New Developments in Flow Chemistry 20 November 2013 Christian Hornung Research Scientist CSIRO Materials Science and Engineering
|
|
|
- Jocelin Pearson
- 6 years ago
- Views:
Transcription
1 uture of Chemical Manufacturing: rom Pots to Pipes New Developments in low Chemistry 20 November 2013 Christian Hornung Research Scientist CSIR Materials Science and Engineering
2 utline 1 New Developments in low Chemistry DSM Process ptimization (Ritter Reaction) presented in Munich, June 2013 EPSRC Continuous Crystallization presented in Munich, June 2013 Univ. South Australia Continuous Solvent Extraction of Metals presented in Singapore, Nov NUS Crystallization from Microfluidic Emulsions presented in Singapore, Nov Continuous low Processing of RAT Polymers Synthesis of Homo Polymers ptimization and Scale up Reactor Characterization (Residence Time Distribution) low Synthesis of lock Copolymers RAT End Group Removal / Modification CSIR. Continuous Processing & Microreactor Technology
3 utline 1 New Developments in low Chemistry DSM Process ptimization (Ritter Reaction) presented in Munich, June 2013 EPSRC Continuous Crystallization presented in Munich, June 2013 Univ. South Australia Continuous Solvent Extraction of Metals presented in Singapore, Nov NUS Crystallization from Microfluidic Emulsions presented in Singapore, Nov Continuous low Processing of RAT Polymers Synthesis of Homo Polymers ptimization and Scale up Reactor Characterization (Residence Time Distribution) low Synthesis of lock Copolymers RAT End Group Removal / Modification CSIR. Continuous Processing & Microreactor Technology
4 Continuous low Processing at CSIR CSIR. Continuous Processing & Microreactor Technology
5 Continuous low Processing at CSIR CSIR. Continuous Processing & Microreactor Technology
6 Continuous low Processing at CSIR CSIR. Continuous Processing & Microreactor Technology
7 Continuous low Processing at CSIR CSIR. Continuous Processing & Microreactor Technology
8 Microfluidic Solvent Extraction of Metal Ions and Complexes from Leach Solutions Containing Nanoparticles for Cu and Cr extractions h = 1 refers to complete phase separation Craig Priest Priest, C., Zhou, J., Klink, S., Sedev, R., Ralston, J., Microfluidic solvent extraction of metal ions and complexes from leach solutions containing nanoparticles, Chemical Engineering & Technology, 35, 1312 (2012)
9 Spherical Crystallization of Glycine from Monodisperse Microfluidic Emulsions Saif A. Khan Arpad I. Toldy, Abu Zayed M. adruddoza, Lu Zheng, T. Alan Hatton, Rudiyanto Gunawan, Raj Rajagopalan, and Saif A. Khan; Cryst. Growth Des., 2012, 12 (8), pp
10 utline 1 New Developments in low Chemistry DSM Process ptimization (Ritter Reaction) presented in Munich, June 2013 EPSRC Continuous Crystallization presented in Munich, June 2013 Univ. South Australia Continuous Solvent Extraction of Metals presented in Singapore, Nov NUS Crystallization from Microfluidic Emulsions presented in Singapore, Nov Continuous low Processing of RAT Polymers Synthesis of Homo Polymers ptimization and Scale up Reactor Characterization (Residence Time Distribution) low Synthesis of lock Copolymers RAT End Group Removal / Modification CSIR. Continuous Processing & Microreactor Technology
11 RAT Polymerization RAT: Reversible Addition ragmentation Chain Transfer Controlled radical polymerization Chains continuously re initiated Tailored molecular weight (M n ~ moles RAT agent) Mostly living (dormant) chain ends with fast activation/deactivation n average, all chains grow simultaneously Narrow molecular weight distribution Access to complex architectures (blocks) Conjugation to reactive molecules (drugs, biomolecules, etc.) blocks grafts stars Conventional Polymerization RAT Polymerization dormant chains dead chains Monomer(s) insert here Molecular Weight (g mol -1 ) CSIR. RAT Polymerisation
12 Continuous low Processing at CSIR Vapourtec R2/R4 system Uniqsis lowsyn AMT Coflore CRD gas liquid reactor module tubular reactor modules Liquid / Gas Liquid and Slurry Reactions: organic synthesis of small molecules synthesis of new materials: e.g. polymers, ionic liquids CRD tubular scale up reactor CSIR. Continuous Processing & Microreactor Technology
![monomers: conversion [%] 100 95 90 85 80 75](/docs-images/72/67456218/images/13-3.jpg "70 65 60 55 pdma batch segmented flow")
13 RAT Polymerisation in Continuous low two different operation modes: RAT agents: monomers: conversion [%] pdma batch segmented flow continuous flow time [h] C.H. Hornung, C. Guerrero-Sanchez, M. rasholz, S. Saubern, J. Chiefari, G. Moad, E. Rizzardo, S.H. Thang, rg. Process Res. Dev., 2011, 15(3),
