Overview of the Molecule:


 Barnaby Victor Nash
 1 years ago
 Views:
Transcription
1 Prtein Mdeling Event Guide t Scring the Invitatinal PreBuild Mdel Fr Science Olympiad 2016 Invitatinal Cmpetitin These instructins are t help the event supervisr and scring judges use the rubric develped by the MSOE Center fr BiMlecular Mdeling when scring the Science Olympiad Invitatinal PreBuild MiniTber mdels f sepiapterin reductase, based n 1sep.pdb. Each categry n the rubric is addressed within these instructins and is accmpanied by a shrt descriptin and picture, if apprpriate. Overview f the Mlecule: Clr Cde: Salmn alpha helices Yellw beta strands White  lps Blue tip Nterminus Red tip Cterminus αhelix #5 CTerminus 3 10 helix 2  ptinal αhelix #4 αhelix #3 βstrand #4 αhelix #2 β strand #3 β strand # helix 1  ptinal β strand #1 NTerminus αhelix #1a αhelix #1b 1
2 Nte abut Scring: As yu wrk thrugh this guide, it may be helpful t use bth the mdel and the images. Yu can quickly rient the mdel with the images by lining up the blue and red ends. 1. Order f Secndary Structures: (2.25 pts; 0.25 pts fr each bld bullet pint in the crrect rder) T receive these pints, the sequence f the secndary structures shuld be in the fllwing rder: N terminus β1 turn 1 (shrt 3 10 helix 1 turn 1a) α1a α1b [may appear as a single lng helix r tw helices with a tiny turn between] turn 2 β2 turn 3 (shrt 3 10 helix 2 turn 3a) α2 turn 4 β3 turn 5 α3 turn 6 α4 turn 7 α5 turn 8 β4 C terminus Deduct 0.25 pt fr each secndary structure (helix r βstrand) element that is nt in the crrect rder, r is missing. (If tw elements are reversed, deduct 0.5 pt. If a single element is missing, deduct 0.25 pt.) Secndary structures that are ut f rder shuld nt be cunted. Please refer t the figure n previus page, r t the physical mdel, t assist in scring the mdel. Nte that the 3 10 helices are nly 3 amin acids lng and may nt appear. D nt deduct pints fr the presence r absence f these helices. 2. Blue Cap n Nterminal Amin Acid (Leu93) (2 pts) The blue cap needs t be lcated at the Nterminus f the prtein, which is lcated at the beginning f beta strand #1. This end f the mlecule has a beta strand fllwed by a lng lp, then a lng alpha helix that runs parallel t this strand. Please see the figure t the right fr the crrect psitining f the blue end cap. Scring fr this feature is all r nne credit. NTerminus 2
3 3. Red Cap n Cterminal Amin Acid (Asp261) (2 pts) CTerminus T receive credit, the red cap needs t be lcated at the C terminus f the prtein, which is lcated at the end f beta strand #4. This end f the mlecule has a shrt beta strand preceded by a sharp turn, then tw alpha helices that lie at right angles t each ther. Please see the figure t the right fr the crrect psitining f the red end cap. Scring fr this feature is all r nne credit. 4. Mdel has 5 alpha helices accrding t Jml selectin criteria. (1 pt per helix fr a ttal f 5 pts) T receive these pints, there shuld be 5 helices within the mdel. Fr the purpses f scring, cnsider α1a and α1b as a single lng helix. Please see figure t the right fr the crrect lcatin f these helices. (Helices are clred salmn n the mdel and n the figure t the right.) Alpha helices 1a and 1b cunt as ne helix D nt cunt 3 10 helices Fr the purpses f this mdel, an alpha helix MUST have at least tw turns. Any lps in the mdel that are nt at least tw turns will nt be deemed an alpha helix. Deduct 1 pt fr each extra helix. Fr example, if a mdel has 6 helices, then the mdel wuld receive 4 pts rather than the full 5 pts. Alpha helices 5. Alpha helices are righthanded (1 pt each; ttal f 5 pts) Alpha helices are righthanded. Check each alpha helix in the mdel t cnfirm that the helix is righthanded. Fr each righthanded helix, the mdel shuld receive 1 pt, fr a ttal f 5 pts if all five helices are crrect. T determine if the helix is righthanded, find ne f the ends f the helix and imagine that the helix is a spiral staircase. Pretend that yu are climbing that staircase and yu need t have a handrail and the helix is the handrail, which is always n the utside edge f the staircase. If yu wuld put yur right hand n the tber as yu g up the staircase, yu have a righthanded helix. If yu wuld put yur left hand n the tber, yu have a lefthanded helix and the mdeled helix wuld nt receive credit. Lefthanded vs righthanded helices 3
