Chapter 8: Energy and Metabolism
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1 Chapter 8: Energy and Metabolism Why do organisms need energy? How do organisms manage their energy needs? Defining terms and issues: energy and thermodynamics metabolic reactions and energy transfers Harvesting and using energy ATP is the main energy currency in cells energy harvesting (redox reactions) Regulating reactions: Enzymes
2 Discuss energy conversions and the 1st and 2nd law of thermodynamics Be sure to use the terms work potential energy kinetic energy entropy What are Joules (J) and calories (cal)?
3 Chapter 8: Energy and Metabolism Why do organisms need energy? How do organisms manage their energy needs? Defining terms and issues: energy and thermodynamics metabolic reactions and energy transfers Harvesting and using energy ATP is the main energy currency in cells energy harvesting (redox reactions) Regulating reactions: Enzymes
4 Energy and Thermodynamics energy for work: change in state or motion of matter
5 Energy and Thermodynamics energy for work: change in state or motion of matter expressed in Joules or calories 1 kcal = 4184 kj
6 Energy and Thermodynamics energy for work: change in state or motion of matter expressed in Joules or calories 1 kcal = 4184 kj energy conversion: energy form change potential / kinetic
7 Energy and Thermodynamics potential energy (capacity to do work)
8 Energy and Thermodynamics potential energy (capacity to do work) kinetic energy (energy of motion, actively performing work) chemical bonds: potential energy work is required for the processes of life
9 Discuss energy conversions and the 1st and 2nd law of thermodynamics Be sure to use the terms work potential energy kinetic energy entropy What are Joules (J) and calories (cal)?
10 Energy and Thermodynamics Laws of thermodynamics describe the constraints on energy usage
11 The laws of thermodynamics are sometimes stated as: In energy conversions, You can t win, and you can t break even Explain
12 Laws of Thermodynamics First law: the total amount of energy (+ matter) in a closed system remains constant
13 Laws of Thermodynamics First law: the total amount of energy (+ matter) in a closed system remains constant also called conservation of energy
14 Laws of Thermodynamics First law: the total amount of energy (+ matter) in a closed system remains constant also called conservation of energy note: the universe is a closed system living things are open systems
15 Laws of Thermodynamics First law: the total amount of energy (+ matter) in a closed system remains constant also called conservation of energy note: the universe is a closed system living things are open systems You can t win
16 Laws of Thermodynamics Second law: in every energy conversion some energy is converted to heat energy heat energy is lost to the surroundings heat energy cannot be used for work
17 Laws of Thermodynamics Second law: in every energy conversion some energy is converted to heat energy heat energy is lost to the surroundings heat energy cannot be used for work energy converted to heat in the surroundings increases entropy (spreading of energy)
18 Laws of Thermodynamics Second law: in every energy conversion some energy is converted to heat energy heat energy is lost to the surroundings heat energy cannot be used for work energy converted to heat in the surroundings increases entropy (spreading of energy) thus, this law can also be stated as: Every energy conversion increases the entropy of the universe
19 Laws of Thermodynamics Second law: Upshot: no energy conversion is 100% efficient You can t break even Just to maintain their current state, organisms must get a constant influx of energy because of energy lost in conversions
20 The laws of thermodynamics are sometimes stated as: In energy conversions, You can t win, and you can t break even Explain
21 Differentiate between: anabolism and catabolism exergonic and endergonic reactions
22 Metabolism: anabolism + catabolism metabolism divided into anabolism (anabolic reactions) anabolic reactions are processes that build complex molecules from simpler ones
23 Metabolism: anabolism + catabolism metabolism divided into anabolism (anabolic reactions) anabolic reactions are processes that build complex molecules from simpler ones catabolism (catabolic reactions) catabolic reactions are processes the break down complex molecules into simpler ones