14 RAT Polymerisation in Continuous low polydispersity index [-] conversion [%] ) ) 92 2) ) ) 3) ) ) C 80 C 90 C 100 C 80 C 80 C 100 C NIPAM 1 NIPAM 2 NIPAM 3 NIPAM 4 DMA 5 na 6 VAc 7 5) 85 7) C 80 C 90 C 100 C 80 C 80 C 100 C NIPAM 1 NIPAM 2 NIPAM 3 NIPAM 4 DMA 5 na 6 VAc 7 5) 7) 81 8) 8) Mn [g/mol] 5 x10 ml ) ) ) ) C 80 C 90 C 100 C 80 C 80 C 100 C NIPAM 1 NIPAM 2 NIPAM 3 NIPAM 4 DMA 5 na 6 VAc 7 HN NIPAM SCALE UP: 50 ml flow reactor capable of producing 1.36 kg polymer (pdma) per day. N DMA 5) na 7) VAc 8) C.H. Hornung, C. Guerrero-Sanchez, M. rasholz, S. Saubern, J. Chiefari, G. Moad, E. Rizzardo, S.H. Thang, rg. Process Res. Dev., 2011, 15(3),
15 Scale-up of the RAT Process Synthesis of Acid unctional Polymers in Water: H H S n S S H H HN S n S S H S 3 H DI water Inline degasser Tubular low Reactor: tubing ID 6 mm static mixers reactor volume 108 ml min 0.5 L stock sol. per run N 2 Supply ml/min Polymer Monomer Solution CSIR. Microreactor Technology submitted to Processes, 2013
16 Scale-up of the RAT Process Synthesis of polyacrylic acid in water: Tubular continuous flow reactor (6 mm ID, V R = 108 ml) 0.5 L monomer solution per run / experiment RAT agent: trithiocarbonate containing carboxylic acid groups average conversion at steady state: 95% Problems with scale up in batch: temperature gradients concentration gradients dead zones inefficient mixing small scale batch comparison at identical conditions: 95% small ideal system Laboratory large non ideal system Industry CSIR. Microreactor Technology submitted to Processes, 2013
17 Scale-up of the RAT Process Temperature Profiles: paac 2 5 ml MW paac 3 20 ml MW paac ml R paac ml R paac ml flow T [ C] t [min] Problems with scale up in batch: temperature gradients concentration gradients dead zones inefficient mixing small ideal system Laboratory large non ideal system Industry CSIR. Microreactor Technology submitted to Processes, 2013
18 Reaction Profiling Axial dispersion in tubular reactors 1 3 : at reactor inlet: ideal plug Reaction Profiles taken on Vapourtec SS tubular reactor modules (1 2.2 mm ID): 4 multiple NMR samples in 2 to 7 min intervals conversion profile Pe crit = 100 laminar flow profile at reactor outlet: dispersed plug well defined fluid segment (e.g. monomer solution or tracer dye) dispersed fluid segment different flow rate Pe = 503 Pe = mm ID 2.2 mm ID different reactor tube diameter 10 or 20 ml PLUG LW CRITERIA 1 2 : Pe v l D ax d 2 2 v D ax D 192 D Pe 100 reactor behaves plug flow like different sample size Pe 100 axial dispersion is significant (1) G.I. Taylor, Proc. R. Soc. London, Ser. A, 1953, 219, /// (2). Levenspiel, Chemical Reaction Engineering, Wiley: New York, (3) C.H. Hornung and M.R. Mackley, Chem. Eng. Sci., 2009, 64, /// (4) C. H. Hornung, X. Nguyen, G. Dumsday, S. Saubern, Macromol. React. Eng., 2012, 6,
![Inline Degassing / Integrated low Process inline degasser 2 concentration [mg/l] 7 6 nitrogen 0.2 l/min nitrogen 0.5 l/min 5 nitrogen 0.](/docs-images/72/67456218/images/19-6.jpg "7 l/min in line degasser 1 loop 4 3 2 1 0 0 5 10 15 20 degassing time [min] measurement of dissolved oxygen in aqueous systems: % 2 Deoxygenating time for 40 ml of monomer stock solution: atch freeze")
19 Inline Degassing / Integrated low Process inline degasser 2 concentration [mg/l] 7 6 nitrogen 0.2 l/min nitrogen 0.5 l/min 5 nitrogen 0.7 l/min in line degasser 1 loop degassing time [min] measurement of dissolved oxygen in aqueous systems: % 2 Deoxygenating time for 40 ml of monomer stock solution: atch freeze pump thaw min atch nitrogen purging 5 20 min low inline degassing continuous C. H. Hornung, X. Nguyen, G. Dumsday, S. Saubern, Macromol. React. Eng., 2012, 6,
20 Synthesis of lock Copolymers in low HM PLYMER DI LCK Reactor system: Vapourtec R2/R4 SS 10 ml coils Method Ratio M:R:I Solvent Reaction Temp. [ C] Reaction TIme [min] Conv. [%] M n theo [g/mol] M n GPC [g/mol] M w /M n [ ] batch 100 : 1.0 : 0.2 MeCN 70 / / / cont 100 : 1.0 : 0.2 MeCN 70 / / 60 / batch 100 : 0.5 : 0.1 MeCN 80 / / / batch 100 : 0.5 : 0.1 Acetone 75 / / / cont 100 : 0.5 : 0.1 Acetone 75 / / 40 / DMA / ta DMA / ta DMA / ta C.H. Hornung, X. Nguyen, S. Kyi, J. Chiefari, S. Saubern, Aust. J. Chem., 2013, 66,
21 RAT End Group Removal / Modification block copolymers X X "click" R n-1 SH block conjugates copolymers RAT Y Y X ATRP nucleophiles X Cu I R n-1 thermolysis Y Y S X X R' X X X X R n-1 S Z R n-1 H [H] R Y Y radical-induced n-1 S Z [4+2] R' Y Y reduction Y Y S 2 X X Co II R' R' R n-1 R' 2 R' M Y Y hetero Diels Alder [H] N addition-fragmentationcoupling X X X X R X X R n-1 N n-1 Y Y R n-1 H Y Y Y Y NMP radical-induced oxidation X R n-1 Y X Y H block copolymers G. Moad, E. Rizzardo, S.H. Thang, End-functional polymers, thiocarbonylthio group removal/transformation and reversible addition-fragmentation-chain transfer (RAT) polymerization, Polymer International, 2011, 60(1), 9-25.
