Stability Indicating Assay Method for Montelukast Sodium in Pharmaceutical Formulations by RP-HPLC
|
|
- Lizbeth Shields
- 6 years ago
- Views:
Transcription
1 Mastanaiah Thummisetty et al /J. Pharm. Sci. & Res. Vol.3(8), 20, Stability Indicating Assay Method for Montelukast Sodium in Pharmaceutical Formulations by RP-HPLC Mastanaiah Thummisetty a,b,dr. Jayapal Reddy Sama a,b,. V. Surya Narayana Rao b, and. P. Reddanna a a. Department of Animal Sciences, School of Life Sciences, University of Hyderabad, India. b. Department of Chemistry, Sri Krishnadevaraya Univeristy, Anantapur, India. Abstract-Montelukast Sodium is used to treat asthma. A simple, precise cost effective and stability indicating RP-HPLC method has been developed and validated for the determination of Montelukast Sodium in pharmaceutical formulations. Separation of Montelukast Sodium from its potentional degradents were achieved with in shorter run time with required resolution, accuracy and precision thus enabling the utility of the method for routine analysis. Chromatographic separation was achieved on a Zorbax SB Phenyl column( mm,.8μ) using a mobile phase-a consisting of 0.5% trifluro acetic acid in milli-q grade water and mobile phase-b Consist of 0.5% trifluro acetic acid in acetonitrile at a flow rate of.2ml per minute. The detection was made at 238nm. The retention time of Montelukast Sodium was 8.9 minutes. The method was found linear over the range of 5-5 µg per ml. The proposed method was validated as per the ICH and USP guidelines. Key words: Montelukast Sodium, HPLC and validation INTRODUCTION Montelukast sodium( Fig ) is chemically (R-(E))-- (((-(3-(2-(7-chloro-2-quinolinyl) ethenyl)phenyl)- 3(2-(-hydroxy-- methylethyl)phenyl)propyl)thio)methyl)cyclopropan eacetic acid, monosodium salt[ 2]. Montelukast is a leukotriene receptor antagonist (LTRA) used for the treatment of asthma and to relieve symptoms of seasonal allergies in children and adults[3 5]. It is a potent selective inhibitor of leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor cyslt[6 7]. Literature survey reveals that liquid chromatography with fluorescence detector[8], stereoselective high performance liquid chromatography (HPLC) for montelukast and its S-enantiomer[9], column switching HPLC with fluorescence detector[0], semi-automated 96-well protein precipitation[], HPLC with derivative spectroscopy[2], pressurized liquid extraction followed by HPLC[3] and LC-MS methods[4 6] have been reported for the estimation of montelukast sodium. The present study illustrates development and validation of a Stability indicating simple, accurate and precise method for assay of Montelukast sodium by RP-HPLC in bulk and in tablet dosage form. Figure : Chemical Structure of Montelukast Sodium MATERIALS AND METHODS I. Chemicals and Reagents Montelukast Sodium working standards were procured from Cipla Labs, and the tested pharmaceutical formulations were procured from commercial pharmacy. Trifluroacetic acid, acetonitrile, methanol were of suitable analytical grade. II. Apparatus and Chromatographic Conditions HPLC analysis was performed on Agilent HPLC system with diode array detector. Separations were carried on a Zorbax SB Phenyl ( mm, i.d.,.8 μm particle size) using gradient elution. The flow rate was.2 ml min-. UV detection was performed at 238 nm. HPLC Column temperature was 30 C. Peak identity was confirmed by retention time comparison and the HPLC was operated at room temperature. Time Mobile phase A (%) Mobile phase B (%) (Minute) III. Preparation of Mobile Phase Mobile Phase-A: 0.5% of trifluroacetic Acid in milli-q grade water, filtered through a 0.45 μm nylon filter (Millipore, USA) and degassed by sonication prior to use. Mobile Phase-B: 0.5% of trifluroacetic Acid in Acetonitrile, filtered through a 0.45 μm nylon filter (Millipore, USA) and degassed by sonication prior to use. Diluents: Mixed 300ml of milli-q grade water and 700ml of methanol. 373
2 Mastanaiah Thummisetty et al /J. Pharm. Sci. & Res. Vol.3(8), 20, IV. Preparation of Standard Solution The standard solution of mountaleucast 200ppm was prepared by dissolving the working standard in the diluents. V. Preparation of Sample Solution The sample solution of mountaleucast 200ppm was prepared by transferring 0 tablets of 0mg in to 500ml of volumetric flask, added 350 ml of diluents and sonicated for 30minutes with intermediate shaking and made up to volume with diluents. Centrifuged the portion of solution at 4000rpm for 0minutes. RESULTS AND DISCUSSION Method Development Drug quality control, stability, metabolism, pharmacokinetics, and toxicity studies all necessitate the determination of drugs in pharmaceutical formulations and biological samples. Correspondingly, efficient and validated analytical methods are very critical requirements for all these investigations. Chromatographic parameters were preliminary optimized to develop a stability indicating assay method for mountaleucast with short analyses time (<22 min). Since mountaleucast is highly sensitive Figure 2: Chromatogram of Blank to light and oxidation. It tends to degrade while storage for long time. So these degradents need to separate from main analyte to show the stability indicating assay mehod, to separate the degradents from main analyte chosen the gradient program. The sample retention increases with increased column length so a shorter column (50 x 4.6 mm i.d..8µm) was selected to have a shortest possible runtime not compromising on the resolution. In order to identify a suitable organic modifier, various organic solvents like acetonitrile and methanol were tested. Methanol produced high column pressures due to the high viscosity. Acetonitrile was found to display advantageous separations. Various buffers at different ph was verified only trifluro acetic acid is giving the sharp peak compare to other buffers, so trifluro acetic acid at 0.5% was selected. Different gradient programs were tied to separate all the impurities from main analyte with high resolution, optimized the gradient program by choosing initial three minutes isocratic mode followed by linear gradient and initial stabilization mode. Figure 3: Chromatogram of Placebo Figure 4: Chromatogram of Standard Figure 5: Chromatogram of Sample Figure 6: Chromatogram of Spiked Sample 374
