 5 N 5 N 4 N 3 N 2 N 1 + c ESI Full ms N Instrument scan range = 190 to 2000 M 1 =166.08, was out of range N M N N 4 M 3 M M 5 N m/z Figure S18 Tandem mass spectrum of ISO1 Table S1 Calculated and observed m/z of the fragments of ISO1 Fragment Calculated Observed Fragment Calculated Observed (m/z) (m/z) (m/z) (m/z) M n/a * N M N M N M N M N *m/z was out of the instrument scan range S25
26 N 2 N 3 M 1 M 2 M 3 M 4 M 5 N 5 N 4 N 3 N 2 N 1 T: ITMS + c ESI Full ms @cid50.00 [ ] M M M 3 M m/z N 4 N m/z m/z Instrument scan range = 190 to 2000 M 1 = and N 1 = , were out of range Figure S19 Tandem mass spectrum of ISO2 Table S2 Calculated and observed m/z of the fragments of ISO2 Fragment Calculated Observed Fragment Calculated Observed (m/z) (m/z) (m/z) (m/z) M n/a * N n/a * M N M N M N M N *m/z was out of range of the instrument scan range S26
27 Figure S20 1 H NMR spectra (400 MHz, CDCl 3 ) of 16-mer polymer (i) before and (ii) after cleavage from fluorous tag with assigned proton signals. The alkyl region could not be assigned due to large number of overlapped proton signals; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and MeOH respectively. S27
28 Figure S21 Tandem mass spectrum of 16-mer polymer S28
29 Table S3 Calculated and observed m/z of the fragments of 16-mer polymer Fragment Calculated Observed Fragment Calculated Observed (m/z) (m/z) (m/z) (m/z) M n/a * N n/a * M N ** M N M N M N M N M N *** M *** N n/a * *m/z was out of range of the instrument scan range ** (M+H-H 2 O) + was observed *** (M+2H) 2+ was observed S29
30 Figure S22 1 H NMR spectra (400 MHz, CDCl 3 ) of 2a; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and tetramethylsilane respectively. The product is a mixture of two rotational isomers. 1 H NMR (400 MHz, CDCl 3 ): δ 2.95 (m, 1.7H), δ 2.98 (m, 1.3H), 3.93 (m, 1H), 4.01 (m, 1H), 5.14 (m, 2H), 5.62 (m, 1H), 5.74 (m, 1H) and 6.42 (m, 2H), inset: LCMS calculated for (M+H) , observed S30
31 Figure S23 1 H NMR spectra (400 MHz, CDCl 3 ) of 2b; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and tetramethylsilane respectively. The product is a mixture of two rotational isomers. 1 H NMR (400 MHz, CDCl 3 ): δ 0.86 (m, 3H), 1.25 (m, 2H), 1.48 (m, 2H), 3.24 (t, 1H, J=8 Hz), 3.32 (t, 1H, J=8 Hz), 3.89 (m, 1H), 3.97 (m, 1H), 5.11 (m, 2H), 5.60 (m,1h), 5.75 (m,1h), 6.38 (m,2h); inset: LCMS calculated for (M+H) , observed S31
32 Figure S24 1 H NMR spectra (400 MHz, CDCl 3 ) of 2c; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and tetramethylsilane respectively. The product is a mixture of two rotational isomers. 1 H NMR (400 MHz, CDCl 3 ): δ 2.22 (s, 6H), 2.43 (m, 2H), 3.39 (t, 0.8H, J= 8 Hz), 3.48 (t, 1.2H, J= 8 Hz), 3.98 (m, 1.2H), 4.04 (m, 0.8H), 5.15 (m, 2H), 5.64 (m, 1H), 5.76 (m, 1H), 6.43 (m, 2H); inset: LCMS calculated for (M+H) , observed , is for (M+H- NHMe 2 ) +. S32
33 Figure S25 1 H NMR spectra (400 MHz, CDCl 3 ) of 2d; *, and represent the residual proton signals of CDCl 3, CH 2 Cl 2 and tetramethylsilane respectively. The product is a mixture of two rotational isomers. 1 H NMR (400 MHz, CDCl 3 ): δ 0.89 (m, 3H), 0.91 (m, 3H), 1.96 (m, 1H), 3.13 (d, 1H, J= 8 Hz), 3.24 (d, 1H, J= 8 Hz), 3.97 (m, 1H), 4.04 (m, 1H), 5.16 (m, 2H), 5.66 (m, 1H), 5.79 (m, 1H), 6.46 (m, 2H); inset: LCMS calculated for (M+H) , observed S33
