Yibing Wu, Ph.D. Education: 2001: Ph. D, Department of Chemistry Supervisor: Prof. Wenxia Tang Nanjing University, Nanjing, China

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1 Yibing Wu, Ph.D. Department of Biochemistry & Biophysics University of Pennsylvania School of Medicine Philadelphia, PA Field of Specialization Experienced in the study of structure, function, dynamics and interaction of biological macromolecules by Nuclear Magnetic Resonance (NMR) spectroscopy Research Experiences: Dec Present Dec Nov Sep Nov Mar Sep Staff Scientist Supervisor: Prof. Bill DeGrado University of Pennsylvania Staff Scientist Supervisor: Prof. Thomas Szyperski State University of New York at Buffalo & Northeast Structural Genomics (NESG) consortium Postdoctoral Research Fellow Supervisor: Prof. Sharon Campbell University of North Carolina at Chapel Hill Postdoctoral Research Fellow Supervisor: Dr. Yun-Xing Wang NCI-Frederick, National Institutes of Health Education: 2001: Ph. D, Department of Chemistry Supervisor: Prof. Wenxia Tang Nanjing University, Nanjing, China 1995: BS, Department of Chemical Engineering Sichuan University, Chengdu, China NMR Structures Deposited in PDB: 18 protein structures as the first author and 15 structures as a collaborator 2 DNA structures as the first author Publications: 1. Computational design of a PAK1 binding protein

2 Y. Wu, page 2 Ramesh K Jha, Andrew Leaver-Fay, Shuangye Yin, Yibing Wu, Glenn L Butterfoss, Thomas Szyperski, Nikolay V Dokholyan, Brian Kuhlman Journal of Molecular Biology, Accepted 2. Clean absorption Mode NMR data acquisition based on time-proportional phase incrementation Yibing Wu, Arindam Ghosh and Thomas Szyperski Journal of Structural and Functional Genomics, 2009, 10, Simultaneous prediction of protein folding and docking at high resolution Rhiju Das, Ingemar André, Yang Shen, Yibing Wu, Alexander Lemak, Sonal Bansal,Cheryl H. Arrowsmith, Thomas Szyperski, David Baker Proceedings of the National Academy of Sciences, 2009, 106, Clean absorption-mode NMR data acquisition Yibing Wu, Arindam Ghosh and Thomas Szyperski Angewandte Chemie, 2009, 48, Differences in Conformation and Conformational Dynamics Between Cisplatin and Oxaliplatin DNA Adducts Stephen G. Chaney, Srinivas Ramachandran, S., Shantanu Sharma, Nikolay Dokholyan, Brenda Temple, Debadeep Bhattacharyya, Yibing Wu and Sharon Campbell Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy, 2009, 0, , 6. Consistent blind protein structure generation from NMR chemical shift data Yang Shen, Oliver Lange, Frank Delaglio, Paolo Rossi, James M. Aramini, Gaohua Liu, Alexander Eletsky, Yibing Wu, Kiran K. Singarapu, Alexander Lemak, Alexandr Ignatchenko, Cheryl H. Arrowsmith, Thomas Szyperski, Gaetano T. Montelione, David Baker and Ad Bax Proceedings of the National Academy of Sciences, 2008, 105, Solution structures of a DNA dodecamer duplex with and without a Cisplatin 1,2-d(GG) intrastrand cross-link: comparison with the Same DNA duplex containing an Oxaliplatin 1,2- d(gg) intrastrand cross-link Yibing Wu, Debadeep Bhattacharyya, Candice L. King, Irene Baskerville-Abraham, Sung-Ho Huh, Gunnar Boysen, James A. Swenberg, Brenda Temple, Sharon L. Campbell and Stephen G. Chaney Biochemistry. 2007; 46(22): RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi Donghan Lee, Joseph D. Walsh, Irina Mikhailenko, Ping Yu, Molly Migliorini, Yibing Wu, Susan Krueger, Joseph E. Curtis, Bradley Harris, Stephen Lockett, Steve C. Blacklow, Dudley K. Strickland and Yun-Xing Wang Molecular Cell, 2006, 22, NMR assignment of domain 3 of the receptor-associated protein (RAP) Donghan Lee, Joseph D. Walsh, Ping Yu, Molly Migliorini, Yibing Wu, Dudley K. Strickland and Yun-Xing Wang

3 Y. Wu, page 3 Journal of Biomolecular NMR,2006, 36: NMR solution structure of an Oxaliplatin 1,2-d(GG) intrastrand cross-link in a DNA dodecamer duplex Yibing Wu, Padmanava Pradhan, Jody Havener, Gunnar Boysen, James Swenberg, Sharon Campbell and Stephen Chaney Journal of Molecular Biology, 2004, 341, Protein interactions with platinum DNA adducts: from structure to function Stephen Chaney, Sharon Campbell, Brenda Temple, Ekaterina Bassett, Yibing Wu and Mihir Faldu Journal of Inorganic Biochemistry, 2004, 98(10), Recognition and Processing of Cisplatin- and Oxaliplatin-DNA Adducts Stephen G. Chaney, Sharon L. Campbell, Ekaterina Bassett and Yibing Wu Critical Reviews in Oncology/Hematology, 2005, 53(1); NMR structural studies of domain 1 of receptor-associated protein Yibing Wu, Molly Migliorini, Ping Yu, Joseph Walsh, Dudely K. Strickland and Yun-Xing Wang Journal of Biomolecular NMR, 2004, 29: H, 13 C and 15 N resonance assignments of domain 1 of receptor associated protein. Yibing Wu, Molly Migliorini, Ping Yu, Dudely K. Strickland and Yun-Xing Wang Journal of Biomolecular NMR, 2003, 26: NMR study of the conformational transition of cytochrome c upon the displacement of Met80 by exogenous ligand: structural and magnetic characterization of azidoferricytochrome c. Yong Yao, Yibing Wu, Chengmin Qian, Keqong Ye, Jinfeng Wang and Wenxia Tang. Biophysical Chemistry 2003, 103(1): The solution structure of cytochrome b 5 mutant (E44A/E48A/E56A/D60A) and its interaction with cytochrome c Yibing Wu, Yunhua Wang, Chengmin Qian, Jun Lu, Ercheng Li, Wenhu Wang, Junxia Lu, Yi Xie, Jinfeng Wang, Dexi Zhu, Zhongxian Huang and Wenxia Tang European Journal of Biochemistry, 2001, 268(6): Effects of extrinsic axial imidazole ligand on molecular structure and electronic structure of cytochrome c Lucia Banci, Ivano Bertini, Gaohua Liu, Jun Lu, Tim Reddig, Wenxia Tang, Yibing Wu, Yong Yao and Dexi Zhu Journal of Biochemical and Inorganic Chemistry, 2001, 6(5-6): NMR studies on solution structure of imidazole- cytochrome c Yibing Wu, Jun Lu, Yong Yao, Wenxia Tang, Dexi Zhu, Lucia Banci, Ivano Bertini, Gaohua Liu and Tim Reddig Chemical Journal Of Chinese Universities, 2001, 22 (6): 947 ( in Chinese)

4 Y. Wu, page NMR studies of 4-methylimidazole binding to cytochrome c: effects of substitute methyl on the binding affinity, the orientation of the ligand plane, and the electronic structure of the heme Yong Yao, Yibing Wu, Chengmin Qian and Wenxia Tang Journal of chemical society Dalton transactions, 2000,22, Kinetic studies of imidazole and its methyl derivative binding to metmyoglobin: effects of substitute methyl on the binding affinity Chengmin Qian,Yong Yao, Yibing Wu and Wenxia Tang Biometals, (3), Electrochemical study on the alkaline isomerization of cytochrome c and ligand-binding cytochrome c in the presence of pyridine and 2-methyl-pridine Yong Yao, Huangxian Ju, Yibing Wu, Sijun Yang and Wenxia Tang Chinese Journal of Inorganic Chemistry, 2000, 16(2), NMR studies on solution structure of cytochrome b 5 mutant (E44A/E48A/E56A/D60A) Yibing Wu, Jun Lu, Chengmin Qian, Ercheng Li, Jinfeng Wang, Wenxia Tang, Dexi Zhu Yunhua Wang, Wenhu Wang, Junxia Lu, Yi Xie and Zhongxian Huang Chemical Journal of Chinese Universities, 2000, 21(11) 1631 (in Chinese) 23. Compositions and conformations of several transitional metal complexes with a nonapeptide hormone oxytocin Hua Wei, Xuemei Luo, Yibing Wu, Yong Yao, Zijian Guo and Longgen Zhu Journal of chemical society Dalton transactions, 2000, Effects of some charged amino acid mutations on the electron self-exchange kinetics of ctochrome b 5 Dejian Ma, Yibing Wu, Chengmin Qian and Wenxia Tang Inorganic Chemistry, 1999,38, Patent: Nuclear Magnetic Resonance Spectroscopy Data Acquisition Schemes for Phase-sensitive Detection of Pure Absorption Mode Signals Devoid of Dispersive Components Arising from Phase Errors Thomas Szyperski, Arindam Ghose and Yibing Wu, Pending Presentation: Title: GFT-NMR based high throughput structure determination exemplified for NESG targets Sr500a and NeT4 9th Annual Upstate NMR Symposium (SUNY-ESF, Oct 12 th, 2007) Title: Protocol for NMR-based Structural Genomics 10th Annual Upstate NMR Symposium (Rochester Institute of Technology, Oct 17 th, 2008) Posters: International Conference on Magnetic Resonance in Biological System (San Diego, Aug 20-25, 2008)

5 Y. Wu, page 5 47 th ENC conference(the Asilomar Conference Centre, Pacific Grove, California, Apr 23-28, 2006) Southeastern Regional Meeting of the American Chemical Society (Research Triangle Park, NC, November 10-13, 2004) Keystone Symposia (Frontiers in Structural Biology, Snowbird, Utah, April 13 19, 2004) Albany 2003, The 13th Conversation ( Bimolecular structure and dynamics, Albany, NY, June 17-21, 2003) Keystone Symposia (Frontiers of NMR in Molecular Biology VIII, Taos, NM, Feb 4-10, 2003) National Cancer Institute Second Annual Fellows and Young Investigators Retreat (Baltimore, MD, Feb 25-26, 2002) Honors: Awarded Excellent Graduate Scholarship from Nanjing University in 2000 Awarded Scholarships during college studies at Sichuan University

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