3 Mastanaiah Thummisetty et al /J. Pharm. Sci. & Res. Vol.3(8), 20, Method Validation The above method was validated according to ICH and USP guidelines to establish the performance characteristics of a method (expressed in terms of analytical parameters) to meet the requirements for the intended application of the method. System Suitability In order to determine the adequate resolution and reproducibility of the proposed methodology, suitability parameters including retention time, asymmetry factor, %RSD of retention time and peak areas were investigated. The results are summarized in Table. Table: System Suitability Parameter Result Acceptance Criteria Tailing Factor.2 NMT 2.0 %RSD of Peak Area 0.6 NMT 2.0% %RSD of retention time 0.0 NMT 2.0% Specificity The specificity of an analytical method may be defined as the ability to unequivocally determine the analyte in the presence of additional components such as impurities, products and matrix. Specificity was evaluated by preparing the analytical placebo and it was confirmed that the signal measured was caused only by the analytes. A solution of analytical placebo (containing all the tablet excipients except Montelukast was prepared according to the sample preparation procedure and injected. To identify the interference by these excipients, a mixture of inactive ingredients (placebo), standard solutions, and the commercial pharmaceutical preparations were analyzed by the developed method. The representative chromatograms did not show any other peaks, which confirmed the specificity of the method. Peak purity of Montelukast Sodium was also evaluated for confirming the purity of the individual peak of Montelukast.In all the samples Peak purity is more than acceptance limits (Peak purity should be not less than 0.99 on Agilent EZChrom Elite software (version # 3.2.)). Interference from Impurities: All the impurities are Injected indivudialy and spiked into test at 0.3% of test concentration and injected in to the system. All the impurities are well separated from each other and from main analyte. The Spiked chromatogram was shown in Figure- 6. Forced Studies: Drug product and placebo were subjected to forced at various stressed conditions like acid, base, hydrolysis, peroxide, heat, photo light, U.V light and Humidity. All the samples were analyzed for peak purity of Montelukast peak. In all the samples Peak purity is more than acceptance limits. (Peak purity should be not less than 0.99 on Agilent EZChrom Elite software (version # 3.2.)). The results are summarized in Table 2. Table: 2 Forced Degradation Data Sample % Net Procedure condition Acid N HCl on bench top for 2Hrs Alkali N NaOH at 60 C 2Hours Peroxide.0% H 2 O 2 on bench top for Hour Water 60 C for 5Hours UV 200 W /m 2 /hours.2.00 Photolight Thermal Humidity 200 million Lux Hours Peak Purity C for 7 Days % RH at 25 C for 7 days Linearity: The linearity of an analytical procedure is its ability (within a given range) to obtain test results which are directly proportional to the concentration (amount) of analyte in the sample. Linearity of detector response for Montelukast was established by analyzing serial dilutions of a stock solution of the working standard. Five concentrations ranging from 50% to 50% of the test concentration were prepared and analyzed. The final concentration of each solution in µg per ml was plotted against peak area response. Slope, correlation coefficient (R) and intercept were found to be , and The linear graphs was shown in Figure- 7 Figure 7. Linearity graph for Montelukast Precision: The precision of an analytical procedure expresses the closeness of agreement (degree of scatter) between a series of measurements obtained from 375
4 Mastanaiah Thummisetty et al /J. Pharm. Sci. & Res. Vol.3(8), 20, multiple sampling of the same homogeneous sample under the prescribed conditions. Precision may be considered at three levels: repeatability, intermediate precision and reproducibility. Six replicate samples were prepared and analyzed as per the sample preparation procedure. Assay of each replicate, the average of 6 replicates, its standard deviation, %RSD and the 95% confidence interval were calculated.. The results are shown in Table 3. Table: 3 Precision Sample No. % Assay Mean ( X ) 00.9 s %RSD 0.3 Lower 95% CI 00.7 Upper 95% CI 0. Accuracy: The accuracy of an analytical procedure expresses the closeness of agreement between the value which is accepted either as a conventional true value or an accepted reference value and the value found. Recovery study was performed at 50%, 75%, 00%, 25% and 50% of the target concentration by spiking placebo blend with the drug substance. Six replicates each were spiked at 50% & 50% levels, and 3 replicates each at 75%, 00% and 25% levels. Spiked samples were extracted and analyzed. The amount spiked, amount recovered, percent recovery and its mean were calculated. The results are shown in Table 4. Range: The range of an analytical procedure is the interval between the upper and lower concentration (amounts) of analyte in the sample (including these concentrations) for which it has been demonstrated that the analytical procedure has a suitable level of precision, accuracy and linearity. The results are shown in Table 5. Robustness: The robustness of an analytical procedure is a measure of its capacity to remain unaffected by small, but deliberate variations in method parameters and provides an indication of its reliability during normal usage. The variations like flow rate of mobile phase, column temperature, does not have any significant effect on the method performance. Table: 4 Recovery Sample No. Spike Level Amount Spiked, mg Amount Recovered, mg Percent Recovery Mean Percent Recovery % % % % % Table 5: Range Parameter Acceptance Criteria Result Linearity R Precision %RSD of 6 Replicates NMT 2.0% 0.3% to 0.97% Accuracy Recovery 97.0% to 03.0% 99.0%-0.4%