24 Differentiate between: anabolism and catabolism exergonic and endergonic reactions
25 Chemical Reactions and Free Energy Chemical reactions involve changes in chemical bonds
26 Chemical Reactions and Free Energy Chemical reactions involve changes in chemical bonds changes in substance concentrations
27 Chemical Reactions and Free Energy Chemical reactions involve changes in chemical bonds changes in substance concentrations changes in free energy free energy = energy available to do work in a chemical reaction (such as: create a chemical bond) free energy changes depend on bond energies and concentrations of reactants and products bond energy = energy required to break a bond; value depends on the bond
28 Chemical Reactions and Free Energy left undisturbed, reactions will reach dynamic equilibrium when the relative concentrations of reactants and products is correct forward and reverse reaction rates are equal; concentrations remain constant
29 Chemical Reactions and Free Energy left undisturbed, reactions will reach dynamic equilibrium when the relative concentrations of reactants and products is correct forward and reverse reaction rates are equal; concentrations remain constant cells manipulate relative concentrations in many ways so that equilibrium is rare
30 Chemical Reactions and Free Energy exergonic reactions the products have less free energy than reactants the difference in energy is released and is available to do work
31 Chemical Reactions and Free Energy exergonic reactions the products have less free energy than reactants the difference in energy is released and is available to do work exergonic reactions are thermodynamically favored; thus, they are spontaneous, but not necessarily fast (more on activation energy later)
32 Chemical Reactions and Free Energy catabolic reactions are usually exergonic ATP + H 2 O ADP + P i is highly exergonic
33 Chemical Reactions and Free Energy endergonic reactions the products have more free energy than the reactants the difference in free energy must be supplied (stored in chemical bonds)
34 Chemical Reactions and Free Energy endergonic reactions the products have more free energy than the reactants the difference in free energy must be supplied (stored in chemical bonds) endergonic reactions are not thermodynamically favored, so they are not spontaneous
35 Chemical Reactions and Free Energy
36 Chemical Reactions and Free Energy How to get energy for an endergonic reaction?
37 Chemical Reactions and Free Energy How to get energy for an endergonic reaction? couple with an exergonic one!
38 Chemical Reactions and Free Energy How to get energy for an endergonic reaction? couple with an exergonic one! together, the coupled reactions must have a net exergonic nature
39 Chemical Reactions and Free Energy How to get energy for an endergonic reaction? couple with an exergonic one! together, the coupled reactions must have a net exergonic nature reaction coupling requires that the reactions share a common intermediate(s)
40 Chemical Reactions and Free Energy EXAMPLE: A B (exergonic) C D (endergonic)
41 Chemical Reactions and Free Energy EXAMPLE: A B (exergonic) C D (endergonic) Coupled: A + C B + D (overall exergonic)
42 Chemical Reactions and Free Energy EXAMPLE: A B (exergonic) C D (endergonic) Coupled: A + C B + D (overall exergonic) Actually: A + C I B + D
43 Chemical Reactions and Free Energy EXAMPLE: A B (exergonic) C D (endergonic) Coupled: A + C B + D (overall exergonic) Actually: A + C I B + D typically, the exergonic reaction in the couple is ATP + H 2 O ADP + P i anabolic reactions are usually endergonic
44 Chemical Reactions and Free Energy EXAMPLE: A B (exergonic) C D (endergonic) Coupled: A + C B + D (overall exergonic) Actually: A + C I B + D typically, the exergonic reaction in the couple is ATP + H 2 O ADP + P i anabolic reactions are usually endergonic This will be explored in more detail in an example in a bit, but first some more about ATP
45 Chapter 8: Energy and Metabolism Why do organisms need energy? How do organisms manage their energy needs? Defining terms and issues: energy and thermodynamics metabolic reactions and energy transfers Harvesting and using energy ATP is the main energy currency in cells energy harvesting (redox reactions) Regulating reactions: Enzymes
46 Why is ATP so darned important? What is a phosphorylated intermediate? How much ATP is in a cell at any given time? Why must cells keep a high ATP/ADP ratio?