34 Figure S26 1 H NMR spectra (400 MHz, CDCl 3 ) of 2e; * and represent the residual proton signals of CDCl 3 and tetramethylsilane respectively. 1 H NMR (400 MHz, CDCl 3 ): δ 3.89 (m, 2H), 5.10 (m, 2H), 5.58 (dd, 1H, J= 0.8, 0.4 Hz), 5.79 (m, 1H), 6.20 (m, 2H), 6.66 (s, 1H); inset: LCMS calculated for (M+H) , observed S34
35 Figure S27 1 H NMR spectra (400 MHz, CDCl 3 ) of 2f; * and represent the residual proton signals of CDCl 3 and CH 2 Cl 2 respectively. The product is a mixture of two rotational isomers. 1 H NMR (400 MHz, CDCl 3 ): δ 3.44 (t, 0.6H, J=4 Hz), 3.52 (t, 1.4H, J= 4 Hz), 3.69 (t, 0.7H, J= 4 Hz), 3.73 (t, 1.3H, J= 4 Hz), 3.82 (s, 1H), 4.01 (m, 2H), 5.15 (m, 2H), 5.66 (m, 1H), 5.77 (m, 1H), 6.40 (m, 2H); inset: LCMS calculated for (M+H) , observed S35
36 Figure S28 1 H NMR spectra (400 MHz, CDCl 3 ) of 2g; * represents the residual proton signals of CDCl 3. The product is a mixture of two rotational isomers. 1 H NMR (400 MHz, CDCl 3 ): δ 0.88 (t, 3H, J=7.6 Hz), 1.58 (m, 2H), 3.24 (t, 1H, 7.6 Hz), 3.33 (t, 1H, 7.6 Hz), 3.94 (m, 1H), 4.03 (m, 1H),5.15 (m, 2H), 5.64 (m, 1H), 5.77 (m, 1H), 6.44 (m, 2H); inset: LCMS calculated for (M+H) , observed S36
37 Figure S29 1 H NMR spectra (400 MHz, CDCl 3 ) of 2h; * and represent the residual proton signals of CDCl 3 and CH 2 Cl 2 respectively. The product is a mixture of two rotational isomers. 1 H NMR (400 MHz, CDCl 3 ): δ 2.90 (m, 2H), 3.61 (m, 2H), 3.85 (m, 1.1H), 4.04 (m, 0.9H), 5.16 (m, 2H), 5.68 (m, 1H), 5.80 (m, 1H), 6.42 (m, 2H), 7.26 (m, 5H); inset: LCMS calculated for (M+H) , observed S37
38 a c c e g c, c b d f g A f g,g d e a b Figure S30 1 H NMR spectra (400 MHz, CDCl 3 ) of A with assigned proton signals S38
39 Figure S31 1 H NMR spectra (400 MHz, CDCl 3 ) of B with assigned proton signals S39
40 Figure S32 1 H NMR spectra (400 MHz, CDCl 3 ) of C with assigned proton signals S40
41 Figure S33 1 H NMR spectra (400 MHz, CDCl 3 ) of D with assigned proton signals S41
42 Figure S34 1 H NMR spectra (400 MHz, CDCl 3 ) of E with assigned proton signals S42
43 Figure S35 1 H NMR spectra (400 MHz, CDCl 3 ) of F with assigned proton signals S43
SUPPLEMENTARY INFORMATION
Synthetic chemistry ML5 and ML4 were identified as K P.(TREK-) activators using a combination of fluorescence-based thallium flux and automated patch-clamp assays. ML5, ML4, and ML5a were synthesized using
More informationSupporting Material. 2-Oxo-tetrahydro-1,8-naphthyridine-Based Protein Farnesyltransferase Inhibitors as Antimalarials
Supporting Material 2-Oxo-tetrahydro-1,8-naphthyridine-Based Protein Farnesyltransferase Inhibitors as Antimalarials Srinivas Olepu a, Praveen Kumar Suryadevara a, Kasey Rivas b, Christophe L. M. J. Verlinde
More informationSupporting Information for
Page of 0 0 0 0 Submitted to The Journal of Organic Chemistry S Supporting Information for Syntheses and Spectral Properties of Functionalized, Water-soluble BODIPY Derivatives Lingling Li, Junyan Han,
More informationTetrahydrofuran (THF) was distilled from benzophenone ketyl radical under an argon
SUPPLEMENTARY METHODS Solvents, reagents and synthetic procedures All reactions were carried out under an argon atmosphere unless otherwise specified. Tetrahydrofuran (THF) was distilled from benzophenone
More informationSupplemental data. Supplemental Figure 1: Alignment of potential ERRE1 and 2 in human, mouse and rat. PEPCK promoter.
