Approved Courses for General Science students with Major/Minors in Biological Sciences

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1 Approved Courses for General Science students with Major/Minors in Biological Sciences List C: Physiology, cell and developmental biology BIOIN 301 Bioinformatics. * (fi 6) (first term, 3-0-0). Introduction to computational tools and databases used in the collection and analysis of sequence data and other analytical data from high-throughput molecular biology studies. Students will use existing tools, and learn the underlying algorithms and their limitations. Prerequisite: any 200-level Biological Sciences course or consent of instructor. Credit cannot be obtained for both BIOIN 301 and BIOL 501. BIOIN 401 Bioinformatics II. *3 (fi 6) (second term, 3-0-3). Advanced topics in bioinformatics will be covered. A major part of the course will be devoted to teambased projects involving writing novel bioinformatics tools to deal with current problems in bioinformatics. Prerequisites: BIOIN 301, a 300-level CMPUT course and a 300-level GENET course. (Offered jointly by the Departments of Computing Science and Biological Sciences). [Biological Sciences]. BIOL 341 Ecotoxicology. *3 (fi 6) (either term, 3-0-0). An overview of the adverse effects of chemicals or physical agents on biological systems in an ecological context. This course takes a multidisciplinary approach to understanding biological effects and their assessment. Prerequisites: BIOL 208, ZOOL 241, and CHEM 164 or 261, or instructor consent BIOL 391 Techniques In Molecular Biology and Bioinformatics. *3 (fi 6) (either term, 0-1s-6). A laboratory course introducing students to techniques in gene manipulation, protein expression and bioinformatics by following a gene through a thematic series of molecular manipulations. Restricted to Honors and Specialization students in Biological Sciences and consent of instructor. Prerequisites: BIOL 207 and BIOCH 200. Not to be taken by students currently enrolled in GENET 420 or with credit in GENET 420. Credit can be obtained for only one of BIOL 391, IMIN 391 or MMI 391. BIOL 409 Zoonoses. *3 (fi 6) (first term, 3-0-0). This course will examine the biology of zoonotic agents and the implication of host-pathogen interactions to disease susceptibility and resistance. Students will apply these basic concepts towards the understanding of issues governing pathogenesis, pathology, epidemiology, control and surveillance of zoonotic diseases. Focus will be placed on zoonotic agents currently having a significant impact on animal and public health. Lectures will be followed by active discussion of selected readings. Prerequisites: one of ZOOL 352, ZOOL 354, ENT 392 or equivalent, and consent of instructor. Credit cannot be obtained for both BIOL 409 and BIOL 509. BIOL 445 Current Topics In Animal and Cell Physiology *3 (fi 6) (first term, 0-3s-0). Survey, discussion and evaluation of literature dealing with current advances and selected topics in animal and cell physiology. Prerequisite: ZOOL 340 or 342 or 343, or PHYSL 372. Credit may be obtained more than once. Offered in alternate years. BOT 303 Plant Development. *3 (fi 6) (second term, 3-0-0). The generation of a functional plant requires the spatially coordinated acquisition of numerous cell identities. Examines developmental processes in plants at the molecular and cellular level and will cover: body axis establishment and tissue pattern formation during embryogenesis, cell-to-cell communication in patterning events and differentiation processes, and cell differentiation patterns in tissue systems. Emphasis throughout the course will be on current research using developmental mutants. Prerequisites: BIOL 201 and 207; one of BOT 205, 210 or 240/340 strongly recommended. BOT 308 Plant Anatomy. *3 (fi 6) (either term, 0-1s-3). Seed plant structure and development with particular emphasis on flowering plants. The course covers origin, development, and function of meristems (apical, primary, and lateral), tissue and organ development, wood structure and identification, floral anatomy, embryogenesis, and fruit structure. 1

