Quadrupole Storage Mass Spectrometry
|
|
- Joy Wiggins
- 6 years ago
- Views:
Transcription
1 Quadrupole Storage Mass Spectrometry RAYMOND E. MARCH AND RICHARD J. HUGHES Trent University Peterborough, Ontario, Canada with a historical review by John F. J. Tbdd University of Kent Canterbury, Kent, England WILEY A WILEY-INTERSCIENCE PUBLICATION JOHN WILEY & SONS New York / Chichester / Brisbane / Toronto / Singapore
2 CONTENTS CHAPTER 1. HISTORICAL REVIEW OF THE DEVELOPMENT OF THE QUADRUPOLE ION TRAP /. F. J. Todd 1 Introduction Principles of Operation 2 l.ii. Utilization of the Quadrupole Ion Trap 6 (i) Mass-Selective Modes of Operation 6 (a) Mass-Selective Detection, 6 (b) Mass-Selective Storage, 13 (ii) Ion Loss Processes 16 (a) Unstable Trajectories, 17 (b) Interactions, 17 (c) Nonlinear Resonances, 21 (d) Self-Emptying, The QUISTOR-Quadrupole Combination 22 l.iv. Theoretical Aspects of Ion Trap Operation 25 I.V. Research Activities with the Quadrupole Ion Trap 28 l.vi. Mass-Selective Ejection 30 CHAPTER 2. THEORY OF QUADRUPOLE MASS SPECTROMETRY 31 Introduction Introduction to the Mathieu Equation 31 2.II. Stability Diagrams 37 2.III. The Complete Solution to the Mathieu Equation 39 2.IV. The Quadrupole Mass Filter 41 (i) Development of the Field Equations 42 xni
3 XIV CONTENTS (ii) Quadrupole Mass Filter Stability Diagram 44 (a) Mass Scanning, 47 (b) Resolution, 49 2.V. The Quadrupole Ion Trap (QUISTOR) 52 (i) Development of the Field Equations 52 (ii) Quadrupole Ion Trap Stability Diagrams 56 (a) Operating Modes, 57 (b) Derivation of the Parameters for Modes I, II, and III, 59 (c) Summary, 62 2.VI. Ion Motion in Quadrupole Fields 63 (i) Numerical Methods 63 (ii) Initial Value Problems 65 (iii) Boundary Value Problems 66 (iv) Matrix Methods 70 (v) Calculation of A, B, Cz n, and ß 71 2.VII. Ion Velocities and Kinetic Energies 74 (i) Introduction 74 (ii) Averaging of Trajectories 74 (iii) Psuedo-Potential Well Method 76 (iv) Phase-Space Dynamics 78 2.VIII. Matrix Methods and Phase-Space Dynamics for Modeling the Quadrupole Ion Trap 88 (i) Introduction 88 (ii) Matrix Methods 89 (iii) Phase-Space Dynamics 94 (a) EUiptical Boundaries in Phase-Space, 97 (b) Application to Quadrupole Device Modeling, 104 (iv) Examples of Practical Calculations 105 (a) Ion Transmission Efficiencies, 105 (b) Ion Energetics, 107 (v) Conclusion 110 CHAPTER 3. THE PHYSICS OF THE ION TRAP 111 Introduction 111
4 CONTENTS XV 3.1. Operational Modes of the Ion Trap 111 (i) Total Storage with In Situ Detection 112 (ii) Total Storage with Pulse-Out Analysis 114 (iii) Mass-Selective Storage with Pulse-Out Detection 117 (iv) Total Storage with Mass-Selective (Axial) Injection II. Ion Trajectory Studies 126 (i) Trajectories in Two-Dimensional Quadrupole Fields 126 (ii) Trajectories in Three-Dimensional Quadrupole Fields 137 (iii) A Simulation Study 145 (a) Introduction, 145 (b) Description of the Program, 145 (c) Residts of the Simulation, III. The Ionic Environment 161 (i) Introduction 161 (ii) An Introduction to Temporal Invariance 164 (iii) Space-Charge Effects 166 (iv) Temporal Invariance Formalism 168 (a) The Evolution of Statistical Properties in the Presence of Space Charge for a Specific Working Condition, 171 (b) Influence of the Drive Frequency on Space-Charge Phenomena, 175 (c) Inf luence of the Working Point, 175 (d) Influence of the Parameter q, 176 (e) Influence of the Parameters ß x,ß z, 176 (f) Summary, IV. QUISTOR Resonant Excitation (QRE) 183 (i) Ionic Oscillations in the Ion Trap 183 (ii) QRE and the Argon System 186 (iii) Resonant Excitation and the Ion Chemistry of 2-Propanol 188 (iv) The Investigation of Space Charge within the Trap V. Sample Calculations 196
5 XVI CONTENTS CHAPTER 4. CHEMISTRY IN THE QUADRUPOLE ION TRAP 209 Introduction Bimolecular Processes II. Proton Affinity Determination 217 (i) Experimental 218 (ii) Ketene 219 (iii) Diacetone Alcohol 220 (iv) Mesityl Oxide 221 (v) Isopropyl Acetate III. Spectroscopy of Gaseous Ions IV. Photochemistry of Gaseous Ions 224 (i) QUISTOR Photodissociation Studies 224 (ii) 2-Propanol 227 (a) Verification ofreaction Pathways, 232 (b) Isotopic Analogues of 2-Propanol, 234 (c) Structure of m/z 79: (CH 3 ) 2 CHOH H + OH 2, 235 (d) Ion Relaxation, 236 (iii) Mixed Associative Ions 239 (iv) IRMPD of Sulfur-Containing Ions 239 (a) Ethanethiol, 239 (b) 1-Propanethiol and 2-Propanethiol, 240 (c) 2-Hydroxyethanethiol, 241 (v) Isomer Differentiation by Multiphoton Dissociation 241 (vi) Photodissociation Rates 245 (vii) Wavelength Dependence of IRMPD V. Photodissociation Using a Fiber-Optic Interface VI. Confinement of Ions Injected into a Quadrupole Ion Trap 258 (i) Ion Injection with Delayed Trapping Potential under Collision-Free Conditions 260 (a) Pidsed Ion Injection, 260 (b) Concentric Ion Beam Injection, 264 (c) Pulsed Ion Injection with Interparticle Interactions, 265
