Lab to Market. T.A. Abinandanan Indian Institute of Science Bengaluru
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1 Lab to Market T.A. Abinandanan Indian Institute of Science Bengaluru
2 Simputer (2002) from IISc pioneered the concept of research-based start-ups
3 NanoSniff from IIT-B
4 PathShodh (IISc)
5 NHHID (Anna University)
6 The journey begins with a breakthrough insight / idea And proceeds through Scientific validation through research Technology development / demonstration Make in India: Funding, Management, Institutional support
7 Government Initiatives: The Full Picture Scientific research SERB, DST, DBT, DeITY, CSIR... Technology development High-Risk-High-Reward, IMPRINT, UAY, BIRAC Manufacturing and marketing Make in India Incentives to promote ease of doing business.
8 We start with two examples
9 Magnetic Nanoparticles and Medical Imaging Electrolithography
10 Nanoparticles for Bio-Imaging: Magnetic Resonance Imaging and Fluorescence Imaging Relaxivity Nanoparticles in MRI: not good Nanoparticles in MRI: good
11 Nanoparticles for Bio-Imaging: Magnetic Resonance Imaging and Fluorescence Imaging Effect of Nanoparticle Arrangement on Graphene Oxide Magnetic Nanoparticles Graphene Oxide Sheet μ is magnetic moment of the nanoparticle, Ng is the number of nanoparticles in an agglomerate Best arrangement : Graphene Oxide partially reduced-still hydrophilic and Coupling of magnetic moments between agglomerated nanoparticles
12 Nanoparticles for Bio-Imaging: Magnetic Resonance Imaging and Fluorescence Imaging Core-Shell Geometry Exchange-coupled magnetic nanoparticles for efficient Hyperthermia and Imaging MnFe2O4 Fe3O4 Geometry MnFe2O4-Fe3O4 Relaxivity Value 184 mm-1s-1 CoFe2O4 96 mm-1s-1 MnFe2O4 83 mm-1s-1
13 Nanoparticles for Bio-Imaging: Magnetic Resonance Imaging and Fluorescence Imaging Core-Shell Geometry Nanoparticles for Multimodal Bio-Imaging 0.2 µm Co-Ferrite nanoparticle Agglomerates in ZnO capsule High Value of Proton Relaxivity obtained from the Agglomeration and magnetic coupling of CoFe2O4 particles Fluorescence images of Hela cells incubated with CoFe2O4-ZnO nanoparticles.
14 Magnetic Nanoparticles and Medical Imaging Electrolithography
15 Liquid Electromigration in Very Thin Films Appliction of electric current through thin film of Cr leads to its melting and flow in radially symmetric fashion: Liquid Electromigration Cathode Can this idea be used to develop a lithography technique?
16 Basic Idea Behind Electrolithography A static quill produces a large dot whereas a traversing quill creates myriads of shapes with sharp edges µm And just like writing with a quill, we need to learn how to control and optimize writing with an electrode!
17 Optimized Steps of Electrolithography Process Placing a polymer (PMMA) layer in between metal layer and the substrate allows deposition of thick films
18 A Few Example Fabricated Linear structures Narrowest Au line drawn by AFM tip Ti line drawn in probe station Parallel Ti lines drawn by AFM tip Scalable a few tens of nanometres to a few micrometres Sub-100 nm resolution under ambient conditions Repeatable and continuous with no effect on earlier scribed patterns
19 Curved Lines and Direct Mask Printing on Transparent Glass Cr on Si Cr on glass Transparent opening Curved as well as closed shapes can also be drawn Masks can be fabricated by removal of opaque metallic layer deposited on transparent substrate
20 A Game Changing Exciting Opportunity with Origin in Serendipity Requirements of our technology Fine tips Piezo controllers for fine tip movement Low power source measurement unit Table top Lithography Tool Operating Power (W) Direct laser Table top UV based E-beam writing based lithography toolwriting tool electrolithography lithography tool tool An affordable technology: Inexpensive to install and operate. Instalation cost (USD) Operating Power (W) Instalation Cost (USD)
21 Next Step Technology Development / Demonstration
22 BIRAC
23 IMPRINT India
24 Support for translational research and technology development BIRAC IMPRINT India Uchchatar Avishkar Yojana 3:1 funding between Government and Industry
25 NanoSniff from IIT-B
26 PathShodh (IISc)
27 NHHID (Anna University)
28 There are some, only some, things under a researcher s control lab, equipment, students. Funding programs exists for scientific research and technology development / demonstration. Taking it from here in the lab to there in the market needs many further steps. Need for strong backing: Institutions: Research Park at IIT-M, Society for Innovation and Development at IISc Funding: Angel investors, Venture capital firms, Investment banks Management: Manufacturing, Manpower, Marketing
29 India Innovates
30 Make in India
31 Thank You!
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