2 Prerequisites: BIOL 108 or SCI 100. BOT 205 recommended. May not be taken for credit if credit already obtained in BOT 209 or 309. BOT 340 Plant Physiology. *3 (fi 6) (first term, 3-0-3). This course explores how plants function. Topics include water transport and the soil-plant-atmosphere continuum, photosynthesis and carbon resource utilization, nitrogen nutrition and symbioses, photosensing, and responses to environmental stresses such as attack by pests and pathogens. Laboratories introduce both classical and contemporary methods in plant physiology. Prerequisites: BIOL 107; CHEM 101 or 164 or 261; and a 200-level Biological Sciences course or PL SC 221. Credit cannot be obtained for both BOT 240 and 340. SCI 100 may be used in lieu of BIOL 107 and CHEM 101. BOT 380 Drug Plants. *3 (fi 6) (second term, 3-0-0). Survey of historical and current use of important drug-producing plants. Evaluation of the chemistry and physiology of biologically active compounds from poisonous, analgesic, and hallucinogenic plants, and the current uses of such plant products. Use of plant biotechnology to develop drug producing plants. Prerequisite: a 200-level Biological Sciences course or BIOCH 200. BOT 205 recommended. BOT 445 Molecular Plant Physiology. *3 (fi 6) (second term, 3-0-0). Plant responses to their environment are underpinned by myriad molecular events. This course examines the molecular and cellular biology of plant responses to environmental cues, with an emphasis on signaling and regulation of gene expression mediating physiological responses. Topics such as plant cell walls, phytohormone action, photoreceptors, and programmed cell death will be covered. Prerequisite: BOT 382 or GENET 364 or consent of the instructor. BOT 240 or 340 recommended. Credit cannot be obtained for both BOT 445 and BOT 545. Offered in alternate years. ENT 321 Insect Physiology. *3 (fi 6) (either term, 3-0-0). Biochemical and physiological adaptations that have allowed insects and their relatives to become extremely successful in most habitats, ways in which insect functions differ from those of other animals, and use of insect models for general physiological and biochemical research. Prerequisites: BIOL 107 or SCI 100 and ENT 220. ENT 378 Insect Pathology. *3 (fi 6) (first term, 3-0-0). An introduction to the diseases of insects and related arthropods. The use of insect pathogens to reduce pest damage in forestry and agriculture. Roles of diseases in insect population dynamics, Biotechnology and insect pathogens. Prerequisite: *3 in Entomology or Microbiology. Not open to first-year students. ENT 392 Medical and Veterinary Entomology. *3 (fi 6) (second term, 3-0-0). An account of the influence of the anthropods on the health of man and domestic animals, and the interactions between anthropod vectors and vertebrate pathogens. Prerequisite: any Entomology course or consent of instructor. GENET 375 Introduction to Molecular Genetics Techniques. *3 (fi 6) (second term, 0-1s-6). A laboratory course in which students will be introduced to modern techniques in molecular genetics. These may include cytogenetics, recombinant DNA techniques, PCR, DNA sequencing, methods of detecting gene expression, and genome analysis. Prerequisites: GENET 270, MICRB 265, and a 300- level GENET course. Enrolment is limited, and registration is by consent of instructor. GENET 412 Genetic Control of Animal Development. *3 (fi 6) (first term, 3-1s-0). Gene action during development; identification and analysis of the networks of genetic elements regulating developmental decisions. The course will focus on processes that have been elucidated from genetically tractable and model systems. Prerequisites: any two GENET 300-level lecture courses, or any GENET 300-level lecture course and ZOOL 303. Credit cannot be obtained for both GENET 412 and 512. IMIN 200 Infection and Immunity. *3 (fi 6) (second term, 3-0-0). Introduces the principles and mechanisms of immunity in eukaryotes. Provides an overview of the major groups of infectious agents (virus, bacteria, parasites) and examines selected microorganisms within the context of the host response to pathogens and pathogen evasion strategies. Pre or corequisites: BIOCH 2

3 200 and MICRB 265. May not be taken for credit if credit already obtained in BIOCH 450. (Offered jointly by the Departments of Biological Sciences and Medical Microbiology and Immunology). [Biological Sciences]. IMIN 324 Basic Virology. *3 (fi 6) (first term, 3-0-0). An introduction to the structure, replication, and taxonomy of bacteriophages, plant, insect, and animal viruses. Their role in disease and methods of control and detection is also discussed. Prerequisites: BIOL 207, IMIN 200 and BIOCH 200 or 205. May not be taken for credit if credit already obtained in INT D 224. (Offered jointly by the Departments of Biological Sciences and of Medical Microbiology and Immunology.) [Biological Sciences] IMIN 371 Introduction to Immunology. *3 (fi 6) (first term, 3-0-0). Survey course introducing the student to immunological concepts. Topics include the clonal selection theory, antibody structure and specificity, genetic basis of immune diversity, antibody-antigen reactions, cell interactions in immune responses, the molecular basis of non-self recognition, MHC molecules and transplantation, tolerance, effector mechanism of immunity, hypersensitivity and immunodeficiency. Prerequisites: BIOCH 200 or 205, BIOL 207, and IMIN 200. May not be taken for credit if credit already obtained in INT D 371. (Offered jointly by the Department of Biological Sciences and