5 Mastanaiah Thummisetty et al /J. Pharm. Sci. & Res. Vol.3(8), 20, CONCLUSIONS A simple, rapid, cost effective and accurate RP- HPLC method was developed for the Stability indicating assay method for Montelukast Sodium in pharmaceutical formulations. The analytical conditions and the solvent system developed provided good resolution between Montelukast Sodium and its potentional degradents within a short run time. The HPLC method was validated and demonstrated good linearity, precision, accuracy, specificity and stability indicating. Thus, the developed HPLC method can be utilized for routine analysis stability studies for Montelukast Tablets. ACKNOWLEDGMENTS The authors are thankful to Cipla labs for providing the working standards of Montelukast Sodium. REFERENCES []. Vanheek M, France C F and Compton D S, Pharmacol Exp Ther., 997, 283, 57. [2]. A. W. Alberts, J. Chen, G. Kuron, V. Hunt, J. Huff, C. Hoffman, J. Rothrock, M. Lopez, H. Joshua, E. Harris, A. Patchett, R. Monaghan, S. Currie, E. Stapley, G. Albers- Schonberg, O. Hensens, J. Hirshfield, K. Hoogsteen, J. Liesch, and J. Springer. Proc. Nati. Acad. Sci. USA. 77, 3957 (980) [3]. Lipka L, Kerzner B and Corbelli J, Am J Cardiol., 2003, 9, 48. [4]. E. Leitersdorf. Int. J. Clin.Pract. 56(2), 6 (2002). [5]. M.Von Heek, C. Farley, D.S. Compton. Br. J. Phamacol. 34, 409 (200). [6]. Melani L, Mills R and Hassman D, Eur Heart J., 2003, 24, 77. [7]. Vuletic M, Cindric M and Kouznjak J D, J Pharm Biomed Anal., 2005, 37, 75. [8]. Carlucci G, and Mazzeo P, J Pharm Biomed Anal., 992, 0, 693. [9]. Ochiai H, Chiyama N K and Imagaki S, J Chromatogr B, 997, 694, 2. [0]. Wang L and Asgharnejad M, J Pharm Biomed Anal., 2000, 2, 243. []. Srinivasu M K, Narasaraju A and Omreddy G, J Pharm Biomed Anal., 2002, 29, 75. [2]. Yang H, Feng Y and Luan Y, J Chromatogr B, 2003, 785, 369. [3]. Tokano T, and Abe S, Biomed Environ Mass Spectrom., 990, 9, 577. [4]. Sistla R, Tata V S S K and Diwan P V, J Pharm Biomed Anal., 2005, 39, 57. [5]. Oswald S, Scheuch E, Cascorbid I. and Siegmund W, J Chromatogr B, 2006, 830,
7. Stability indicating analytical method development and validation of Ramipril and Amlodipine in capsule dosage form by HPLC.
7. Stability indicating analytical method development and validation of and in capsule dosage form by HPLC. 7.1 INSTRUMENTS AND MATERIALS USED 7.1.1 INSTRUMENTS 1. Shimadzu LC-2010 CHT with liquid chromatograph
More informationMethod Development and Validation Of Prasugrel Tablets By RP- HPLC
Method Development and Validation Of Prasugrel Tablets By RP- HPLC K.Sonia*, Ndwabe Hamunyare, K.Manikandan Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM University, Kattankulathur,
More informationStability-indicating HPLC determination of tolterodine tartrate in pharmaceutical dosage form
Indian Journal of Chemical Technology Vol. 13, May 2006, pp. 242-246 Stability-indicating HPLC determination of tolterodine tartrate in pharmaceutical dosage form Vinay Saxena a *, Zahid Zaheer b & Mazhar
More informationVolume 6, Issue 2, January February 2011; Article-015
Research Article DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR THE DETERMINATION OF DAPOXETINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION USING AN EXPERIMENTAL DESIGN Pratik Mehta*, Ujjwal Sahoo,
More informationDETERMINATION OF DRUG RELEASE DURING DISSOLUTION OF NICORANDIL IN TABLET DOSAGE FORM BY USING REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
CHAPTER 9 DETERMINATION OF DRUG RELEASE DURING DISSOLUTION OF NICORANDIL IN TABLET DOSAGE FORM BY USING REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY CHAPTER 9 Determination of drug release during
More informationCHAPTER - IV. Acharya Nagarjuna University, Guntur 105
CHAPTER - IV Acharya Nagarjuna University, Guntur 105 A STABILITY-INDICATING LC METHOD FOR LENALIDOMIDE Lenalidomide, 3-(4-amino-1-oxo-3H-isoindol-2-yl) piperidine-2, 6-dione (fig. 4.1), is a novel oral
More informationDevelopment and Validation of Stability-Indicating RP-HPLC Method for Estimation of Atovaquone
Available online at www.ijpcr.com International Journal of Pharmaceutical and Clinical Research 2012; 4(4): 68-72 Research Article ISSN 0975 1556 Development and Validation of Stability-Indicating RP-HPLC
More informationCHAPTER INTRODUCTION OF DOSAGE FORM AND LITERATURE REVIEW
75 CHAPTER 3 DEVELOPMENT AND APPLICATION OF STABILITY-INDICATING HPLC METHOD FOR THE DETERMINATION OF NEVIRAPINE AND ITS IMPURITIES IN COMBINATION DRUG PRODUCT 3.1 INTRODUCTION OF DOSAGE FORM AND LITERATURE
More informationA Simple, Novel Validated Stability Indicating RP-HPLC method for estimation of Duloxetine HCl in Capsule Pharmaceutical Formulation
Pharmaceutical Research A Simple, Novel Validated Stability Indicating RP-HPLC method for estimation of Duloxetine HCl in Capsule Pharmaceutical Formulation Manisha Puranik* a, Sailesh Wadher b and Kritika
More informationRP-HPLC Method Development and Validation of Dapagliflozin in Bulk and Tablet formulation
221 IJPAR Volume 2 Issue 4 Oct - Dec -2013 ISSN: 2320-2831 Available Online at: [Research article] RP-HPLC Method Development and Validation of Dapagliflozin in Bulk and Tablet formulation Jeyabaskaran.M
More informationInternational Journal of Pharmacy and Pharmaceutical Sciences Vol 2, Issue 1, 2010
International Journal of Pharmacy and Pharmaceutical Sciences Vol 2, Issue 1, 2010 RP HPLC ESTIMATION OF EZETIMIBE IN TABLET DOSAGE FORMS NAGARAJU. P *, KRISHNACHAITHANYA. K, CHANDRABABU. D, SRINIVAS.