6 CONTENTS xvn (ii) Ion Injection with Continuous Trapping Potential under Collision-Free Conditions 265 (iii) Ion Injection with Continuous Trapping Potential and Collisional Conditions VII. Ejection of Ions Stored in a Quadrupole Ion Trap 269 CHAPTER 5. THE CYLINDRICAL ION TRAP 271 Introduction Theoretical Treatments II. Numerical Analysis 276 (i) Successive Displacement 278 (ii) Overrelaxation 278 (iii) Potential Distributions III. Experimental Ion Storage Traps of Cylindrical Geometry 281 (i) Ion Storage Mass Spectra 282 (ii) Stability Diagram Determination IV. Experimental Stability Diagrams and Mass-Selective Storage Mass Spectra 288 (i) Stability Diagrams 288 (ii) Mass-Selective Storage Mass Spectra 297 (a) Effect of Am Bias, 299 (b) Effect of Storage Time, V. Secular Frequency of Ion Motion VI. Influence of Space Charge on the Maximum Density of Stored Ions VII. Applications of Cylindrical Ion Traps 305 (i) Mechanistic Studies 305 (ii) Metastable Ion Decay Processes 308 (a) Time-Resolved Photoionization Mass Spectrometry, 308 (b) Time-Resolved Cluster Ion Dissociation, 312 (iii) Laser Probing of Trapped Ions VIII. Alternative Geometries for the Radio Frequency Quadrupole Ion Store 315
7 XV1H CONTENTS 5.IX. Ion Trapping Methods X. Conclusion 319 CHAPTER 6. THE FINNIGAN MAT ION TRAP DETECTOR (ITD ) 321 Introduction Ion Trajectory Control II. Ion Trap Detector 323 (i) Gas Chromatography 323 (ii) Gas Chromatography/Mass Spectrometry III. Review of Ion Trap Containment Theory 324 (i) Introduction 324 (ii) Description of the Instrument 325 (iii) Mathieu Equation and Stability Diagram IV. Mass Analysis by Mass-Selective Instability 329 (i) Mass-Selective Instability; Mode of Operation 329 (ii) Effects of Low Molecular Weight Background Gas 331 (iii) Dynamic Range and Detection Limit V. Operating Modes 336 (i) Chemical Ionization Mass Spectral Mode 336 (ii) Tandem Mass Spectrometry 339 (iii) The Ion Trap as a Tandem Mass Spectrometer VI. Automatic Gain Control 344 (i) Mode of Operation 345 (ii) Dynamic Range with Automatic Gain Control VII. Comparisons of the Performance of the Ion Trap Detector 350 (i) Methane Reagent Ion Population 350 (ii) Measurements of Urinary Organic Acids 350 (a) Quantitative Limits, 352 (b) Quantitative Metabolie Profiles, 352
8 CONTENTS XIX (c) Procedure for SmaU Sample Volumes, 354 (d) Conclusion, 357 (iii) Toxicological Application 357 (a) Sensitivity Limits, 357 (b) Sensitivity Comparison, VIII. Miscellaneous Applications 359 (i) Direct Equilibrium Head-Space Analysis with an Ion Trap Detector 359 (ii) Gas Chromatograph-Fourier Transform Infrared Spectrometer-Ion Trap Detector System 360 (iii) Dications in the Ion Trap Detector 361 (iv) Isomer Distinction by Ion/Molecule Reactions 362 (v) Supercritical Fluid Chromatography and Mass Spectrometry with an Ion Trap Detector IX. Conclusion 364 CHAPTER 7. ION TRAP MASS SPECTROMETER (ITMS ) 365 Introduction Tandem Mass Spectrometric Mode 365 (i) Repetitive Tandem Mass Spectrometry 371 (ii) Chemical Ionization Tandem Mass Spectrometry 372 (iii) Isolation of a Single Ion Species in the Ion Trap 373 (iv) Removal of a Single Ion Species from the Ion Trap 378 (v) Internal Energy Control II. Automatic Reaction Control III. Comparison of Performance 383 (i) Comparisons of the Ion Trap Mass Spectrometer with the Triple Quadrupole Mass Spectrometer 383 (a) Collision-Induced Dissociation of Protonated Species, 383 (b) Energy-Resolved Mass Spectra, 384
9 XX CONTENTS (c) Daughter Ion Mass Spectra, 386 (ii) Comparison of the Ion Trap Mass Spectrometer with a Sector Instrument of Reverse Geometry IV. Combined Application of DC and RF Voltages 389 (i) Specific Ion Reactor Mode 390 (ii) Ion Isolation from a Known Environment 391 (iii) Extension of the Mass Range of the Ion Trap Mass Spectrometer V. Fourier Transform Ion Trap Mass Spectrometer VI. Negative Ion Studies in the Ion Trap Mass Spectrometer 398 (i) Introduction 398 (ii) Early Negative Ion Trapping Studies 401 (iii) Negative Ion Storage Studies with an Ion Trap Mass Spectrometer 406 (a) Negative Ion Chemical Ionization Mass Spectrometry, 408 (b) Negative Ion Chemical Ionization Tandem Mass Spectrometry, VII. Conclusion 414 References 415 Bibliography 445 Theses 443 APPENDIX PATENTS ON THE QUADRUPOLE ION TRAP 451 AUTHOR INDEX 457 CHEMICAL INDEX 459 SUBJECT INDEX 463
This is the total charge on an ion divided by the elementary charge (e).
