蕭崇德副教授中原大學生物科技系表皮幹細胞研究室

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1 蕭崇德副教授中原大學生物科技系表皮幹細胞研究室 中壢市中北路 200 號 TEL: (O); (Lab); FAX: Website: 學歷台灣大學 漁業科學博士 2002 ( 指導老師蔡懷楨博士 ) 台灣大學 漁業科學碩士 1998 ( 指導老師羅秀婉博士 ) 台灣大學 動物學系學士 1995 ( 指導老師郭欽明博士 ) 經歷中原大學 生物科技系 ( 所 ) 副教授 (2013/08- 迄今 ) 中原大學 生物科技系 ( 所 ) 助理教授 (2007/ /07) 中央研究院 基因體中心 訪問學者 (2009/ /12) ( 沈家寧老師指導 ) 中央研究院 細胞與個體生物研究所 博士後研究員 (2007/ /07) ( 黃鵬鵬老師指導 ) 新加坡 分子與細胞生物研究所 訪問學者 (2006/ /12) ( 江運金老師指導 ) 中央研究院 細胞與個體生物研究所 博士後研究員 (2003/ /02) ( 黃鵬鵬老師指導 ) 中央研究院 分子生物研究所 博士後研究員 (2003/ /09) ( 沈哲鯤老師指導 ) 研究專長次世代定序技術的開發與應用斑馬魚疾病動物模式之建立表皮幹細胞之訊息調控與發育生物學基因體學 基因轉殖 基因剔除與突變篩選技術 蕭博士西元 2002 年畢業於台灣大學漁業科學博士專業, 之後分別在台灣中央研究院與新加坡 IMCB 擔任博士後研究 ( ), 西元 2007 年起任教於中原大學, 目前職位是生物科技系副教授 蕭博士專長為魚類功能性基因組與生物訊息學研究, 發表 51 篇重要研究成果於 Oncotargets Bioinformatics Developmental Biology PLoS One 等國際 SCI 重要期刊 也擔任多種國際期刊如 Journal of Next Generation Sequencing & Applications PLoS One Heretidas (Beijing) Journal of Ocean University of China Expert Opinion on Drug Discovery Journal of Diabetes and Endocrinology PLoS Computational Biology Gene Express Patterns 的論文審查委員或編輯委員 蕭博士同時承接多項的研究計劃, 由 年度已經成功申請到台幣 22,672,000 的科研經費 蕭博士是兩岸斑馬魚會議的發起人與主辦人, 目前已經承辦過三屆的海峽兩岸斑馬魚學術研討會, 與大陸科研人員保持良

2 好的學術互動 蕭博士是台灣最早從事魚類基因轉殖 基因敲除 抗體篩選與基 因組學分析的專家, 獲邀成為台灣多家知名生物技術公司的產學合作顧問, 與產 業研發保持良好互動, 多項研發專利技術也已經成功授權給生技公司, 達成學用 合一的優良示範 主要發表文章 2015 (12 papers) Hsiao CD, Shen KN, Ching TY, Wang YH, Ye JJ, Tsai SY, Wu SC, Chen CH, Wang CH*. The complete mitochondrial genome of the cryptic lineage A big-fin reef squid, Sepioteuthis lessoniana (Cephalopoda: Loliginidae) in Indo-West Pacific. Mitochondrial DNA (In press) Loh KH, Shao KT, Chen HM, Chen CH, Loo PL, Then YH, Lim PE, Chong VC, Shen KN*, Hsiao CD. Next generation sequencing yields the complete mitochondrial genome of the longfang moray, Enchelynassa canina (Anguilliformes: Muraenidae). Mitochondrial DNA (In press) Loh KH, Shao KT, Chen HM, Chen CH, Chong VH, Loo PL, Shen KN*, Hsiao CD*. Next generation sequencing yields the complete mitochondrial genome of the Zebra moray,gymnomuraena zebra (Anguilliformes: Muraenidae). Mitochondrial DNA (In press) Shen KN, Tsai SY, Chen CH, Hsiao CD*, Durand JD. Next generation sequencing yields the complete mitochondrial genome of the largescale mullet, Liza macrolepis(teleostei: Mugilidae). Mitochondrial DNA (In press) Shen KN, Chen CH, Hsiao CD*, Durand JD. Next generation sequencing yields the complete mitochondrial genome of the flathead mullet, Mugil cephalus cryptic species in East Australia (Teleostei: Mugilidae). Mitochondrial DNA (In press) Shen KN, Chang CW, Chen CH, Hsiao