4 6. Mdel has 4 βstrands accrding t Jml selectin criteria (0.5 pt per βstrand fr a ttal f 2 pts) Beta strands T receive these pints, there shuld be 4 βstrands within the mdel. Please see figure t the right fr the crrect lcatin f these beta strands. (βstrands are clred yellw n the mdel and n the figure t the right.) βstrands need t be clearly distinguishable frm lps; there may be sme slight zigzag flding f the tber t indicate the upanddwn psitining f the amin acids. Alternately, teams might clrcde their beta strands t distinguish them frm lps r write n the tber indicating the lcatin f the βstrands. Please see phts belw depicting βstrands mdeled using tbers. If there are mre than 4 βstrands in the mdel, deduct 1 pt fr each extra strand. Fr example, if the mdel has 5 βstrands, the mdel shuld receive 3 pts, rather than the full 4 pts. 4
5 7. All βstrands are parallel. (1 pt; 0.25 pt per strand) βstrands need t have the same directinality frm N t C. If yu rient the mdel s the N terminus is at the bttm, as yu trace thrugh the mdel, each strand will be traced frm bttm t tp. Please see figure at right fr clarificatin. Fr each strand that is traced frm bttm t tp, award 0.25 pt. 8. Mdel has 1 βsheet. (1 pt) This mdel has 1 βsheet arranged frm the 4 βstrands. A βsheet is cmpsed f tw r mre strands lying parallel t each ther, thugh the plane f the βsheet may be twisted instead f flat. Nte that due t the twisting f the sheet, strands are essentially parallel t adjacent strands, but the end strands may nt be parallel t each ther. Please see the picture at the right and the mdel fr crrect alignment f the strands. T receive credit, the mdel must have a single βsheet. If ne f the strands des nt lie parallel t adjacent strands, deduct 0.25 pt. If there are tw sets f tw parallel strands, deduct 0.5 pt. Βsheet frms twisted plane; each strand is parallel t adjacent strands 5
6 Items #9  #14 refer t the 3dimensinal shape f the mdel. 9. Mdel has three distinct layers (1.5 pts fr each layer, fr a ttal f 4.5 pts) Layer 3 This prtein has three distinct layers. Layers 1 and 3 cnsist f alpha helices. Layer 2 cnsists f a single beta sheet. There is als a 3 10 helix in this layer; d nt deduct pints if the 3 10 helix is nt visible. Layer 2 If ne f the layers is nt clearly distinguishable frm the thers, please deduct 1.5 pts. If the beta sheet is nt sandwiched between the layers f alpha helices, deduct 1.5 pts. Layer 1 If the mdel has mre than three layers, then deduct 1.5 pts fr each additinal layer. Fr example, if the mdel has fur layers, the mdel shuld receive 3 pts, rather than the full 4.5 pts. 10. Layer 1 has tw lng helices. (1 pt each, fr a ttal f 2 pts) Layer 1 cnsists f helices 1a, 1b and 2. Helices 1a and 1b may be distinct r may appear as a single helix. Please see the mdel and image t right t identify these helices. Helix 2 The helices shuld lie in the same plane, but at abut a 15 angle relative t each ther. 15 If the images are in the same plane, but are nt at a 15 angle, deduct 0.5 pt. Helix 1a Helix 1b 6
7 11. Layer 2 cntains a furstranded βsheet. (2 pts) Strand 1 Strand 1 f the βsheet shuld be parallel and abve helix 1a. See mdel and figure at right t see this alignment. If strand 1 is nt parallel t helix 1a, deduct 0.5 pt. Helix 1a Strand 4 f the βsheet shuld be at a 45 angle relative t helix 5. See mdel and figure at right t see this alignment. 45 If strand 4 is nt at a 45 angle relative t helix 5, deduct 0.5 pt. 12. Layer 3 cntains 3 medium helices. (3 pts) Layer 3 cnsists f helices 3, 4 and 5; these helices are shrter than the helices in layer 1. Deduct 1 pt fr each helix that is nt clearly in this layer. Layer 3 Layer 3 is nt flat like layers 1 and 2, but instead frms a triangular peak. Please see mdel and image at right t identify this triangular peak. If layer 3 des nt have a triangular shape, deduct 0.5 pt. 7