![5 time [min] example: pdma Reaction conditions: SS reactor coil 10 ml Reaction time: 120 min Reaction temperature: 100 C before](/docs-images/72/67456218/images/22-3.jpg "after ~ 100% conversion for pdma, ps, pnipam C. H. Hornung, A. Postma, S. Saubern, J. Chiefari, Macromol. React. Eng.")
22 Radical Induced End Group Removal - complete desulfurization unreactive end group - organic solvents or water - comparison: batch v flow process pdma flow batch before g/mol / g/mol / g/mol / 1.03 steel reactor coil time [min] example: pdma Reaction conditions: SS reactor coil 10 ml Reaction time: 120 min Reaction temperature: 100 C before after ~ 100% conversion for pdma, ps, pnipam C. H. Hornung, A. Postma, S. Saubern, J. Chiefari, Macromol. React. Eng. 2012, 6,
23 low Thermolysis Two Step Process Reaction conditions: SS reactor coil 10 ml Reaction time: 60 min Reaction temperature: C pmma before thermolysis after thermolysis polymer reactor 1 (polymerisation) reactor 2 (thermolysis) molar ratio M/R/I T [ C] t [h] conversion [%] M n [g/mol] Ð [-] pma 10 ml 5 ml 100/1.2/ / / 1 97 / pma batch batch 100/1.2/ / / 1 97 / pmma 10 ml 5 ml 100/1.2/ / / 1 46 / ~ pmma 10 ml 5 ml 100/1.2/ / / 1 59 / ~ pmma 2 10 ml 5 ml 100/1.2/ / / 1 84 / ~ polymerisation thermolysis (1) J. Chiefari, C.H. Hornung, A. Postma, S. Saubern, RAT Polymers, 2011, W , /// (2) to be submitted to Polymer, 2013
24 Conclusions ully Integrated low Process Continuous low Processing bridges the gap from laboratory / discovery scale to preparation / small production scale: mg to kg Integrated Processing allows for combination of several processing steps to form one continuous production line, e.g. purification, block co polymers, Efficient Processing is achieved by using micro and millimetre scale flow geometries enhanced heat and mass transfer, large surface to volume ratio CSIR. Continuous Processing & Microreactor Technology
25 Thank you Acknowledgements Ivan Martinez Thomas Kohl Xuan Nguyen Julien Rosselgong Nenad Micic Alan Young Paul Savage John Tsanaktsidis John Chiefari Ezio Rizzardo San Thang Graeme Moad Simon Saubern Tash Polyzos Almar Postma Stella Kyi Maria Espiritu Carlos Guerrero Sanchez CSIR Material Science and Engineering Christian Hornung Research Scientist t e christian.hornung@csiro.au w mail: ag 10, Clayton South Victoria 3169 Australia
Process Intensification for Chemical Manufacturing using Continuous Flow Processing
Process Intensification for Chemical Manufacturing using Continuous Flow Processing Christian Hornung Senior Research Scientist Director, Centre for Industrial Flow Chemistry 31 May 2017 CSIRO MANUFACTURING
Synthesis of RAFT block copolymers in a multi-stage continuous flow process inside a tubular reactor
NOTICE: this is the author s version of a work that was accepted for publication in Australian Journal of Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections,
Preparation of 1:1 alternating, nucleobase-containing copolymers for use in sequence-controlled polymerization
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2014 Supporting Information for Preparation of 1:1 alternating, nucleobase-containing copolymers
RAFT Fundamentals A History and Recent Developments CSIRO Manufacturing Flagship
RAFT Fundamentals A History and Recent Developments CIRO Manufacturing Flagship Graeme Moad MACRO 2016 Istanbul 17 July 2016 CIRO MANUFACTURING Outline RAFT Polymerization Description and History RAFT
Scale-up of the Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization Using Continuous Flow Processing
Processes 2014, 2, 58-70; doi:10.3390/pr2010058 Communication OPEN ACCESS processes ISSN 2227-9717 www.mdpi.com/journal/processes Scale-up of the Reversible Addition-Fragmentation Chain Transfer (RAFT)
Contents. Efficient synthesis of 5-(chloromethyl)furfural (CMF) from high fructose corn syrup (HFCS) using continuous flow processing
Electronic Supplementary Material (ESI) for Reaction Chemistry & Engineering. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information (ESI) Efficient synthesis of 5-(chloromethyl)furfural
Radical Polymerization and Click Chemistry. Surfaces using Gamma Irradiation. Supporting Information*
Synthesis of Block Copolymers via Atom Transfer Radical Polymerization and Click Chemistry grafted from Pre-functionalized Polypropylene Surfaces using Gamma Irradiation Supporting Information* Ollie Foster,
Communication Macro-RAFT Synthesis by Single Unit Monomer Insertion (SUMI) into Dithiobenzoate RAFT Agents Towards Biological Precision
OPEN ACCESS http://sciforum.net/conference/ecm-1 Communication Macro-RAFT Synthesis by Single Unit Monomer Insertion (SUMI) into Dithiobenzoate RAFT Agents Towards Biological Precision Joris J. Haven 1,
SUPPORTING INFORMATION
SUPPORTING INFORMATION Optimizing The Generation Of Narrow Polydispersity ArmFirst Star Polymers Made Using RAFT Polymerization Julien Ferrera, a Jay Syrett, b Michael Whittaker, a David Haddleton, b Thomas
Supporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supporting Information Synthesis of Poly(dihydroxystyrene-block-styrene) (PDHSt-b-PSt) by the RAFT
