YOUR PARTNER IN PARTICLE CHARACTERIZATION

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Arleen Cooper
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1 YOUR PARTNER IN PARTICLE CHARACTERIZATION

SERVICES escubed limited provides comprehensive analytical and research and development services in colloidal, particulate and powder technology to customers across all sectors.

2 SERVICES escubed limited provides comprehensive analytical and research and development services in colloidal, particulate and powder technology to customers across all sectors. We have experience and expertise to develop analytical methods, characterize your materials, particle design, understand physical structure-property relationships and to optimize your manufacturing process to maximise your profits. We are proud to be the only UK approved 3rd party independent contract laboratory for Malvern Instruments Limited. Working in partnership with business we provide... GMP method development, validation and Batch Release Research, development and manufacturing support Routine QA analytical services Particle design services Formulation design Problem solving and trouble shooting Expert witness support REACH compliance PARTICLE AND COLLOID CHARACTERIZATION We offer quality assurance and method development work in the following key areas: Particle Size and Distribution Zeta Potential Particle Density Rheology Particle Shape Electron Microscopy Specific Surface Area and Porosity X-Ray Microtomography X-Ray Powder Diffraction Powder Flow Differential Scanning Calorimetry Atomic Force Microscopy Some of the techniques available are outlined in this brochure. If you require other services or the technique or instrument you desire is not listed here please do not hesitate to contact us. Tel: +44 (0) Web: escubed ltd your partner in particle characterization *indicates equipment accessed within University of Leeds

$PARTICLE SIZING We have a range of laser diffraction techniques and instruments which cover the particle size range 0.6nm to 3.5mm.$ $01µm - 3500µm Malvern Mastersizer 2000 Type of Analyser: Laser Diffraction Dispersion Types: Wet and Dry (Hydro G, Hydro S, µp and$ $8467 for Laser Diffraction Measurements Malvern Zetasizer Nano ZS Type of Analyser: Dynamic Light Scattering with NIBS Sample Volume: 12μl$ Measurement Range: 0.6nm 6μm Temperature Range: 2 90 C CPS Disc Centrifuge Type of Analyser: Centifugal Sedimentation Measurement Range: 0.

Measurement Range: 0.6nm 6μm Temperature Range: 2 90 C CPS Disc Centrifuge Type of Analyser: Centifugal Sedimentation Measurement Range: 0.

measurement of small quantities of material.

3 PARTICLE SIZING We have a range of laser diffraction techniques and instruments which cover the particle size range 0.6nm to 3.5mm. Malvern Mastersizer 3000 Type of Analyser: Laser Diffraction Dispersion Types: Wet and Dry (HydroMV, Aero S) Dispersion Cell Volumes: 120ml Measurement Range: 0.01µm µm Malvern Mastersizer 2000 Type of Analyser: Laser Diffraction Dispersion Types: Wet and Dry (Hydro G, Hydro S, µp and Scirocco) Sample Volume: 1000ml, 150ml, 18ml Measurement Range: 0.2μm 2000μm escubed limited is a UKAS accredited testing laboratory No for Laser Diffraction Measurements Malvern Zetasizer Nano ZS Type of Analyser: Dynamic Light Scattering with NIBS Sample Volume: 12μl Measurement Range: 0.6nm 6μm Temperature Range: 2 90 C CPS Disc Centrifuge Type of Analyser: Centifugal Sedimentation Measurement Range: 0.01µm-40µm PARTICLE IMAGING/COUNTING Complementing the laser techniques our on- and off-line imaging/ counting analysers allow the measurement of small quantities of material. Beckman Coulter Counter Multisizer IV Type of Analyser: Electro Zone Sensing Sample Volume: 50μl 2000μl Measurement Range: 0.4µm-1600µm Nanosight LM10 NTA System* Type of Analyser: Nano particle tracking analysis Sample Volume: 500μl and above Measurement Range: 15nm 600nm Retsch AS200 Type of Analyser: Sieve Shaker Sample Volume: up to 3kg Measurement Range: 32µm 4mm

ZETA POTENTIAL Our state-of-the-art facilities enable the measurement of zeta potential in dilute to concentrated suspensions and from nanometer particle sizesup to

5 60 volume percent Sample Volume: 250ml Temperature Range: Ambient Malvern Zetasizer Nano ZS with Titrator Measurement Method: M3 PALS Technology Concentration Range:

75ml Temperature Range: 2 90 C RHEOLOGY Our rheological facility provides data on the flow behaviour of non- Newtonian materials, determination of viscoelastic behaviour

Malvern Instruments Kinexus Ultra Plus Rheometer Measurement Parameters: Yield stress and shear rate Yield stress and shear rate, stress and strain controlled,

creaming effects of materials. Two complementary systems are used for fast and slow settling systems.