8 Fr items #13  #14 please refer t the rientatin f the mdel in the image at the right. N terminus 13. N terminus is lcated in layer 2 (the middle layer) n the narrw side f the mlecule. (0.5 pt) When the mdel is rientated with the N terminus at the tp and facing yu, the structure shuld be brader at the base and narrwer at the tp, much like a pine tree. C terminus If the N terminus is nt lcated near the apex f the triangle, assign a scre f C terminus shuld be in the middle f the mdel and n the back side relative t the N terminus. (0.5 pt) When the mdel is riented as abve with the N terminus at 12 clck, the C terminus shuld be lcated at 3 clck. If the C terminus is nt lcated at 3 clck, deduct 0.25 pt. With the mdel riented as abve, with the N terminus in the frnt f the mdel, the C terminus shuld be in the back f the mdel. If the C terminus is nt n the ppsite f the mdel frm the N terminus, deduct 0.25 pt. 15. Students submitted a 3x5 card with explanatin f the mdel (1.25 pt) The 3x5 card submitted with the mdel shuld describe the mdel in terms f what additinal features have been added t the mdel s that the judge is nt left guessing what the mdel represents. If the card is larger than 3x5, r n 3x5 card is attached, award a scre f 0. If a card is attached but exceeds the 3x5 size, yu may use the infrmatin n the card t assess the creative additins t the mdel, but n credit will be assigned here. 8
9 16. Creative additins t the mdel. (Nte that there are many pssible creative additins t this mdel; each creative additin is wrth 1 pt; teams may have mre than 4 creative additins, but may earn n mre than 4 pts ttal in this sectin. If yu are using the electrnic scre sheet, it will autmatically calculate the sum f pints and recrd a maximum f 4 pts.) Beery Twin Mutatins and Implicatins (1 pt maximum) The Beery Twins are cmpund heterzygtes; each f them has tw different mutatins in their sepiapterin reductase alleles. One allele has the mutatin frm their Dad, and the ther allele has the mutatin frm their Mm. Teams may elect t display these mutatins and describe their effects n the prtein structure. The mdel built fr the cmpetitin is frm the muse, and there are slight variatins frm the human structure. Teams shuld be given full credit fr using EITHER the muse r the HUMAN numbering system as they describe these mutatins. Lys151 in βstrand 2 Asp145 in lp The first mutatin is at residue Arg150 (which crrespnds t Lys151 in the muse mdel here). The lcatin f this mutatin is in βstrand 2 in the mdel and the backbne is clred light green. This residue frms a salt bridge with Asp144 (Asp145 in the muse). This residue is lcated in the lp between helix 2 and β strand 2. In the image at the right, Asp145 has a purple backbne. This residue is NOT displayed n the mdel. Shuld be clse t interact Displaying Arg150 (Lys151) (0.25 pt) Displaying Asp144 (Asp145) (0.25 pt) If bth f these amin acids are displayed, they shuld be riented t display their interactin with each ther. See image at right fr clarificatin. (0.25 pt) The secnd mutatin results in changing Lys251 t a stp cdn. Lys251 (Phe251 in muse) is lcated in the lp between helix 5 and βstrand 4 near the C terminus. This mutatin results in early truncatin f the prtein. Sme f the residues in the C terminal regin are imprtant in substrate binding. Residue 251 is clred green in the mdel and in the image at the right. Truncatin at residue 251 Displaying Lys251 (Phe251) (0.25 pt) 9