SS Vorlesung Polymermaterialien Polymerisationsmethoden
Professur Polymerchemie SS 2017 Vorlesung Prof. Michael Sommer 1 www.tu-chemnitz.de Content Free radical polymerization (PS, PMMA) Controlled radical polymerization Ionic polymerization (cationic, anionic)
Investigation into the mechanism of photo-mediated RAFT polymerization involving the reversible photolysis of the chain-transfer agent
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2017 Investigation into the mechanism of photo-mediated RAFT polymerization involving the reversible
Hyperbranched Poly(N-(2-Hydroxypropyl) Methacrylamide) via RAFT Self- Condensing Vinyl Polymerization
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2016 Hyperbranched Poly(N-(2-Hydroxypropyl) Methacrylamide) via RAFT Self- Condensing Vinyl
Effect of Molecular Structure of Side Chain Polymers on "Click" Synthesis of Thermosensitive Molecular Brushes
University of Tennessee, Knoxville Trace: Tennessee Research and Creative Exchange University of Tennessee Honors Thesis Projects University of Tennessee Honors Program 5-2017 Effect of Molecular Structure
Block copolymers containing organic semiconductor segments by RAFT polymerization
Block copolymers containing organic semiconductor segments by RAFT polymerization Ming Chen, Matthias Häussler, Graeme Moad, Ezio Rizzardo Supplementary Material Radical polymerizations in the presence
Synthesis of Random Copolymers Poly (methylmethacrylate-co-azo monomer) by ATRP-AGET
Macromol. Symp. 2009, 283 284, 51 55 DI: 10.1002/masy.200950908 51 Synthesis of Random Copolymers Poly (methylmethacrylate-co-azo monomer) by ATRP-AGET M.A. ájera, L.E. Elizalde,* Y. Vázquez, G. de los
One-pot polymer brush synthesis via simultaneous isocyanate coupling chemistry and grafting from RAFT polymerization
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2014 One-pot polymer brush synthesis via simultaneous isocyanate coupling chemistry and grafting
Introduction to Polymerization Processes
Introduction to Polymerization Processes Reference: Aspen Polymers: Unit Operations and Reaction Models, Aspen Technology, Inc., 2013. 1- Polymer Definition A polymer is a macromolecule made up of many
Polymerisation of Sodium 4-Styrenesulfonate via Atom Transfer Radical Polymerisation
Polymerisation of Sodium 4-Styrenesulfonate via Atom Transfer Radical Polymerisation Peter D. Iddon, Kay L. Robinson and Steven P. Armes ACS Philadelphia Meeting August 2004 Email: P.Iddon@shef.ac.uk Introduction
IPR 2009 UNIVERSIDAD NACIONAL. Gabriel Jaramillo-Soto. Prof. Eduardo Vivaldo Lima
UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICOM PROGRAMA DE DOCTORADO EN INGENIERÍA FACULTAD DE QUÍMICA Reversible Addition-Fragmentation chain Transfer (RAFT) polymerization in supercritical Carbon Dioxide (scco
Chapter 5. Ionic Polymerization. Anionic.
Chapter 5. Ionic Polymerization. Anionic. Anionic Polymerization Dr. Houston S. Brown Lecturer of Chemistry UH-Downtown brownhs@uhd.edu What you should know: What is anionic polymerization? What is MWD,
Combined metallocene catalysts: an efficient technique to manipulate long-chain branching frequency of polyethylene
Macromol. Rapid Commun. 20, 541 545 (1999) 541 Combined metallocene catalysts: an efficient technique to manipulate long-chain branching frequency of polyethylene Daryoosh Beigzadeh, João B. P. Soares*,
SOLUTION STYRENE POLYMERIZATION IN A MILLIREACTOR
SOLUTION STYRENE POLYMERIZATION IN A MILLIREACTOR L. FULLIN 1, E. MELLONI 1 and A.S. VIANNA Jr 1 1 Universidade de São Paulo, Departamento de Engenharia Química E-mail for contact: ardson@usp.br ABSTRACT
Electronic Supplementary Information (ESI)
Electronic Supplementary Information (ESI) Effects of Poly(Vinyl Pivalate)-based Stabiliser Architecture on CO 2 -Solubility and Stabilising Ability in Dispersion Polymerisation of N-Vinyl Pyrrolidone
LIVING/CONTROLLED RADICAL POLYMERIZATION IN A CONTINUOUS TUBULAR REACTOR
LIVING/CONTROLLED RADICAL POLYMERIZATION IN A CONTINUOUS TUBULAR REACTOR by THOMAS EDWARD ENRIGHT A thesis submitted to the Department of Chemical Engineering In conformity with the requirements for the
Quick guide to selecting columns and standards for Gel Permeation Chromatography and Size Exclusion Chromatography SELECTION GUIDE
Quick guide to selecting columns and standards for Gel Permeation Chromatography and Size Exclusion Chromatography SELECTION GUIDE Introduction Gel permeation chromatography (GPC) and size exclusion chromatography
Photo-Cleavage of Cobalt-Carbon Bond: Visible. Light-Induced Living Radical Polymerization Mediated by. Organo-Cobalt Porphyrins
Photo-Cleavage of Cobalt-Carbon Bond: Visible Light-Induced Living Radical Polymerization Mediated by Organo-Cobalt Porphyrins Yaguang Zhao, Mengmeng Yu, and Xuefeng Fu* Beijing National Laboratory for
Supporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supporting Information Nanoparticle-to-vesicle and nanoparticle-to-toroid transitions of ph-sensitive
