Arrow Pushing in Organic Chemistry
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1 Arrow Pushing in Organic Chemistry An Easy Approach to Understanding Reaction Mechanisms Daniel E. Levy
2
3 Arrow Pushing in Organic Chemistry
4
5 Arrow Pushing in Organic Chemistry An Easy Approach to Understanding Reaction Mechanisms Daniel E. Levy
6 Copyright # 2008 by John Wiley & Sons, Inc. All rights reserved Published by John Wiley & Sons, Inc., Hoboken, New Jersey Published simultaneously in Canada No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Sections 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, (978) , fax (978) , or on the web at Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, (201) , fax (201) , or online at Limit of Liability/Disclaimer of Warranty: While the publisher and author have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials. The advice and strategies contained herein may not be suitable for your situation. You should consult with a professional where appropriate. Neither the publisher nor author shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages. For general information on our other products and services or for technical support, please contact our Customer Care Department within the United States at (800) , outside the United States at (317) or fax (317) Wiley also publishes its books in variety of electronic formats. Some content that appears in print may not be available in electronic format. For more information about Wiley products, visit our web site at Library of Congress Cataloging-in-Publication Data is available. ISBN Printed in the United States of America
7 Dedicated to the memory of Henry Rapoport ( ) Professor of Chemistry, Emeritus University of California Berkeley A true teacher and mentor
8
9 Contents PREFACE ACKNOWLEDGMENTS ABOUT THE AUTHOR xi xiii xv 1. Introduction Definition of Arrow Pushing Functional Groups Nucleophiles and Leaving Groups Summary 8 Problems Acids What are Acids? What is Resonance? How is Acidity Measured? Relative Acidities Inductive Effects Inductive Effects and Relative Acidities Relative Acidities of Hydrocarbons Summary 34 Problems 35 vii
10 viii CONTENTS 3. Bases and Nucleophiles What are Bases? What are Nucleophiles? Leaving Groups Summary 55 Problems S N 2 Substitution Reactions What is an S N 2 Reaction? What are Leaving Groups? Where Can S N 2 Reactions Occur? S N 2 0 Reactions Summary 73 Problems S N 1 Substitution Reactions What is an S N 1 Reaction? How are S N 1 Reactions Initiated The Carbocation Molecular Structure and Orbitals Stability of Carbocations Carbocation Rearrangements ,2-Hydride Shifts ,2-Alkyl Shifts Preventing Side Reactions Summary 96 Problems Elimination Reactions E1 Eliminations E2 Eliminations How Do Elimination Reactions Work? Summary 108 Problems Addition Reactions Addition of Halogens to Double Bonds Markovnikov s Rule Additions to Carbonyls ,2-Additions ,4-Additions Addition Elimination Reactions Summary 125 Problems 126
11 CONTENTS ix 8. Moving Forward Functional Group Manipulations Name Reactions Reagents Final Comments 144 Problems 146 Appendix 1. pk a Values of Protons Associated with Common Functional Groups 155 Appendix 2. Answers and Explanations to Problems 159 Chapter 1 Solutions 159 Chapter 2 Solutions 173 Chapter 3 Solutions 191 Chapter 4 Solutions 205 Chapter 5 Solutions 223 Chapter 6 Solutions 233 Chapter 7 Solutions 243 Chapter 8 Solutions 261 Appendix 3. Student Reaction Glossary 283 Index 287 Periodic Table of the Elements 301
12
13 Preface Organic chemistry is a general requirement for most students pursuing degrees in the fields of biology, physiology, medicine, chemical engineering, biochemistry, and chemistry. Consequently, many of the students studying organic chemistry initially do so out of obligations to required curriculum rather than out of genuine interest in the subject. This is, in fact, expected as almost all college students find themselves enrolling in classes in which they either have no interest or cannot foresee application of the subject to their future vocation. Alternatively, there are students who are intrigued with the potential application of organic chemistry to fields including pharmaceuticals, polymers, pesticides, food science, and energy. However, whichever group represents the individual students, there is always a common subset of each that tenuously approaches the study of organic chemistry due to rumors or preconceived notions that the subject is extremely difficult and requires extensive memorization. Having personally studied organic chemistry, and tutored many students in the subject, I assure you that this is not the case. When first presented with organic chemistry course material, one can easily be caught up in the size of the book, the encyclopedic presentation of reactions, and the self-questioning of how one can ever decipher the subject. These students frequently compile endless sets of flash cards listing specific chemical reactions and their associated names. Like many of my classmates, I began to approach the subject in this manner. However, this strategy did not work for me as I quickly realized that memorization of reactions did not provide any deductive or predictive insight into the progression of starting materials to products and by what mechanisms the transformations occurred. In fact, the fundamental fault in the memorization strategy is that in order to be effective, the student must not only memorize all chemical reactions and associated reaction names, but also all associated reaction mechanisms and potential competing processes. It was not until I abandoned the memorization strategy that I began to do well in organic chemistry and develop a true appreciation for the subject and how the science benefits society. The presumption that introductory organic chemistry entails very little memorization is valid and simplifies the subject provided the student adheres to the philosophy that the study xi
14 xii PREFACE of organic chemistry can be reduced to the study of interactions between organic acids and bases. From this perspective, organic chemistry students can learn to determine the most acidic proton in a given molecule, determine the most reactive site (for nucleophilic attack), determine the best reactants (nucleophiles and electrophiles), and how to predict reaction products. In learning to predict these components of organic reactions, the beginning organic chemist will be able to deduce reasonable routes from starting materials to products using the basic mechanistic types involved in introductory organic chemistry. Furthermore, through an understanding of how electrons move, extrapolations from ionic or heterolytic mechanisms can be used to explain free radical and electrocyclic processes. Finally, by utilizing the principles discussed in this book, the student will gain a better understanding of how to approach the more advanced reaction types discussed as the introductory organic chemistry course progresses. The goal of this book is not to present a comprehensive treatment of organic chemistry. Furthermore, this book is not intended to be a replacement for organic chemistry texts or to serve as a stand-alone presentation of the subject. This book is intended to supplement organic chemistry textbooks by presenting a simplified strategy to the study of the subject in the absence of extensive lists of organic reactions. Through application of the principles presented herein, it is my hope that this book, when used as intended, will aid the beginning student in approaching organic chemistry as I did with little memorization and much understanding. DANIEL E. LEVY, PH.D.
15 Acknowledgments I would like to express my deepest appreciation to my wife, Jennifer, and to my children, Aaron, Joshua, and Dahlia, for their patience and support while writing this book. I would also like to express a special thanks to Dr. Lane Clizbe for his editorial contributions. xiii
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