10 Dimerizatin Dmain (1 pt maximum) Asn116 Sepiapterin reductase functins as a dimer. T receive credit fr this features, students nly have t display the prtins f the required mdel that interact with the secnd mnmer. Helices E and F f the prtein (labeled as 1a and 1b in the prebuild mdel) interact with the secnd mnmer. If teams mentin this interactin f helices n their 3x5 card, award 0.25 pt. (Nte teams d nt need t include the names f the helices t receive credit, but shuld mentin that the interactin with the ther mnmer is alng the helix.) Asn116 and Asn141 interact with the same Asn141 Dimerizatin regin amin acids n the secnd mnmer via charge interactins. These amin acids are displayed with a blue backbne in the image abve right, but NOT n the mdel. Teams shuld receive 0.25 pt fr each f these tw amin acids that is displayed in the prper lcatin n the prtein, fr a maximum f 0.5 pt. These amin acids shuld be arranged n the backbne s they face utward, away frm the mdel. They shuld be in an rientatin that wuld allw them t interact with a secnd prtein. Award 0.25 pt if bth are facing utward, r if nly ne f these amin acids is displayed and facing utward. If tw amin acids are displayed, and ne is facing utward and the ther is facing inward, award 0.1 pt. If bth amin acids are facing inward, n credit is awarded. Cfactr and Cfactr Binding Site (1 pt maximum) NADP is a required cfactr f sepiapterin reductase. It is displayed in range n the mdel and in the image at the right. Award 0.25 pt if NADP is displayed. Award 0.25 pt if NADP is the crrect lcatin and rientatin in the mdel. NADP is crdinated (held in place) by three residues, nly ne f which is in the truncated versin f the mdel. Leu127 is shwn in the image at the right (but nt n the mdel) with a purple backbne. Award 0.25 pt if Leu127 is displayed, and is riented twards NADP (r the pcket where NADP sits.) Arg43 and Leu71 als crdinate NADP, but they are nt part f the prtein that is mdeled fr the cmpetitin. If teams mentin that BOTH f these amin acids help t hld the NADP in place, award 0.25 pt. If they nly include ne f these amin acids, award 0.1 pt. 10
11 Catalytic Site (1 pt maximum) The catalytic site f sepiapterin reductase includes Tyr171, which is the amin acid needed fr prtein transfer, and Lys175 and Arg178, which may facilitate prtn transfer. All three f these residues are n helix 2 Helix 2 Award 0.25 pt fr each f the three residues that are displayed n helix 2 fr a maximum f 0.75 pt. Award 0.25 pt if the three residues are stacked ne n tp f the ther and facing twards the inside f the prtein. Please see image at right fr crrect psitining f these residues; these are NOT shwn n the mdel. Catalytic residues are displayed in cpk clring and the backbne is clred green. Binding Pcket (1 pt maximum) Stacked catalytic residues Substrate The substrate fits snugly int a binding pcket, which includes the catalytic residues, but several ther residues as well. These residues include: Leu105 Leu159 Cys160 Tyr165 Trp168 Met206 Leu219 Leu223 Leu226 Aps258 Tyr260 Each f these residues is depicted in the image t the right (but nt n the mdel). These amin acids have a purple backbne. Nte that all residues pint tward the bipterin substrate (shwn in image and n the judging mdel). All amin acids in active site shuld pint twards substrate T receive full credit, teams must display a minimum f three f these amin acids pinting tward the substrate (whether displayed r nt) and identify these amin acids n the 3x5 card. Award 0.25 pt fr each f the amin acids listed abve that are displayed, up t a maximum f three amin acids. (0.75 pt maximum) Award 0.25 pt if all amin acids in the active site are pinting twards the substrate (r the pcket where the substrate sits). Nte that the substrate des nt need t be displayed t receive credit. Deduct 0.25 pt if the amin acids are displayed, but are nt listed n the 3x5 card. 11