Investigating Nitroxide-Mediated Radical Polymerization of Styrene over a Range of Reaction Conditions
Investigating Nitroxide-Mediated Radical Polymerization of Styrene over a Range of Reaction Conditions A. Nabifar N. T. McManus A. Penlidis Institute for Polymer Research (IPR) Department of Chemical Engineering
Utilization of star-shaped polymer architecture in the creation of high-density polymer
Electronic Supplementary Material (ESI) for Biomaterials Science. This journal is The Royal Society of Chemistry 2014 Supplementary Information Utilization of star-shaped polymer architecture in the creation
Supplementary Information. "On-demand" control of thermoresponsive properties of poly(n-isopropylacrylamide) with cucurbit[8]uril host-guest complexes
![Supplementary Information. On-demand control of thermoresponsive properties of poly(n-isopropylacrylamide) with cucurbit[8]uril host-guest complexes](/thumbs/88/115455573.jpg "Supplementary Information. On-demand control of thermoresponsive properties of poly(n-isopropylacrylamide) with cucurbit[8]uril host-guest complexes")
upplementary Information "n-demand" control of thermoresponsive properties of poly(n-isopropylacrylamide) with cucurbit[8]uril host-guest complexes Urs Rauwald, Jesús del Barrio, Xian Jun Loh, and ren
Supported cobalt mediated radical polymerization (SCMRP) of vinyl acetate and recycling of the cobalt complex 1
Supported cobalt mediated radical polymerization (SCMRP) of vinyl acetate and recycling of the cobalt complex 1 Valérie Sciannamea, Antoine Debuigne, Yasmine Piette, Robert Jérôme and Christophe Detrembleur
Analysis of Star Polymers Using the Agilent 1260 Infinity Multi-Detector GPC/SEC System
Analysis of Star Polymers Using the Agilent 1260 Infinity Multi-Detector GPC/SEC System Application Note Material testing Authors Kayleigh McEwan, Rajan K. Randev, and David M. Haddleton University of
Contents 1. Kinetic investigations Characterisation of monoliths made in NMR tubes EDX mapping Nitrogen adsorption...
Supplementary Information Porous, functional, poly(styrene-co-divinylbenzene) monoliths synthesized by RAFT Polymerization Kristine J. Barlow (née Tan),* Xiaojuan Hao. Timothy C. Hughes, Oliver E. Hutt,
Novel Tri-Block Copolymer of Poly (acrylic acid)-b-poly (2,2,3,3,4,4,4- hexafluorobutyl acrylate)-b-poly (acrylic acid) Prepared via Two-Step
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry Please do 2016 not adjust margins Electronic Supplementary Information (ESI) for Novel Tri-Block
Supporting Information. Vesicles of double hydrophilic pullulan and. poly(acrylamide) block copolymers: A combination
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2017 Supporting Information Vesicles of double hydrophilic pullulan and poly(acrylamide) block
Comparison between Polymerization Techniques for synthesis of Energetic Thermoplastic Elastomers. Khalifa Al-Kaabi and Albert Van Reenen
Comparison between Polymerization Techniques for synthesis of Energetic Thermoplastic Elastomers Khalifa Al-Kaabi and Albert Van Reenen Department for Chemistry and Polymer Science, University of Stellenbosch,
Engineering. Green Chemical. S. Suresh and S. Sundaramoorthy. and Chemical Processes. An Introduction to Catalysis, Kinetics, CRC Press
I i Green Chemical Engineering An Introduction to Catalysis, Kinetics, and Chemical Processes S. Suresh and S. Sundaramoorthy CRC Press Taylor & Francis Group Boca Raton London New York CRC Press is an
MODIFICATION WITH A SULFONATE MONOMER
Thesis - MOLECULAR STRUCTURES AND FUNCTIONAL MODIFICATIONS OF POLY(VINYL ALCOHOL) CHAPTER 8 BY TOHEI MORITANI MODIFICATION WITH A SULFONATE MONOMER A functional monomer containing sodium sulfonate group,
Photocontrolled RAFT Polymerization Mediated by a
Supporting Information Photocontrolled RAFT Polymerization Mediated by a Supramolecular Catalyst Liangliang Shen, Qunzan Lu, Anqi Zhu, Xiaoqing Lv, and Zesheng An* Institute of Nanochemistry and Nanobiology,
1. Introductory Material
CHEE 321: Chemical Reaction Engineering 1. Introductory Material 1b. The General Mole Balance Equation (GMBE) and Ideal Reactors (Fogler Chapter 1) Recap: Module 1a System with Rxn: use mole balances Input
Supporting information to: Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, Berlin,
Supporting information to: Polymerization of ternary inclusion complexes of interacting monomer pairs with γ-cyclodextrin Niels ten Brummelhuis* and Maria T. Heilmann Department of Chemistry, Humboldt-Universität
In-line Monitoring of Continuous and Segmented Flow Processes
In-line Monitoring of Continuous and Segmented Flow Processes Catherine Carter, cc541@cam.ac.uk The Ley Group, Department of Chemistry, University of Cambridge Introduction Why do flow chemistry? Safety
Lecture 8. Polymers and Gels
Lecture 8 Polymers and Gels Variety of polymeric materials Polymer molecule made by repeating of covalently joint units. Many of physical properties of polymers have universal characteristic related to
Chapter 3: Stoichiometry