12.2 Fundamentals and general terms Accelerator mass spectrometry An ultra-sensitive technique using tandem accelerators employed mainly for the study of long-lived radioisotopes, and stable isotopes at
More informationINDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY
INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY Edited by AKBAR MONTASER George Washington University Washington, D.C. 20052, USA WILEY-VCH New York Chichester Weinheim Brisbane Singapore Toronto CONTENTS
More informationMass Analyzers. Principles of the three most common types magnetic sector, quadrupole and time of flight - will be discussed herein.
Mass Analyzers After the production of ions in ion sources, the next critical step in mass spectrometry is to separate these gas phase ions according to their mass-to-charge ratio (m/z). Ions are extracted
More informationIon trap. 3D Quadrupole Trap. -Mass spectrometer -Ion trap (Quadrupol Ion Storage, Quistor) 18. April
Ion trap 3D Quadrupole Trap -Mass spectrometer -Ion trap (Quadrupol Ion Storage, Quistor) 18. April 011 1 The trajectories of the ions can be given: They form Mathieu differential equations: with r + Ion
More informationMass Analyzers. Ion Trap, FTICR, Orbitrap. CU- Boulder CHEM 5181: Mass Spectrometry & Chromatography. Prof. Jose-Luis Jimenez
Mass Analyzers Ion Trap, FTICR, Orbitrap CU- Boulder CHEM 5181: Mass Spectrometry & Chromatography Prof. Jose-Luis Jimenez Last Update: Oct. 014 Some slides from Dr. Joel Kimmel (007) MS Interpretation
More informationTypes of Analyzers: Quadrupole: mass filter -part1
16 Types of Analyzers: Sector or double focusing: magnetic and electric Time-of-flight (TOF) Quadrupole (mass filter) Linear ion trap Quadrupole Ion Trap (3D trap) FTICR fourier transform ion cyclotron
More informationHarris: Quantitative Chemical Analysis, Eight Edition
Harris: Quantitative Chemical Analysis, Eight Edition CHAPTER 21: MASS SPECTROMETRY CHAPTER 21: Opener 21.0 Mass Spectrometry Mass Spectrometry provides information about 1) The elemental composition of
More informationFourier Transform Infrared Spectrometry
Fourier Transform Infrared Spectrometry \ ' PETER R. GRIFFITHS Department of Chemistry University of California Riverside, California JAMES A. de HASETH Department of Chemistry University of Georgia Athens,
More informationIntroduction to the Q Trap LC/MS/MS System
www.ietltd.com Proudly serving laboratories worldwide since 1979 CALL +1.847.913.0777 for Refurbished & Certified Lab Equipment ABI Q Trap LC/MS/MS Introduction to the Q Trap LC/MS/MS System The Q Trap
More informationMASS ANALYSER. Mass analysers - separate the ions according to their mass-to-charge ratio. sample. Vacuum pumps
ION ANALYZERS MASS ANALYSER sample Vacuum pumps Mass analysers - separate the ions according to their mass-to-charge ratio MASS ANALYSER Separate the ions according to their mass-to-charge ratio in space
More informationMS/MS .LQGVRI0606([SHULPHQWV
0DVV6SHFWURPHWHUV Tandem Mass Spectrometry (MS/MS) :KDWLV0606" Mass spectrometers are commonly combined with separation devices such as gas chromatographs (GC) and liquid chromatographs (LC). The GC or
More informationFundamentals of Mass Spectrometry. Fundamentals of Mass Spectrometry. Learning Objective. Proteomics
Mass spectrometry (MS) is the technique for protein identification and analysis by production of charged molecular species in vacuum, and their separation by magnetic and electric fields based on mass
More informationTANDEM MASS SPECTROSCOPY
TANDEM MASS SPECTROSCOPY 1 MASS SPECTROMETER TYPES OF MASS SPECTROMETER PRINCIPLE TANDEM MASS SPECTROMETER INSTRUMENTATION QUADRAPOLE MASS ANALYZER TRIPLE QUADRAPOLE MASS ANALYZER TIME OF FLIGHT MASS ANALYSER
More informationFourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS)
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) The first steps along the way to FT- ICR-MS date back to the 1930s, when Ernest Lawrence, at the University of California - Berkeley,
More informationMS Goals and Applications. MS Goals and Applications
MS Goals and Applications 3 Several variations on a theme, three common steps Form gas-phase ions choice of ionization method depends on sample identity and information required Separate ions on basis
More informationWeek 5: Fourier Tranform-based Mass Analyzers: FT-ICR and Orbitrap
Week 5: Fourier Tranform-based Mass Analyzers: FT-ICR and Orbitrap 1 Last Time Mass Analyzers; CAD and TOF mass analyzers: 2 Fourier Transforms A transform is when you change your analytical space without
More information(Refer Slide Time 00:09) (Refer Slide Time 00:13)
(Refer Slide Time 00:09) Mass Spectrometry Based Proteomics Professor Sanjeeva Srivastava Department of Biosciences and Bioengineering Indian Institute of Technology, Bombay Mod 02 Lecture Number 09 (Refer
More informationAccelerator Physics. Tip World Scientific NEW JERSEY LONDON SINGAPORE BEIJING SHANGHAI HONG KONG TAIPEI BANGALORE. Second Edition. S. Y.
