Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure
|
|
- Elaine Morgan
- 5 years ago
- Views:
Transcription
1 Supporting Information Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure Shuaidong Huo,,,, Ying Jiang,, Akash Gupta, Ziwen Jiang, Ryan Landis, Singyuk Hou, Xing-Jie Liang,,, * and Vincent M. Rotello, * Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience; and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, First North Road, Zhongguancun, Beijing , P. R. China University of Chinese Academy of Sciences, Beijing , P. R. China S. H. and Y. J. contributed equally to this work. * Address correspondence to liangxj@nanoctr.cn and rotello@chem.umass.edu
2 Chemicals. Chloroauric acid ( 99.8%) used for gold nanoparticle synthesis was bought from Strem Chemicals Inc. (Newburyport, MA). Sodium borohydride was purchased from Acros (New Jersey, USA). Unless otherwise noted, all chemicals were used as received without further purification. Milli-Q water (18.2 MΩ cm, Millipore System Inc.) was used throughout this study. Synthesis of nanoparticles. The procedure for 2, 4 and 6 nm zwitterionic gold nanoparticles synthesis was based on the Brust-Schiffrin method. 1,2 Briefly, Chloroauric acid (5.0 mg in 500 μl) and zwitterionic ligand 3,4 were dissolved in 700 μl of methanol/acetic acid 6:1 (v/v). 100 μl of sodium borohydrate (10.0 mg) in ice-cold water was added dropwise with rapid stirring. After continuous stirring for 3 h, nanoparticle solution was formed, and the solvent was then removed under vacuum at 40 C. The residues were dissolved in 10 ml de-ionized water, and the solution was then dialyzed (dialysis membrane, Thermo Scientific, MWCO=10000) for 72 h against de-ionized water, which was changed every 8 h. 2, 4, and 6 nm particles were obtained via adjusting the molar ratio of chloroauric acid and zwitterionic ligand (1:3, 1:1 and 3:1, respectively). Characterization of as-prepared gold nanoparticles. The morphology of the AuNPs was examined using a FEI TecaniT12 microscope with an accelerating voltage of 120 kv. Particle hydrodynamic diameter was measured on a Malvern Zetasizer (Nano series, Malvern Instruments Inc, USA) with a He-Ne laser (633 nm) and a backscattering angle of 173º. The molecular peak of ligand was determined by MALDI-MS (Bruker Autoflex III MALDI-TOF MS, 200 shots-20 off-laser 55%, with ion suppression up to 400 Da). S2
3 Mammalian cell viability assay. NIH-3T3 cells (ATCC CRL-1658) were purchased from American Type Culture Collection (ATCC, Manassas, VA) and maintained in Low-glucose Dulbecco's modified Eagle's medium (DMEM) with 10% fetal bovine serum (FBS) and 1% antibiotic (100 U/mL penicillin and 100 μg/ml streptomycin). Cells were cultured at 37 C under a humidified atmosphere of 5% CO 2 (96-well plate, cells/well). Media was removed and cells were washed with phosphate-buffered saline (PBS) before addition of NPs with each MIC concentration. Then, cells were incubated for another 24 h before cell viability determination using Alamar blue assay according to the manufacturer's protocol (Invitrogen Biosource). After incubation, 200 μl of solution from each wells was transferred in a 96-well black microplate and quantified (excitation/emission: 560 nm/590 nm) on a SpectroMax M5 microplate reader (Molecular Device) to determine the cellular viability. Cells without any NPs treatment were normalized as 100%. Each experiment was performed in triplicate. S3
4 Table S1. Dynamic light scattering analysis and zeta-potential measurements of as-synthesized nanoparticles in 5 mm phosphate buffer (ph = 7.4). S4
5 Figure S1. LDI-MS spectrum of zwitterionic gold nanoparticles with (A) SN (m/z 601.1), and (B) NS (m/z 530.2) ligand modifications. S5
6 Table S2. MIC values (nm) of zwitterionic Au-SN and Au-NS NPs against Gram-negative (P. aeruginosa) and Gram-positive (A. azurea) bacterial strains. Cultures were performed in triplicate, and at least two independent experiments were repeated on different days. S6
7 Figure S2. Visualizing morphological changes in cell membranes using TEM at a low magnification. Gram-negative (P. aeruginosa) and Gram-positive (A. azurea) bacterial strains were treated with 6 nm Au-SN NPs at their MIC concentration for 3 h. S7