1 Supplemental data A Supplemental Figure 1: Alignment of potential ERRE1 and 2 in human, mouse and rat PEPCK promoter. 2 A B C Supplemental Figure 2: Molecular structures of 4-T analogs. a-b, GSK5182
More informationSupporting Information for
Electronic Supplementary Material (ESI) for New Journal of Chemistry. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2017 Supporting Information for
More informationAziridine in Polymers: A Strategy to Functionalize Polymers by Ring- Opening Reaction of Aziridine
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2015 Electronic Supplementary Information (ESI) Aziridine in Polymers: A Strategy to Functionalize
More informationScalable Synthesis of Fmoc-Protected GalNAc-Threonine Amino Acid and T N Antigen via Nickel Catalysis
Scalable Synthesis of Fmoc-Protected GalNAc-Threonine Amino Acid and T N Antigen via Nickel Catalysis Fei Yu, Matthew S. McConnell, and Hien M. Nguyen* Department of Chemistry, University of Iowa, Iowa
More informationTuning Porosity and Activity of Microporous Polymer Network Organocatalysts by Co-Polymerisation
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supporting Information Tuning Porosity and Activity of Microporous Polymer Network Organocatalysts
More informationElectronic Supplementary Material (ESI) for Medicinal Chemistry Communications This journal is The Royal Society of Chemistry 2012
Supporting Information. Experimental Section: Summary scheme H 8 H H H 9 a H C 3 1 C 3 A H H b c C 3 2 3 C 3 H H d e C 3 4 5 C 3 H f g C 2 6 7 C 2 H a C 3 B H c C 3 General experimental details: All solvents
More informationSupporting Information. A fluorogenic assay for screening Sirt6 modulators
This journal is The Royal Society of Chemistry 213 Supporting Information A fluorogenic assay for screening Sirt6 modulators Jing Hu, Bin He, Shiva Bhargava, Hening Lin* Department of Chemistry and Chemical
More informationSupporting Information
Supporting Information Organocatalytic Enantioselective Formal Synthesis of Bromopyrrole Alkaloids via Aza-Michael Addition Su-Jeong Lee, Seok-Ho Youn and Chang-Woo Cho* Department of Chemistry, Kyungpook
More informationElectronic Supplementary Material
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2016 Electronic Supplementary Material A Novel Functionalized Pillar[5]arene: Synthesis, Assembly
More informationCoupling of 6 with 8a to give 4,6-Di-O-acetyl-2-amino-2-N,3-O-carbonyl-2-deoxy-α-Dglucopyranosyl-(1 3)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose.
General Experimental Procedures. NMR experiments were conducted on a Varian Unity/Inova 400-MHz Fourier Transform NMR Spectrometer. Chemical shifts are downfield from tetramethylsilane in CDCl 3 unless
More informationAll solvents and reagents were used as obtained. 1H NMR spectra were recorded with a Varian
SUPPLEMETARY OTE Chemistry All solvents and reagents were used as obtained. 1H MR spectra were recorded with a Varian Inova 600 MR spectrometer and referenced to dimethylsulfoxide. Chemical shifts are
More informationSupplementary Note 1 : Chemical synthesis of (E/Z)-4,8-dimethylnona-2,7-dien-4-ol (4)
Supplementary Note 1 : Chemical synthesis of (E/Z)-4,8-dimethylnona-2,7-dien-4-ol (4) A solution of propenyl magnesium bromide in THF (17.5 mmol) under nitrogen atmosphere was cooled in an ice bath and
More informationElectronic Supplementary Information for. A Redox-Nucleophilic Dual-Reactable Probe for Highly Selective
Electronic Supplementary Information for A Redox-Nucleophilic Dual-Reactable Probe for Highly Selective and Sensitive Detection of H 2 S: Synthesis, Spectra and Bioimaging Changyu Zhang, 1 Runyu Wang,
More informationSupporting Information
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 214 Supporting Information Rapid and sensitive detection of acrylic acid using a novel fluorescence
More informationSynthesis of borinic acids and borinate adducts using diisopropylaminoborane
Synthesis of borinic acids and borinate adducts using diisopropylaminoborane Ludovic Marciasini, Bastien Cacciuttolo, Michel Vaultier and Mathieu Pucheault* Institut des Sciences Moléculaires, UMR 5255,
More informationKinetics experiments were carried out at ambient temperature (24 o -26 o C) on a 250 MHz Bruker
Experimental Materials and Methods. All 31 P NMR and 1 H NMR spectra were recorded on 250 MHz Bruker or DRX 500 MHz instruments. All 31 P NMR spectra were acquired using broadband gated decoupling. 31
More informationSupporting Information