the Department of Medical Microbiology and Immunology.) [Biological Sciences] IMIN 372 Research Techniques in Immunology. *3 (fi 6) (second term, 1-0-3). A lecture and laboratory course covering theory and practice behind selected immunological techniques. Techniques covered may include: lymphocyte isolation, flow cytometry, mixed lymphocyte reactions, immunocytochemistry, immunoprecipitation, ELISA, western blotting, expression cloning and monoclonal antibody technology. Labs will sometimes require students to return the next day to check on plates or cultures. Prerequisite: IMIN 371. May not be taken for credit if credit already obtained in INT D 372. (Offered jointly by the Departments of Biological Sciences and Medical Microbiology and Immunology). [Biological Sciences] IMIN 401 Comparative Immunology. *3 (fi 6) (second term, 3-0-0). The phylogeny and evolution of immune systems. Examines the various strategies for disease resistance used by all organisms from plants to humans. The use and evolution of specific components of innate and adaptive immunity will be considered within the context of the biology of the organisms. This course involves both lectures and graded discussions. Prerequisites: IMIN 371 and permission of instructor. Credit cannot be obtained for both IMIN 401 and IMIN 501. (Offered jointly by the Departments of Biological Sciences and Medical Microbiology and Immunology). [Biological Sciences]. IMIN 405 Innate Immunity. *3 (fi 6) (first term, 3-0-0). This course covers topics of innate immunity with emphasis on strategies for pathogen recognition, local and systemic activation of the innate immune response, and regulation of innate effector mechanisms. Innate defense strategies against pathogens as well as detection and elimination of tumors will also be covered. Lectures will be followed by active discussions of selected readings pertaining to current research in the subject area. Prerequisites: IMIN 371 or consent of instructor. Credit cannot be obtained for both IMIN 405 and 505. (Offered jointly by the Departments of Biological Sciences and Medical Microbiology and Immunology). [Biological Sciences]. IMIN 410 Bioinformatics for Molecular Biologists. *3 (fi 6) (second term, 3-0-1). This course will introduce the student to common and advanced methods in bioinformatics. In a mix of lectures and hands-on computer sessions, the student will solve realistic biological questions in the areas of sequence analysis, distant homology detection, phylogeny, correlating sequence to structure, protein structure analysis, and genomics. The student will obtain a thorough understanding of bioinformatics methods, but the focus is on application of methods in the context of molecular biology research rather than studying details of the algorithms or computer programming. Prerequisite: consent of instructor. BIOCH 320 or 330 highly recommended. Priority given to senior students in the IMIN program. (Offered jointly by the Departments of Biological Sciences and Medical Microbiology and Immunology). [Biological Sciences]. 3

4 IMIN 452 Advanced Immunology. *3 (fi 6) (second term, 3-1s-0). A lecture course on the detailed mechanisms of the immune system, describing recent discoveries in cellular and molecular immunology. Topics include mechanisms of T-cell receptor selection, antigen processing, activation of B and T lymphocytes, cellular collaboration, negative and positive regulatory mechanisms in immunity, transplantation, cytokine actions and interactions, autoimmunity, interaction between immune systems and pathogens, and immunogenetics. Prerequisites: BIOCH 200 and IMIN 371. May not be taken for credit if credit already obtained in MMI 552. (Offered jointly by the Department of Biological Sciences, the Department of Medical Microbiology and Immunology and the Department of Oncology). [Biological Sciences] MA SC 415 Structure and Function in Animals. *3 (fi 6) (first term, 4 weeks). This course examines the form and function of invertebrates and vertebrates using a comparative approach. The subject areas include morphology and evolution, systems physiology, biomechanics, and development. The local marine and coastal fauna are used to illustrate the principles. The course includes fieldwork and a series of laboratory exercises and experiments. ZOOL 241 Animal Physiology I: Homeostasis. *3 (fi 6) (first term, 3-1s-0). Survey of physiological systems that regulate levels of gases, food, energy, temperature, water, and ions. Examples from invertebrates and vertebrates. Students with credit in PHYSL 210 or 212 or 214 may not obtain credit in ZOOL 241. Prerequisite: BIOL 107 or SCI 100. ZOOL 242 Animal Physiology II: Intercellular Communication. *3 (fi 6) (second term, 3-1s-0). Endocrinology, immunology and neural, sensory, motor, and reproductive physiology. Examples from invertebrates and vertebrates. Students