8 Figure S3. Propidium iodide staining assay of Gram-negative (P. aeruginosa) control group, and Gram-positive (A. azurea) bacterial strain after 3 h incubation with 6 nm zwitterionic NPs at MIC concentration. S8
9 Figure S4. Qualified leakage percentage of bacteria penetrated by the 6 nm core zwitterionic nanoparticles using ImageJ based on confocal fluorescence images. S9
10 Figure S5. Cell viability assay of gold nanoparticles featuring different size and surface ligand on NIH-3T3 cells. NIH-3T3 cells were treated with each NP s MIC concentration for 24 h. Mean values ± standard deviation, N = 3. S10
11 Figure S6. Hemolytic activity of gold nanoparticles featuring different size and surface ligand at different concentrations on human red blood cells (RBCs) for 30 min at 37 C. The mixture was centrifuged to detect the cell-free hemoglobin in the supernatant. Hemolysis (%) was calculated using water as a positive (+) control. RBCs incubated with PBS were used as negative (-) control. Error bars represent standard deviations (N = 3). S11
12 Figure S7. Hemolytic activity of gold nanoparticles featuring different size and surface ligand at different concentrations on human red blood cells (RBCs) for 24 h at 37 C. The mixture was centrifuged to detect the cell-free hemoglobin in the supernatant. Hemolysis (%) was calculated using water as a positive (+) control. RBCs incubated with PBS were used as negative (-) control. Error bars represent standard deviations (N = 3). S12
13 REFERENCE 1. Brust, M.; Walker, M.; Bethell, D.; Schiffrin, D. J.; Whyman, R. Synthesis of Thiol-Derivatised Gold Nanoparticles in A Two-Phase Liquid-Liquid System. J. Chem. Soc., Chem. Commun. 1994, Huo, S. D.; Jin, S. B.; Ma, X. W.; Xue, X. D.; Yang, K. N.; Kumar, A.; Wang, P. C.; Zhang, J. C.; Hu, Z. B.; Liang, X. J. Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry. ACS Nano 2014, 8, Jiang, Y.; Huo, S. D.; Mizuhara, T.; Das, R.; Lee, Y. W.; Hou, S.; Moyano, D. F.; Duncan, B.; Liang, X. J.; Rotello, V. M. The Interplay of Size and Surface Functionality on the Cellular Uptake of Sub-10 nm Gold Nanoparticles. ACS Nano 2015, 9, Mizuhara, T.; Saha, K.; Moyano, D. F.; Kim, C. S.; Yan, B.; Kim, Y. K.; Rotello, V. M. Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor ph. Angew. Chem. Int. Ed. 2015, 54, S13
Biodistributions of Gold Nanoparticles
Supporting information Surface Charge Controls the Sub-Organ Biodistributions of Gold Nanoparticles Sukru Gokhan Elci, Ying Jiang, Bo Yan, Sung Tae Kim, Krishnendu Saha, Daniel F. Moyano, Gulen Yesilbag
More informationAggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces.
Aggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces. Steven C. Hayden, a Gengxiang Zhao, e Krishnendu Saha, c Ronnie L. Phillips, a Xiaoning Li, c Oscar R. Miranda, c Vincent M.
More informationSupporting Information
Supporting Information Phenyl-Modified Carbon Nitride Quantum Dots with Distinct Photoluminescence Behavior Qianling Cui, Jingsan Xu,* Xiaoyu Wang, Lidong Li,* Markus Antonietti, and Menny Shalom anie_201511217_sm_miscellaneous_information.pdf
More informationThe Blue Two Photon Fluorescence Metal Cluster Probe. Precisely Marking Cell Nuclei of Two Cell Lines
Electronic Supplementary Information The Blue Two Photon Fluorescence Metal Cluster Probe Precisely Marking Cell Nuclei of Two Cell Lines Yaling Wang, a, Yanyan Cui, a, Ru Liu, a Yueteng Wei, a Xinglu
More informationSupporting Information. Carbon Imidazolate Framework-8 Nanoparticles for
Supporting Information Carbon Nanodots@Zeolitic Imidazolate Framework-8 Nanoparticles for Simultaneous ph-responsive Drug Delivery and Fluorescence Imaging Liu He, a Tingting Wang, b Jiping An, c Xiaomeng
More informationHybrid Gold Superstructures: Synthesis and. Specific Cell Surface Protein Imaging Applications
Supporting Information Hybrid Gold Nanocube@Silica@Graphene-Quantum-Dot Superstructures: Synthesis and Specific Cell Surface Protein Imaging Applications Liu Deng, Ling Liu, Chengzhou Zhu, Dan Li and Shaojun
More informationSupporting Information. Near infrared light-powered Janus mesoporous silica nanoparticle motors