More informationISSN: ; CODEN ECJHAO E-Journal of Chemistry , 9(1), 35-42
ISSN: 0973-4945; CODEN ECJHAO E-Journal of Chemistry http://www.e-journals.net 2012, 9(1), 35-42 RP-HPLC Method Development and Validation for the Determination and Stability Indicative Studies of Montelukast
More informationValidation of Stability-Indicating RP-HPLC Method for the Assay of Ibrutinib in Pharmaceutical Dosage form
Validation of Stability-Indicating RP-HPLC Method for the Assay of Ibrutinib in Pharmaceutical Dosage form 8.1 Introduction Ibrutinib (IBR) is an anticancer drug targeting B-cell malignancies (blood cancer
More informationInt. J. Pharm. Sci. Rev. Res., 30(2), January February 2015; Article No. 09, Pages: 63-68
Research Article Stability indicating RP-HPLC Method for Determination of FexoFenadine Hydrochloride and its Related Substances in Active Pharmaceutical Substance Abhay Gupta* 1, Dr. Birendra Srivastava,
More informationImpact factor: 3.958/ICV: 4.10 ISSN:
Impact factor: 3.958/ICV: 4.10 ISSN: 0976-7908 99 Pharma Science Monitor 9(4), Oct-Dec 2018 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com
More informationDEVELOPMENT AND VALIDATION OF RP-HPLC METHOD TO DETERMINE CINITAPRIDE HYDROGEN TARTARATE IN BULK AND PHARMACEUTICAL FORMULATION
Research Article ISSN:2230-7346 Journal of Global Trends in Pharmaceutical Sciences Vol.3, Issue 2, pp -619-627, April June 2012 DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD TO DETERMINE CINITAPRIDE HYDROGEN
More informationSTABILITY INDICATING METHOD OF RELATED IMPURITIES IN VENLAFAXINE HYDROCHLORIDE SUSTAINED RELEASE TABLETS
Issn No: 976-39 RESEARCH ARTICLE STABILITY INDICATING METHOD OF RELATED IMPURITIES IN VENLAFAXINE HYDROCHLORIDE SUSTAINED RELEASE TABLETS CHETLAPALLI SATYA SRINIVAS 1, P.RENUKA DEVI 2 and GAMPA VIJAYAKUMAR*
More informationPraveen kumar.m 1 *, Sreeramulu.J 2. *Corres.author: Mobile no: India.
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.3, No.1, pp 321-328, Jan-Mar 2011 Development and validation of a Stabilityindicating Reversed-Phase High Performance
More informationSIMULTANEOUS RP HPLC DETERMINATION OF CAMYLOFIN DIHYDROCHLORIDE AND PARACETAMOL IN PHARMACEUTICAL PREPARATIONS.
Ind. J. Anal. Chem Vol. 7 11. 2008 SIMULTANEOUS RP HPLC DETERMINATION OF CAMYLOFIN DIHYDROCHLORIDE AND PARACETAMOL IN PHARMACEUTICAL PREPARATIONS. Authors for correspondence : R. R. Singh1*, M. V. Rathnam,
More informationDEVELOPMENT AND VALIDATION OF A STABILITY-INDICATING RP-HPLC METHOD FOR ASSAY OF IRBESARTAN IN PURE AND PHARMACEUTICAL DOSAGE FORM
Research Article DEVELOPMENT AND VALIDATION OF A STABILITY-INDICATING RP-HPLC METHOD FOR ASSAY OF IRBESARTAN IN PURE AND PHARMACEUTICAL DOSAGE FORM Praveen kumar.m 1 *, Sreeramulu.J 2 1 Department of Chemistry,
More informationMashhour Ghanem 1 and Saleh Abu-Lafi 2 * ABSTRACT ARTICLE INFO
. Journal of Applied Pharmaceutical Science Vol. 3 (10), pp. 051-058, October, 2013 Available online at http://www.japsonline.com DOI: 10.7324/JAPS.2013.31009 ISSN 2231-3354 Validation of a Stability-Indicating
More informationKEYWORDS: Acetaminophen, Doxylamine succinate, Dextromethorphan hydrobromide.
International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 6718, ISSN (Print): 2319 670X Volume 3 Issue 7 July 2014 PP.08-12 Analytical method development and validation of acetaminophen,
More informationVALIDATION OF A UPLC METHOD FOR A BENZOCAINE, BUTAMBEN, AND TETRACAINE HYDROCHLORIDE TOPICAL SOLUTION
VALIDATION OF A UPLC METHOD FOR A BENZOCAINE, BUTAMBEN, AND TETRACAINE HYDROCHLORIDE TOPICAL SOLUTION Andrew J. Aubin and Tanya L. Jenkins Waters Corporation, Milford, MA, USA INTRODUCTION Benzocaine (4-Aminobenzoic
More informationSTABILITY INDICATING RP HPLC METHOD FOR ANALYSIS OF DORZOLAMIDE HCl IN THE BULK DRUG AND IT S PHARMACEUTICAL DOSAGE FORM
International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 3, Issue 3, 2011 Research Article STABILITY INDICATING RP HPLC METHOD FOR ANALYSIS OF DORZOLAMIDE HCl IN THE BULK DRUG
More informationDevelopment and Validation of Stability Indicating RP-HPLC Method for the Determination of Anagrelide HCl in Pharmaceutical Formulation
ISSN 0976 3333 Available Online at www.ijpba.info International Journal of Pharmaceutical & Biological Archives 2013; 4(2): 342-346 ORIGINAL RESEARCH ARTICLE Development and Validation of Stability Indicating
More informationSTABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF EPROSARTAN IN PURE AND PHARMACEUTICAL FORMULATION
STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF EPROSARTAN IN PURE AND PHARMACEUTICAL FORMULATION Praveen Kumar.M 1 *, Sreeramulu.J 2 1 Department of chemistry, Rayalaseema University, Kurnool-518002,
More informationSaudi Journal of Medical and Pharmaceutical Sciences
Saudi Journal of Medical and Pharmaceutical Sciences Scholars Middle East Publishers Dubai, United Arab Emirates Website: http://scholarsmepub.com/ ISSN 2413-4929 (Print) ISSN 2413-4910 (Online) Stability
More informationChapter 4: Verification of compendial methods
Chapter 4: Verification of compendial methods Introduction In order to ensure accurate and reliable test results, the quality control laboratory (QCL) needs to use analytical methods (and accompanying
More informationJournal of Pharmaceutical and Biomedical Analysis Letters. Analysis Letters
Naga Jyothi. C et al, JPBMAL, 2015, 3(1): 242 246 ISSN: 2347-4742 Journal of Pharmaceutical and Biomedical Analysis Letters Journal Home Page: www.pharmaresearchlibrary.com/jpbmal Research Article Open
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2014, 5(1):34-39 ISSN: 0976-8688 CODEN (USA): PSHIBD Advance simultaneous determination of paracetamol, thiocolchicoside and aceclofenac
More informationIn the present analytical project, an attempt has been made to develop a simple, economical and reliable liquid
ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF GATIFLOXACIN IN PHARMACEUTICAL FORMULATIONS Syeda kulsum,
More informationAvailable online Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2013, 5(12):1230-1236 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Rapid simultaneous determination of naproxen
More informationResearch Article. Identification and characterization of unknown impurity in zolmitriptan tablets by a sensitive HPLC method
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2014, 6(12):548-553 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Identification and characterization of unknown
More informationIsocraticc Reverse Phase HPLC Method-Determination and Validation of Cilostazol
K. Krishna Chaitanya et al IJCPS, 2013: Vol. 1(4):257-262 ISSN: 2321-3132 Research Article International Journal of Chemistry and Pharmaceutical Sciences IJCPS, 2013: Vol. 1(4): 257-262 (Online at www.pharmaresearchlibrary.com/ijcps)
More informationINTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND LIFE SCIENCES
A. Chenthilnathan et al IJRPLS, 2014, 2(2): 185-190 Research Article Available online at www.pharmaresearchlibrary.com/ijrpls ISSN: 2321-5038 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND LIFE SCIENCES
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(2):274-279 A simple and validated reverse phase HPLC
More informationAnalytical method development and validation of carvedilol in bulk and tablet dosage form by using uv spectroscopic method as per ich guidelines
IJPAR Vol.6 Issue 2 April - June -2017 Journal Home page: ISSN:2320-2831 Research article Open Access Analytical method development and validation of carvedilol in bulk and tablet dosage form by using
More informationDissolution study and method validation of alprazolam by high performance liquid chromatography method in pharmaceutical dosage form
Research Journal of Recent Sciences ISSN 2277-252 Dissolution study and method validation of alprazolam by high performance liquid chromatography method in pharmaceutical dosage form Abstract Rele Rajan
More informationTEMPLATE FOR AN EXAMPLE STANDARD TEST METHOD
APPENDIX V TEMPLATE FOR AN EXAMPLE STANDARD TEST METHOD Validating Chromatographic Methods. By David M. Bliesner Copyright 2006 John Wiley & Sons, Inc. 159 160 APPENDIX V Title: Effective: Document No:
