KYORITSU CHEMICAL-CHECK Lab., Corp. Revised 2016/05/20 No.3602 IC Reagent Set 1/6. Safety Data Sheet

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1 1/6 Safety Data Sheet Reference No Issue: 28 th August 2013 Revision: 20 th May Chemical product and company identification Product name IC Reagent Set Model TOC-IC-R Company name KYORITSU CHEMICAL CHECK Lab., Corp. Address 37-11, Den-enchofu 5-chome, Ota-ku, Tokyo , Japan Tel Fax Person in charge Seiji ISHII Recommended uses and restrictions Reagent for water quality measurement 2. Hazards identification [GHS Classification] Physical hazards: Classification not possible (no data for GHS classification available) Health hazards: Acute toxicity (oral): Category 4 Acute toxicity (inhalation: dust, mist): Category 3 Skin corrosion/irritation: Category 1 Serious eye damage/eye irritation: Category 1 Germ cell mutagenicity: Category 2 (applicable only R-1 reagent) Specific target organ toxicity (single exposure): Category 1 (respiratory organs) (applicable R-2 reagent) Specific target organ toxicity (repeated exposure): Category 1 (respiratory organs), Category 2 (liver, hematopoietic organs) For those health hazards not listed above are not classified or classification not possible (no data for GHS classification available) Environmental hazards: Not classified or classification not possible (no data for GHS classification available) [GHS labeling elements] [Signal word] Danger [Hazard statements] Harmful if swallowed. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of causing genetic defects. (applicable only R-1 reagent) Causes damage to respiratory organs. Causes damage to respiratory organs through prolonged or repeated exposure. May cause damage to liver, hematopoietic organs through prolonged or repeated exposure.

2 2/6 [Precautionary statements] Keep out of reach of children and store in the cool, dry, and dark place. Carefully read instructions before use and do not use for other purposes. Wear personal protective equipment if necessary. Do not inhale reagents. Wash contaminated clothing. Wash hands well before and after handling. Avoid release to the environment. 3. Composition/ information on ingredients Discrimination of single substance or mixture: Mixture Reagent name R-1 reagent R-2 reagent Chemical name Strontium chloride hexahydrate Buffer Water Lithium hydroxide monohydrate Extender Content < 5% < 0.01% > 94.99% < 15% > 85% Chemical formula SrCl 2.6H 2 O H 2 O LiOH.H 2 O METI No. (reference number under CSCL in Japan) (1)-261 (1)-712 CAS No Reagent name R-3 reagent Chemical name Potassium dihydrogen Water phosphate Content < 15% > 85% Chemical formula KH 2 PO 4 H 2 O METI No. (reference number under CSCL in (1)-452 Japan) CAS No First-aid measures If reagents or test solutions; Enter in eyes: Immediately rinse with water for more than 15 minutes followed by the treatment by an ophthalmologist. Contact with skin: Immediately wash out contaminated site with plenty of water. Enter into mouth: Immediately rinse mouth with plenty of water. If any symptoms appear after above measures, immediately get medical advice or treatment. Especially in case ingested reagents or test solutions, drink plenty of water or milk and immediately get medical advice or treatment. 5. Fire-fighting measures Extinguishing methods: Suitable extinguishing media: Cut off ignition sources and extinct by a suitable media. Water (mist), powder, carbon dioxide, dry sand. 6. Accidental release measures In case of outdoor use: Avoid spill of reagents and waste solutions. In case of indoor use: If spilled on a table or floor, wipe off immediately spilled reagents and dispose of them. Do not contact with eyes and skin. Concentrated waste solutions should not be released into sewer or rivers.

3 3/6 7. Handling and storage Handling: Reagents or measurement solutions should not contact with eyes or skin and avoid ingestion. Since R-2 reagent and absorption solution are ph12, strongly alkaline and corrosive, care should be made so that contact with eyes, skin or inhalation will not occur. Especially for outdoor use, ensure to bring back reagents, waste solutions after the measurement and used containers. Storage: Avoid direct sunlight and store in a cool, dry and dark place. 8. Exposure controls and personal protection Administrative control level Working environment standard: Not established Occupational exposure limits Japan Society for Occupational health : 1 mg (LiOH)/m 3 (only for Lithium hydroxide monohydrate) ACGIH (TLVs) : Not established OSHA (PEL) : Not established Engineering measures: In case of indoor use it is recommended to be sealed exposure source or install local exhaust ventilation. Install hand and eye washer near handling place and it is recommended to indicate the location. Protective equipment: Recommended to wear protective glasses and gloves 9. Physical and chemical properties Physical state: R-1: liquid reagent 160 ml x 1 poly-bottle in a poly bag R-2: powder reagent 0.05 g x 40 poly-tubes in an aluminum laminated bag R-3: liquid reagent 80 ml x 1 poly-bottle in a poly bag Color: R-1 and R-3: clear and colorless, R-2: white Odor: R-1 ~ R-3: no odor ph: R-1: 6, absorption solution after adding R-2: 12, test solution after measurement: 4 Melting point, boiling point, flash point, ignition point, lower explosion limit, vapor pressure, density, relative density, solubility, Pow, kinetic viscosity: not available as a mixture 10. Stability and reactivity Avoid leaving in a place where high temperature, humid or under direct sunlight. Stable under normal use conditions and no dangerous reactions under specific conditions are expected. No information on hazardous decomposition product is available. 11. Toxicological information No data on mixture is available. Data on each reagent are shown below. R-1 reagent Strontium chloride hexahydrate (no data on solution is available): Acute toxicity (oral): Not classified based on the following data; rat LD 50 = 2,250 mg/kg (CICAD 77(2010)) Germ cell mutagenicity: Classified as Category 2 because of positive results in chromosome tests with bone marrow cell (in vivo genetic mutagenicity assays to body cell) of oral administration in mouse (ATSDR (2004)). Carcinogenicity: Classification not possible because of insufficient data; It was reported (CICAD 77 (2010)) that the effect on reproduction was not observed in the test by drinking water administration over three generations of rats. However it was also described that, the effects on fertility can not be evaluated with this information.(cicad 77 (2010)) Reproductive toxicity: Classification not possible because of insufficient data Specific target organ toxicity (repeated exposure): Classification not possible because of insufficient data; In multiple tests by drinking water administration or diet of rats or mouce, the major findings is the effect on