47 ATP is the main energy currency in cells One way that organisms manage their energy needs is to use ATP as a ready energy source for many reactions
48 ATP is the main energy currency in cells ATP nucleotide with adenine base, ribose sugar, and a chain of 3 phosphate groups
49 ATP is the main energy currency in cells last two phosphate groups are joined to the chain by unstable bonds; breaking these bonds is relatively easy and releases energy; thus:
50 ATP is the main energy currency in cells hydrolysis of ATP to ADP and inorganic phosphate (P i ) releases energy ATP + H 2 O ADP + P i
51 ATP is the main energy currency in cells hydrolysis of ATP to ADP and inorganic phosphate (P i ) releases energy ATP + H 2 O ADP + P i the amount of energy released depends in part on concentrations of reactants and products is generally ~30 kj/mol
52 ATP is the main energy currency in cells Intermediates when ATP hydrolysis is coupled to a reaction to provide energy
53 ATP is the main energy currency in cells Intermediates when ATP hydrolysis is coupled to a reaction to provide energy often phosphorylated compounds glucose glucose-6-phosphate
54 ATP is the main energy currency in cells Intermediates when ATP hydrolysis is coupled to a reaction to provide energy often phosphorylated compounds the inorganic phosphate is transferred onto another compound rather than being immediately released glucose glucose-6-phosphate
55 ATP is the main energy currency in cells Intermediates when ATP hydrolysis is coupled to a reaction to provide energy often phosphorylated compounds the inorganic phosphate is transferred onto another compound rather than being immediately released a phosphorylated compound is in a higher energy state glucose glucose-6-phosphate
56 ATP is the main energy currency in cells EXAMPLE of a coupled reaction: glucose + fructose sucrose + H 2 O (endergonic; requires ~27 kj/mol) ATP + H 2 O ADP + P i (exergonic; provides ~30 kj/mol) coupled: glucose + fructose + ATP + H 2 O sucrose + H 2 O + ADP + P i simplified: glucose + fructose + ATP sucrose +ADP + P i with intermediates: glucose + fructose + ATP + H 2 O glucose-p + fructose + ADP sucrose + H 2 O + ADP + P i (net exergonic, releases ~3 kj/mol)
57 ATP is the main energy currency in cells EXAMPLE of a coupled reaction: glucose + fructose sucrose + H 2 O (endergonic; requires ~27 kj/mol) ATP + H 2 O ADP + P i (exergonic; provides ~30 kj/mol)
58 ATP is the main energy currency in cells EXAMPLE of a coupled reaction: glucose + fructose sucrose + H 2 O (endergonic; requires ~27 kj/mol) ATP + H 2 O ADP + P i (exergonic; provides ~30 kj/mol) coupled: glucose + fructose + ATP + H 2 O sucrose + H 2 O + ADP + P i
59 ATP is the main energy currency in cells EXAMPLE of a coupled reaction: glucose + fructose sucrose + H 2 O (endergonic; requires ~27 kj/mol) ATP + H 2 O ADP + P i (exergonic; provides ~30 kj/mol) coupled: glucose + fructose + ATP + H 2 O sucrose + H 2 O + ADP + P i simplified: glucose + fructose + ATP sucrose +ADP + P i
60 ATP is the main energy currency in cells EXAMPLE of a coupled reaction: glucose + fructose sucrose + H 2 O (endergonic; requires ~27 kj/mol) ATP + H 2 O ADP + P i (exergonic; provides ~30 kj/mol) coupled: glucose + fructose + ATP + H 2 O sucrose + H 2 O + ADP + P i simplified: glucose + fructose + ATP sucrose +ADP + P i with intermediates: glucose + fructose + ATP + H 2 O glucose-p + fructose + ADP sucrose + H 2 O + ADP + P i (net exergonic, releases ~3 kj/mol)
61 ATP is the main energy currency in cells Thus, energy transfer in cellular reactions is often accomplished through transfer of a phosphate group from ATP
62 ATP is the main energy currency in cells Making ATP involves an endergonic condensation reaction reverse of an exergonic reaction is always endergonic ADP + P i ATP + H 2 O
63 ATP is the main energy currency in cells Making ATP involves an endergonic condensation reaction reverse of an exergonic reaction is always endergonic ADP + P i ATP + H 2 O endergonic, usually requires more than ~30 kj/mol
64 ATP is the main energy currency in cells Making ATP involves an endergonic condensation reaction reverse of an exergonic reaction is always endergonic ADP + P i ATP + H 2 O endergonic, usually requires more than ~30 kj/mol must be coupled with an exergonic reaction; typically from a catabolic pathway (more on that later)
65 ATP is the main energy currency in cells Overall, ATP is typically created in catabolic reactions and used in anabolic reactions, linking those aspects of metabolism
66 ATP is the main energy currency in cells Cells maintain high levels of ATP relative to ADP maximizes energy available from hydrolysis of ATP
67 ATP is the main energy currency in cells Cells maintain high levels of ATP relative to ADP maximizes energy available from hydrolysis of ATP ratio typically greater than 10 ATP: 1 ADP
68 ATP is the main energy currency in cells Overall concentration of ATP still very low supply typically only enough for a few seconds at best
69 ATP is the main energy currency in cells Overall concentration of ATP still very low supply typically only enough for a few seconds at best instability prevents stockpiling
70 ATP is the main energy currency in cells Overall concentration of ATP still very low supply typically only enough for a few seconds at best instability prevents stockpiling must be constantly produced in a typical cell, the rate of use and production of ATP is about 10 million molecules per second resting human has less than 1 g of ATP at any given time but uses about 45 kg per day
71 Why is ATP so darned important? What is a phosphorylated intermediate? How much ATP is in a cell at any given time? Why must cells keep a high ATP/ADP ratio?
72 What are redox reactions used for in cells? How (generally) can you tell which of two similar compounds is reduced and which is oxidized? Give some examples of compounds commonly used in redox reactions in cells
73 Redox reactions are also used for energy transfer Redox reactions are used to harvest energy from some chemicals The acceptors of that energy typically cannot be used directly as energy currency
74 Redox reactions are also used for energy transfer Redox reactions are used to harvest energy from some chemicals The acceptors of that energy typically cannot be used directly as energy currency Electrons can also be used for energy transfer
75 Redox reactions are also used for energy transfer Redox reactions are used to harvest energy from some chemicals The acceptors of that energy typically cannot be used directly as energy currency Electrons can also be used for energy transfer Redox reactions: recall reduction, gain electrons; oxidation, lose electrons; both occur simultaneously in cells (generally no free electrons in cells)
76 Redox reactions are also used for energy transfer Redox reactions are used to harvest energy from some chemicals The acceptors of that energy typically cannot be used directly as energy currency Electrons can also be used for energy transfer Redox reactions: recall reduction, gain electrons; oxidation, lose electrons; both occur simultaneously in cells (generally no free electrons in cells) Typically, the oxidized substance gives up energy with the electron, the reduced substance gains energy with the electron
77 0804 Redox Reactions Slide number: 6 Loss of electron (oxidation) o o e + _ A + B A B A* B* Gain of electron (reduction) Low energy High energy Copyright The McGraw-Hill Companies, Inc Permission required for reproduction or display
78 Redox reactions are also used for energy transfer chain of redox reactions / electron transfers common more on electron transport chains later
79 Redox reactions are also used for energy transfer chain of redox reactions / electron transfers common more on electron transport chains later each electron transfer releases free energy free energy can be used for other chemical reactions
80 Redox reactions are also used for energy transfer chain of redox reactions / electron transfers common more on electron transport chains later each electron transfer releases free energy free energy can be used for other chemical reactions proton often removed as well if so, equivalent of a hydrogen atom is transferred
81 Redox reactions are also used for energy transfer Catabolism typically involves: removal of hydrogen atoms from nutrients (such as carbohydrates) transfer of the protons and electrons to intermediate electron acceptors
82 Redox reactions are also used for energy transfer intermediate acceptor example: nicotinamide adenine dinucleotide (NAD + )
83 Redox reactions are also used for energy transfer intermediate acceptor example: nicotinamide adenine dinucleotide (NAD + ) Use XH 2 to represent a nutrient molecule: XH 2 + NAD + X + NADH + H +
84 Redox reactions are also used for energy transfer intermediate acceptor example: nicotinamide adenine dinucleotide (NAD + ) Use XH 2 to represent a nutrient molecule: XH 2 + NAD + X + NADH + H + Often, the reduced form is just called NADH
85 Redox reactions are also used for energy transfer Reduced state stores energy, which is partially released as free energy when NADH is oxidized
86 Redox reactions are also used for energy transfer Reduced state stores energy, which is partially released as free energy when NADH is oxidized The free energy usually winds up being used to make ATP
87 Redox reactions are also used for energy transfer Other commonly used acceptors are NADP +, FAD, and cytochromes NADP + /NADPH important in photosynthesis FAD/FADH 2 flavin adenine dinucleotide Cytochromes small iron-containing proteins; iron serves as electron acceptor
88 What are redox reactions used for in cells? How (generally) can you tell which of two similar compounds is reduced and which is oxidized? Give some examples of compounds commonly used in redox reactions in cells
89 Chapter 8: Energy and Metabolism Why do organisms need energy? How do organisms manage their energy needs? Defining terms and issues: energy and thermodynamics metabolic reactions and energy transfers Harvesting and using energy ATP is the main energy currency in cells energy harvesting (redox reactions) Regulating reactions: Enzymes