More informationApplication Note. Author. Abstract. Pharmaceutical QA/QC. Siji Joseph Agilent Technologies, Inc. Bangalore, India
Effective use of pharmacopeia guidelines to reduce cost of chromatographic analysis Optimized, cost-effective HPLC analysis of atorvastatin by varying column dimensions within the USP allowed limts
More informationA Stability Indicating UPLC Method for Candesartan in Bulk Drug Samples
American Journal of Analytical Chemistry, 2012, 3, 704-709 http://dx.doi.org/10.4236/ajac.2012.310093 Published nline ctober 2012 (http://www.scirp.org/journal/ajac) A Stability Indicating UPLC Method
More informationDEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC ASSAY METHOD OF ZOLMITRIPTAN IN PURE AND PHARMACEUTICAL DOSAGE FORMS
RESEARCH ARTICLE DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC ASSAY METHOD OF ZOLMITRIPTAN IN PURE AND PHARMACEUTICAL DOSAGE FORMS K.PARAMESWARA RAO, G.V.RAMANA Department of Chemistry, Andhara
More informationQuantitation of Sodium Bisulfite in Pharmaceutical Formulation by RP-HPLC
Quantitation of Sodium Bisulfite in Pharmaceutical Formulation by RP-HPLC Chapter-3 Overview: The present chapter deals with the determination of sodium bisulfite (inorganic compound) as antioxidant in
More informationDevelopment and Validation of a HPLC Method for Determination of Anastrozole in Tablet Dosage Form
ISSN: 0973-4945; CODEN ECJHAO E- Chemistry http://www.e-journals.net 2011, 8(2), 794-797. Development and Validation of a HPLC Method for Determination of Anastrozole in Tablet Dosage Form D.SATHIS KUMAR
More informationDevelopment of Validated Analytical Method of Mefenamic Acid in an Emulgel (Topical Formulation)
Development of Validated Analytical Method of Mefenamic Acid in an Emulgel (Topical Formulation) TEENA OSWAL*, DR.SURYAKANT BHOSALE, DR. SONALI NAIK MET Institute Of Pharmacy Met Complex, Bandra Reclamation,
More informationInternational Journal of Pharmaceutical Research & Analysis
149 International Journal of Pharmaceutical Research & Analysis e-issn: 2249 7781 Print ISSN: 2249 779X www.ijpra.com RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE
More informationResearch Article METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ELBASVIR AND GRAZOPREVIR BY RP-HPLC
ISSN 2395-3411 Available online at www.ijpacr.com 248 Research Article METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ELBASVIR AND GRAZOPREVIR BY RP-HPLC Mantha Vebkatesh* and A. Yasodha
More informationASEAN GUIDELINES FOR VALIDATION OF ANALYTICAL PROCEDURES
ASEAN GUIDELINES FOR VALIDATION OF ANALYTICAL PROCEDURES Adopted from ICH Guidelines ICH Q2A: Validation of Analytical Methods: Definitions and Terminology, 27 October 1994. ICH Q2B: Validation of Analytical
More informationA RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF PARA- PHENYLENEDIAMINE IN PURE FORM AND IN MARKETED PRODUCTS
A RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF PARA- PHENYLENEDIAMINE IN PURE FORM AND IN MARKETED PRODUCTS CH.MOUNIKA*, M.KINNERA Research Article SIR.C.R.REDDY COLLEGE OF PHARMACEUTICAL SCIENCES, ELURU.
More information2.1 2,3 Dichloro Benzoyl Cyanide (2,3 DCBC) and survey of. manufactured commonly for the bulk drug industry, few references were
. Introduction.,3 Dichloro Benzoyl Cyanide (,3 DCBC) and survey of analytical methods,3-dcbc substance, is the although advanced intermediate,3-dcbc is a of lamotrigine well-known bulk drug chemical manufactured
More informationAnalytical Method Development and Validation of Lafutidine in Tablet dosage form by RP-HPLC
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol. 3, No.3, pp 1403-1407, July-Sept 2011 Analytical Method Development and Validation of Lafutidine in Tablet dosage form
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEX: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE
More informationJournal of Chemical and Pharmaceutical Research, 2017, 9(10): Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2017, 9(10):286-293 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development and Validation of UPLC Method for the
More informationMethod Development and Validation for the Estimation of Darunavir in Rat Plasma by RP-HPLC
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More informationDevelopment and validation of RP-LC method for lisinopril dihydrate in bulk and its pharmaceutical formulations
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (7):340-344 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CDEN: DPLEB4
More informationJournal of Chemical and Pharmaceutical Research, 2017, 9(1): Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2017, 9(1):118-122 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development and Validation of High Performance Liquid
More informationJournal of Chemical and Pharmaceutical Research, 2012, 4(6): Research Article. Estimation of zaleplon by a new RP-HPLC method
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2012, 4(6):3010-3014 Research Article ISS : 0975-7384 CODE(USA) : JCPRC5 Estimation of zaleplon by a new RP-HPLC method Tentu.
