FACULTY OF PHARMACY UNIVERSITY OF TORONTO. COURSE LENGTH: FALL x ; SPRING: ; YEAR:

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1 FACULTY OF PHARMACY UNIVERSITY OF TORONTO YEAR: COURSE NUMBER: COURSE TITLE: CHM 223H1 Physical Chemistry For Pharmacy REQUIRED: x ELECTIVE: COURSE LENGTH: FALL x ; SPRING: ; YEAR: NUMBER OF HOURS: LECTURE 37.5 TUTORIAL 12 PRACTICAL 0 Term 1 Term 2 COURSE COORDINATOR: Term #1 COORDINATOR: Term #2 COORDINATOR: Name ; Phone Dr. D.F. McIntosh Room 223, Lash Miller Chemical Laboratories, 80 St. George Street, Tel: dmcintos@chem.utoronto.ca N/A INSTRUCTORS: Dr. D.F. McIntosh OFFICE HOUR: Thursdays (3:00 4:00 pm) LM 223 LECTURE HOURS AND LOCATIONS: Tuesdays (3:00 4:30 pm) LM 159 Fridays (2:00 3:30 pm) LM 159 TUTORIAL HOURS, LOCATIONS AND TUTORIAL LEADERS: (A L) Mondays (3:00 4:00 pm) GB 244 Megan Oh (M Z) Mondays (3:00 4:00 pm) GB 248 Brian Lam

2 -2- TEXTBOOK(S): (A) REQUIRED x ; (B) RECOMMENDED Name: Physical Chemistry For The Chemical And Biological Sciences Author: Raymond Chang Publisher: University Science Books Year: 3rd Edition (2000) PREREQUISITES: CHM (138H, 139H / 151Y); MAT (135Y / 137Y / 157Y) COURSE GOALS AND OBJECTIVES: The course goals include: 1: To gain an understanding of the First and Second Laws of Thermodynamics as well as Gibbs Free Energy 2: To apply the concepts from the First and Second Laws of Thermodynamics as well as Gibbs Free Energy to real phenomena. 3: To gain an understanding of solution properties and behaviour. 4: To gain an understanding of equilibria in gaseous systems, solutions, chemical reactions and related systems. 5: To gain an understanding of the kinetics of reactions. RATIONALE FOR INCLUSION IN CURRICULUM: This course provides students with a firm foundation in basic physical chemistry which is a fundamental building block necessary for future courses including pharmaceutics and pharmacokinetics. TEACHING METHOD/FORMAT: The course format consists of two 90 minute lectures delivered each week on Tuesdays and Fridays. In addition there is also a one hour tutorial where assigned problems are discussed by a teaching assistant. STUDENT EVALUATION PROCEDURES: The evaluation procedure includes a midterm test and a final exam worth 45% and 55%, respectively, of the final grade.

3 -3- MISSED TEST/EXAM POLICY: If a student misses a midterm or final exam, s/he must file an appeal or petition with the registrar to seek permission to write a make-up test/exam. If the appeal is approved, s/he may write the make-up test/exam which will then be weighted the same as the missed test/exam. If the appeal is NOT approved, a grade of zero will be assigned for the test/exam. DETAILED COURSE EVALUATION FORMAT: Component % Contribution To Final Grade Midterm test: 45 Final exam: 55 Total: 100

4 -4- DETAILED COURSE OUTLINE: TOPIC HOURS (approx.) Section 1: Review and Definitions 1 Define a system (open, closed, isolated), surroundings, properties of matter Review of gas laws, real gases, ideal gases Section 2: Molecules and their Energies 2 Equipartition of Energy Theorem, Quantum Mechanics Theory Introduction to Heat Capacities Section 3: The First Law of Thermodynamics 5 Revisiting Heat Capacities Definitions and Concepts Define terms: Adiabatic, Diathermic, Isothermal Understand: Work (types of work) and Heat State Functions Introduction to the First Law of Thermodynamics Enthalpy Adiabatic Expansion of an Ideal Gas Thermochemistry Hess s Law Bond Energies and Bond Enthalpies Section 4: The Second Law of Thermodynamics 4 Difference between Spontaneous and Non-Spontaneous Processes Define Entropy in terms of Statistical Probabilities Define Entropy in Terms of Thermodynamics Introduction to Second Law of Thermodynamics Entropy Changes for Systems at Phase Transitions Entropy Changes for Chemical Reactions