90 What do enzymes do for cells, and how do they do it? Be sure to use the following terms: catalyst (or catalyze) activation energy enzyme-substrate complex active site induced fit
91 Enzymes Manipulation of reactions is essential to and largely defining of life
92 Enzymes Manipulation of reactions is essential to and largely defining of life Organisms use enzymes to manipulate the speed of reactions
93 Enzymes Manipulation of reactions is essential to and largely defining of life Organisms use enzymes to manipulate the speed of reactions Understanding life requires understanding how enzymes work
94 Enzymes Enzymes regulate chemical reactions in living organisms An enzyme is an organic molecule (typically a protein) that acts as a catalyst
95 Enzymes Enzymes regulate chemical reactions in living organisms An enzyme is an organic molecule (typically a protein) that acts as a catalyst catalyst increases the rate of a chemical reaction without being consumed in the reaction (the catalyst recycles back to its original state)
96 Enzymes Enzymes regulate chemical reactions in living organisms An enzyme is an organic molecule (typically a protein) that acts as a catalyst catalyst increases the rate of a chemical reaction without being consumed in the reaction (the catalyst recycles back to its original state) enzymes (catalysts) only alter reaction rate; thermodynamics still governs whether the reaction can occur
97 Fig 89 (TEArt) Copyright The McGraw-Hill Companies, Inc Permission required for reproduction or display 1 Bond Active site The substrate, sucrose, consists of glucose and fructose bonded together Enzyme 2 The substrate binds to the enzyme, forming an enzymesubstrate complex H 2 O 3 4 The binding of the substrate and enzyme places stress on the glucosefructose bond, and the bond breaks Glucose Fructose Products are released, and the enzyme is free to bind other substrates
98 0809 Enzyme Catalytic Cycle Slide number: 2 1 The substrate, sucrose, consists of glucose and fructose bonded together Bond Active site Enzyme Copyright The McGraw-Hill Companies, Inc Permission required for reproduction or display
99 0809 Enzyme Catalytic Cycle Slide number: 3 1 The substrate, sucrose, consists of glucose and fructose bonded together Bond Active site Enzyme Copyright The McGraw-Hill Companies, Inc Permission required for reproduction or display
100 0809 Enzyme Catalytic Cycle Slide number: 4 Bond 1 The substrate, sucrose, consists of glucose and fructose bonded together 2 The substrate binds to the enzyme, forming an enzymesubstrate complex Active site Enzyme Copyright The McGraw-Hill Companies, Inc Permission required for reproduction or display
101 0809 Enzyme Catalytic Cycle Slide number: 5 Bond 1 The substrate, sucrose, consists of glucose and fructose bonded together 2 The substrate binds to the enzyme, forming an enzymesubstrate complex H 2 O Active site Enzyme 3 The binding of the substrate and enzyme places stress on the glucose-fructose bond, and the bond breaks Copyright The McGraw-Hill Companies, Inc Permission required for reproduction or display
102 0809 Enzyme Catalytic Cycle Slide number: 6 Bond Active site 1 The substrate, sucrose, consists Glucose of glucose and fructose bonded together 2 The substrate binds to the enzyme, forming an enzymesubstrate complex Enzyme 3 H 2 O The binding of the substrate and enzyme places stress on the glucose-fructose bond, and the bond breaks 4 Fructose Products are released, and the enzyme is free to bind other substrates Copyright The McGraw-Hill Companies, Inc Permission required for reproduction or display
103 Enzymes work by lowering activation energy of a reaction all reactions have a required energy of activation
104 Enzymes work by lowering activation energy of a reaction all reactions have a required energy of activation energy required to break existing bonds and bring reactants together
105 Enzymes work by lowering activation energy of a reaction all reactions have a required energy of activation energy required to break existing bonds and bring reactants together must be supplied in some way before the reaction can proceed
106 activation energy Enzymes catalysts greatly reduce the activation energy requirement, making it easier for a reaction to occur
107 Enzymes Enzymes lower activation energy by forming a complex with the substrate(s) the ability to form an enzyme-substrate complex is highly dependent on the shape of the enzyme
108 Enzymes Enzymes lower activation energy by forming a complex with the substrate(s) the ability to form an enzyme-substrate complex is highly dependent on the shape of the enzyme the site where the substrate(s) binds to the enzyme is called the active site