More informationWork plan & Methodology: HPLC Method Development
Work plan & Methodology: HPLC Method Development The HPLC analytical Method developed on the basis of it s chemical structure, Therapeutic category, Molecular weight formula, pka value of molecule, nature,
More informationDevelopment And Validation Of Rp-Hplc Method For Determination Of Velpatasvir In Bulk
International Journal of Engineering Science Invention (IJESI) ISSN (Online): 2319 6734, ISSN (Print): 2319 6726 www.ijesi.org PP. 36-41 Development And Validation Of Rp-Hplc Method For Determination Of
More informationDevelopment and validation a RP-HPLC method: Application for the quantitative determination of quetiapine fumarate from marketed bulk tablets
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2016, 8(1):142-146 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Development and validation a RP-HPLC method: Application
More informationDevelopment and Validation of a HPLC Method for Chlorphenamine Maleate Related Substances in Multicomponents Syrups and Tablets
Development and Validation of a HPLC Method for Chlorphenamine Maleate Related Substances in s Syrups and Tablets Larisa Alagić-Džambić*, Midhat Vehabović, Edina Čekić, Mirsad Džambić Development Department,
More informationDEVELOPMENT AND VALIDATION OF ULTRA PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ASSAY OF OMEPRAZOLE BLEND
Page38 Research Article Biological Sciences DEVELOPMENT AND VALIDATION OF ULTRA PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ASSAY OF OMEPRAZOLE BLEND M.N Brinda 1*, Dr. V. Krishna Reddy 1, E.Sasikiran
More informationJ Pharm Sci Bioscientific Res (4): ISSN NO
Development and Validation of Stability Indicating Analytical Method for Simultaneous Estimation of Perindopril and Potassium in Their Combined Marketed Dosage Form ABSTRACT: Gurjeet Kaur*, Nikhil Patel
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Chemica Sinica, 2011, 2 (2): 230-239 ISSN: 0976-8505 CODEN (USA) CSHIA5 Stress degradation studies on Iloperidone and development of a stabilityindicating
More informationSimultaneous HPLC Determination of Methocarbamol, Paracetamol and Diclofenac Sodium
ISSN: 0973-4945; CODEN ECJHAO E- Chemistry http://www.e-journals.net 2011, 8(4), 1620-1625 Simultaneous HPLC Determination of Methocarbamol, Paracetamol and Diclofenac Sodium DESHMUKH HAFSA, S. CHANDA
More informationANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF IVABRADINE HCL IN BULK AND FORMULATION
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF IVABRADINE HCL IN BULK AND FORMULATION Gauri Korgaonkar *, Vaishali B. Jadhav, Ashish Jain Shri d.d. vispute college of pharmacy & research center, Panvel,
More informationA NEW HPLC METHOD FOR THE QUANTIFICATION OF PANTOPRAZOLE IN PHARMACEUTICALS
Int. J. Chem. Sci.: 6(2), 2008, 579-586 A NEW HPLC METHOD FOR THE QUANTIFICATION OF PANTOPRAZOLE IN PHARMACEUTICALS K. BASAVAIAH, U. R. ANIL KUMAR and K. THARAPA Department of Chemistry, University of
More informationJournal of Drug Delivery and Therapeutics
Available online on 15.01.2018 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research 2011-17, publisher and licensee JDDT, This is an Open
More informationResearch Article. Figure 1. Chemical structure of doxofylline. Indonesian J. Pharm. Vol. 24 No. 1 : ISSN-p :
Research Article Indonesian J. Pharm. Vol. 24 No. 1 : 14 21 ISSN-p : 0126-1037 DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHY AND SPECTROSCOPIC METHODS FOR THE ANALYSIS OF DOXOFYLLINE IN PHARMACEUTICAL
More informationAnalytical method development and validation of gabapentin in bulk and tablet dosage form by using UV spectroscopic method
IJPAR Vol.6 Issue 2 April - June -2017 Journal Home page: www.ijpar.com ISSN:2320-2831 Research article Open Access Analytical method development and validation of gabapentin in bulk and tablet dosage
More informationDevelopment and Validation of Sensitive RP-HPLC Method for the Estimation of Glibenclamide in Pure and Tablet Dosage Forms
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (15):101-106 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationChapter-4 EXPERIMENTAL WORK BY RP-HPLC
Chapter-4 EXPERIMENTAL WORK BY RP-HPLC 4.0 EXPERIMENTAL WORK BY RP-HPLC 4.1. DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR THE DETERMINATION OF NIFLUMIC ACID 4.1.1. MATERIALS AND METHODS OF NIFLUMIC
More informationDevelopment and validation of stability indicating reverse phase high performance liquid chromatography method for Timolol Maleate
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.6, No.5, pp 1429-1435, Sept-Oct 2014 Development and validation of stability indicating reverse phase high performance
More informationValidated spectrophotometric determination of Fenofibrate in formulation
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2010, 1 (1): 173-178 Validated spectrophotometric determination of Fenofibrate in formulation Krishna R. Gupta*, Sonali S. Askarkar,
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2010, 2(5):399-417 Method develpopment and validation of Hydrochloride
More informationRapid and simultaneous determination of paracetamol, ibuprofen and related impurity of ibuprofen by UPLC/DAD
Pharmaceutical Sciences Asia Pharm Sci Asia 2018; 45 (4), 213-220 Research Article DOI :10.29090/psa.2018.04.017.0056 Rapid and simultaneous determination of paracetamol, ibuprofen and related impurity
More informationDEVELOPMENT OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL DOSAGE FORMS
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article DEVELOPMENT OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF CANDESARTAN CILEXETIL AND
More informationStability indicating RP-HPLC method for determination of azilsartan medoxomil in bulk and its dosage form
IJPAR Vol.3 Issue 4 Oct-Dec-2014 Journal Home page: ISSN: 2320-2831 Research article Open Access Stability indicating RP-HPLC method for determination of azilsartan medoxomil in bulk and its dosage form
More informationOriginal Article Mahidol Univ J Pharm Sci 2016; 43 (1), P.T. Dung 1*, K.X. Hai 1 1
Original Article Mahidol Univ J Pharm Sci 2016; 43 (1), 37-44 Simultaneous determination of paracetamol, phenylephrine, chlorpheniramine and related compound 4-aminophenol in multi-components pharmaceuticals
More informationDEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ANALYSIS OF GABAPENTIN IN PURE AND PHARMACEUTICAL FORMULATIONS
Int. J. Chem. Sci.: 10(4), 2012, 2209-2217 ISSN 0972-768X www.sadgurupublications.com DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ANALYSIS OF GABAPENTIN IN PURE AND PHARMACEUTICAL FORMULATIONS
More informationAvailable online at Scholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2012, 4 (6):1760-1767 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CDEN: DPLEB4
More informationDepartment of Quality Assurance, Luqman College of Pharmacy, GULBARGA (K.S.) INDIA ABSTRACT
Int. J. Chem. Sci.: 12(3), 2014, 871-879 ISSN 0972-768X www.sadgurupublications.com DEVELPMENT AND VALIDATIN F A RAPID RP HPLC METHD FR THE DETERMINATIN F CINITAPRIDE HYDRGEN TARTARATE IN PURE AND ITS
More informationStability Indicating RP-HPLC Method for Determination of Valsartan in Pure and Pharmaceutical Formulation
ISSN: 0973-4945; CODEN ECJHAO E- Chemistry http://www.e-journals.net 2010, 7(1), 246-252 Stability Indicating RP-HPLC Method for Determination of Valsartan in Pure and Pharmaceutical Formulation S. K.