4 4/6 bone, shows the enhancement of bone sclerosis effect and the excess thickening of the osteoid with the calcification depression. The influence of the growth suppression, the excess thickening of epiphyseal growth plate, and the calcification disorders and the absorption of metaphysis has been reported (IRIS (2002)).These are the findings of a high dose beyond the guidance value range both. NOAEL in test by drinking water administration of rats for nine weeks is 525 mg/kg (conversion value in 90 days as strontium chloride: 658 mg/kg/day). In addition, the influence in test by drinking water administration of rats for three months is not histopathologically observed, and in this case the the dose (conversion value as strontium chloride: 145 mg / kg / day) is beyond the guidance value. Therefore, it is not classified in the oral route, but there is no data for the other route, and the influence is unknown, it is assumed Classification not possible as a classification of specific target organ toxicity (repeated exposure). Water: Acute toxicity: Oral-rat LD 50 >90 ml/kg (used 90g/kg for the calculation of ATEmix below) R-2 reagent Lithium hydroxide monohydrate: Acute toxicity (oral): Category 3 based on the following data; rat-ld50: 210 mg/kg(rtecs(2000)) Acute toxicity (inhalation): Category 3 based on the following data; dust, mist-rat-lc50: 0.96 mg/l 4H Skin corrosion/ irritation: Category 1 based on the following data; No animal data were found, however it is reported Causes skin burns in each of hazard data sources, ICSC (1998), HSFS (2004) and GESTIS (2006). Serious eye damage/ eye irritation: Category 1 based on the following data; No animal data were found, however it is reported Causes serious burns in each of hazard data sources, ICSC (1998) and GESTIS (2006). Specific target organ toxicity (single exposure): Category 1 based on the following data; It is reported that causes respiratory irritation and lung edema in ICSC (1998) and HSFS(2004). Specific target organ toxicity (repeated exposure): Category 1 based on the following data; Effects on respiratory organs were observed in an animal test (RTECS (2000)). It is reported that cough and bronchitis associated with inflammation and breathing difficulty in HSFS (2004). Category 2 based on the following data; Effects on liver and hematopoietic organs were observed in much smaller value than it of Category 1 with oral administration (RTECS (2000)). But it may be a mistake. R-3 reagent Potassium dihydrogen phosphate: Acute toxicity (oral): rat-ldl 0 = 4,640 mg/kg (RTECS) Acute toxicity (skin): rabbit-ld 50 > 4,640 mg/kg (RTECS) Water: Same as above. GHS classifications of each R-1 ~ R-3 reagents are shown below. [Acute toxicity (oral)] R-2 reagent: Classified as Category 4 (Warning, Harmful if swallowed) based on application of the additive equation of LD50 (rat) values of each ingredient. R-1 reagent: Not classified based on application of the additive equation of LD50 (rat) values of each ingredient. [Acute toxicity (inhalation: dust, mist)] R-2 reagent: Classified as Category 3 (Danger, Toxic if inhaled) based on application of the additive equation of LD50 (rat) values of each ingredient. [Skin corrosion/ irritation] R-2 reagent: Classified as Category 1 (Danger, Causes severe skin burns and eye damage.) because ph of R-2 reagent is > [Serious eye damage/ eye irritation] R-2 reagent: Classified as Category 1 (Danger, Causes serious eye damage.) because ph of R-2 reagent is > [Germ cell mutagenicity] R-2 reagent: Classified as Category 2 (Warning, Suspected of causing genetic defects.) because it contains more than or equal to 3% of substance of Category 2.