109 Enzymes Enzymes lower activation energy by forming a complex with the substrate(s) the ability to form an enzyme-substrate complex is highly dependent on the shape of the enzyme the site where the substrate(s) binds to the enzyme is called the active site when the enzyme-substrate complex forms, there are typically shape changes in the enzyme and substrate(s) called induced fit
110 Enzymes ES complex typically very unstable
111 Enzymes ES complex typically very unstable short-lived
112 Enzymes ES complex typically very unstable short-lived breaks down into released product(s) and a free enzyme that is ready to be reused
113 Enzymes ES complex typically very unstable short-lived breaks down into released product(s) and a free enzyme that is ready to be reused overall: enzyme + substrate(s) ES complex enzyme + product(s)
114 What do enzymes do for cells, and how do they do it? Be sure to use the following terms: catalyst (or catalyze) activation energy enzyme-substrate complex active site induced fit
115 What are the four main things that enzymes do to lower activation energy?
116 Enzymes reduction in activation energy is due primarily to four things:
117 Enzymes reduction in activation energy is due primarily to four things: an enzyme holds reactants (substrates) close together in the right orientation for the reaction, which reduces the reliance on random collisions
118 Enzymes reduction in activation energy is due primarily to four things: an enzyme holds reactants (substrates) close together in the right orientation for the reaction, which reduces the reliance on random collisions an enzyme may put a strain on existing bonds, making them easier to break
119 Enzymes reduction in activation energy is due primarily to four things: an enzyme holds reactants (substrates) close together in the right orientation for the reaction, which reduces the reliance on random collisions an enzyme may put a strain on existing bonds, making them easier to break an enzyme provides a microenvironment that is more chemically suited to the reaction
120 Enzymes reduction in activation energy is due primarily to four things: an enzyme holds reactants (substrates) close together in the right orientation for the reaction, which reduces the reliance on random collisions an enzyme may put a strain on existing bonds, making them easier to break an enzyme provides a microenvironment that is more chemically suited to the reaction sometimes the active site of the enzyme itself is directly involved in the reaction during the transition states
121 Enzymes enzyme + substrate(s) ES complex enzyme + product(s)
122 What are the four main things that enzymes do to lower activation energy?
123 How are enzymes named (what suffixes indicate an enzyme)?
124 Enzyme names Enzymes many names give some indication of substrate
125 Enzyme names Enzymes many names give some indication of substrate most enzyme names end in ase (example: sucrase)
126 Enzyme names Enzymes many names give some indication of substrate most enzyme names end in ase (example: sucrase) some end in zyme (example: lysozyme)
127 Enzyme names Enzymes many names give some indication of substrate most enzyme names end in ase (example: sucrase) some end in zyme (example: lysozyme) some traditional names are less indicative of enzyme function (examples: pepsin, trypsin)
128 Enzymes Enzymes are generally highly specific overall shape as well as spatial arrangements in the active site limit what enzyme-substrate complexes can readily form
129 Enzymes the amount of specificity depends on the particular enzyme example of high specificity: sucrase splits sucrose, not other disaccharides
130 Enzymes the amount of specificity depends on the particular enzyme example of high specificity: sucrase splits sucrose, not other disaccharides example of low specificity: lipase splits variety of fatty acids from glycerol
131 Enzymes enzymes are classified by the kind of reaction they catalyze The International Union of Biochemistry and Molecular Biology has developed a nomenclature for enzymes; the top-level classification is Oxidoreductases: catalyze oxidation/reduction reactions Transferases: transfer a functional group (eg a methyl or phosphate group) Hydrolases: catalyze the hydrolysis of various bonds Lyases: cleave various bonds by means other than hydrolysis and oxidation Isomerases: catalyze isomerization changes within a single molecule Ligases: join two molecules with covalent bonds The complete nomenclature can be browsed at