Chapter 3: Stoichiometry Chem 6A Michael J. Sailor, UC San Diego 1 Announcements: Thursday (Sep 29) quiz: Bring student ID or we cannot accept your quiz! No notes, no calculators Covers chapters 1 and
Chemical Engineering Seminar Series
Effect of Reaction Conditions on Copolymer Properties Loretta Idowu Keywords: copolymer composition distribution; radical polymerization kinetics; semi-batch starved feed; hydroxyl-functionality Non-functional
POLYMERIZATION REACTION MONITORING FOR PSA PRODUCTION USING AN ATR-FTIR PROBE
POLYMERIZATION REACTION MONITORING FOR PSA PRODUCTION USING AN ATR-FTIR PROBE Renata Jovanović, Doctoral student, Department of Chemical Engineering, University of Ottawa, Ottawa, Canada, (jovanovi@genie.uottawa.ca)
Autonomous Fluorescence Regulation in Responsive Polymer Systems Driven by a Chemical Oscillating Reaction **
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2016 Electronic Supporting Information Autonomous Fluorescence Regulation in Responsive Polymer
Flow Photochemistry made easy in the advanced Vapourtec UV-150 Flow Photoreactor
Flow Photochemistry made easy in the advanced Vapourtec UV-150 Flow Photoreactor Michael elgemöller and Duncan Guthrie Emails: michael.oelgemoeller@jcu.edu.au and duncan.guthrie@vavourtec.com Continuous-flow
Synthesis and Characterization of Well-defined PAA- PEG Multi-responsive Hydrogels by ATRP and Click Chemistry
Electronic Supplementary Material (ES) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Support information Synthesis and Characterization of Well-defined PAA- PEG Multi-responsive
Supporting Information
Supporting Information Effect Of TiO 2 Nanoparticle Surface Functionalization On Protein Adsorption, Cellular Uptake and Cytotoxicity: The Attachment Of PEG Comb Polymers Using Catalytic Chain Transfer
A Little Bit on Polymers and More on Radical Polymerizations
Leo Hendrick Baekeland The Bakelizer A Little Bit on Polymers and More on Radical Polymerizations Justin Barry Group Meeting 10/7/2015 Overview of Presentation Global demand Polymerization Basic nomenclature
Living p-quinodimethane Polymerization for the Synthesis of Well-Defined PPV Materials: Progress and Challenges
Living p-quinodimethane Polymerization for the Synthesis of Well-Defined PPV Materials: Progress and Challenges Thomas Junkers Hasselt University Wetenschapspark 1 BE 3590 Diepenbeek www.polymatter.net
The ph-responsive behaviour of aqueous solutions of poly(acrylic acid) is dependent on molar mass
Electronic Supplementary Material (ESI) for Soft Matter. This journal is The Royal Society of Chemistry 2016 The ph-responsive behaviour of aqueous solutions of poly(acrylic acid) is dependent on molar
Mole: base unit for an amount of substance A mole contains Avogadro s number (N A ) of particles (atoms, molecules, ions, formula units )
Mole: base unit for an amount of substance A mole contains Avogadro s number (N A ) of particles (atoms, molecules, ions, formula units ) N A 6.0 10 mol -1 1 mol substance contains N A Molar mass (g/mol)
Synthesis of Controlled Polymer Nanospheres by a Reversible Addition- Fragmentation Chain Transfer (RAFT) Miniemulsion Polymerization
Synthesis of Controlled Polymer Nanospheres by a Reversible Addition- Fragmentation Chain Transfer (RAFT) iniemulsion Polymerization Huije Lee, Sang Eun Shim, Byung H. Lee, Soonja Choe* Department of Chemical
Polymer Molecular Weight
Chapter 3 Polymer Molecular Weight 3.1 Introduction Polymer molecular weight is important because it determines many physical properties. Some examples include the temperatures for transitions from liquids
Jung Min Lee, Ok Hyung Kim, Sang Eun Shim, Byung H. Lee, and Soonja Choe* Department of Chemical Engineering, Inha University, Inchon , Korea
Macromolecular Research, Vol. 13, No. 3, pp 36-4 (005) Reversible Addition-Fragmentation Chain Transfer (RAFT) Bulk Polymerization of Styrene : Effect of R-Group Structures of Carboxyl Acid Group Functionalized
Supporting Information
Supporting Information UCST or LCST? Composition-Dependent Thermoresponsive Behavior of Poly(N-Acryloylglycinamide-co-Diacetone Acrylamide) Wenhui Sun, Zesheng An*, Peiyi Wu * Experimental Materials Glycinamide
Deep Desulfurization of Diesel using a Single-Phase Micro-reactor
Excerpt from the Proceedings of the COMSOL Conference 2009 Boston Deep Desulfurization of Diesel using a Single-Phase Micro-reactor Jake Jones, 1 Alex Yokochi, 1 and Goran Jovanovic *1 1 School of Chemical,
HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat
Electronic Supplementary Material (ESI) for Chemical Science. This journal is The Royal Society of Chemistry 206 Supporting information HIV anti-latency treatment mediated by macromolecular prodrugs of
Polymerization-Induced Thermal Self-Assembly (PITSA)
Electronic Supplementary Material (ESI) for Chemical Science. This journal is The Royal Society of Chemistry 2014 Electronic Supplementary Information for Polymerization-Induced Thermal Self-Assembly (PITSA)
Copper-Mediated Atom Transfer Radical Polymerisation (ATRP) of Acrylates in Protic Solution.