Accelerator Physics Second Edition S. Y. Lee Department of Physics, Indiana University Tip World Scientific NEW JERSEY LONDON SINGAPORE BEIJING SHANGHAI HONG KONG TAIPEI BANGALORE Contents Preface Preface
More informationPROTEIN SEQUENCING AND IDENTIFICATION USING TANDEM MASS SPECTROMETRY
PROTEIN SEQUENCING AND IDENTIFICATION USING TANDEM MASS SPECTROMETRY Michael Kinter Department of Cell Biology Lerner Research Institute Cleveland Clinic Foundation Nicholas E. Sherman Department of Microbiology
More informationRADIATION DETECTION AND MEASUREMENT
RADIATION DETECTION AND MEASUREMENT SECOND EDITION GLENN F. KNOLL Professor of Nuclear Engineering The University of Michigan Ann Arbor, Michigan WILEY JOHN WILEY & SONS New York Chichester Brisbane Toronto
More informationMass Spectrometry in MCAL
Mass Spectrometry in MCAL Two systems: GC-MS, LC-MS GC seperates small, volatile, non-polar material MS is detection devise (Agilent 320-MS TQ Mass Spectrometer) Full scan monitoring SIM single ion monitoring
More informationPHYSICAL VAPOR DEPOSITION OF THIN FILMS
PHYSICAL VAPOR DEPOSITION OF THIN FILMS JOHN E. MAHAN Colorado State University A Wiley-Interscience Publication JOHN WILEY & SONS, INC. New York Chichester Weinheim Brisbane Singapore Toronto CONTENTS
More informationIntroduction to GC/MS
Why Mass Spectrometry? Introduction to GC/MS A powerful analytical technique used to: 1.Identify unknown compounds 2. Quantify known materials down to trace levels 3. Elucidate the structure of molecules
More informationThe Aerosol Ion Trap Mass Spectrometer (AIMS): Instrument development and first experimental results
The Aerosol Ion Trap Mass Spectrometer (AIMS): Instrument development and first experimental results A. Kürten 1, J. Curtius 1 and S. Borrmann 1,2 1 Johannes Gutenberg-University Mainz, Germany 2 Max Planck
More informationChemistry 311: Topic 3 - Mass Spectrometry
Mass Spectroscopy: A technique used to measure the mass-to-charge ratio of molecules and atoms. Often characteristic ions produced by an induced unimolecular dissociation of a molecule are measured. These
More informationDiode Lasers and Photonic Integrated Circuits
Diode Lasers and Photonic Integrated Circuits L. A. COLDREN S. W. CORZINE University of California Santa Barbara, California A WILEY-INTERSCIENCE PUBLICATION JOHN WILEY & SONS, INC. NEW YORK / CHICHESTER
More informationLecture 8: Mass Spectrometry
intensity Lecture 8: Mass Spectrometry Relative abundance m/z 1 Ethylbenzene experiment CH 2 CH 3 + m/z = 106 CH 2 + m/z = 91 C 8 H 10 MW = 106 CH + m/z = 77 + 2 2 What information can we get from MS spectrum?
More informationGRADUATE COURSE IN MASS SPECTROMETRY: LECTURE 2
DEPARTMENTS OF CHEMISTRY AND BIOCHEMISTRY GRADUATE COURSE IN MASS SPECTROMETRY: LECTURE 2 Mass Analysers Shabaz Mohammed October 20, 2015 High Vacuum System Turbo pumps Diffusion pumps Rough pumps Rotary
More informationLecture 8: Mass Spectrometry
intensity Lecture 8: Mass Spectrometry Relative abundance m/z 1 Ethylbenzene CH 2 CH 3 + m/z = 106 CH 2 + m/z = 91 C 8 H 10 MW = 106 CH + m/z = 77 + 2 2 What information can be obtained from a MS spectrum?
More informationHuashun Zhang. Ion Sources. With 187 Figures and 26 Tables Э SCIENCE PRESS. Springer
Huashun Zhang Ion Sources With 187 Figures and 26 Tables Э SCIENCE PRESS Springer XI Contents 1 INTRODUCTION 1 1.1 Major Applications and Requirements 1 1.2 Performances and Research Subjects 1 1.3 Historical
More informationX-Rays From Laser Plasmas
X-Rays From Laser Plasmas Generation and Applications I. C. E. TURCU CLRC Rutherford Appleton Laboratory, UK and J. B. DANCE JOHN WILEY & SONS Chichester New York Weinheim Brisbane Singapore Toronto Contents
More informationMS Goals and Applications. MS Goals and Applications
MS Goals and Applications 1 Several variations on a theme, three common steps Form gas-phase ions choice of ionization method depends on sample identity and information required Separate ions on basis
More informationAnswers to questions on exam in laser-based combustion diagnostics on March 10, 2006
Answers to questions on exam in laser-based combustion diagnostics on March 10, 2006 1. Examples of advantages and disadvantages with laser-based combustion diagnostic techniques: + Nonintrusive + High
More informationCEE 772 Lecture #27 12/10/2014. CEE 772: Instrumental Methods in Environmental Analysis
Updated: 10 December 2014 Print version CEE 772: Instrumental Methods in Environmental Analysis Lecture #21 Mass Spectrometry: Mass Filters & Spectrometers (Skoog, Chapt. 20, pp.511 524) (Harris, Chapt.