with credit in PHYSL 210 or 212 or 214 may not obtain credit in ZOOL 242. Prerequisite: BIOL 107 or SCI 100. ZOOL 303 Animal Developmental Biology. *3 (fi 6) (first term, 3-0-3). An introduction to basic principles in animal development both in vertebrates and invertebrates. This course examines how the molecular, cellular and comparative approaches are integrated to explain the development of the egg into the embryo, and the cellular interactions that culminate in the development of organ systems. Prerequisite: BIOL 201 or CELL 201. Credit may be obtained in only one of ENT 202, ZOOL 202 and ZOOL 303. ZOOL 340 Comparative Environmental Physiology. *3 (fi 6) (second term, 3-0-0). A comparative examination of the integrated responses of animals to environmental changes. This course focuses on both the acute physiological and long-term adaptations to dealing with environmental challenges. Focus is on biochemical and physiological responses to extreme environments. Prerequisite: ZOOL 241 or PHYSL 210 or 212 or 214. ZOOL 342 Neurobiology. *3 (fi 6) (second term, 3-0-0). Nerve cells, nervous systems and neuromuscular systems from molecular, physiological, behavioral, and developmental perspectives. Examples from both invertebrates and vertebrates are given. Prerequisite: ZOOL 242 or PHYSL 210 or 212. ZOOL 343 Comparative Endocrinology. *3 (fi 6) (first term, 3-0-0). Endocrine systems and actions of hormones at the tissue, cell and molecular levels; vertebrate systems are emphasized. Prerequisite: ZOOL 242 or PHYSL 210 or 212 or 214. ZOOL 344 Laboratory Exercises in Animal Physiology. *3 (fi 6) (first term, 1-0-4). Physiological topics are reinforced in experimental lab exercises. Labs include computer simulations, artificial tissue models and animal models. Prerequisite: ZOOL 241 or 242 or PHYSL 210 or 212 or 214. ZOOL 352 Principles of Parasitism. *3 (fi 6) (first term, 3-3s-0). An introduction to protozoan, helminth and arthropod parasites of animals; principles of host and parasite adaptations, host defense, pathology, epidemiology, and ecology, and control of parasitic infections. World wide web-based laboratory tutorials emphasize morphology, life cycles, behavior, systematics and 4

5 life history of parasites. Prerequisite: a 200-level Biological Sciences course (ZOOL 250 and IMIN 200 recommended). ZOOL 370 Ethological Mechanisms. *3 (fi 6) (second term, 3-0-3). Animal behavior from an ethological perspective, with emphasis on the mechanisms underlying a variety of behaviors. The material is intended to complement that of ZOOL 371. Prerequisite or corequisite: ZOOL 241 or 242. ZOOL 402 Current Topics in Developmental Biology. *3 (fi 6) (second term, 0-3s-0). Discussion of selected topics in animal developmental biology from a molecular and cellular perspective. Evaluation of the primary literature and communication skills are emphasized. Prerequisite: ENT 302, or ZOOL 302 or 303. Credit for this course may be obtained more than once. Offered in alternate years. ZOOL 441 Current Topics on Homeostasis. *3 (fi 6) (either term, 0-3s-0). Discussion of selected topics in cardiac, gut, renal, respiratory, temperature, and metabolic physiology. Evaluation of the primary literature and communication skills are emphasized. Prerequisite: ZOOL 340. Credit for this course may be obtained more than once. Offered in alternate years. ZOOL 442 Current Topics in Intercellular Communication. *3 (fi 6) (either term, 0-3s-0). Discussion of selected topics in endocrinology, immunology, and neurobiology from molecular, cellular, and wholeanimal perspectives. Evaluation of the primary literature and communication skills are emphasized. Prerequisite: ZOOL 342 or 343 or 352 or PMCOL 371. Credit for this course may be obtained more than once. Offered in alternate years. ZOOL 450 ZOOL 450 Biology and Evolution of Invertebrate. *3 (fi 6) (second term, 2-0-3). Invertebrate evolution and adaptations including topics on feeding and nutrition, motility, reproduction and development, and sensory systems. Emphasis will be on material from the primary literature. Laboratory exercises will involve advanced training in techniques of microscopy. Prerequisite: ZOOL 250. ZOOL 303 and ZOOL 351 recommended. Credit cannot be obtained for both ZOOL 450 and 550. ZOOL 452 Experimental Parasitology. *3 (fi 6) (second term, 3-0-3). Experimental approaches to the study of parasitism, including topics on ecology, biochemistry, cell biology, genetics, molecular biology, pathology, and immunology of host-parasite relationships. Laboratory exercises cover experimental design, methods of collecting and processing host and parasite samples, and evaluation of parasitic infections in hosts. The emphasis is on parasites of laboratory hosts. Prerequisite: ZOOL 352 or MMI 426 or consent of instructor. 5

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