Supporting Information Synthesis of the natural product Marthiapeptide A Yuqi Zhang 1, Md. Amirul Islam 1 and Shelli R. McAlpine 1* 1 School of Chemistry, University of New South Wales, Sydney, NSW 2052
More informationSynthesis of Peptide-Grafted Comb Polypeptides via Polymerisation of NCA-Peptides
Supporting Information to Synthesis of Peptide-Grafted Comb Polypeptides via Polymerisation of NCA-Peptides Hiroshi Enomoto, Benjamin Nottelet, Soultan Al Halifa, Christine Enjalbal, Mathieu Dupré, Julien
More informationSupporting Information
Supporting Information Total Synthesis of (±)-Grandilodine B Chunyu Wang, Zhonglei Wang, Xiaoni Xie, Xiaotong Yao, Guang Li, and Liansuo Zu* School of Pharmaceutical Sciences, Tsinghua University, Beijing,
More informationElectronic Supplementary Information
Electronic Supplementary Information Proof of Principle for a Molecular 1:2 Demultiplexer to Function as an Autonomously Switching Theranostic Device Sundus Erbas-Cakmak, Ozgur Altan Bozdemir, Yusuf Cakmak,
More information2017 Reaction of cinnamic acid chloride with ammonia to cinnamic acid amide
217 Reaction of cinnamic acid chloride with ammonia to cinnamic acid amide O O Cl NH 3 NH 2 C 9 H 7 ClO (166.6) (17.) C 9 H 9 NO (147.2) Classification Reaction types and substance classes reaction of
More informationSynthesis of Levulinic Acid based Poly(amine-co-ester)s
Electronic Supplementary Material (ESI) for Green Chemistry. This journal is The Royal Society of Chemistry 2018 Synthesis of Levulinic Acid based Poly(amine-co-ester)s Yann Bernhard, Lucas Pagies, Sylvain
More informationSupporting Information
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2016 Supporting Information TEMPO-catalyzed Synthesis of 5-Substituted Isoxazoles from Propargylic
More informationSupporting Information
Supporting Information Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2012 Subcellular Localization and Activity of Gambogic Acid Gianni Guizzunti,* [b] Ayse Batova, [a] Oraphin Chantarasriwong,
More informationSupporting Information For:
Supporting Information For: Peptidic α-ketocarboxylic Acids and Sulfonamides as Inhibitors of Protein Tyrosine Phosphatases Yen Ting Chen, Jian Xie, and Christopher T. Seto* Department of Chemistry, Brown
More informationSupporting Information
Supporting Information Towards Singlet Oxygen Delivery at a Measured Rate: A Selfreporting Photosensitizer Sundus Erbas-Cakmak #, Engin U. Akkaya # * # UNAM-National Nanotechnology Research Center, Bilkent
More informationAn Efficient Total Synthesis and Absolute Configuration. Determination of Varitriol
An Efficient Total Synthesis and Absolute Configuration Determination of Varitriol Ryan T. Clemens and Michael P. Jennings * Department of Chemistry, University of Alabama, 500 Campus Dr. Tuscaloosa, AL
More informationHow to build and race a fast nanocar Synthesis Information
How to build and race a fast nanocar Synthesis Information Grant Simpson, Victor Garcia-Lopez, Phillip Petemeier, Leonhard Grill*, and James M. Tour*, Department of Physical Chemistry, University of Graz,
More informationSupporting Information
Supporting Information Precision Synthesis of Poly(-hexylpyrrole) and its Diblock Copolymer with Poly(p-phenylene) via Catalyst-Transfer Polycondensation Akihiro Yokoyama, Akira Kato, Ryo Miyakoshi, and
More informationSupporting Information. Enantioselective Organocatalyzed Henry Reaction with Fluoromethyl Ketones
Supporting Information Enantioselective Organocatalyzed Henry Reaction with Fluoromethyl Ketones Marco Bandini,* Riccardo Sinisi, Achille Umani-Ronchi* Dipartimento di Chimica Organica G. Ciamician, Università
More informationSupporting information. An improved photo-induced fluorogenic alkene-tetrazole reaction for protein labeling
Supporting information An improved photo-induced fluorogenic alkene-tetrazole reaction for protein labeling X. Shang, 1 R. Lai, 1,3 X. Song, 1 H. Li, 1,3 W. Niu, 2 and J. Guo 1 * 1. Department of Chemistry,
More informationSupporting Information
Supporting Information An Extremely Active and General Catalyst for Suzuki Coupling Reactions of Unreactive Aryl Chlorides Dong-Hwan Lee and Myung-Jong Jin* School of Chemical Science and Engineering,
More informationSupporting Information
Supporting Information Facile polyisobutylene functionalization via thiol-ene Click chemistry Andrew J. D. Magenau, Justin W. Chan, Charles E. Hoyle, and Robson F. Storey School of Polymers and High Performance