More informationIon traps. Quadrupole (3D) traps. Linear traps
Ion traps Quadrupole (3D) traps Linear traps 3D-Ion traps A 3D-ion trap can be considered the tridimensional analogue of the linear quadrupole mass analyzer: B A C D The central ring electrode of the 3D-ion
More informationCEE 772: Instrumental Methods in Environmental Analysis
Updated: 10 December 2014 Print version CEE 772: Instrumental Methods in Environmental Analysis Lecture #21 Mass Spectrometry: Mass Filters & Spectrometers (Skoog, Chapt. 20, pp.511-524) (Harris, Chapt.
More informationWADA Technical Document TD2003IDCR
IDENTIFICATION CRITERIA FOR QUALITATIVE ASSAYS INCORPORATING CHROMATOGRAPHY AND MASS SPECTROMETRY The appropriate analytical characteristics must be documented for a particular assay. The Laboratory must
More informationMass Spectrometry. What is Mass Spectrometry?
Mass Spectrometry What is Mass Spectrometry? Mass Spectrometry (MS): The generation of gaseous ions from a sample, separation of these ions by mass-to-charge ratio, and measurement of relative abundance
More informationPRINCIPLES OF PLASMA DISCHARGES AND MATERIALS PROCESSING
PRINCIPLES OF PLASMA DISCHARGES AND MATERIALS PROCESSING Second Edition MICHAEL A. LIEBERMAN ALLAN J, LICHTENBERG WILEY- INTERSCIENCE A JOHN WILEY & SONS, INC PUBLICATION CONTENTS PREFACE xrrii PREFACE
More informationParticle-Induced X-Ray Emission Spectrometry (PIXE)
Particle-Induced X-Ray Emission Spectrometry (PIXE) Edited by SVEN A. E. JOHANSSON Department of Nuclear Physics Lund Institute of Technology Lund, Sweden JOHN L. CAMPBELL Department of Physics University
More informationPractical Quadrupole Theory: Peak Shapes at Various Ion Energies
Practical Quadrupole Theory: Peak Shapes at Various Ion Energies Randall E. Pedder ABB Inc., Analytical-QMS Extrel Quadrupole Mass Spectrometry, 575 Epsilon Drive, Pittsburgh, PA 15238 (Poster presented
More informationfor the Novice Mass Spectrometry (^>, John Greaves and John Roboz yc**' CRC Press J Taylor & Francis Group Boca Raton London New York
Mass Spectrometry for the Novice John Greaves and John Roboz (^>, yc**' CRC Press J Taylor & Francis Group Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Croup, an informa business
More informationInstrumental Analysis. Mass Spectrometry. Lecturer:! Somsak Sirichai
303351 Instrumental Analysis Mass Spectrometry Lecturer:! Somsak Sirichai Mass Spectrometry What is Mass spectrometry (MS)? An analytic method that employs ionization and mass analysis of compounds in
More informationSOLID STATE PHYSICS. Second Edition. John Wiley & Sons. J. R. Hook H. E. Hall. Department of Physics, University of Manchester
SOLID STATE PHYSICS Second Edition J. R. Hook H. E. Hall Department of Physics, University of Manchester John Wiley & Sons CHICHESTER NEW YORK BRISBANE TORONTO SINGAPORE Contents Flow diagram Inside front
More informationThree dimensional Paul traps may benefit from. Linear Quadrupoles with Added Hexapole Fields
Linear Quadrupoles with Added Hexapole Fields Nikolai Konenkov Department of General Physics, Ryazan State Pedagogical University, Ryazan, Russia Frank Londry Pan Galactic Scientific, Omemee, Ontario,
More informationExtrel Application Note
Extrel Application Note Real-Time Plasma Monitoring and Detection of Trace H 2 O and HF Species in an Argon Based Plasma Jian Wei, 575 Epsilon Drive, Pittsburgh, PA 15238. (Presented at the 191st Electrochemical
More informationChemistry Instrumental Analysis Lecture 35. Chem 4631
Chemistry 4631 Instrumental Analysis Lecture 35 Principle components: Inlet Ion source Mass analyzer Ion transducer Pumps Signal processor Mass analyzers Quadrupole Time of Flight Double Focusing Ion
More informationInfrared photodissociation spectroscopy of protonated formic. acid and acetic acid clusters
Infrared photodissociation spectroscopy of protonated formic acid and acetic acid clusters Yoshiya Inokuchi and Nobuyuki Nishi * Institute for Molecular Science, Myodaiji, Okazaki 444-8585, Japan Abstract
More informationAbstract... I. Acknowledgements... III. Table of Content... V. List of Tables... VIII. List of Figures... IX
Abstract... I Acknowledgements... III Table of Content... V List of Tables... VIII List of Figures... IX Chapter One IR-VUV Photoionization Spectroscopy 1.1 Introduction... 1 1.2 Vacuum-Ultraviolet-Ionization
More informationDesign considerations for linear Paul trap mass spectrometer under development
Design considerations for linear Paul trap mass spectrometer under development S.Sevugarajan and A.G.Menon Department of Instrumentation, Indian Institute of Science, Bangalore 561, India. Abstract This
More informationLaser Ionization Mass Analysis
Laser Ionization Mass Analysis Edited by AKOS VERTES George Washington University Washington, D.C. RENAAT GIJBELS FRED ADAMS University of Antwerp (UIA) Antwerp, Belgium A WILEY-INTERSCIENCE PUBLICATION
More informationO WILEY- MODERN NUCLEAR CHEMISTRY. WALTER D. LOVELAND Oregon State University. DAVID J. MORRISSEY Michigan State University
MODERN NUCLEAR CHEMISTRY WALTER D. LOVELAND Oregon State University DAVID J. MORRISSEY Michigan State University GLENN T. SEABORG University of California, Berkeley O WILEY- INTERSCIENCE A JOHN WILEY &
More informationMolecular Mass Spectrometry
Molecular Mass Spectrometry Mass Spectrometry: capable of providing information about (1) Elemental composition of samples of matter: atomic mass (2) Structures of inorganic, organic, and biological molecules
More informationMass Spectrometry. Hyphenated Techniques GC-MS LC-MS and MS-MS
Mass Spectrometry Hyphenated Techniques GC-MS LC-MS and MS-MS Reasons for Using Chromatography with MS Mixture analysis by MS alone is difficult Fragmentation from ionization (EI or CI) Fragments from
More informationVibrational Spectroscopy of Molecules on Surfaces
Vibrational Spectroscopy of Molecules on Surfaces Edited by John T. Yates, Jr. University of Pittsburgh Pittsburgh, Pennsylvania and Theodore E. Madey National Bureau of Standards Gaithersburg, Maryland
More informationINTRODUCTION TO MODERN VIBRATIONAL SPECTROSCOPY
INTRODUCTION TO MODERN VIBRATIONAL SPECTROSCOPY MAX DIEM Department of Chemistry City University of New York Hunter College A Wiley-Interscience Publication JOHN WILEY & SONS New York Chichester Brisbane
More informationTheory and Design for Mechanical Measurements
Theory and Design for Mechanical Measurements Third Edition Richard S. Figliola Clemson University Donald E. Beasley Clemson University John Wiley & Sons, Inc. New York / Chichester / Weinheim / Brisbane
More informationTechnical Note # TN-24 Extending the Capacity in Modern Spherical High Capacity Ion Traps (HCT)
Bruker Daltonics Technical Note # TN-24 Extending the Capacity in Modern Spherical High Capacity Ion Traps (HCT) During the last decade, RF ion traps have become a workhorse of the analytical laboratory
More informationSurface Analysis - The Principal Techniques
Surface Analysis - The Principal Techniques Edited by John C. Vickerman Surface Analysis Research Centre, Department of Chemistry UMIST, Manchester, UK JOHN WILEY & SONS Chichester New York Weinheim Brisbane
More informationFOCUS: VAN BERKEL, 2005 BIEMANN MEDAL AWARDEE Determination of Cooling Rates in a Quadrupole Ion Trap
FOCUS: VAN BERKEL, 2005 BIEMANN MEDAL AWARDEE Determination of Cooling Rates in a Quadrupole Ion Trap David M. Black, Anne H. Payne, and Gary L. Glish Department of Chemistry, University of North Carolina
More informationWolfgang Demtroder. Molecular Physics. Theoretical Principles and Experimental Methods WILEY- VCH. WILEY-VCH Verlag GmbH & Co.
Wolfgang Demtroder Molecular Physics Theoretical Principles and Experimental Methods WILEY- VCH WILEY-VCH Verlag GmbH & Co. KGaA v Preface xiii 1 Introduction 1 1.1 Short Historical Overview 2 1.2 Molecular
More informationCalibration of Particle Instruments in Space Physics
SR-007 September 2007 Calibration of Particle Instruments in Space Physics Editors Martin Wüest INFICON Ltd, Balzers, Principality of Liechtenstein David S. Evans Space Environment Center, NOAA, Boulder
More informationIonization Techniques Part IV
Ionization Techniques Part IV CU- Boulder CHEM 5181 Mass Spectrometry & Chromatography Presented by Prof. Jose L. Jimenez High Vacuum MS Interpretation Lectures Sample Inlet Ion Source Mass Analyzer Detector
More informationRichard Miles and Arthur Dogariu. Mechanical and Aerospace Engineering Princeton University, Princeton, NJ 08540, USA
Richard Miles and Arthur Dogariu Mechanical and Aerospace Engineering Princeton University, Princeton, NJ 08540, USA Workshop on Oxygen Plasma Kinetics Sept 20, 2016 Financial support: ONR and MetroLaser
More informationTHEORY OF MAGNETIC RESONANCE
THEORY OF MAGNETIC RESONANCE Second Edition Charles P. Poole, Jr., and Horacio A. Farach Department of Physics University of South Carolina, Columbia A Wiley-lnterscience Publication JOHN WILEY & SONS
More informationDoctor of Philosophy
FEMTOSECOND TIME-DOMAIN SPECTROSCOPY AND NONLINEAR OPTICAL PROPERTIES OF IRON-PNICTIDE SUPERCONDUCTORS AND NANOSYSTEMS A Thesis Submitted for the degree of Doctor of Philosophy IN THE FACULTY OF SCIENCE
More informationINTRODUCTION TO NUCLEAR AND PARTICLE PHYSICS
INTRODUCTION TO NUCLEAR AND PARTICLE PHYSICS ASHOK DAS THOMAS FERBEL University of Rochester JOHN WILEY & SONS, INC. NEW YORK CHICHESTER BRISBANE TORONTO SINGAPORE CONTENTS Preface and Introduction Apologies