CD*. Next generation sequencing yields the complete mitochondrial genome of the Regal angelfish, Pygoplites diacanthus (Perciformes: Pomacanthidae). Mitochondrial DNA (In press) Shen KN, Chang CW, Chen CH, Chassaing A, Hsiao CD*. Next generation sequencing yields the complete mitochondrial genome of the Japanese angelfish, Centropyge interrupta (Perciformes: Pomacanthidae). Mitochondrial DNA (In press) Shen KN, Chang CW, Loh KH, Chen CH, Hsiao CD*. Next generation sequencing yields the complete mitochondrial genome of the Clarion angelfish, Holacanthus clarionensis (Perciformes: Pomacanthidae). Mitochondrial DNA (In press) Shen KN, Chang CW, Chen CH, Hsiao CD*. The complete mitochondrial genome of the Tiger angelfish, Apolemichthys kingi (Perciformes: Pomacanthidae). Mitochondrial DNA (In press) Shen KN, Loh KH, Chen CH, Hsiao CD*. The complete mitochondrial genome of the

3 Blue-face angelfish, Pomacanthus xanthometapon (Perciformes: Pomacanthidae).Mitochondrial DNA (In press) Hsiao CD, Shen KN, Chen CH, Chang CW*. The complete mitochondrial genome of the Vermiculated angelfish (Chaetodontoplus mesoleucus) (Perciformes: Pomacanthidae).Mitochondrial DNA (In press) Ye JJ, Shen KN, Chen CH, Hsiao CD, Chang CW*. The complete mitochondrial genome of the Emperor angelfish, Pomacanthus imperator (Perciformes: Pomacanthidae).Mitochondrial DNA (In press) 2014 (11 papers) Shen KN, Chang CW, Chen CH, Hsiao CD*. The complete mitochondrial genome of the Spectacled angelfish, Chaetodontoplus conspicillatus (Perciformes: Pomacanthidae). Mitochondrial DNA (In press) Shen KN, Chen CH, Hsiao CD*. Next generation sequencing yields the complete mitochondrial genome of the Hornlip mullet, Plicomugil labiosus (Teleostei: Mugilidae). Mitochondrial DNA (In press) Shen KN, Yen TC, Chen CH, Ye JJ, Hsiao CD*. The complete mitochondrial genome of the cryptic lineage B big-fin reef squid, Sepioteuthis lessoniana (Cephalopoda: Loliginidae) in Indo-West Pacific. Mitochondrial DNA (In press). Shen KN, Yen TC, Chen CH, Li HY, Chen PL, Hsiao CD*. Next generation sequencing yields the complete mitochondrial genome of the flathead mullet, Mugil cephalus cryptic species NWP2 (Teleostei: Mugilidae). Mitochondrial DNA (In press). Chang TY, Huang TS, Wang HW, Chang SJ, Lo HH, Chiu YL, Wang YL, Hsiao CD, Tsai CH, Chan CH, You RI, Wu CH, Tsai TN, Cheng SM, Cheng CC*. mirnome traits analysis on endothelial lineage cells discloses biomarker potential circulating micrornas which affect progenitor activities. BMC Genomics. 