12 Substrate in Active Site (1 pt maximum) Bipterin is bund t sepiapterin reductase in the active site pcket. This is displayed in cpk clring in the mdel and in the image at the right. Assign 1 pt if bipterin is displayed in the mdel. Deduct 0.5 pt if bipterin is nt described n the 3x5 card but is displayed in the mdel. bipterin Additin f the Rest f the Prtein (1 pt maximum) The prebuild mdel cntains nly the Cterminal prtin f the prtein (amin acids ). Teams may include the rest f the prtein at the N terminus (amin acids 292). These additinal amin acids are depicted in the image at the right (but nt n the mdel). The lps f the added prtin are gray, the helices red, and the sheets bright yellw. T earn full credit the mdel must include: Layer 1: ne additinal, medium length helix adjacent t helix 1a and 1b. (0.25 pt) Layer 2: Three additinal beta strands, extending the single beta sheet. These strands shuld be added t the sheet n the side ppsite f the C terminus (red endcap). (0.25 pt) Layer 3: Tw additinal helices, running in the same directin as helix 5 and frming a twisted plane. (0.25 pt) The required mdel shuld be clearly distinguished frm the additinal sectin f the mdel. Teams may chse t use different clr backbnes, labels, r ther distinguishing features s it is clear what part f the mdel is the required mdel and what is an additinal feature. (0.25 pt) 12
13 Additin f a Secnd Mnmer t Frm a Dimer (1 pt maximum) Sepiapterin reductase functins as a dimer. Teams may pt t display a secnd mnmer t shw hw the dimer interacts. the image at right (secnd mnmer is in gray) t see the rientatin f the mnmers. T receive full credit fr this creative additin: See Layer 1 f the tw dimers must be face t face, with helices aligned. (0.25 pt). The secnd mnmer must have a triangular pine tree shape (see #13 fr an image f this triangular shape. (0.5 pt) The secnd mnmer must be upside dwn relative t the first. This can be easily sptted by lking fr the pine tree shape f the tw mnmers (ne will be upside dwn), and als bserving that the N termini f the tw mdels (blue endcap) will be diagnally ppsite in the dimer. (0.25 pt) Additinal Features Nt Described Abve (1 pt maximum) It is up t the event supervisr t determine whether the additin t the mdel is apprpriate and accurate. In rder t receive pints, the additins must be n the mdel and a cmplete descriptin and explanatin f significance must be included n the 3x5 nte card. 17. Additins t mdel are apprpriate t functin f the prtein (2 pt) T receive credit fr this feature, the creative additins need t be relevant t telling the functinal stry f the prtein. Credit shuld be awarded t thse prteins that meet the fllwing criteria: Mdel has creative additins Mdels that are just the tber (r ther mdeling material) will nt receive credit. Additins are apprpriate t the functin f the prtein Mdels that have ALL sidechains displayed shuld nt receive credit. If all sidechains are displayed, the team did nt recgnize the significance f a select few amin acids t the enzyme functin. The fcus f adding the amin acids shuld be n the nes that play a rle in the functin f the prtein. Additinally, credit shuld nt be awarded if amin acids utside f thse that play a specific functinal rle in the prtein are displayed. 13
Guide to Using the Rubric to Score the Klf4 PREBUILD Model for Science Olympiad National Competitions
Guide t Using the Rubric t Scre the Klf4 PREBUILD Mdel fr Science Olympiad 20102011 Natinal Cmpetitins These instructins are t help the event supervisr and scring judges use the rubric develped by the
More informationGuide to Using the Rubric to Score the Caspase3 PreBuild Model for Science Olympiad National Competition
Guide t Using the Rubric t Scre the Caspase3 PreBuild Mdel fr Science Olympiad 20112012 Natinal Cmpetitin These instructins are t help the event supervisr and scring judges use the rubric develped by
More informationGuide to Using the Rubric to Score the Myc/Max ONSITE Build Model for Science Olympiad 2011 NATIONAL Tournament
Guide t Using the Rubric t Scre the Myc/Max ONSITE Build Mdel fr Science Olympiad 2011 NATIONAL Turnament These instructins are t help the event supervisr and scring judges t use the rubric develped by
More informationA B C. 2. Some genes are not regulated by gene switches. These genes are expressed constantly. What kinds of genes would be expressed constantly?