5 5/6 [Specific target organ toxicity (single exposure)] R-2 reagent: Classified as Category 1 (Danger, Causes damage to respiratory organs.) because it contains more than or equal to 10% of substance of Category 1. [Specific target organ toxicity (repeated exposure)] R-2 reagent: Classified as Category 1 (Danger, Causes damage to respiratory organs through prolonged or repeated exposure.) and Category 2 (Warning, May cause damage to liver, hematopoietic organs through prolonged or repeated exposure.) because it contains more than or equal to 10% of substance of Category 1 (respiratory organs) and Category 2 (liver and hematopoietic system). R-1 ~ R-3 reagents: [Acute toxicity (dermal)], [Acute toxicity (inhalation: vapor)], [Respiratory or skin sensitization], [Carcinogenicity], [Reproductive toxicity], [Aspiration hazard] and R-1 and R-3 reagents: [Acute toxicity (inhalation: dust, mist)], [Skin corrosion/ irritation], [Serious eye damage/ eye irritation], [Specific target organ toxicity (single exposure)], [Specific target organ toxicity (repeated exposure)], R-2 and R-3 reagents: [Germ cell mutagenicity], R-3 reagents: [Acute toxicity (oral)] Classifications are not possible because of data lack. 12. Ecological information No data on mixture is available. Data on each reagent are shown below. R-1 reagent Strontium chloride hexahydrate: Hazardous to the aquatic environment Acute: Not classified because of the following data: Crustacea (Daphnia magna): 48-h EC 50 = 125 mg/l (AQUIRE, 2011) Hazardous to the aquatic environment Chronic: Not classified based on Strontium chloride hexahydrate is not classified as the acute toxicity, and it does not indicate poor water solubility (aqueous solubility = 547 g/l (NITE, 2010)). Harmful effects on the ozone layer: Classification is not possible because the substance is not described in Annex to Montreal Protocol. R-2 reagent Lithium hydroxide monohydrate: Harmful effects on the ozone layer: Classification is not possible because the substance is not described in Annex to Montreal Protocol.. R-3 reagent Potassium dihydrogen phosphate: Harmful effects on the ozone layer: Classification is not possible because the substance is not described in Annex to Montreal Protocol. GHS classifications as a mixture of each R-1, R-2 and R-3 reagents are shown below. [Hazardous to the aquatic environment acute] R-1 reagent: Not classified based on the application of additive equation. R-2 and R-3 reagents: Classifications are not possible because of data lack. [Hazardous to the aquatic environment chronic] R-1 reagent: Not classified based on the application of additive equation. R-2 and R-3 reagents: Classifications are not possible because of data lack. [Harmful effects on the ozone layer]: All reagents: Classification is not possible because each of the substances is not described in Annex to Montreal Protocol. 13. Disposal considerations ph of test solution after measurement is 4, acidic. ph of absorption solution is 12, alkaline. Always dispose according to local regulations.

6 6/6 14. Transport information In addition to precautionary measures regarding handling and storage, avoid rough handling so as not to break containers. It is recommended to ship by air because under high temperature for long period may lead to deterioration. UN number 3262 Proper shipping name: Corrosive solid, Alkaline Inorganic, N.O.S. UN classification: Class 8 (corrosive substances) Packing group: II Civil Aeronautics Act: Same as above. Applicable as Excepted Quantities of Dangerous Goods. Poisonous and Deleterious Substances Control Act: Not applicable (The product is a preparation and not applicable as a deleterious substance) Fire Service Act: Not applicable Total weight of the product: ca.210 g/kit 15. Regulatory information PRTR Act: Not Applicable. Industrial Safety and Health Act: Applicable This product contains more than 0.3% of each of lithium hydroxide monohydrate in R-2 reagent. : Cabinet order, article 18, shall be notified the Name of the substances, #2 : Cabinet order, article 18-2, shall be indicated the Name of the substances, #2 16. Other information Reference literature 15,911 no Kagaku Shouhin, The Chemical Diary Co., Ltd. (2011) NITE, GHS Classification, ID22A4120 Strontium chloride ( ) Material Safety Data Sheet No.JW190418, Wako Pure Chemical Industries, Ltd. ( ) NITE, GHS Classification, ID813 Lithium hydroxide monohydrate ( , ) Material Safety Data Sheet No.JW120121, Wako Pure Chemical Industries, Ltd. ( ) Material Safety Data Sheet No.JW160424, Wako Pure Chemical Industries, Ltd. ( ) Koukuu Kikenbutsu Yusou Houreisyu, Ed. MLIT, HOUBUN SHORIN CO., LTD. (2015) JIS Z 7252:2014 Classification of chemicals based on Globally Harmonized System of Classification and Labelling of Chemicals (GHS) (Japanese Industrial Standards Committee) JIS Z 7253:2012 Hazard communication of chemicals based on GHS-Labelling and Safety Data Sheet (SDS) (Japanese Industrial Standards Committee) UN GHS (tentative translation, forth revised version), GHS Kankei Syocho Renraku Kaigi (2011) Ministry of Economy, Trade and Industry, GHS Classification Guidance for Enterprises 2013 Revised Edition (2013) NOTE) This information is not always exhaustive and use with care. This data sheet only provides information but any description cannot be warranted. Descriptions may possibly be changed because of new findings or modification of the current knowledge. Precautions only cover normal handling. This English SDS is prepared in the cooperation with the Chemicals Evaluation and Research Institute (CERI), Japan.