132 How are enzymes named (what suffixes indicate an enzyme)?
133 Explain the terms cofactor, apoenzyme, and coenzyme
134 Enzymes Many enzymes require additional chemical components (cofactors) to function
135 Enzymes Many enzymes require additional chemical components (cofactors) to function apoenzyme + cofactor active enzyme (bound together)
136 Enzymes Many enzymes require additional chemical components (cofactors) to function apoenzyme + cofactor active enzyme (bound together) alone, an apoenzyme or a cofactor has little if any catalytic activity
137 Enzymes Many enzymes require additional chemical components (cofactors) to function apoenzyme + cofactor active enzyme (bound together) alone, an apoenzyme or a cofactor has little if any catalytic activity cofactors may or may not be changed by the reaction
138 Enzymes cofactors can be organic or inorganic organic examples (coenzymes): ADP, NAD +, NADP +, FAD typically changed by the catalyzed reaction
139 Enzymes cofactors can be organic or inorganic organic examples (coenzymes): ADP, NAD +, NADP +, FAD typically changed by the catalyzed reaction inorganic examples: metal ions like Ca 2+, Mg 2+, Fe 3+, etc typically not changed by the catalyzed reaction
140 Enzymes cofactors can be organic or inorganic organic examples (coenzymes): ADP, NAD +, NADP +, FAD typically changed by the catalyzed reaction inorganic examples: metal ions like Ca 2+, Mg 2+, Fe 3+, etc typically not changed by the catalyzed reaction most vitamins are coenzymes or part of coenzymes, or are used for making coenzymes
141 Fig 83 (TEArt) Copyright The McGraw-Hill Companies, Inc Permission required for reproduction or display Enzyme Energy-rich molecule H H NAD + NAD + NAD + H NAD H Product 1 Enzymes that harvest hydrogen atoms have a binding site for NAD + located near another binding site NAD + and an energy-rich molecule bind to the enzyme 2 In an oxidationreduction reaction, a hydrogen atom is transferred to NAD +, forming NADH NAD H 3 NADH then diffuses away and is available to other molecules
142 Fig 8A
143 Explain the terms cofactor, apoenzyme, and coenzyme
144 Discuss the effects of temperature and ph on enzyme activity
145 Enzymes are most active under optimal conditions each enzyme has an optimal temperature most effective as a catalyst at the optimal temperature
146 Enzymes are most active under optimal conditions each enzyme has an optimal temperature most effective as a catalyst at the optimal temperature rate of drop-off in effectiveness away from optimal temperature depends on the enzyme
147 Enzymes are most active under optimal conditions each enzyme has an optimal temperature most effective as a catalyst at the optimal temperature rate of drop-off in effectiveness away from optimal temperature depends on the enzyme high temperatures tend to denature enzymes
148 Enzymes are most active under optimal conditions each enzyme has an optimal temperature most effective as a catalyst at the optimal temperature rate of drop-off in effectiveness away from optimal temperature depends on the enzyme high temperatures tend to denature enzymes human enzymes have temperature optima near human body temperature (37 C)
149 Enzymes are most active under optimal conditions each enzyme has an optimal ph again, most effective at the optimum; drop-off varies
150 Enzymes are most active under optimal conditions each enzyme has an optimal ph again, most effective at the optimum; drop-off varies extremes of ph tend to denature enzymes
151 Enzymes are most active under optimal conditions each enzyme has an optimal ph again, most effective at the optimum; drop-off varies extremes of ph tend to denature enzymes a particular organism shows more variety in enzyme ph optima than in temperature optima, but most of its enzymes will still be optimal at the ph normally found in the cytosol of its cells