Supporting Information Near infrared light-powered Janus mesoporous silica nanoparticle motors Mingjun Xuan,, Zhiguang Wu,, Jingxin Shao, Luru Dai, Tieyan Si,, * and Qiang He, * State Key Laboratory of
More informationSupporting Information
Supporting Information A Low-Temperature Solid-Phase Method to Synthesize Highly Fluorescent Carbon Nitride Dots with Tunable Emission Juan Zhou, Yong Yang, and Chun-yang Zhang* Single-Molecule Detection
More informationMagnetic Janus Nanorods for Efficient Capture, Separation. and Elimination of Bacteria
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2016 Magnetic Janus Nanorods for Efficient Capture, Separation and Elimination of Bacteria Zhi-min
More informationRole of Surface Charge of Inhibitors on Amyloid Beta Fibrillation
Supporting Information Role of Surface Charge of Inhibitors on Amyloid Beta Fibrillation SWATHI SUDHAKAR, PANDURANGAN KALIPILLAI, POORNIMA BUDIME SANTHOSH, ETHAYARAJA MANI* POLYMER ENGINEERING AND COLLOID
More information1 Synthesis and characterization of the amphiphilic ionic dendrimers
Electronic Supplementary Material (ESI) for Soft Matter. This journal is The Royal Society of Chemistry 2015 Supplementary information 1 Synthesis and characterization of the amphiphilic ionic dendrimers
More informationSupporting Information
Supporting Information One-Step Synthesis of Amine-Functionalized Hollow Mesoporous Silica Nanoparticles as Efficient Antibacterial and Anticancer Materials Nanjing Hao, Kalana W. Jayawardana, Xuan Chen
More informationImproved Biocompatibility of Surface Functionalized Dendrimer-Entrapped Gold Nanoparticles
Improved Biocompatibility of Surface Functionalized Dendrimer-Entrapped Gold Nanoparticles Xiangyang Shi, Suhe Wang, Haiping Sun, James R. Baker, Jr. Michigan Nanotechnology Institute for Medicine and
More informationDepartment of Materials Science and Engineering, Clemson University, Clemson, SC 29634, United States
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2015 Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesin
More informationSupporting Information
Supporting Information Dumbbell-Like Au-Fe 3 Nanoparticles for Target-Specific Platin Delivery Chenjie Xu, Baodui Wang, and Shouheng Sun* Department of Chemistry, Brown University, Providence, Rhode Island
More informationSUPPLEMENTARY INFORMATION
t DOI: 10.1038/NCHEM.2284 Supramolecular Regulation of Bioorthogonal Catalysis in Cells Using Nanoparticle-Embedded Transition Metal Catalysts Gulen Yesilbag Tonga, Youngdo Jeong, Bradley Duncan, Tsukasa
More informationElectronic Supplementary Information (ESI) Near-infrared light and ph-responsive
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information (ESI) Near-infrared light and ph-responsive Au@carbon/calcium
More informationTwo-photon-excited near-infrared emissive carbon dots as multifunctional agents for fluorescence imaging and photothermal therapy
Electronic Supplementary Material Two-photon-excited near-infrared emissive carbon dots as multifunctional agents for fluorescence imaging and photothermal therapy Minhuan Lan 1,, Shaojing Zhao 1,, Zhenyu
More informationSupplementary Information. Pluronic polymer capped biocompatible mesoporous silica nanocarriers
Supplementary Information Pluronic polymer capped biocompatible mesoporous silica nanocarriers Adem Yildirim,* ab Gokcen Birlik Demirel, bc Rengin Erdem, ab Berna Senturk, ab Turgay Tekinay, ab and Mehmet
More informationSupporting information to. Guanidinium-dendronized Perylene bisimides as stable, water-soluble fluorophores for live-cell imaging
Supporting information to Guanidinium-dendronized Perylene bisimides as stable, water-soluble fluorophores for live-cell imaging Juan Zhou, a Jun Zhang, a Yanbang Lai, b Zhe Zhou, a Yang Zhao, a Hongyu
More informationA Simple Fluorescein Derived Colorimetric and Fluorescent off - on Sensor For The Detection of Hypochlorite
Electronic Supplementary Material (ESI) for Analytical Methods. This journal is The Royal Society of Chemistry 2018 Supporting information A Simple Fluorescein Derived Colorimetric and Fluorescent off
More informationIn vivo monitoring of hydrogen sulfide using a cresyl violet-based ratiometric fluorescence probe
Electronic Supplementary Information for: In vivo monitoring of hydrogen sulfide using a cresyl violet-based ratiometric fluorescence probe Qiongqiong Wan, Yanchao Song, Zhao Li, Xinghui Gao and Huimin
More informationSupporting Information
Supporting Information Functionalized Nano-MoS 2 with Peroxidase Catalytic and Near- Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications Wenyan Yin, a,#, * Jie Yu,
More informationSupplementary Information A Highly Selective and Sensitive Nanoprobe for Detection and Imaging of Superoxide Anion Radical in Living Cells
Supplementary Information A Highly Selective and Sensitive Nanoprobe for Detection and Imaging of Superoxide Anion Radical in Living Cells Na Li, Hui Wang, Mei Xue, Chenyang Chang, Zhenzhen Chen, Linhai
More informationSupplementary Information. Development of a conjugated polymer-based fluorescent probe for selective detection of HOCl
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry C. This journal is The Royal Society of Chemistry 2015 Supplementary Information Development of a conjugated polymer-based fluorescent
More informationSupporting Information. Ugi Reaction of Natural Amino Acids: A General Route toward Facile Synthesis of Polypeptoids for Bioapplications
Supporting Information Ugi Reaction of Natural Amino Acids: A General Route toward Facile Synthesis of Polypeptoids for Bioapplications Xiaojie Zhang,, Shixue Wang,,#, Jing Liu, Zhigang Xie, Shifang Luan,
More informationMultifunctional polyphosphazene-coated multi-walled carbon. nanotubes for the synergistic treatment of redox-responsive
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2017 Supporting information for Multifunctional polyphosphazene-coated multi-walled carbon
More informationSupporting Information. Simple Bacterial Detection and High-Throughput Drug Screening. Based on Graphene-Enzyme Complex
Supporting Information Simple Bacterial Detection and High-Throughput Drug Screening Based on Graphene-Enzyme Complex Juan-Li, Ling-Jie Wu, Shan-Shan Guo, Hua-E Fu, Guo-Nan Chen* and Huang-Hao Yang* The
More informationCollege of Life Science and Bioengineering, Beijing University of Technology, No.100, PingLeYuan, ChaoYang District, Beijing, , P.R.
Supporting information A T 1 -Mediated Nanosensor for Immunoassay Based on Activatable MnO 2 Nano-Assembly Zixin Liu, #, Yunlei Xianyu #, Wenshu Zheng #, Jiangjiang Zhang, Yunjing Luo *, Yiping Chen *,
More informationConstruction of nanoantennas on the outer bacterial membrane
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Electronic Supplementary Information Construction of nanoantennas on the outer bacterial membrane
More informationThree Dimensional Nano-assemblies of Noble Metal. Nanoparticles-Infinite Coordination Polymers as a Specific
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Electronic Supplementary Information Three Dimensional Nano-assemblies of Noble Metal Nanoparticles-Infinite
More informationppm Supplementary Figure 1 1 H NMR spectra. Titration of 1 in D 2 O with increasing amounts of CB[8] (400 MHz, 25 C, [PP] = 2[CB[8]] = 8.0 mm).
ppm Supplementary Figure 1 1 H NMR spectra. Titration of 1 in D 2 O with increasing amounts of CB[8] (4 MHz, 25 C, [PP] = 2[CB[8]] = 8. mm). ppm ppm Supplementary Figure 2 1 H NMR spectra. (a) Titration
More informationHighly Sensitive and Selective Colorimetric Visualization of Streptomycin in Raw Milk Using Au Nanoparticles Supramolecular Assembly
SUPPORTING INFORMATION Highly Sensitive and Selective Colorimetric Visualization of Streptomycin in Raw Milk Using Au Nanoparticles Supramolecular Assembly Jiayu Sun, Jiechao Ge, Weimin Liu, Zhiyuan Fan,
More informationLaser desorption/ionization on the layer of graphene nanoparticles coupled with mass spectrometry for characterization of polymer
Laser desorption/ionization on the layer of graphene nanoparticles coupled with mass spectrometry for characterization of polymer Minghua Lu, a Yongquan Lai, a Guonan Chen, b and Zongwei Cai* a a Department
More informationPolymer Science, Series A, 2017, Vol. 59, No. 3 SUPPORTING INFORMATION. The Screening and Evaluating of Chitosan/β-cyclodextrin
Polymer Science, Series A, 2017, Vol. 59, No. 3 SUPPORTING INFORMATION The Screening and Evaluating of Chitosan/β-cyclodextrin Nanoparticles for Effective Delivery Mitoxantrone Hydrochloride Yiwen Wang,
More informationSupplementary Material:
Supplementary Material: Water soluble amphiphilic gold nanoparticles with structured ligand shells Oktay Uzun, Ying Hu, Ayush Verma, Suelin Chen, Andrea Centrone, and Francesco Stellacci* Department of
More informationIntracellular Adenosine Triphosphate Deprivation Through Lanthanide-doped Nanoparticles
SUPPORTING INFORMATION Intracellular Adenosine Triphosphate Deprivation Through Lanthanide-doped Nanoparticles Jing Tian,, Xiao Zeng, Xiaoji Xie, Sanyang Han, Oi-Wah Liew, Փ Yei-Tsung Chen, Փ Lianhui Wang,*,,
More informationSupporting Information
Supporting Information Surfactant-Free Preparation of Au@Resveratrol Hollow Nanoparticles with Photothermal Performance and Antioxidant Activity Wenjing Wang, Qi Tang, Tianrong Yu, Xing Li, Yang Gao, Jing
More informationFast ph-assisted functionalization of silver nanoparticles with monothiolated DNA
Supporting Information for Fast ph-assisted functionalization of silver nanoparticles with monothiolated DNA Xu Zhang ab, Mark R. Servos b, and Juewen Liu* a a Department of Chemistry and Waterloo Institute
More informationChromo-fluorogenic Detection of Aldehydes with a Rhodamine Based Sensor Featuring an Intramolecular Deoxylactam
Chromo-fluorogenic Detection of Aldehydes with a Rhodamine Based Sensor Featuring an Intramolecular Deoxylactam Zhu Li, 1,2,3 Zhongwei Xue, 1,3 Zhisheng Wu, 1 Jiahuai Han 2 and Shoufa Han 1, * 1 Department
More informationThe cytotoxicity of gold nanoparticles is dispersitydependent
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2015 The cytotoxicity of gold nanoparticles is dispersitydependent Dengtong Huang, Hualu
More informationEncapsulation of enzyme in metal ion-surfactant nanocomposites for
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2017 Supporting information for Encapsulation of enzyme in metal ion-surfactant nanocomposites for catalysis
More informationSupporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Supporting Information Self-Sacrificial Template-Induced Modulation of Conjugated Microporous Polymer
More information3D Dendritic Gold Nanostructures: Seeded Growth of Multi-Generation Fractal Architecture
-Supporting Information- 3D Dendritic Gold Nanostructures: Seeded Growth of Multi-Generation Fractal Architecture Ming Pan, Shuangxi Xing, Ting Sun, Wenwen Zhou, Melinda Sindoro, Hui Hian Teo, Qingyu Yan,
More informationBottom-up Optimization of SERS Hot Spots. Supplementary Information
Bottom-up Optimization of SERS Hot Spots Laura Fabris, * Department of Materials Science and Engineering, Institute for Advanced Materials Devices ad Nanotechnology, Rutgers, The State University of New
More informationSupplementary Information
Supplementary Information Fabrication of Novel Rattle-Type Magnetic Mesoporous carbon Microspheres for Removal of Microcystins Xinghua Zhang and Long Jiang* Beijing National Laboratory for Molecular Science
More informationSpecifically colorimetric recognition of calcium, strontium, barium. ions using 2-mercaptosuccinic acid-functionalized gold nanoparticles
Electronic Supporting Information (ESI) for Specifically colorimetric recognition of calcium, strontium, barium ions using 2-mercaptosuccinic acid-functionalized gold nanoparticles and its use in reliable
More informationSupplementary information
Supplementary information General Strategy for Direct Cytosolic Protein Delivery via Protein- Nanoparticle Co-Engineering Rubul Mout, Moumita Ray, Tristan Tay, Kanae Sasaki, Gulen Yesilbag Tonga, Vincent
More informationElectronic supplementary information
Electronic supplementary information Surface plasmon resonance enhanced upconversion luminescence in aqueous media for TNT selective detection Nina Tu and Leyu Wang* State Key Laboratory of Chemical Resource
More informationSupporting Information
Supporting Information Construction and biological applications of electrochemically active, anti-biofouling polymer adlayers on transparent electrode surfaces Eun Jeong Kim, a Hee-Young Shin, a Sang-Jin
More information1 Supporting Information. 2 3 Materials and methods: 4 Chemicals: Fmoc-amino acids were obtained from GL Biochem (Shanghai).
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 1 Supporting Information 2 3 Materials and methods: 4 Chemicals: Fmoc-amino acids were obtained
More informationGold Nanoshell Coated Thermo-pH Dual Responsive Liposomes for Resveratrol Delivery and Chemophotothermal
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry B. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information (ESI) Gold Nanoshell Coated Thermo-pH
More informationSupporting Information. Time-Resolved Botulinum Neurotoxin A Activity Monitored using. Peptide-Functionalized Au Nanoparticle Energy Transfer Sensors
Electronic Supplementary Material (ESI) for Chemical Science. This journal is The Royal Society of Chemistry 2014 Supporting Information Time-Resolved Botulinum Neurotoxin A Activity Monitored using Peptide-Functionalized
More informationSupporting Information
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2017 ROS-mediated Carbon Monoxide and Drug Release from Drug-conjugated Carboxyboranes Theppawut
More informationSupporting Information
Supporting Information Materials Multiwalled carbon nanotubes (MWNTs, φ = 10-30 nm) were purchased from Nanotech Port Co. Ltd. (Shenzhen, China). Tetraethylorthosilicate (TEOS, >98 %), Triton X-100 and
More informationRational design of a ratiometric fluorescent probe with a large emission shift for the facile detection of Hg 2+
Rational design of a ratiometric fluorescent probe with a large emission shift for the facile detection of Hg 2+ Weimin Xuan, a Chen Chen, b Yanting Cao, a Wenhan He, a Wei Jiang, a Kejian Li, b* and Wei
More informationBifunctional peptides: Precisely Biomineralize Au Clusters and Specifically Stain Cell Nuclei
Electronic Supplementary Information Bifunctional peptides: Precisely Biomineralize Au Clusters and Specifically Stain Cell Nuclei Yaling Wang, Yanyan Cui, Yuliang Zhao*, Ru Liu, Zhipeng Sun, Wei Li, and
More informationA Novel Detection Technique of Hydrazine Hydrate: Modality Change of Hydrogen-Bonding Induced Rapid and Ultrasensitive Colorimetric Assay
A Novel Detection Technique of Hydrazine Hydrate: Modality Change of Hydrogen-Bonding Induced Rapid and Ultrasensitive Colorimetric Assay Zhenlu Zhao, a Kelong Ai, b Guo Zhang, b Ying Gao, a Xiuyun Yang,*
More informationSupporting Information. for. Advanced Materials, adma Wiley-VCH 2006
Supporting Information for Advanced Materials, adma.200601546 Wiley-VCH 2006 69451 Weinheim, Germany Supporting Information Synthesis of Magnetic Microspheres with Immobilized Metal Ions for Enrichment
More informationIN VITRO TOXICITY AND INTRACELLULAR UPTAKE OF FLAME SYNTHESIZED IRON OXIDE NANOPARTICLES: AN ALTERNATIVE TO WET SYNTHESIS METHODS.
IN VITRO TOXICITY AND INTRACELLULAR UPTAKE OF FLAME SYNTHESIZED IRON OXIDE NANOPARTICLES: AN ALTERNATIVE TO WET SYNTHESIS METHODS Kivilcim Buyukhatipoglu, Drexel University, Philadelphia, PA Tiffany Miller,
More informationHyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy
Supporting Information Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy L.Palanikumar, 1 Jimin Kim, 1 Jun Yong Oh, 1 Huyeon Choi,
More informationSupporting Information. Temperature dependence on charge transport behavior of threedimensional
Supporting Information Temperature dependence on charge transport behavior of threedimensional superlattice crystals A. Sreekumaran Nair and K. Kimura* University of Hyogo, Graduate School of Material
More informationSelf-assembly of PEGylated Gold Nanoparticles. with Satellite Structures as Seeds
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 216 Electronic Supplementary Information for Self-assembly of PEGylated Gold Nanoparticles with Satellite
More informationSupplementary Information. Core-Shell Silver/Polymeric Nanoparticles-Based Combinatorial Therapy against Breast Cancer In-vitro
Supplementary Information Core-Shell Silver/Polymeric Nanoparticles-Based Combinatorial Therapy against Breast Cancer In-vitro Nancy M. El-Baz 1,2, Laila Ziko 1,3, Rania Siam 1,3, Wael Mamdouh 1,2 * 1
More informationRatiometric Fluorescence Imaging of Cellular Glutathione
Supporting Information for: Ratiometric Fluorescence Imaging of Cellular Glutathione Gun-Joong Kim, Kiwon Lee, Hyockman Kwon, and Hae-Jo Kim, * Department of Chemistry, and Department of Bioscience and
More informationElectronic Supplementary Information. Zhen Zheng, Gongyu Li, Chengfan Wu, Miaomiao Zhang, Yue Zhao, and Gaolin Liang*
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information Intracellular synthesis of D-aminoluciferin for bioluminescence
More informationSupplementary Information
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2016 Supplementary Information Near infrared mediated photoactivation of cytotoxic Re(I)
More informationSupporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supporting Information Nanoparticle-to-vesicle and nanoparticle-to-toroid transitions of ph-sensitive
More informationElectronic Supplementary Information
Electronic Supplementary Information Polymer-coated spherical mesoporous silica for ph-controlled delivery of insulin Sae Rom Choi a,, Dong-jin Jang b,, Sanghyun Kim a, Sunhyung An c, Jinwoo Lee c, Euichaul
More informationSupporting Information
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Supporting Information Au nanoparticles supported on magnetically separable Fe 2 O 3 - graphene
More informationAnti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens
Anti-Inflammatory Isoquinoline with Bis-seco-aporphine Skeleton from Dactylicapnos scandens Bei Wang,,, Zi-Feng Yang,, Yun-Li Zhao, Ya-Ping Liu, Jun Deng, Wan-Yi Huang, Xiao-Nian Li, Xin-Hua Wang *, and
More informationA General and Reversible Phase Transfer Strategy Enabling Nucleotides Modified High-Quality Water-Soluble Nanocrystals
Supplementary Information A General and Reversible Phase Transfer Strategy Enabling Nucleotides Modified High-Quality Water-Soluble Nanocrystals Lu Liu, and Xinhua Zhong* EXPERIMENTAL SECTION Chemicals.
More informationSupporting Information
Copyright WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 01. Supporting Information for Adv. Mater., DOI:.0/adma.01 Color-Tunable Photoluminescent Fullerene Nanoparticles Jinyoung Jeong, Juyeon Jung,
More informationChiral Surface of Nanoparticles Determines the Orientation of Adsorbed Transferrin and its Interaction with Receptors
Supporting information Chiral Surface of Nanoparticles Determines the Orientation of Adsorbed Transferrin and its Interaction with Receptors Xinyi Wang,,,# Mingzhe Wang,,# Rong Lei, Shui fang Zhu, Yuliang
More informationSacrifical Template-Free Strategy
Supporting Information Core/Shell to Yolk/Shell Nanostructures by a Novel Sacrifical Template-Free Strategy Jie Han, Rong Chen and Rong Guo* School of Chemistry and Chemical Engineering, Yangzhou University,
More informationSupporting Information
Supporting Information Precisely Controllable Core-Shell Ag@Carbon Dots Nanoparticles: Application to in Situ Super-Sensitive Monitoring of Catalytic Reactions Jing Jin, Shoujun Zhu, Yubin Song, Hongyue
More informationSupporting Information
Supporting Information Au-HKUST-1 Composite Nanocapsules: Synthesis with a Coordination Replication Strategy and Catalysis on CO Oxidation Yongxin Liu, 1 Jiali Zhang, 1 Lingxiao Song, 1 Wenyuan Xu, 1 Zanru
More informationSupplementary Material (ESI) for Chemical Communications This journal is (c) The Royal Society of Chemistry Supporting information for:
Supporting information for: Preparation of 1-D Nanoparticle Superstructures with Tailorable Thicknesses using Gold-Binding Peptide Conjugates: New Insights into Fabrication Process and Mechanism Leekyoung
More informationSupporting Information:
Supporting Information: In Situ Synthesis of Magnetically Recyclable Graphene Supported Pd@Co Core-Shell Nanoparticles as Efficient Catalysts for Hydrolytic Dehydrogenation of Ammonia Borane Jun Wang,
More informationSupporting Information. Experimental details
Electronic Supporting Information Experimental details Chemicals and reagents Pseudoboehmite (78.4 wt% Al 2 O 3 ), phosphoric acid (85 wt%), triethylamine (TEA, 99%), tetrabutyl titanate (IV) (99%) and
More informationSupporting Information. Shape-controlled Synthesis of Colloidal Superparticles from Nanocubes
Supporting Information Shape-controlled Synthesis of Colloidal Superparticles from Nanocubes Tie Wang 1, Xirui Wang 1, Derek LaMontagne 1, Zhongliang Wang 1, Zhongwu Wang 2, and Y. Charles Cao 1* 1 Department
More informationDevelopment of a Reversible Fluorescent Gold Sensor with High. Selectivity
Supporting Information for Development of a Reversible Fluorescent Gold Sensor with igh Selectivity Jiaoliang Wang, Weiying Lin*, Lin Yuan, Jizeng Song, and Wensha Gao State Key Laboratory of Chemo/Biosensing
More informationSupporting Information
Supporting Information Interconversion between Superatomic 6-Electron and 8-Electron Configurations of M@Au 24 (SR) 18 Clusters (M = Pd, Pt) Kyuju Kwak, Qing Tang, Minseok Kim, De-en Jiang, and Dongil
More informationUsing an environmentally-relevant panel of Gramnegative bacteria to assess the toxicity of polyallylamine hydrochloride-wrapped gold nanoparticles
Electronic Supplementary Material (ESI) for Environmental Science: Nano. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information Using an environmentally-relevant panel
More informationCupreous Complex-Loaded Chitosan Nanoparticles for Photothermal Therapy
Supporting Information: Cupreous Complex-Loaded Chitosan Nanoparticles for Photothermal Therapy and Chemotherapy of Oral Epithelial Carcinoma Min Lin, Dandan Wang, Shuwei Liu, Tingting Huang, Bin Sun,
More informationSupporting Information
Electronic Supplementary Material (ESI) for Chemical Communications. This journal is The Royal Society of Chemistry 2016 Supporting Information Single-crystalline Pd square nanoplates enclosed by {100}
More informationSupporting Information
Supporting Information D Nanoporous Ag@BSA Composite Microspheres As Hydrogen Peroxide Sensor Quanwen Liu a, *, Ting Zhang b, Lili Yu c, Nengqin Jia c, Da-Peng Yang d * a School of Chemistry and Materials
More informationIntensely luminescent gold(i) phosphinopyridyl clusters: visualization of unsupported aurophilic interactions in solution
Electronic Supplementary Material (ESI) for Chemical Communications. This journal is The Royal Society of Chemistry 2017 Supplementary Information Intensely luminescent gold(i) phosphinopyridyl clusters:
More informationSupporting information
Electronic Supplementary Material (ESI) for Analyst. This journal is The Royal Society of Chemistry 2014 Supporting information Quantized double layer charging of Au 130 (SR) 50 Nanomolecules Vijay Reddy
More informationSupporting Materials Ultra-small Sub-10 nm Near Infrared Fluorescent Mesoporous Silica Nanoparticles
Supporting Materials Ultra-small Sub-10 nm Near Infrared Fluorescent Mesoporous Silica Nanoparticles Kai Ma, Hiroaki Sai and Ulrich Wiesner* Department of Materials Science and Engineering, Cornell University,
More informationSupporting Information for
Supporting Information for Crosslinked Polymer-Stabilized anocomposites for the Treatment of Bacterial Biofilms Ryan. Landis, Akash Gupta, Yi-Wei Lee, Li-Sheng Wang, Bianka Golba,, ± ice Couillaud,, Roxane
More informationMn 12 Single-Molecule Magnet Aggregates as Magnetic Resonance Imaging Contrast Agents
Electronic Supplementary Information Mn 12 Single-Molecule Magnet Aggregates as Magnetic Resonance Imaging Contrast Agents Yinglin Wang, a Wen Li, a Shengyan Zhou, b Daliang Kong, b Haishan Yang, b and
More informationSupporting Information. for A Water-Soluble Switching on Fluorescent Chemosensor of. Selectivity to Cd 2+
Supporting Information for A Water-Soluble Switching on Fluorescent Chemosensor of Selectivity to Cd 2+ Weimin Liu, a Liwei Xu, a Ruilong Sheng, a Pengfei Wang,*,a Huaping Li*,b and Shikang Wu a a Laboratory
More informationCorygaline A, Hexahydrobenzophenanthridine Alkaloid with. Unusual Carbon Skeleton from Corydalis bungeana Turcz.
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2018 Supporting Information for Corygaline A, Hexahydrobenzophenanthridine Alkaloid
More informationElectronic Supplementary Information (ESI) for the paper:
Electronic Supplementary Material (ESI) for Nanoscale. This journal is The Royal Society of Chemistry 2017 Electronic Supplementary Information (ESI) for the paper: [Ag59(2,5-DCBT)32] 3- : A new cluster
More informationElectronic supplementary information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2018 Electronic supplementary information Heterogeneous nucleation and growth of highly crystalline
More information- Supporting Information - Controlled Assembly of Eccentrically Encapsulated Gold Nanoparticles
- Supporting Information - S1 Controlled Assembly of Eccentrically Encapsulated Gold Nanoparticles Tao Chen, Miaoxin Yang, Xinjiao Wang, Li Huey Tan, Hongyu Chen* Division of Chemistry and Biological Chemistry,
More informationVitamin E-Labeled Polyethylenimine for in vitro and in vivo Gene Delivery
Supporting Information Vitamin E-Labeled Polyethylenimine for in vitro and in vivo Gene Delivery Jinxing Liu, Mengke Feng, Duanwei Liang, Jiali Yang, Xinjing Tang* State Key Laboratory of Natural and Biomimetic
More informationImpact of multivalent charge presentation on peptide
Supporting Information File 1 for Impact of multivalent charge presentation on peptide nanoparticle aggregation Daniel Schöne 1, Boris Schade 2, Christoph Böttcher 2 and Beate Koksch* 1 Address: 1 Institute
More informationHighly Efficient and Low Toxic Skin Penetrants Composed of Amino Acid Ionic Liquids
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 206 Supplementary Material (ESI) for RSC Advances Highly Efficient and Low Toxic Skin Penetrants
More information