15: 802. Huang SY, Feng CW, Hung HC, Chakraborty C, Chen CH, Chen WF, Jean YH, Wang HM, Sung CS, Sun YM, Wu CY, Liu W, Hsiao CD, Wen ZH*. A novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema. PLoS One 9:e Chen CH, Lin DS, Cheng CW, Lin CJ, Lo YK, Yen CC, Lee YL*, Hsiao CD*. Cdc6 cooperates with c-myc to promote genome instability and EMT in zebrafish. Oncotarget 5: Lim KH*, Lin HC, Chen GS, Chiang, YH, Hsiao CD, Kuo YY. CALR Mutations in Myeloproliferative Neoplasms. International Journal of Gerontology 8:105. Feng CW, Wen ZH, Huang SY, Hung HC, Chen CH, Yang SN, Chen NF, Wang HM, Hsiao CD, Chen WF. Effects of 6-Hydroxydopamine Exposure on Motor Activity and Biochemical Expression in Zebrafish (Danio Rerio) Larvae. Zebrafish 11:

4 Yen CC*, Hsiao CD, Chen WM, Wen YS, Lin YC, Chang TW, Yao FY, Hung SC, Wang JY, Chiu JH, Wang HW, Lin CH, Chen TH, Chen PC, Liu CL, Tzeng CH, Fletcher JA. Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. Oncotarget. 5: Lin DS*, Chuang TP, Chiang MF, Ho CS, Hsiao CD, Huang YW, Wu TY, Wu JY, Chen YT, Chen TC, Li LH. De novo MECP2 duplication derived from paternal germ line result in dysmorphism and developmental delay. Gene. 533: (5 papers) Chen SY, Shih HY, Lin SJ, Hsiao CD, Li ZC, Cheng YC*. Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. J Cell Sci. 126: Lin CY, Huang CC, Wang WD, Hsiao CD, Cheng CF, Wu YT, Lu YF, Hwang SP*. Low temperature mitigates cardia bifida in zebrafish embryos. PLoS One. 8:e Shih DF, Hsiao CD, Min MY, Lai SL, Yang CW, Lee WT*, Lee SJ*. Aromatic L-Amino Acid Decarboxylase (AADC) Is Crucial for Brain Development and Motor Functions. PLoS One. 8:e Lin DS*, Chiang MF, Ho CS, Hsiao CD, Lin CY, Wang NL, Chuang CK, Huang YW, Chang PC, Liu HL. Low-frequency enzyme replacement therapy in late-onset pompe disease. Muscle Nerve 47: Hsiao CD*. Memorial Article on Chi-Bin Chien. Hereditas (Beijing), 35: (Invited review article) 2012 (3 papers) Chen CF, Chen CP, Hsiao CD*. Zebrafish research in Taiwan. Hereditas (Beijing). In press. (Invited review article) Chu CY, Chen CF, Rajendran R. Samuel, Shen CN, Chen TH, Yen CC, Chuang CK, Lin DS, Hsiao CD*. Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 7:e Chen YC, Chen YC, Lin WD, Hsiao CD, Chiu HW, Ho JM*. Bio301: a web-based EST annotation pipeline that facilitates functional comparison studies. ISRN Bioinformatics (In press) (6 papers) Huang SH, Hsiao CD, Lin DS, Chow CY, Chang CJ, Liau I*. Imaging of Zebrafish In Vivo with Second-Harmonic Generation Reveals Shortened Sarcomeres Associated with Myopathy Induced by Statin. PLoS One. 6:e24764.