More informationMass Spectrometry. Electron Ionization and Chemical Ionization
Mass Spectrometry Electron Ionization and Chemical Ionization Mass Spectrometer All Instruments Have: 1. Sample Inlet 2. Ion Source 3. Mass Analyzer 4. Detector 5. Data System http://www.asms.org Ionization
More informationFUNDAMENTALS OF POLARIZED LIGHT
FUNDAMENTALS OF POLARIZED LIGHT A STATISTICAL OPTICS APPROACH Christian Brosseau University of Brest, France A WILEY-INTERSCIENCE PUBLICATION JOHN WILEY & SONS, INC. New York - Chichester. Weinheim. Brisbane
More informationFOCUS: QUADRUPOLE ION TRAPS ACCOUNT AND PERSPECTIVE
Matrix Methods for the Calculation of Stability Diagrams in Quadrupole Mass Spectrometry FOCUS: QUADRUPOLE ION TRAPS ACCOUNT AND PERSPECTIVE N. V. Konenkov and M. Sudakov* Department of General Physics,
More informationMass Spectrometry and Proteomics - Lecture 2 - Matthias Trost Newcastle University
Mass Spectrometry and Proteomics - Lecture 2 - Matthias Trost Newcastle University matthias.trost@ncl.ac.uk Previously: Resolution and other basics MALDI Electrospray 40 Lecture 2 Mass analysers Detectors
More informationApplication Note GA-301E. MBMS for Preformed Ions. Extrel CMS, 575 Epsilon Drive, Pittsburgh, PA I. SAMPLING A CHEMICAL SOUP
Application Note MBMS for Preformed Ions, 575 Epsilon Drive, Pittsburgh, PA 15238 (Poster Presented at 45th ASMS Conference on Mass Spectrometry, June 1-5, 1997) In order to accurately characterize a plasma
More informationMass Spectroscopy. Base peak. Molecular Ion peak. The positively charged fragments produced are separated, based on their mass/charge (m/z) ratio. M+.
Mass spectrometry is the study of systems causing the formation of gaseous ions, with or without fragmentation, which are then characteried by their mass to charge ratios (m/) and relative abundances.
More informationTable of Contents... XI
Table of Contents Table of Contents... XI 1 Introduction...1 Learning Objectives...1 1.1 Aims and Scope...3 1.1.1 Filling the Black Box...5 1.2 What Is Mass Spectrometry?...5 1.2.1 Mass Spectrometry...6
More informationChemistry Instrumental Analysis Lecture 34. Chem 4631
Chemistry 4631 Instrumental Analysis Lecture 34 From molecular to elemental analysis there are three major techniques used for elemental analysis: Optical spectrometry Mass spectrometry X-ray spectrometry
More informationTHE OBSERVATION AND ANALYSIS OF STELLAR PHOTOSPHERES
THE OBSERVATION AND ANALYSIS OF STELLAR PHOTOSPHERES DAVID F. GRAY University of Western Ontario, London, Ontario, Canada CAMBRIDGE UNIVERSITY PRESS Contents Preface to the first edition Preface to the
More informationContents. Preface to the First Edition Preface to the Second Edition
Contents Preface to the First Edition Preface to the Second Edition Notes xiii xv xvii 1 Basic Concepts 1 1.1 History 1 1.1.1 The Origins of Nuclear Physics 1 1.1.2 The Emergence of Particle Physics: the
More informationNOVEL INSTRUMENTATION AND METHOD DEVELOPMENT FOR A QUADRUPOLE ION TRAP MASS SPECTROMETER. G. Asher Newsome
NOVEL INSTRUMENTATION AND METHOD DEVELOPMENT FOR A QUADRUPOLE ION TRAP MASS SPECTROMETER G. Asher Newsome A dissertation submitted to the faculty of the University of North Carolina at Chapel Hill in partial
More informationThermo Fisher Scientific, San Jose, CA; 2 Kelleher Lab, Northwestern University, Evanston, IL; 3
Second-Generation Electron Transfer Dissociation (ETD) on the Thermo Scientific Orbitrap Fusion Mass Spectrometer with Improved Functionality, Increased Speed, Christopher Mullen, 1 Lee Earley, 1 Jean-Jacques
More informationIntroduction to Elemental Analysis
Introduction to Elemental Analysis A dust storm charges across the Sahara desert, whipping up sand and blowing it west, towards the ocean. Meanwhile, in the middle of the Atlantic Ocean, a team of scientist
More informationFAIMS Technology at a Glance
FAIMS Technology at a Glance Field asymmetric ion mobility spectrometry (FAIMS), also known as differential mobility spectrometry (DMS), is a gas detection technology that separates and identifies chemical
More informationNUMERICAL METHODS FOR ENGINEERING APPLICATION
NUMERICAL METHODS FOR ENGINEERING APPLICATION Second Edition JOEL H. FERZIGER A Wiley-Interscience Publication JOHN WILEY & SONS, INC. New York / Chichester / Weinheim / Brisbane / Singapore / Toronto
More informationTendenze nell innovazione della strumentazione in spettrometria di massa:
Tendenze nell innovazione della strumentazione in spettrometria di massa: Trappola lineare, orbitrap, ion mobility e nuova strumentazione René Magritte La Condition Humaine 1 Ion Trap Mass Spectrometry
More informationEXPLORING SCANNING PROBE MICROSCOPY WITH MATHEMATICA
