COMMUNITY COLLEGE OF RHODE ISLAND CHEMISTRY DEPARTMENT. Syllabus and Course Information. for. Survey of Biomedical Chemistry CHEM 1010.

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1 COMMUNITY COLLEGE OF RHODE ISLAND CHEMISTRY DEPARTMENT Syllabus and Course Information for Survey of Biomedical Chemistry CHEM 1010 Fall 2003 Credits: 5 Lecture: 3 hours/week Recitation: 1 hour/week Lab: 3 hours/week Instructor: Nicholas Alteri M.S. Office: 1232 Phone: nalteri@ccri.edu Required Texts: Chemistry An Introduction to General, Organic, & Biological Chemistry, 8 th Edition by Karen Timberlake Laboratory Manual for Fundamentals of General, Organic, and Biological Chemistry, 6 th Edition, by John Holum, et al. Recommended Text: Study Guide with Selected Solutions by Karen Timberlake

2 CHEM-1010 Survey of Biomedical Chemistry 2 SYLLABUS I. Measurements Physical Quantities and Measurements, The Factor-Label Method in Calculations, Accuracy and Precision, SI Units, Density, Temperature II. Atoms and Elements Elements & Symbols, The Periodic Table, Atomic Theory, Atomic Number & Mass Number, Isotopes, Electron Energy Levels III. Nuclear Chemistry Ionizing Radiations-Measurements, Nuclear Equations, Half-Life, Medical Applications of Radionuclides, Fission and Fusion IV. Chemical Compounds and Chemical Bonds Valence Electrons, Ionic Compounds, The Octet Rule, Molecular Compounds, Polyatomic Ions, Polar Molecules, The Fluorapatite Structure V. Chemical Reactions & Stoichiometry Chemical Changes, Chemical Equations, Types of Reactions, The Mole Concept VI. Energy & Matter VII. Solutions Changes of State and Energy, Energy & Chemical Reactions, Chemical Equilibrium Solubility, Concentration Units, Dilution, Dispersions, Dialysis, Osmosis, Colligative Properties VIII. Acids and Bases Acid and Base Theory, Acid/Base Strength, Auto-Ionization of Water, the ph concept, Reactions of Acids & Bases, Buffers IX. Introduction to Organic Chemistry Organic vs. Inorganic Compounds, Structural Features of Organic Molecules, Alkanes and Nomenclature, Physical and Chemical Properties Relative to Functional Groups

3 X. Unsaturated Hydrocarbons 3 Alkenes, Alkynes, Aromatics, Nomenclature, Cis-Trans isomerism, Physical and Chemical Properties, Selected Reactions XI. Organic Compounds with Oxygen and Sulfur Alcohols, Phenols, Thiols, Ethers, Aldehydes, Ketones, Nomenclature, Physical and Chemical Properties, Selected Reactions XII. Carboxylic Acids, Esters, Amines, and Amides Nomenclature, Physical and Chemical Properties, Selected Reactions X. Carbohydrates XI. Lipids XI. Proteins An Overview of Biochemistry, Monosaccharides, Disaccharides, Polysaccharides, Basic Biochemical Reactions Classification of Lipid Types, Physical and Chemical Properties of Triacylglycerols & Phospholipids, Steroids, Role in Cell Membranes Amino Acids-The Building Blocks of Proteins, Primary, Secondary, Tertiary, and Quaternary Structures of Proteins, Physical and Chemical Properties of Proteins, Classifications of Proteins, Enzymes (time permitting), Function, Specificity, Activity, Regulation

4 CHEM-1010 GRADING INFORMATION 4 1. Weekly quizzes will be given during the recitation period. The quiz material will be from the previous week's lectures. Each quiz is worth 10 points. There are no make-ups for missed quizzes, and the best 10 quiz grades will be counted for your grade. 2. There will be three hourly exams given during the semester. The tentative dates are: Friday, October 3, Exam 1 Friday, October 31, Exam 2 Friday, December 5, Exam 3 Each exam is worth 100 points. There are no make-ups for missed exams, but only the best two exam grades will be counted for your grade. 3. A final cumulative examination worth 250 points will be given during the final examination period. The registrar will announce the date of the exam. 4. Laboratory prestudies are worth 10 points each, and are due the Monday before the scheduled laboratory. Late prestudies will not be graded. The best twelve prestudies will be counted for your grade. Laboratory reports are due one week after the experiment date. They are worth 25 points each, and the best twelve labs will be counted. Late lab reports will not be graded. 5. The total number of points possible for the course is 970 points. Grades will be assigned on the following point scale: Graded Items Point Value Point Range Grade Quizzes A Prestudies B Exams C Labs D Final Exam 250 below 582 F Total Points 970

5 W e e k Date Chem 1010 Laboratory Schedule Fall 2003 Lab # Title, Page Prestudy Due 1 Sept. 3 Lab Techniques, Significant Figures Sept. 10 #1 Measurement of Volume, p. 31 #2 Measurement of Mass & Determination of Density, p Sept. 17 #4 Evidence of a Chemical Reaction, p. 43 #5 Heat Energy & Chemical Changes, p. 47 #10 Conservation of Mass, p Sept. 24 #11 Weight Relations in Chemical Changes, p. 71 #12 Moles of Reactants vs. Moles of Products, p Oct. 1 #26 Reactions of Hydronium Ions, p. 147 #28 Tests of Various Ions, p. 155 Start Lab #29, p. 159 Sept. 9 Sept. 16 Sept. 23 Sept Oct. 8 #29 Constituents of Bones & Teeth, p. 155 Oct. 7 7 Oct. 22 #75 Determination of Ascorbic Acid, p. 377 (Bring a sample of juice to lab) 8 Oct. 29 #41 Studies in Structural Organic Chemistry: Isomerism, p. 220 #43 Exercises in Structural Organic Chemistry: Hydrocarbons, p Nov. 5 #44 Structure and Solubility, p. 233 #54 Basicity of Amines, p. 267 #33 Reactions to Stress by Systems in Dynamic Equilibrium, p Nov. 12 #45 Oxidation of Alcohols, p. 237 #48 Oxidation of Carbonyl Compounds, p. 247 #49 Carboxylic Acids & Their Salts, p. 251 Oct. 21 Oct. 28 Nov. 4 Nov Nov. 19 #61 Tests For Carbohydrates, p. 301 Nov Nov. 26 #64 Tests for Lipids, p. 313 #65 Properties & Constituents of a Phospholipid, p Dec. 3 #68 Reactions of Proteins, p. 333 #71 Factors Affecting Enzymatic Activity (Parts C & D), p Dec. 10 #40 Determination of Half-Life, p. 215 Locker check-out Nov. 25 Dec. 2 Dec. 9 From: Fundamentals of General, Organic, & Biological Chemistry, Holum et al, 6 th edition

6 6 Chem 1010 Laboratory Procedure & Reports Working in the chemistry laboratory is not only educational but can also be enjoyable. Chemistry is a "hands-on" subject. In order for you to get the most out of your laboratory you must prepare for the laboratory session by reading the experimental procedures, etc., before you come to the laboratory. You will work individually unless told otherwise. Use the laboratory manual data sheets to enter your data and observations in black ink. If you make a mistake or want to change an entry, just draw one line through the discarded entry and write the new information or value next to it. DO NOT ERASE OR SCRIBBLE OUT DATA! It is expected that you don't copy answers or results form someone else. Any reported work which is not your own could result in a zero grade for that particular laboratory. Your laboratory report must have: a title sheet, an abstract, and the question & data pages from your laboratory manual. The pages must be stapled together in the above order. The title page and abstract must be typed. The title page must include your name, the name(s) and number(s) of the experiments, and the experiment due date. When more than one experiment is done in a laboratory session, only one title page and abstract is required. The abstract is a brief, concise summary of the experiment. It should be no more than two or three paragraphs. Include the purpose, any special techniques, and most importantly, the results. If unknowns are assigned, include the unknown number(s) and the results. Do not include a step-by-step account of procedure! Also, write the abstract in passive voicepast tense. A sample abstract is written below: The Determination of ph of Various Substances, Experiment #30, was conducted to become familiar with the relationship between acids/bases and ph, and to compare different methods of measuring ph. The ph of approximately twenty different substances and two unknowns was measured using a ph meter, ph paper, and seven acid/base indicators. Some of the acid/base indicators used included phenolphthalein, methyl red, and thymol blue. The results show the ph meter to be the most objective way to measure ph. However, values obtained from all three methods were usually consistent. For example, the ph of 0.01 M HCl measured 2.10 with the ph meter, measured 2.4 with ph paper, and measured between 2 and 3 with acid/base indicators. Unknown #34 was determined to have a ph of 5.25, and unknown #54 was measured to have a ph of Since both these ph values are below 7, both unknowns are acidic.

7 Assigned Problems for Chem Timberlake Chapter Review Exercises 1 2, 4, 6, 8, 10, 12, 18, 20, 28, 30, 40, 44, 46, 48, 54, , 8, 10, 12, 14, 16, 20, 26, 30, 32, 34, 40, 42, 46, 58, , 8, 10, 12, 14, 16, 18, 20, 22, 26, 30, 32, 34, 42, , 8, 12, 14, 18, 22, 24, 28, 30, 32, 34, 44, 46, 48, 52, 58, 60, 62, 64, 66, 74, , 4, 6, 12, 14, 16, 20, 22, 24, 26, 28, 32, 38, 40, 42, 44, 50, 52, , 6, 8, 12, 16, 26, 30, 34, 36, 40, , 4, 6, 8, 10, 16, 26, 28, 32, 34, 38, 40, 42, 44, 46, 50, 54, 58, 60, , 4, 6, 8, 10, 12, 14, 16,18, 32, 34, 36, 38, , 4, 6, 10, 12, 14, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 44, , 6, 10, 12, 14, 18, 22, 32, 36, , 6, 8, 12, 16, 18, 20, 22, 24, 26, 28, 32, 34, 36, 38, 40, 42, 54, 60, 62, 70, 72, , 6, 10, 12, 14, 16, 18, 20, 24, 29, 30, 32, 34, 36, 40, 42, 44, 48, 51, 52, 58, 60, 62, , 6, 8, 12, 14, 18, 22, 26, 28, 30, 36, 38, 40, 42, , 4, 6, 8, 14, 22, 24, 30, 32, 34, 38, 42, 44, 46, 48, 54, 56, , 6, 8, 10, 14, 18, 20, 24, 26, 28, 32, 34, 36, 38, 40, 42, 50, 52, 54, 58, 60 The assigned questions/problems will be collected but not returned. Photocopy your work if you want to use it for study purposes. They will be recorded but not graded.