5 Lin YS, Tsai SC, Lin HC, Hsiao CD, Wu SM*. Changes of glycogen metabolism in the gills and hepatic tissue of tilapia (Oreochromis mossambicus) during short-term Cd exposure. Comp Biochem Physiol C Toxicol Pharmacol. 154: Liu DW, Hsu CH,Tsai SM, Hsiao CD, Wang WP*. A Variant of Fibroblast Growth Factor Receptor 2 (Fgfr2) Regulates Left-Right Asymmetry in Zebrafish. PLoS One. 6:e Chen CF, Chu CY,Chen TH, Lee SJ, Shen CN, Hsiao CD*. Establishment of a transgenic zebrafish line for superficial skin ablation and functional validation of apoptosis modulators in vivo. PLoS One. 6:e Lin DS*, Hsiao CD, Liau I, Lin SP, Chiang MF, Chuang CK, Wang TJ, Wu TY, Jian YR, Huang SF, Liu HL. CNS-targeted AAV5 gene transfer results in global dispersal of vector and prevention of morphological and function deteriorationin CNS of globoid cell leukodystrophy mouse model. Mol Genet Metab. 103: Yeh CM, Liu YC, Chang CJ, Lai SL, Hsiao CD, Lee SJ*. Ptenb mediatesgastrulation cell movements via Cdc42/AKT1 in zebrafish. PLoS One. 6:e (2 papers) Chang WJ, HorngJL, Yan JJ, Hsiao CD, Hwang PP*. The transcription factor,glial cell missing 2, is involved in differentiation and functional regulationof H+-ATPase-rich cells in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 296: R Tseng DY, Chou MY, Tseng YC, Hsiao CD, Huang CJ, Kaneko T, Hwang PP*. Effects of Stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. Am J Physiol Regul Integr Comp Physiol. 296: R (2 papers) Chou MY, Hsiao CD, Chen SC, Chen IW, Liu ST, Hwang PP*. Effects of hypothermia on gene expression in zebrafish gills: upregulation in differentiation andfunction of ionocytes as compensatory responses. J Exp Biol. 211: Lin TY, Liao BK, Horng JL, Yan JJ, Hsiao CD, Hwang PP*. Carbonic anhydrase2-like a and 15a are involved in acid-base regulation and Na+ uptake inzebrafish H+-ATPase-rich cells. Am J Physiol Cell Physiol. 294: C1250-C (1 papers) Hsiao CD, You MS, Guh YJ, Ma M, Jiang YJ, Hwang PP*. A Positive Regulatory Loop between foxi3aand foxi3b is Essential for Specification and Differentiation of the Zebrafish Epidermal Ionocytes. PLoS One 2:e (9 papers)

6 2006. Chen YC, Hsiao CD*, Lin WD, Hu CM, Hwang PP, Ho JM*. ZooDDD: an inter-species database for DDD analysis. Bioinformatics 22: [*Equal contribution] Lin WD*, Chen YC, Ho JM, Hsiao CD. GOBU: an integrative interface for manipulating biological objects. J Inf Sci Eng 22: Chu SL, Weng CF, Hsiao CD, Hwang PP, Chen YC, Ho JM, Lee SJ*. Profile analysis of expressed sequence tags derived from the ovary of tilapia, Oreochromis mossambicus. Aquaculture 251: Hsiao CD, Ekker M, Tsai HJ*. Skin-specific expression of ictacalcin, a member of S100 genes, during zebrafish embryogenesis. Dev Dynamics 228: Hsiao CD, Tsai HJ*. Transgenic zebrafish with fluorescent germ cell: a useful tool to visualize germ cell proliferation and juvenile hermaphroditism in vivo. Dev Biol 262: Huang CJ, Tu CT, Hsiao CD, Hsieh FJ, Tsai HJ*. Germ-line transmission of myocardium-specific GFP transgene reveals critical regulatory elements in the cardiacmyosin light 2 promoter of zebrafish. Dev Dynamics 228: Hsiao CD, Tsai WY, Horng LS, Tsai HJ*. Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish. Dev Dynamics 227: Hsiao CD, Tsai WY, Tsai HJ*. Isolation and expression of two zebrafish homologues of parvalbumin genes related to chicken CPV3 and mammalian oncomodulin. Mech Dev 119S:S Hsiao CD, Hsieh FJ, Tsai HJ*. Enhanced expression and stable transmission of transgenes flanked by inverted terminal repeats from adeno-associated virus in zebrafish. Dev Dynamics 220: