Why study Carbon? Chemistry of Life. Chemistry of Life. Hydrocarbons can grow. Hydrocarbons. Building Blocks. Combinations of C & H

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1 Chemistry of Life Building Blocks Why study Carbon? All of life is built on carbon Cells ~72% 2 O ~25% carbon compounds carbohydrates lipids proteins nucleic acids ~3% salts Na, Cl, K Chemistry of Life Organic chemistry is the study of carbon compounds C atoms are versatile building blocks bonding properties 4 stable covalent bonds Complex molecules assembled like TinkerToys C ydrocarbons Combinations of C & non-polar not soluble in 2 O hydrophobic stable very little attraction between molecules a gas at room temperature methane (simplest C) ydrocarbons can grow 1

2 Isomers Molecules with same molecular formula but different structures (shapes) different chemical properties different biological functions 6 carbons 6 carbons 6 carbons Form affects function Structural differences create important functional significance amino acid alanine L-alanine used in proteins but not D-alanine medicines L-version active but not D-version sometimes with tragic results stereoisomers Form affects function Thalidomide prescribed to pregnant women in 50s & 60s reduced morning sickness, but stereoisomer caused severe birth defects Diversity of molecules Substitute other atoms or groups around the carbon ethane vs. ethanol replaced by a hydroxyl group ( O) nonpolar vs. polar gas vs. liquid biological effects! ethane (C 2 6 ) ethanol (C 2 5 O) Functional groups Parts of organic molecules that are involved in chemical reactions give organic molecules distinctive properties hydroxyl amino carbonyl phosphate Affect reactivity carboxyl makes hydrocarbons hydrophilic increase solubility in water Viva la difference! Basic structure of male & female hormones is identical identical carbon skeleton attachment of different functional groups interact with different targets in the body different effects 2

3 ydroxyl O organic compounds with O = alcohols names typically end in -ol ethanol Carbonyl C=O O double bonded to C if C=O at end molecule = aldehyde if C=O in middle of molecule = ketone Carboxyl COO C double bonded to O & single bonded to O group compounds with COO = acids fatty acids amino acids Amino -N 2 N attached to 2 compounds with N 2 = amines amino acids N 2 acts as base ammonia picks up + from solution Phosphate PO 4 P bound to 4 O connects to C through an O lots of O = lots of negative charge highly reactive transfers energy between organic molecules ATP, GTP, etc. Macromolecules Building Blocks of Life

4 Macromolecules Smaller organic molecules join together to form larger molecules macromolecules 4 major classes of macromolecules: carbohydrates lipids proteins nucleic acids Polymers Long molecules built by linking repeating building blocks in a chain monomers building blocks repeated small units covalent bonds Dehydration synthesis O O 2 O O ow to build a polymer Synthesis joins monomers by taking 2 O out one monomer donates O other monomer donates + together these form 2 O requires energy & enzymes O Dehydration synthesis Condensation reaction O O enzyme 2 O ow to break down a polymer Digestion use 2 O to breakdown polymers reverse of dehydration synthesis cleave off one monomer at a time 2 O is split into + and O + & O attach to ends requires enzymes releases energy ydrolysis Digestion O enzyme O O 2 O Chemistry of Life Properties of Water More about Water Why are we studying water? All life occurs in water inside & outside the cell 4

5 Chemistry of water 2 O molecules form -bonds with each other + attracted to O creates a sticky molecule Elixir of Life Special properties of water 1. cohesion & adhesion surface tension, capillary action 2. good solvent many molecules dissolve in 2 O hydrophilic vs. hydrophobic 3. lower density as a solid ice floats! 4. high specific heat water stores heat 5. high heat of vaporization heats & cools slowly 1. Cohesion & Adhesion ow does 2 O get to top of trees? Cohesion Transpiration is built on cohesion & adhesion bonding between 2 O molecules water is sticky surface tension drinking straw Adhesion bonding between 2 O & other substances capillary action meniscus water climbs up paper towel or cloth 2. Water is the solvent of life Polarity makes 2 O a good solvent polar 2 O molecules surround + & ions solvents dissolve solutes creating solutions What dissolves in water? ydrophilic substances have attraction to 2 O polar or non-polar? 5

6 p What doesn t dissolve in water? ydrophobic substances that don t have an attraction to 2 O polar or non-polar? 3. The special case of ice Most (all?) substances are more dense when they are solid, but not water Ice floats! bonds form a crystal fat (triglycerol) 4. Specific heat 2 O resists changes in temperature high specific heat takes a lot to heat it up takes a lot to cool it down 2 O moderates temperatures on Earth 5. eat of vaporization Evaporative cooling Organisms rely on heat of vaporization to remove body heat Ionization of water & p Water ionizes + splits off from 2 O, leaving O if [ + ] = [ - O], water is neutral if [ + ] > [ - O], water is acidic if [ + ] < [ - O], water is basic p scale how acid or basic solution is O + + O Buffers & cellular regulation p of cells must be kept ~7 p affects shape of molecules shape of molecules affect function therefore p affects cellular function Control p by buffers reservoir of + donate + when [ + ] falls absorb + when [ + ] rises Amount of base added Buffering range 6

7 Any Questions? 7