Copper-Mediated Atom Transfer Radical Polymerisation (ATRP) of Acrylates in Protic Solution. Laura. Pilon *, Steven P. Armes *, Paul Findlay, Steven Rannard. * School of Chemistry, Physics and Environmental
Engineering aspect of emulsion polymerization
Engineering aspect of emulsion polymerization Joong-In Kim Bayer Corp., Plastics, Technology Yonsei University Contents Free radical polymerization kinetics Emulsion polymerization Reactor configuration
of Polystyrene 4-arm Stars Synthesized by RAFT- Mediated Miniemulsions.
Supporting Information to Narrow Molecular Weight and Particle Size Distributions of Polystyrene 4-arm Stars Synthesized by RAFT- Mediated Miniemulsions. Hazit A. Zayas, Nghia P. Truong, David Valade,
SUPPLEMENTARY INFORMATION
Methods: Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity Andrew J. Keefe and Shaoyi Jiang Materials: α-chymotrypsin from bovine pancreas
Supporting Information
Supporting Information Controlled Radical Polymerization and Quantification of Solid State Electrical Conductivities of Macromolecules Bearing Pendant Stable Radical Groups Lizbeth Rostro, Aditya G. Baradwaj,
Self-Assembly and Multi-Stimuli Responsive. Behavior of PAA-b-PAzoMA-b-PNIPAM Triblock. Copolymers
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2017 Supporting Information Self-Assembly and Multi-Stimuli Responsive Behavior of PAA-b-PAzoMA-b-PNIPAM
Reduced graphene oxide composites with water soluble copolymers having tailored lower critical solution temperatures and unique tube-like structure
Reduced graphene oxide composites with water soluble copolymers having tailored lower critical solution temperatures and unique tube-like structure Mina Namvari 1,2, Chandra S. Biswas 1,2, Massimiliano
Sequence-controlled methacrylic multiblock. copolymers via sulfur-free RAFT emulsion. polymerization
DOI: 10.1038/NCHEM.2634 Sequence-controlled methacrylic multiblock copolymers via sulfur-free RAFT emulsion polymerization Nikolaos G. Engelis a, Athina Anastasaki* a,b,gabit Nurumbetov a, Nghia P. Truong
Polymer Reaction Engineering
Polymer Reaction Engineering Polymerization Techniques Bulk Solution Suspension Emulsion Interfacial Polymerization Solid-State Gas-Phase Plasma Polymerization in Supercritical Fluids Bulk Polymerization
Engineering and. Tapio Salmi Abo Akademi Abo-Turku, Finland. Jyri-Pekka Mikkola. Umea University, Umea, Sweden. Johan Warna.
Chemical Reaction Engineering and Reactor Technology Tapio Salmi Abo Akademi Abo-Turku, Finland Jyri-Pekka Mikkola Umea University, Umea, Sweden Johan Warna Abo Akademi Abo-Turku, Finland CRC Press is
ELECTRONIC SUPPORTING INFORMATION Pentablock star shaped polymers in less than 90 minutes via
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2015 ELECTRONIC SUPPORTING INFORMATION Pentablock star shaped polymers in less than 90 minutes
Chemistry 11: General Chemistry 1 Final Examination. Winter 2006
Chemistry 11: General Chemistry 1 Final Examination Winter 2006 Answers are given at the end of the exam. Name 1 Part 1 1. A 0.600 g pure sample of elemental iron (Fe) is dissolved in H 2 SO 4 (aq) to
Chemistry B11 Chapter 5 Chemical reactions
Chapter 5 Chemical reactions Chemical reactions are classified into five groups: A + B AB Synthesis reactions (Combination) H + O H O AB A + B Decomposition reactions (Analysis) NaCl Na +Cl A + BC AC +
Grafting polystyrene on Cellulose (CNC) by surface initiated. Atom Transfer Radical Polymerization (SI ATRP)
Grafting polystyrene on Cellulose (CNC) by surface initiated Abstract Atom Transfer Radical Polymerization (SI ATRP) Zhen Zhang, Gilles Sebe, Xiaosong Wang Grafting polymers on the surface of nanoparticles
Supporting Information. Flow Grignard and Lithiation: Screening Tools and Development of Continuous Processes
for: Flow Grignard and Lithiation: Screening Tools and Development of Continuous Processes for a Benzyl Alcohol Starting Material Michael E. Kopach, *, Kevin P. Cole, Patrick M. Pollock, Martin D. Johnson,
ph dependent thermoresponsive behavior of acrylamide-acrylonitrile UCSTtype copolymers in aqueous media
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2016 Supporting Information ph dependent thermoresponsive behavior of acrylamide-acrylonitrile
Attributes of Real time Micro Analytical Systems to Fully Exploit the Potential of Microscale Processing. Ray Chrisman, University of Washington, USA
Attributes of Real time Micro Analytical Systems to Fully Exploit the Potential of Microscale Processing Ray Chrisman, University of Washington, USA Definition of real time chemical analyzer A device that
Supporting Information. Precise Synthesis of Poly(N-Acryloyl Amino Acid) Through
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2018 Supporting Information Precise Synthesis of Poly(N-Acryloyl Amino Acid) Through Photoinduced
Polymers Reactions and Polymers Production (3 rd cycle)
EQ, Q, DEQuim, DQuim nd semester 017/018, IST-UL Science and Technology of Polymers ( nd cycle) Polymers Reactions and Polymers Production (3 rd cycle) Lecture 5 Viscosity easurements of the viscosity
Use of High Speed/High Resolution Size-Based Chromatographic Separation of Polymeric Mixtures with Offline Infrared Detection