More informationSupporting Information for: Tuning the Binding Properties of a New Heteroditopic Salt Receptor Through Embedding in a Polymeric System
Supporting Information for: Tuning the Binding Properties of a ew Heteroditopic Salt Receptor Through Embedding in a Polymeric System Jan Romanski* and Piotr Piątek* Department of Chemistry, University
More informationSUPPLEMENTARY INFORMATION
doi:10.1038/nature24451 Chemical synthesis of USP7 compounds General 1 H, 13 C and 19 F nuclear magnetic resonance (NMR) spectra were obtained on either Bruker or Varian spectrometers at 300 or 400 MHz,
More informationSupporting Text Synthesis of (2 S ,3 S )-2,3-bis(3-bromophenoxy)butane (3). Synthesis of (2 S ,3 S
Supporting Text Synthesis of (2S,3S)-2,3-bis(3-bromophenoxy)butane (3). Under N 2 atmosphere and at room temperature, a mixture of 3-bromophenol (0.746 g, 4.3 mmol) and Cs 2 C 3 (2.81 g, 8.6 mmol) in DMS
More informationSupporting Information. Labeled Ligand Displacement: Extending NMR-based Screening of Protein Targets
Supporting Information Labeled Ligand Displacement: Extending NMR-based Screening of Protein Targets Steven L. Swann, Danying Song, Chaohong Sun, Philip J. Hajduk, and Andrew M. Petros Global Pharmaceutical
More informationThe First Asymmetric Total Syntheses and. Determination of Absolute Configurations of. Xestodecalactones B and C
Supporting Information The First Asymmetric Total Syntheses and Determination of Absolute Configurations of Xestodecalactones B and C Qiren Liang, Jiyong Zhang, Weiguo Quan, Yongquan Sun, Xuegong She*,,
More informationTriazabicyclodecene: an Effective Isotope. Exchange Catalyst in CDCl 3
Triazabicyclodecene: an Effective Isotope Exchange Catalyst in CDCl 3 Supporting Information Cyrille Sabot, Kanduluru Ananda Kumar, Cyril Antheaume, Charles Mioskowski*, Laboratoire de Synthèse Bio-rganique,
More informationSUPPLEMENTARY INFORMATION
doi:10.1038/nature22309 Chemistry All reagents and solvents were commercially available unless otherwise noted. Analytical LC-MS was carried out using a Shimadzu LCMS-2020 with UV detection monitored between
More informationSupporting Information. Identification and synthesis of impurities formed during sertindole
Supporting Information Identification and synthesis of impurities formed during sertindole preparation I. V. Sunil Kumar* 1, G. S. R. Anjaneyulu 1 and V. Hima Bindu 2 for Address: 1 Research and Development
More informationSUPPLEMENTARY INFORMATION
DOI: 10.1038/NCHEM.2346 Iterative exponential growth of stereo- and sequence-controlled polymers Jonathan C. Barnes, Deborah J. C. Ehrlich, Angela X. Gao, Frank A. Leibfarth, Yivan Jiang, Erica Zhou, Timothy
More informationSUPPLEMENTARY INFORMATION
Supplementary Method Synthesis of 2-alkyl-MPT(R) General information (R) enantiomer of 2-alkyl (18:1) MPT (hereafter designated as 2-alkyl- MPT(R)), was synthesized as previously described 1, with some
More informationCurtius-Like Rearrangement of Iron-Nitrenoid Complex and. Application in Biomimetic Synthesis of Bisindolylmethanes
Supporting Information Curtius-Like Rearrangement of Iron-itrenoid Complex and Application in Biomimetic Synthesis of Bisindolylmethanes Dashan Li,, Ting Wu,, Kangjiang Liang,, and Chengfeng Xia*,, State
More informationPhotooxidations of 2-(γ,ε-dihydroxyalkyl) furans in Water: Synthesis of DE-Bicycles of the Pectenotoxins
S1 Photooxidations of 2-(γ,ε-dihydroxyalkyl) furans in Water: Synthesis of DE-Bicycles of the Pectenotoxins Antonia Kouridaki, Tamsyn Montagnon, Maria Tofi and Georgios Vassilikogiannakis* Department of
More informationSupporting Information
Supporting Information ACA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue Willy M. Chang, a Marianna Dakanali, a Christina C. Capule, a Christina J. Sigurdson, b Jerry
More information[(NHC)Au I ]-Catalyzed Acid Free Hydration of Alkynes at Part-Per-Million Catalyst Loadings
SUPPORTING INFORMATION [(NHC)Au I ]-Catalyzed Acid Free Hydration of Alkynes at Part-Per-Million Catalyst Loadings Nicolas Marion, Rubén S. Ramón, and Steven P. Nolan Institute of Chemical Research of
More informationSupporting Information
Supporting Information Wiley-VCH 25 69451 Weinheim, Germany Direct Asymmetric α-fluorination of Aldehydes [**] Derek D. Steiner, Nobuyuki Mase, Carlos F. Barbas III* [*] Prof. Dr. C. F. Barbas III, Derek
More informationMolecular Imaging of Labile Iron(II) Pools in Living Cells with a Turn-on Fluorescent Probe
Supporting Information for Molecular Imaging of Labile Iron(II) Pools in Living Cells with a Turn-on Fluorescent Probe Ho Yu Au-Yeung, Jefferson Chan, Teera Chantarojsiri and Christopher J. Chang* Departments
More informationSupporting Information
Supporting Information (Tetrahedron. Lett.) Cavitands with Inwardly and Outwardly Directed Functional Groups Mao Kanaura a, Kouhei Ito a, Michael P. Schramm b, Dariush Ajami c, and Tetsuo Iwasawa a * a
More informationLight-Controlled Switching of a Non- Photoresponsive Molecular Shuttle
Supporting Information Light-Controlled Switching of a Non- Photoresponsive Molecular Shuttle Liu-Pan Yang, a,b Fei Jia, a Jie-Shun Cui, a Song-Bo Lu, a and Wei Jiang* a a Department of Chemistry, South
More informationSupporting Information
Supporting Information A Rational Design of Highly Controlled Suzuki-Miyaura Catalyst-Transfer Polycondensation for Precision Synthesis of Polythiophenes and their Block Copolymers: Marriage of Palladacycle
More informationSupporting Information. New Strapped Porphyrins as Hosts for Fullerenes: Synthesis and Complexation Study
Supporting Information New Strapped Porphyrins as Hosts for Fullerenes: Synthesis and Complexation Study Jean-Benoît Giguère and Jean-François Morin* Department of Chemistry and Centre de recherche sur
More informationEffect of Conjugation and Aromaticity of 3,6 Di-substituted Carbazole On Triplet Energy
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2018 Electronic Supporting Information (ESI) for Effect of Conjugation and Aromaticity of 3,6 Di-substituted
More informationMolecular Weight Distribution of Living Chains in Polystyrene Pre-pared by Atom Transfer Radical Polymerization
Molecular Weight Distribution of Living Chains in Polystyrene Pre-pared by Atom Transfer Radical Polymerization Joongsuk Oh, a Jiae Kuk, a Taeheon Lee, b Jihwa Ye, b Huyn-jong Paik, b* Hyo Won Lee, c*
More informationSupporting Information for. A New Method for the Cleavage of Nitrobenzyl Amides and Ethers
SI- 1 Supporting Information for A ew Method for the Cleavage of itrobenzyl Amides and Ethers Seo-Jung Han, Gabriel Fernando de Melo, and Brian M. Stoltz* The Warren and Katharine Schlinger Laboratory
More informationSupporting Information Solid Phase Synthesis of Ultra-Photostable Cyanine NIR dye library
Supporting Information Solid Phase Synthesis of Ultra-Photostable Cyanine IR dye library Raj Kumar Das, a Animesh Samanta, a Hyung-Ho Ha, b and Young-Tae Chang a,c * a Department of Chemistry & MedChem
More informationSimplified platensimycin analogues as antibacterial agents
Simplified platensimycin analogues as antibacterial agents Dragan Krsta, a Caron Ka, a Ian T. Crosby, a Ben Capuano a and David T. Manallack a * a Medicinal Chemistry and Drug Action, Monash Institute
More informationStraightforward Synthesis of Enantiopure (R)- and (S)-trifluoroalaninol
S1 Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is (c) The Royal Society of Chemistry 2010 Straightforward Synthesis of Enantiopure (R)- and (S)-trifluoroalaninol Julien
More informationElectronic Supplementary Information
Electronic Supplementary Information General and highly active catalyst for mono and double Hiyama coupling reactions of unreactive aryl chlorides in water Dong-Hwan Lee, Ji-Young Jung, and Myung-Jong
More informationSUPPORTING INFORMATION
Dynamic covalent templated-synthesis of [c2]daisy chains. Altan Bozdemir, a Gokhan Barin, a Matthew E. Belowich, a Ashish. Basuray, a Florian Beuerle, a and J. Fraser Stoddart* ab a b Department of Chemistry,
More informationElectronic Supplementary Information
S1 Electronic Supplementary Information Direct Aerobic Oxidation of 2-Benzylpyridines in a Gas- Liquid Continuous-Flow Regime Using Propylene Carbonate as Solvent Bartholomäus Pieber and C. Oliver Kappe*
More information1. Reagents: All commercial materials were used as received unless otherwise noted. The following solvents were obtained from a JC Meyer solvent dispe
Supporting Information Pd-catalyzed Mono-selective ortho-c H Alkylation of N-Quinolyl Benzamides: Evidence for Stereo-retentive Coupling of Secondary Alkyl Iodides Shu-Yu Zhang, Qiong Li, Gang He, William
More informationSupporting Information. for. Angew. Chem. Int. Ed. Z Wiley-VCH 2003
Supporting Information for Angew. Chem. Int. Ed. Z53001 Wiley-VCH 2003 69451 Weinheim, Germany 1 Ordered Self-Assembly and Electronic Behavior of C 60 -Anthrylphenylacetylene Hybrid ** Seok Ho Kang 1,
More informationSupporting Information:
Supporting Information: Visible Light Initiated Thiol-Michael Addition Polymerizations with Coumarin-based Photo-base Generators, Another Photoclick Reaction Strategy Xinpeng Zhang, Weixian Xi, Chen Wang,
More informationSelective Formation of Benzo[c]cinnoline by Photocatalytic Reduction of 2,2 Dinitrobiphenyl with TiO 2 and UV light irradiation
Electronic Supplementary Material (ESI) for Chemical Communications. This journal is The Royal Society of Chemistry 2015 Content: Selective Formation of Benzo[c]cinnoline by Photocatalytic Reduction of
More informationSupporting Information
Supporting Information Divergent Reactivity of gem-difluoro-enolates towards Nitrogen Electrophiles: Unorthodox Nitroso Aldol Reaction for Rapid Synthesis of -Ketoamides Mallu Kesava Reddy, Isai Ramakrishna,
More informationNew Substrates and Enzyme Assays for the Detection of Mucopolysaccharidosis III (Sanfilippo Syndrome) Types A, B, C and D by Tandem Mass Spectrometry
Supporting Information for: New Substrates and Enzyme Assays for the Detection of Mucopolysaccharidosis III (Sanfilippo Syndrome) Types A, B, C and D by Tandem Mass Spectrometry Brian J. Wolfe, Farideh
More informationAccessory Information
Accessory Information Synthesis of 5-phenyl 2-Functionalized Pyrroles by amino Heck and tandem amino Heck Carbonylation reactions Shazia Zaman, *A,B Mitsuru Kitamura B, C and Andrew D. Abell A *A Department
More informationSupporting Information For:
Supporting Information For: Highly Fluorinated Ir(III)- 2,2 :6,2 -Terpyridine -Phenylpyridine-X Complexes via Selective C-F Activation: Robust Photocatalysts for Solar Fuel Generation and Photoredox Catalysis
More informationSupporting Information for Synthesis of C(3) Benzofuran Derived Bis-Aryl Quaternary Centers: Approaches to Diazonamide A
Fuerst et al. Synthesis of C(3) Benzofuran Derived Bis-Aryl Quaternary Centers: Approaches to Diazonamide A S1 Supporting Information for Synthesis of C(3) Benzofuran Derived Bis-Aryl Quaternary Centers:
More informationAcid-Base Bifunctional Shell Cross-Linked Micelle Nanoreactor for One-pot Tandem Reaction
Supporting Information Acid-Base Bifunctional Shell Cross-Linked Micelle Nanoreactor for One-pot Tandem Reaction Li-Chen Lee, a# Jie Lu, b# Marcus Weck, b * Christopher W. Jones a * a School of Chemical
More informationEfficient Magnesium Catalysts for the Copolymerization of Epoxides and CO 2 ; Using Water to Synthesize Polycarbonate Polyols
Supporting Information for Efficient Magnesium Catalysts for the Copolymerization of Epoxides and CO 2 ; Using Water to Synthesize Polycarbonate Polyols Michael R. Kember, Charlotte K. Williams* Department
More informationTotal Synthesis of (±)-Vibsanin E. Brett D. Schwartz, Justin R. Denton, Huw M. L. Davies and Craig. M. Williams. Supporting Information
Total Synthesis of (±)-Vibsanin E. Brett D. Schwartz, Justin R. Denton, Huw M. L. Davies and Craig M. Williams Supporting Information General Methods S-2 Experimental S-2 1 H and 13 C NMR Spectra S-7 Comparison:
More informationSelective Reduction of Carboxylic acids to Aldehydes Catalyzed by B(C 6 F 5 ) 3
S1 Selective Reduction of Carboxylic acids to Aldehydes Catalyzed by B(C 6 F 5 ) 3 David Bézier, Sehoon Park and Maurice Brookhart* Department of Chemistry, University of North Carolina at Chapel Hill,
More informationSupporting Information
Supporting Information An efficient and general method for the Heck and Buchwald- Hartwig coupling reactions of aryl chlorides Dong-Hwan Lee, Abu Taher, Shahin Hossain and Myung-Jong Jin* Department of
More informationAminoacid Based Chiral N-Amidothioureas. Acetate Anion. Binding Induced Chirality Transfer
Aminoacid Based Chiral -Amidothioureas. Acetate Anion Binding Induced Chirality Transfer Fang Wang, a Wen-Bin He, a Jin-He Wang, a Xiao-Sheng Yan, a Ying Zhan, a Ying-Ying Ma, b Li-Cai Ye, a Rui Yang,
More informationSupporting Information
Supporting Information Incorporation of a Sugar Unit into a C C N Pincer Pd Complex Using Click Chemistry and Its Dynamic Behavior in Solution and Catalytic Ability toward the Suzuki Miyaura Coupling in
More informationSupporting Information. Table of Contents. 1. General Notes Experimental Details 3-12
Supporting Information Table of Contents page 1. General Notes 2 2. Experimental Details 3-12 3. NMR Support for Timing of Claisen/Diels-Alder/Claisen 13 4. 1 H and 13 C NMR 14-37 General Notes All reagents
More informationSupporting Information