EXPLORING SCANNING PROBE MICROSCOPY WITH MATHEMATICA Dror Sarid University of Arizona A WILEY-1NTERSCIENCE PUBLICATION JOHN WILEY & SONS, INC. New York Chichester Weinheim Brisbane Singapore Toronto CONTENTS
More informationInduced Decomposition and
Environmental Health Perspectives Vol. 36, pp. 33-38, 198 Studies of Negative Ions by Collision- Induced Decomposition and Hydrogen-Deuterium Exchange Techniques by Donald F. Hunt,* Satinder K. Sethi,*
More informationLECTURE-11. Hybrid MS Configurations HANDOUT. As discussed in our previous lecture, mass spectrometry is by far the most versatile
LECTURE-11 Hybrid MS Configurations HANDOUT PREAMBLE As discussed in our previous lecture, mass spectrometry is by far the most versatile technique used in proteomics. We had also discussed some of the
More informationMass Spectrometry. Ionizer Mass Analyzer Detector
GCMS Gas Chromatography Used to separate components of a mixture Mixture is injected, vaporized and carried by an inert gas Compounds separate when they interact with the column at different times Retention
More informationMODELING AND SIMULATION OF LOW TEMPERATURE PLASMA DISCHARGES
MODELING AND SIMULATION OF LOW TEMPERATURE PLASMA DISCHARGES Michael A. Lieberman University of California, Berkeley lieber@eecs.berkeley.edu DOE Center on Annual Meeting May 2015 Download this talk: http://www.eecs.berkeley.edu/~lieber
More informationHistory of Mass spectroscopy. Mass Spectroscopy. Introduction... Uses of Mass Spec. Where are Mass Spectrometers Used? Mass Spectroscopy Units
History of Mass spectroscopy Mass Spectroscopy CHEM 466 Upali Siriwardane Marilyn Cox Jim Plamer http://www.chemistry.ohiostate.edu/~allen/587%20w04/587%20w0 4%20130-136%20std.pdf http://www.cem.msu.edu/~cem333/week1
More informationAnalysis of Opioids Using Isotope Dilution with GCMS-TQ8030 GC/MS/MS. No. GCMS No. SSI-GCMS-1401
Gas Chromatograph Mass Spectrometer No. GCMS-1401 Analysis of Opioids Using Isotope Dilution with GCMS-TQ8030 GC/MS/MS Introduction Development of methods for analysis of drugs of abuse has become a high
More informationWolfgang Demtroder. Laser Spectroscopy. Basic Concepts and Instrumentation. Second Enlarged Edition With 644 Figures and 91 Problems.
Wolfgang Demtroder Laser Spectroscopy Basic Concepts and Instrumentation Second Enlarged Edition With 644 Figures and 91 Problems Springer Contents 1. Introduction 1 2. Absorption and Emission of Light
More informationPhysics of and in Ion Traps
Physics of and in Ion Traps Proposed Topics: TRIUMF, Vancouver June 01 Basics of Paul- and Penning-traps (equ. of motion, trap geometries, influence of trap imperfections,) Ion detection and cooling (Buffer
More informationAutoresonant Ion Trap Mass Spectrometer The RGA Alternative
Autoresonant Ion Trap Mass Spectrometer The GA Alternative 1 What is a Mass Spectrometer? Ionizer Mass Spectrometer Mass Separator Magnetic Sector, Quadrupole or Ion Trap Detector Partial Pressure Measurement
More informationPROTEIN NMR SPECTROSCOPY
List of Figures List of Tables xvii xxvi 1. NMR SPECTROSCOPY 1 1.1 Introduction to NMR Spectroscopy 2 1.2 One Dimensional NMR Spectroscopy 3 1.2.1 Classical Description of NMR Spectroscopy 3 1.2.2 Nuclear
More informationRadiochemistry and Nuclear Methods of Analysis
Radiochemistry and Nuclear Methods of Analysis WILLIAM D. EHMANN Professor, Department of Chemistry University of Kentucky Lexington, Kentucky DIANE E. VANCE Staff Development Scientist Analytical Services
More information2101 Atomic Spectroscopy
2101 Atomic Spectroscopy Atomic identification Atomic spectroscopy refers to the absorption and emission of ultraviolet to visible light by atoms and monoatomic ions. It is best used to analyze metals.
More informationThe development of algebraic methods to compute
Ion Energy in Quadrupole Mass Spectrometry Vladimir Baranov MDS SCIEX, Concord, Ontario, Canada Application of an analytical solution of the Mathieu equation in conjunction with algebraic presentation
More informationSmall Signal Gain in DPAL Systems
Physical Sciences Inc. VG11-010 Small Signal Gain in DPAL Systems Kristin L. Galbally-Kinney, Daniel L. Maser, William J. Kessler, Wilson T. Rawlins, and Steven J. Davis 20 New England Business Center
More informationMass spectrometry and elemental analysis
Mass spectrometry and elemental analysis A schematic representation of a single-focusing mass spectrometer with an electron-impact (EI) ionization source. M: + e _ M +. + 2e _ Ionization and fragmentation
More informationThermo Scientific LTQ Orbitrap Velos Hybrid FT Mass Spectrometer
IET International Equipment Trading Ltd. www.ietltd.com Proudly serving laboratories worldwide since 1979 CALL +847.913.0777 for Refurbished & Certified Lab Equipment Thermo Scientific LTQ Orbitrap Velos
More information