5 -5- Section 5: Gibbs Free Energy 4 Definition of Gibbs Energy (G) Review Conditions for Equilibrium and Spontaneous Processes wrt G Standard Molar Gibbs Energy of Formation Dependence of G on T Dependence of G on P The Use of Partial Differentials Section 6: Phase Diagrams and Real Phenomena 4 Phase Diagrams and Phase Equilibria Sample Applications of Thermodynamics and Phase Diagrams Section 7: Non-Electrolyte Solutions and Simple Mixtures 5 Definition of a Non-Electrolyte Solution Units of Concentrations Partial Molar Volume Partial Molar Gibbs Energy Thermodynamics of Mixing Binary Mixtures of Liquids Properties of Solutions Real Solutions Section 8: Chemical Equlibrium 5 Relationship between Gibbs Energy and Equilibrium Constant Chemical Equilibrium in Gaseous Systems Chemical Equilibrium in Solution Heterogeneous Solutions Partial Molal Free Energy Units-Units-Units Influence of Temperature and Catalysts on Equilibrium Constant Principles of Coupled Reactions Equilibrium in Biological Processes

6 -6- Section 9: Kinetics 7.5 Kinetics in Pharmaceutical Science Rates of Reaction Reaction Order Zero Order Reactions First Order Reactions Second Order Reactions Pseudo-First Order Reactions Half-Life of a Reaction Integrated Rate Laws Molecularity of Reactions Unimolecular and Bimolecular Reactions Parallel Reactions (First-Order) Series Reactions (First-Order) Steady-State Approximation Kinetics of Alcohol Absorption Effect of Temperature on Reaction Rate Arrhenius Parameters (Arrhenius Equation) Chain Reactions The Hydrogen-Bromine Reaction Thermal Explosions Chain Branching Explosions Re-visiting Activation Energy and Energetics of a Reaction Theories of Reaction Rates Transition State Theory Thermodynamic Formulation of Transition State Theory Catalysis Enzyme Reactions Kinetics of Enzymatic Reactions The Michaelis-Menten Mechanism Enzyme Inhibition Feedback Mechanism Reversible Inhibition Competitive Inhibition Non-competitive Inhibition Un-competitive Inhibition Isotope Effects in Chemical Reactions Reactions in Solution Oscillating Reactions Total Hours: 37.5

7 -7- CHM 223 Fall Recommended Problems From: Physical Chemistry for the Chemical and Biological Sciences Raymond Chang University Science Books (2000) ** = very highly recommended Chapter 2 1, 3, 5, 6, 7, 8, 9, 10, 12, 15, 17, 20, 23, 27, 31, 43 Chapter 3 6, 41, 44, 46, 48, 52 Chapter 4 1, 3, 4, 5, 6, 10, 11, 13, 14,16, 17, 18, 19, 20, 21, 23, 25**, 26**, 27, 28, 30, 31**, 32, 33**, 35**, 37, 39, 40, 41, 43, 44, 45, 47, 48, 50, 51, 53, 54, 55, 56, 59, 60, 62, 65, 67, 68, 69**, 71, 73, 77, 79, 80, 83**, 84**, 85** Chapter 5 1, 8, 13, 14, 15, 16, 17, 18, 19**, 20, 22, 25, 26, 27, 28, 29**, 30, 32, 38**, 39, 40, 42, 49

8 -8- Chapter 6 1, 3, 6, 7**, 14, 15, 21, 23, 27, 29, 30, 36, 39**, 40**, 41** Chapter 7 1, 2, 3**, 4, 5, 6, 9, 10**, 11, 14, 16, 17**, 19**, 22, 23, 26**, 36, 37, 38**, 47**, 49, 54**, 55, 57, 58** Chapter 9 1, 2, 4, 6, 7, 8, 9, 11, 12, 16, 18, 20, 29, 37 Chapter 12 1, 2, 4, 7**, 9, 10, 11, 12, 14, 15, 19**, 20**, 23, 25, 26, 30, 32, 34**, 35, 36, 39, 41, 45, 50, 51**, 54, 57**, 59, 60**, 61 Chapter 13 2, 4, 5, 6**, 7, 10, 11, 12**, 13**, 14, 15, 17, 27