4 ZETA POTENTIAL Our state-of-the-art facilities enable the measurement of zeta potential in dilute to concentrated suspensions and from nanometer particle sizesup to granules, fibres, surfaces and plates. Colloidal Dynamics ZetaProbe with Titrator* Measurement Method: Electroacoustic Spectral Analysis Concentration Range: volume percent Sample Volume: 250ml Temperature Range: Ambient Malvern Zetasizer Nano ZS with Titrator Measurement Method: M3 PALS Technology Concentration Range: Sample dependent Sample Volume: Min 0.75ml Temperature Range: 2 90 C RHEOLOGY Our rheological facility provides data on the flow behaviour of non- Newtonian materials, determination of viscoelastic behaviour as a function of time and creep recovery tests. Malvern Instruments Kinexus Ultra Plus Rheometer Measurement Parameters: Yield stress and shear rate Yield stress and shear rate, stress and strain controlled, viscometry, creep and creep recovery, oscillation, interfacial SETTLING The settling properties of emulsions, inks etc are measured to determine the sedimentation and creaming effects of materials. Two complementary systems are used for fast and slow settling systems. Fullbrook Turbiscan LAb Expert* Analysis Method: Gravitational Sample Volume: ~ 20ml Measurement Range: 0.05μm 1μm LUM GmbH Lumifuge 114* Analysis Method: Centrifugal Sample Volume: ~ 1ml Measurement Range: 50nm 1000μm DENSITY MEASUREMENT The density of both porous and non-porous solids are measured using helium displacement. Micromeritics Accupyc 1330 Temperature Range: Ambient Sample Volume: 10ml, 35ml, 100ml Copley JV2000 Pour and Tap Density, Hausner Ratio and Compressibility Ratio Sample Volume: 100ml or 250ml

SPECIFIC SURFACE AREA AND PORE SIZE Complementing our particle size analysis capability, BET surface area and porosimetry measurements on solid

01m²gˉ¹ Support Gases: Nitrogen and Helium Measurement Parameters: BET Measurement Adsorption Isotherms Desorption Isotherms t-plots Pore

to determine the surface properties of the sample.

$2500 Modulated Differntial Scanning Calorimetry X-RAY POWDER DIFFRACTION X-ray powder diffraction (XRD) is a rapid analytical technique$ primarily used for phase identification of a crystalline material and can provide information on unit cell dimensions.

primarily used for phase identification of a crystalline material and can provide information on unit cell dimensions.

interactions and molecular adsorption to different surfaces such as proteins, polymers and cells onto surfaces in a liquid.

5 SPECIFIC SURFACE AREA AND PORE SIZE Complementing our particle size analysis capability, BET surface area and porosimetry measurements on solid materials can be made using gas adsorption. Micromeritics TriStar II 3020 Surface Area Technique: Gas Adsorption Minimum Surface Area: 0.01m²gˉ¹ Support Gases: Nitrogen and Helium Measurement Parameters: BET Measurement Adsorption Isotherms Desorption Isotherms t-plots Pore Volume Analysis Pore Size Analysis SURFACE CONTACT ANGLES Measures the contact angle and surface tensions of substrates using various liquids to determine the surface properties of the sample. KSV Instruments CAM 200* Camera Orientation: Vertical Image Resolution: 512 x 480 pixels Measuring Range: degrees Measurement Parameters: Surface and Interfacial Tension Static Contact Angle Dynamic Contact Angle Surface Free Energy of Solids THERMAL ANALYSIS TA Instruments DSC 2500 Modulated Differntial Scanning Calorimetry X-RAY POWDER DIFFRACTION X-ray powder diffraction (XRD) is a rapid analytical technique primarily used for phase identification of a crystalline material and can provide information on unit cell dimensions. Bruker D8 Advance* QUARTZ CRYSTAL MICROBALANCE WITH DISSIPATION MONITORING (QCM-D) This specialist technique is used to study molecular interactions and molecular adsorption to different surfaces such as proteins, polymers and cells onto surfaces in a liquid. Q-Sense D300* Temperature Range: C Mass Resolution using Sauerbrey: 0.18ng/cm2 Dissipation Resolution: 1 x 10 Sensor Crystals: Gold, Silica, Titania POWDER FLOW COPLEY BEP2 Type of Analysis: Flow through an orifice, Mass vs. time, Angle of Repose, Shear Cell Sample Volume: 50ml to 500ml test dependent.

6 escubed limited, Unit 651 E-H, Street 5, Thorp Arch Estate, Wetherby, LS23 7FZ Tel: +44 (0) Web:

Holographic Characterization of Agglomerates in CMP Slurries

Holographic Characterization of Agglomerates in CMP Slurries Total Holographic Characterization (THC) Comparison of THC to other technologies Dynamic Light Scattering (DLS) Scanning Electron Microscopy