Use of High Speed/High Resolution Size-Based Chromatographic Separation of Polymeric Mixtures with Michael O Leary 1, Jennifer Gough 1, Damian Morrison 1, Alain Creissen 2 1 Waters Corporation, Milford,
GAS FORMULAE THE GENERAL GAS EQUATION. 1 dm = 1000 ml = 1 L. 1cm = 1 ml
GAS FORMULAE THE GENERAL GAS EQUATION PV = nrt Note Useful Conversions P = Pressure ( kpa ) 760 mmhg = 1 atmosphere V = Volume ( L ) = 101,35Pa = 101.35 kpa n = Amount (in mol) of gas ( mol) 1 1 R = Gas
Size exclusion chromatography of branched polymers: Star and comb polymers
Macromol. Theory Simul. 8, 513 519 (1999) 513 Size exclusion chromatography of branched polymers: Star and comb polymers Hidetaka Tobita*, Sadayuki Saito Department of Materials Science and Engineering,
RAFT /MADIX polymerization of N-vinylcaprolactam in water-ethanol solvent mixtures
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2017 Supporting information for RAFT /MADIX polymerization of N-vinylcaprolactam in water-ethanol
From Polymer Gel Nanoparticles to Nanostructured Bulk Gels
From Polymer Gel Nanoparticles to Nanostructured Bulk Gels Zhibing Hu Departments of Physics and Chemistry, University of North Texas Denton, TX 76203, U. S. A. Phone: 940-565 -4583, FAX: 940-565-4824,
Supplemental Information
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2015 Supplemental Information Influence of Less Active Initiator on the Living Performance of Atom
Lonza Factory of Tomorrow for Flow Processes and MicroReactors
Pharma&Biotech Lonza Factory of Tomorrow for Flow Processes and MicroReactors Practical Continuous Flow Technology, Munich, Germany Dominique Roberge / Lonza Ltd, 3930 Visp / 5 June 2013 Lonza Re-design
Bis sulfone Reagents. Figure 1.
Bis sulfone Reagents An intact IgG molecule has four accessible inter chain disulfide bonds that can be reduced to form eight free cysteine thiols, which can serve as sites for conjugation. The reaction
Very low temperature CO oxidation over colloidally deposited gold nanoparticles on Mg(OH) 2 and MgO
Supporing Information Very low temperature CO oxidation over colloidally deposited gold nanoparticles on Mg(OH) 2 and MgO Chun-Jiang Jia, Yong Liu, Hans Bongard, Ferdi Schüth* Max-Planck-Institut für Kohlenforschung,
Development of an organometallic flow chemistry. reaction at pilot plant scale for the manufacture of
Supporting Information Development of an organometallic flow chemistry reaction at pilot plant scale for the manufacture of verubecestat David A. Thaisrivongs*, John R. Naber*, Nicholas J. Rogus, and Glenn
Field-Flow Fractionation of Macromolecules and Structures That Cannot be Characterized by Conventional GPC/SEC Techniques
The Field-Flow Fractionation Platform Field-Flow Fractionation of Macromolecules and Structures That Cannot be Characterized by Conventional GPC/SEC Techniques Trevor Havard, Evelin Moldenhaur, Soheyl
Clearing the Confusion: GPC, SEC, GFC What, When, Why, and How?
Clearing the Confusion: GPC, SEC, GFC What, When, Why, and How? Jean Lane Applications Engineer LC Columns & Consumables Technical Support January 19, 2017 What we will cover What - Clarification of the
Publications (i) Book
Publications 2006-2016 (i) Book 1. Moad G, Solomon DH. 2006. In: The Chemistry of Radical Polymerization Second Edition. Elsevier, Oxford. http://www.sciencedirect.com/science/book/9780080442884 1 Introduction
Well-defined Click-able Copolymers in One-Pot Synthesis
Electronic Supplementary Material (ESI) for hemomm. This journal is The Royal Society of hemistry 2014 Well-defined lick-able opolymers in ne-pot Synthesis egar Ghasdian, Mark A. Ward and Theoni K. Georgiou*
Radical Polymerizations II Special Cases
Radical Polymerizations II pecial Cases Devon A. hipp Department of Chemistry, & Center for Advanced Materials Processing Clarkson University Potsdam, NY 13699-5810 Tel. (315) 268-2393, Fax (315) 268-6610
MODELING OF CONTINUOUS OSCILLATORY BAFFLED REACTOR FOR BIODIESEL PRODUCTION FROM JATROPHA OIL ABSTRACT
MODELING OF CONTINUOUS OSCILLATORY BAFFLED REACTOR FOR BIODIESEL PRODUCTION FROM JATROPHA OIL B. K. Highina, I. M. Bugaje & B. Gutti Department of Chemical Engineering University of Maiduguri, Borno State,
Controlling Multicompartment Morphologies Using Solvent Conditions and Chemical Modification
Supporting Information to Controlling Multicompartment Morphologies Using Solvent Conditions and Chemical Modification by Tina I. Löbling, Olli Ikkala, André H. Gröschel *, Axel H. E. Müller * Materials
Towards Biocompatible Shell Cross-Linked Micelles
Towards Biocompatible Shell Cross-Linked Micelles Colin D Turner, Steven P Armes, Andrew L Lewis School of Chemistry, Physics and Environmental Science, University of Sussex, Falmer, Brighton, BN1 9QJ,
Gel Permeation Chromatography Basics and Beyond eseminar March 13, Jean Lane Technical and Applications Support LSCA, Columns and Supplies
Gel Permeation Chromatography Basics and Beyond eseminar March 13, 2013 Jean Lane Technical and Applications Support LSCA, Columns and Supplies 1 Content Overview of GPC/SEC What is it? Why do we use it?