Supporting Information N-Heterocyclic Carbene-Catalyzed Chemoselective Cross-Aza-Benzoin Reaction of Enals with Isatin-derived Ketimines: Access to Chiral Quaternary Aminooxindoles Jianfeng Xu 1, Chengli
More informationSupplementary Information
Supplementary Information C aryl -C alkyl bond formation from Cu(ClO 4 ) 2 -mediated oxidative cross coupling reaction between arenes and alkyllithium reagents through structurally well-defined Ar-Cu(III)
More informationElectronic Supplementary Information
Electronic Supplementary Material (ESI) for rganic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2014 Electronic Supplementary Information Visible light-mediated dehydrogenative
More informationSupporting Information
Supporting Information Responsive Prodrug Self-Assembled Vesicles for Targeted Chemotherapy in Combination with Intracellular Imaging Hongzhong Chen, Huijun Phoebe Tham,, Chung Yen Ang, Qiuyu Qu, Lingzhi
More informationElectronic Supplementary Information for: agent. Adam J. Plaunt, Kasey J. Clear, and Bradley D. Smith*
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Electronic Supplementary Information for: 19 F NMR indicator displacement assay using synthetic
More informationSupporting Information
An Improved ynthesis of the Pyridine-Thiazole Cores of Thiopeptide Antibiotics Virender. Aulakh, Marco A. Ciufolini* Department of Chemistry, University of British Columbia 2036 Main Mall, Vancouver, BC
More informationSupporting Information
Supporting Information Novel diphenylmethyl-derived amide protecting group for efficient liquid-phase peptide synthesis; AJIPHASE Daisuke Takahashi*, Tatsuya Yano and Tatsuya Fukui Research Institute For
More informationELECTRONIC SUPPLEMENTARY INFORMATION. Modular Logic Gates: Cascading Independent Logic Gates via Metal Ion Signals
ELECTRONIC SUPPLEMENTARY INFORMATION Modular Logic Gates: Cascading Independent Logic Gates via Metal Ion Signals Esra Tanrıverdi Eçik, 1,2 Ahmet Atılgan 1 Ruslan Guliyev, 3 T.Bilal Uyar, 1 Ayşegül Gümüş
More informationSupplementary Information. Low volume shrinkage polymers by photo Polymerization of 1,1- Bis(ethoxycarbonyl)-2-vinylcyclopropanes
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2015 Supplementary Information Low volume shrinkage polymers by photo Polymerization of 1,1-
More informationRegioselective Silylation of Pyranosides Using a Boronic Acid / Lewis Base Co-Catalyst System
Regioselective Silylation of Pyranosides Using a Boronic Acid / Lewis Base Co-Catalyst System Doris Lee and Mark S. Taylor* Department of Chemistry, Lash Miller Laboratories, University of Toronto 80 St.
More informationElectronic Supplementary Information for
Electronic Supplementary Information for Sequence Selective Dual-Emission Detection of (i, i+1) Bis-Phosphorylated Peptide Using Diazastilbene-Type Zn(II)-Dpa Chemosensor Yoshiyuki Ishida, Masa-aki Inoue,
More informationSupplementary Material (ESI) for Chemical Communications This journal is (c) The Royal Society of Chemistry 2008
Supplementary Information for: Scrambling Reaction between Polymers Prepared by Step-growth and Chain-growth Polymerizations: Macromolecular Cross-metathesis between 1,4-Polybutadiene and Olefin-containing
More informationSupporting Information
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2018 Supporting Information Content Synthesis of compounds 2a, 2b in Scheme
More informationN-[2-(dimethylamino)ethyl]-1,8-naphthalimide Derivatives as Photoinitiators under LEDs
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 18 Supporting Information: -[2-(dimethylamino)ethyl]-1,8-naphthalimide Derivatives as Photoinitiators
More informationAmide Directed Cross-Coupling between Alkenes and Alkynes: A Regio- and Stereoselective Approach to Substituted (2Z,4Z)-Dienamides
Supporting Information For the article entitled Amide Directed Cross-Coupling between Alkenes and Alkynes: A Regio- and Stereoselective Approach to Substituted (2Z,4Z)-Dienamides Keke Meng, Jian Zhang,*
More informationEnantioselective Conjugate Addition of 3-Fluoro-Oxindoles to. Vinyl Sulfone: An Organocatalytic Access to Chiral. 3-Fluoro-3-Substituted Oxindoles
Enantioselective Conjugate Addition of 3-Fluoro-Oxindoles to Vinyl Sulfone: An Organocatalytic Access to Chiral 3-Fluoro-3-Substituted Oxindoles Xiaowei Dou and Yixin Lu * Department of Chemistry & Medicinal
More informationSupporting Information
Supporting Information for Engineering of indole-based tethered biheterocyclic alkaloid meridianin into -carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization
More information