152 Discuss the effects of temperature and ph on enzyme activity
153 What is a metabolic pathway?
154 Enzymes Metabolic pathways use organized teams of enzymes the products of one reaction often serve as substrates for the next reaction
155 Enzymes Metabolic pathways use organized teams of enzymes the products of one reaction often serve as substrates for the next reaction removing products (by having them participate the next reaction ) improves reaction rate (avoids equilibrium)
156 Enzymes Metabolic pathways use organized teams of enzymes the products of one reaction often serve as substrates for the next reaction removing products (by having them participate the next reaction ) improves reaction rate (avoids equilibrium) multiple metabolic pathways exit in cells, overlapping in some areas and diverging in others
157 Fig 815
158 What is a metabolic pathway?
159 How do cells regulate enzyme activity? Include the terms: inhibitors activators allosteric site feedback inhibition Also, differentiate between: irreversible and reversible inhibition competitive and noncompetitive inhibition
160 Enzymes Cells can regulate enzyme activity to control reactions increase substrate amount increase reaction rate (up to saturation of available enzyme molecules)
161 Enzymes Cells can regulate enzyme activity to control reactions increase substrate amount increase reaction rate (up to saturation of available enzyme molecules) increase enzyme amount increase reaction rate (as long as substrate amount > enzyme amount)
162 Enzymes Cells can regulate enzyme activity to control reactions increase substrate amount increase reaction rate (up to saturation of available enzyme molecules) increase enzyme amount increase reaction rate (as long as substrate amount > enzyme amount) compartmentation of the enzyme, substrate, and products can help control reaction rate
163 Rate of reaction Rate of reaction When substrate concentration >> enzyme concentration Enzyme concentration Substrate concentration (a) (b)
164 Cells can regulate enzyme activity to control reactions inhibitors and activators of enzymes activators allow or enhance catalytic activity
165 Cells can regulate enzyme activity to control reactions inhibitors and activators of enzymes activators allow or enhance catalytic activity inhibitors reduce or eliminate catalytic activity
166 Cells can regulate enzyme activity to control reactions inhibitors and activators of enzymes activators allow or enhance catalytic activity inhibitors reduce or eliminate catalytic activity sometime, this uses an allosteric site a receptor site on an enzyme where an inhibitor or activator can bind
167 Cells can regulate enzyme activity to control reactions a common example of allosteric control is feedback inhibition the last product in a metabolic pathway binds to an allosteric site of an enzyme in an early step of the pathway (often the first) this product inhibits activity of the enzyme
168 Enzyme #1 (Threonine deaminase) Enzyme #2 Threonine -Ketobutyrate -Aceto- -hydroxybutyrate Enzyme #3,b-Dihydroxy-b-methylvalerate Feedback inhibition (Isoleucine inhibits enzyme #1) Enzyme #4 -Keto-b-methylvalerate Enzyme #5 Isoleucine
169 Fig 920
170 Cells can regulate enzyme activity to control reactions irreversible inhibition enzyme is permanently inactivated or destroyed; includes many drugs and toxins
171 Cells can regulate enzyme activity to control reactions irreversible inhibition enzyme is permanently inactivated or destroyed; includes many drugs and toxins reversible inhibition if inhibitor is removed, the enzyme activity can be recovered
172 Cells can regulate enzyme activity to control reactions reversible inhibition if inhibitor is removed, the enzyme activity can be recovered competitive inhibition inhibitor is similar in structure to a substrate; competes with substrate for binding to the active site
173 Cells can regulate enzyme activity to control reactions reversible inhibition if inhibitor is removed, the enzyme activity can be recovered competitive inhibition inhibitor is similar in structure to a substrate; competes with substrate for binding to the active site noncompetitive inhibition binds at allosteric site, alters enzyme shape to make active site unavailable
174 How do cells regulate enzyme activity? Include the terms: inhibitors activators allosteric site feedback inhibition Also, differentiate between: irreversible and reversible inhibition competitive and noncompetitive inhibition
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