More informationValidated First Order Derivative Spectroscopic Method for the determination of Stavudine in Bulk and Pharmaceutical Dosage Forms
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.3, No.1, pp 18-22, Jan-Mar 2011 Validated First Order Derivative Spectroscopic Method for the determination of Stavudine
More informationImpact factor: 3.958/ICV: 4.10 ISSN:
Impact factor: 3.958/ICV: 4.10 ISSN: 0976-7908 10 Pharma Science Monitor 8(2), Apr-Jun 2017 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com
More informationDepartment of Chemistry, JNTUACE, Kalikiri
Method Development and Validation of Aegle marmeleous M. Swetha 1*, N. Saritha 1, N. Devanna 2 1 Department of Chemistry, JNTUACE, Kalikiri.-517234 2 Department of Chemistry, JNTUA, Anthapuramu -515002
More informationInternational Journal of Research and Reviews in Pharmacy and Applied science.
International Journal of Research and Reviews in Pharmacy and Applied science www.ijrrpas.com Corresponding Author NARENDRA DEVANABOYINA* Ch.DURGAKUMARI, L.NAGARAJU, R.SRIDHARANI PRIYA, S.BHAVITHA Department
More informationSachin Zade, Padma There Sunanda Aswale, and Shashikant Aswale. Lokmanya Tilak Mahavidyalaya, Wani, Dist. Yavatmal, (MS).
International Journal of Scientific & Engineering Research, Volume 7, Issue 4, April-2016 909 Chemical Degradation and Mass Balance Study of Entacapone API by HPLC Abstracts: Sachin Zade, Padma There Sunanda
More informationINDICATING LIQUID CHROMATOGRAPHIC METHOD FOR QUANTIFICATION OF CIPROFLOXACIN HCL, ITS RELEATED SUBSTANCE AND TINIDAZOLE IN TABLET DOSAGE FORM
Innovare Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 6, Issue 5, 2014 Original Article VALIDATED STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD
More informationValidated RP-HPLC Method for Estimation of Cefprozil in Tablet Dosage Form
International Journal of PharmTech Research CDEN (USA): IJPRIF ISSN : 0974-4304 Vol.4, No.3, pp 1228-1232, July-Sept 2012 Validated RP-HPLC Method for Estimation of Cefprozil in Tablet Dosage Form Manzoor
More informationApplication Note. Pharmaceutical QA/QC. Author. Abstract. Siji Joseph Agilent Technologies, Inc. Bangalore, India
Reducing analysis time and solvent consumption for isocratic USP assay methods with current and proposed USP guidelines using the Agilent 129 Infinity LC System An efficient way to reduce cost of analysis
More informationAsian Journal of Research in Chemistry and Pharmaceutical Sciences Journal home page:
Research Article ISSN: 2349 7106 Asian Journal of Research in Chemistry and Pharmaceutical Sciences Journal home page: www.ajrcps.com ESTIMATION OF RAMELTEON IN TABLET DOSAGE FORM BY HPLC M. Jyothsna*
More informationSravani and Haritha Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)
A new development and validated RP-HPLC method for the assay and related substances of Itraconazole in capsule dosage form Sarvani Paruchuri*, Haritha Pavani K Nimra College of Pharmacy, Vijayawada, Andhra
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2015, 6(11):19-27 ISSN: 0976-8688 CODEN (USA): PSHIBD Development and validation of stability indicating high performance liquid
More informationScholars Research Library. Rapid and sensitive RP-HPLC analytical method development and validation of Pioglitazone hydrochloride
Available online at www.scholarsresearchlibrary.com Der Pharmacia Lettre, 2011, 3(3): 128-132 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 Rapid and sensitive RP-HPLC
More informationLC Determination of Deferasirox in Pharmaceutical Formulation
ISSN:2230-7346 Available online http://www.jgtps.com Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.1, Issue 1, pp 42-52, October December 2010 LC Determination of Deferasirox
More informationIntercontinental journal of pharmaceutical Investigations and Research
Kranthi K K et al, ICJPIR 2017, 4(1), XXX-XXX Available online at ISSN: 2349-5448 Intercontinental journal of pharmaceutical Investigations and Research ICJPIR Volume 4 Issue 1 Jan Mar- 2017 Research Article
More informationReverse Phase High Performance Liquid Chromatography method for determination of Lercanidipine hydrochloride in bulk and tablet dosage form
Research Article ISSN: 0974-6943 M.V.Kumudhavalli et al. / Journal of Pharmacy Research 2014,8(11), Available online through http://jprsolutions.info Reverse Phase High Performance Liquid Chromatography
More informationInternational Journal of Pharmaceutical Sciences and Drug Research 2016; 8(4):
Available online at www.ijpsdr.com International Journal of Pharmaceutical Sciences and Drug Research 2016; 8(4): 218-222 Research Article ISSN: 0975-248X CODEN (USA): IJPSPP Development and Validation
More informationJournal of Advanced Scientific Research DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING RP-HPLC METHOD FOR ESTIMATION OF DABIGATRAN ETEXILATE
Damle et al, J Adv Sci Res, 2014, 5(3): 39-44 39 Journal of Advanced Scientific Research Available online through http://www.sciensage.info/jasr ISSN 0976-9595 Research Article DEVELOPMENT AND VALIDATION
More information