STO143 Gene Switches Intrductin Bacteria need t be very efficient and nly prduce specific prteins when they are needed. Making prteins that are nt needed fr everyday cell metablism wastes energy and raw
More informationLab 1 The Scientific Method
INTRODUCTION The fllwing labratry exercise is designed t give yu, the student, an pprtunity t explre unknwn systems, r universes, and hypthesize pssible rules which may gvern the behavir within them. Scientific
More informationmaking triangle (ie same reference angle) ). This is a standard form that will allow us all to have the X= y=
Intrductin t Vectrs I 21 Intrductin t Vectrs I 22 I. Determine the hrizntal and vertical cmpnents f the resultant vectr by cunting n the grid. X= y= J. Draw a mangle with hrizntal and vertical cmpnents
More informationFlipping Physics Lecture Notes: Simple Harmonic Motion Introduction via a Horizontal MassSpring System
Flipping Physics Lecture Ntes: Simple Harmnic Mtin Intrductin via a Hrizntal MassSpring System A Hrizntal MassSpring System is where a mass is attached t a spring, riented hrizntally, and then placed
More informationTHE LIFE OF AN OBJECT IT SYSTEMS
THE LIFE OF AN OBJECT IT SYSTEMS Persns, bjects, r cncepts frm the real wrld, which we mdel as bjects in the IT system, have "lives". Actually, they have tw lives; the riginal in the real wrld has a life,
More informationDifferentiation Applications 1: Related Rates
Differentiatin Applicatins 1: Related Rates 151 Differentiatin Applicatins 1: Related Rates Mdel 1: Sliding Ladder 10 ladder y 10 ladder 10 ladder A 10 ft ladder is leaning against a wall when the bttm
More informationChapter 8 Predicting Molecular Geometries
Chapter 8 Predicting Mlecular Gemetries 81 Mlecular shape The Lewis diagram we learned t make in the last chapter are a way t find bnds between atms and lne pais f electrns n atms, but are nt intended
More informationExperiment #3. Graphing with Excel
Experiment #3. Graphing with Excel Study the "Graphing with Excel" instructins that have been prvided. Additinal help with learning t use Excel can be fund n several web sites, including http://www.ncsu.edu/labwrite/res/gt/gt
More informationBIOLOGY 101. CHAPTER 17: Gene Expression: From Gene to Protein. The Flow of Genetic Information
BIOLOGY 101 CHAPTER 17: Gene Expressin: Frm Gene t Prtein Gene Expressin: Frm Gene t Prtein: CONCEPTS: 17.1 Genes specify prteins via transcriptin and translatin 17.2 Transcriptin is the DNAdirected synthesis
More informationFlipping Physics Lecture Notes: Simple Harmonic Motion Introduction via a Horizontal MassSpring System
Flipping Physics Lecture Ntes: Simple Harmnic Mtin Intrductin via a Hrizntal MassSpring System A Hrizntal MassSpring System is where a mass is attached t a spring, riented hrizntally, and then placed
More informationPhysics 2010 Motion with Constant Acceleration Experiment 1
. