LESSON PLAN. B.Sc - SECOND YEAR ( REGULATION)
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1 DEPARTMENT OF PHYSICS AND NANOTECHNOLOGY LESSON PLAN B.Sc - SECOND YEAR ( REGULATION) THIRD SEMESTER. SRM UNIVERSITY SRM NAGAR, KATTANKULATHUR
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3 SRM UNIVERSITY DEPARTMENT OF PHYSICS AND NANOTECHNOLOGY Second Year B.Sc Physics ( Regulation) Course Code: UPY15302 Course Title: PHYSICS OF BIOLOGICAL SYSTEMS Semester : III Course Time: JULY NOVEMBER-2016 Location: S.R.M.UNIVERSITY OBJECTIVES 1. To make the student understand the principles of biophysics. 2. To enable the student to explore the field of biophysics 3. To make the student understand the basic concepts in biophysics 4. To allow the student to have a deep knowledge of the fundamentals of biophysics.. Assessment Details: Cycle Test I : 10 Marks Cycle Test II : 10 Marks Model Exam : 20 Marks Assignment : 5 Marks Attendance : 5 Marks
4 SRM UNIVERSITY DEPARTMENT OF PHYSICS AND NANOTECHNOLOGY Second Year B.Sc Physics ( Regulation) Semester Course Code Course Title L T P Total of LTP C III UPY15302 PHYSICS OF BIOLOGICAL SYSTEMS UNIT I - INTRODUCTION TO BIOPHYSICS 15 hours Electronic structure of atoms -Types of Bonds - Biomolecules and molecular system - Nucleic acids - Heterocyclic bases-nucleosides-nucleotides-primary - Secondary and tertiary structure of DNA- Ribo nucleic acid (RNA) amino acids-primary structure of proteins - Peptide bond - Secondary- Tertiary and quaternary structure of proteins. UNIT II - BIOPHYSICAL INSTRUMENTATION TECHNIQUES 15 hours Ultrasound - Nuclear magnetic resonance - Positron emission topography - Computer axial tomography - Whole body scanner - Dose calibrators - Gamma scintillation camera - Digital imaging techniques Acquisition - Analysis and processing of data from gamma camera - Enhancement - Topographic reconstruction - Display and recording of image. UNIT III - DIFFUSION AND ENERGY PRODUCTION IN BIOSYSTEMS 15 hours Forces and Flows - Fick s law of diffusion - Brownian motion - Physiological diffusion of ions and molecules - Molecular motors- ATP and Flagellar motors - Actin and myosin - Intracellular cargo transport and Intercellular cargo transport.-importance. Energetics of human performance - Adenosine Triphosphate (ATP) production - Glycolysis. UNIT IV - MEMBRANE ELECTRICAL PROPERTIES 15 hours Membrane Biophysics - Nerve cell- bioelectrical and biochemical conduction of nerve impulses - Membrane potential - Resting potential and action potential - Gross bioelectrical phenomenon of ECG and EEG - Membrane potential-action potential- Goldman and Nernst equation -ECG (Electrocardiogram)-EG (Electroencephalogram) - EMG(Electromyogram) - Channel Ion selectivity UNIT V - FORCE AND MOVEMENT IN BIOLOGICAL SYSTEMS 15 hours Skeletal length - Tension relation - Muscle contraction and relaxation- Calcium dependence of muscle movement - Smooth muscles - Cardiac muscles - Carrier transport across gated channels in different types of muscles - Fluid properties - synovial fluid flow - Arterial blood flow - Arterial stenosis- Lymph - Amniotic fluid - Peritoneal fluid - Cerebrospinal fluid.
5 TEXT BOOKS 1. Patrick 1 st Edition, Cambridge University 2. Willian Bialek, Biophysics: Searching for Principles, 1st Edition, Kindle, REFERENCES Agarwal S. K.,Advanced Biophysics, APH Publishing Corporation,. 3. Daniel M., Basic Biophysics for Biologists, Agrobios (India), Narayanan P., Essential of Biophysics, New Age International (P) Limited,. 5. Roland Glaser, Biophysics, Springer, 2001
6 Lesson Plan Subject Name: Subject Code: PHYSICS OF BIOLOGICAL SYSTEMS UPY15302 Lecture Description Reference Hour 1 UNIT-I: Introduction to biophysics Chapter 1 Page No. 1 Vasantha Physics, Narosa 2 Electronic structure of atoms -Types of Bonds Chapter 1 Page No. 4 Vasantha Physics, Narosa 3 Biomolecules and molecular system Chapter 1 Page No. 6 Vasantha Physics, Narosa 4 Nucleic acids Chapter 1 Page No. 8 Vasantha Physics, Narosa 5 Heterocyclic bases Chapter 1 Page No. 10 Vasantha Physics, Narosa 6 Nucleosides Chapter 1 Page No. 12 Vasantha Physics, Narosa 7 Nucleotides-primary Chapter 1 Page No Secondary and tertiary structure of DNA Chapter1 Page No. 16. Vasantha Physics, Narosa 9 Ribo nucleic acid (RNA) Chapter 1 Page No. 18. S.l 10 amino acids Chapter 1 Page No. 21, 11 Primary structure of proteins - Chapter I1 Page No. 49
7 12 Peptide bond Chapter I1 Page No Secondary structure Chapter I1 Page No Tertiary structure Chapter I1 Page No quaternary structure of proteins. Chapter I1 Page No UNIT-II: Introduction to biophysical instrumentation techniques Chapter V1 Page No. 81, 17 Ultrasound Chapter V1 Page No. 29Vasantha Physics, Narosa 18 Nuclear magnetic resonance Chapter VI1 Page No Positron emission topography Chapter VI1 Page No , 20 Computer axial tomography Chapter VI1I Page No Whole body scanner Chapter VII1 Page No Gamma scintillation camera Chapter V Page No. 11 Patrick
8 24 CYCLE TEST I Unit I & II (Gamma scintillation camera) 25 Digital imaging techniques Chapter V Page No. 13 Patrick 26 Acquisition Chapter V Page No. 14 Patrick 27 Processing of data from gamma camera Chapter V Page No. 17 Patrick 28 Analysis of data from gamma camera Chapter V Page No. 22 Patrick 29 Enhancement and Topographic reconstruction Chapter V Page No.33 Patrick 30 Display andrecording of image. Chapter V Page No. 48 Patrick 25 UNIT-III Introduction to diffusion and energy production in biosystems Chapter IX Page No Forces and Flows Chapter IX Page No. 20
9 31 Fick s law of diffusion Chapter IX Page No Fick s First law of diffusion Chapter IX Page No Fick s second law of diffusion Chapter IX Page No Brownian motion Chapter IX Page No Physiological diffusion of ions and molecules Chapter IX Page No Molecular motors Chapter IX Page No ATP motors Chapter IX Page No Flagellar motors Chapter IX Page No. 38, 41 Intercellular cargo transport Chapter IX Page No. 62, 42 Importance Chapter X Page No. 38,
10 43 Energetics of human performance Chapter X Page No. 21, 44 Adenosine Triphosphate (ATP) production Chapter X1 Page No. 23, 45 Glycolysis. Chapter X1 Page No. 28, CYCLE TEST II Unit II & III 46 UNIT IV - Introduction to membrane electrical properties Chapter X1 Page No. 38,. 47 Membrane Biophysics Chapter X1 Page No. 38, 48 Nerve cell Chapter X1 Page No. 38, 49 bioelectrical and biochemical conduction of nerve impulses Chapter X1 Page No. 38, 50 Membrane potentia Chapter X1 Page No. 38, 51 Resting potential and action potential Chapter X1 Page No. 38, 52 Gross bioelectrical phenomenon of ECG Chapter X1 Page No. 38, 53 EEG Chapter X1 Page No. 38,
11 54 Goldman and Nernst equation Chapter X1 Page No. 38, 55 ECG (Electrocardiogram) Chapter X1 Page No. 38, 56 EG (Electroencephalogram) Chapter X1 Page No. 38, 57 Membrane potential Chapter X1 Page No. 38, 58 Action potential Chapter X1 Page No. 38, 59 EMG (Electromyogram) Chapter X1 Page No. 38, 60 Channel Ion selectivity Chapter X1 Page No. 38, 61 UNIT-V: Introduction to Force and movement in biological systems Chapter X1I Page No. 18, 62 Skeletal length - Tension relation Chapter X1I Page No. 23, 63 Muscle contraction and relaxation Chapter X1I Page No. 25, 64 Calcium dependence of muscle movement Chapter X1I Page No. 27, 65 Smooth muscles - Cardiac muscles Chapter X1I Page No. 31, 66 Carrier transport across gated channels in different types of muscles Chapter X1I Page No. 33,
12 67 Fluid properties Chapter X1I Page No. 35, 68 synovial fluid flow Chapter X1I Page No. 38, 69 Arterial blood flow Chapter X1I Page No. 42, 70 Arterial stenosis- Lymph Chapter X1I Page No. 45, 71 Amniotic fluid - Peritoneal fluid - Cerebrospinal fluid 72 Solving problems related to above 73 topics 74 Revision and Instructions for 75 preparation of University examination Chapter X1I Page No. 48, MODEL EXAMINATION Unit I-V Prepared by: Dr. T. Kalaivani HOD/Physics & Nano Technology
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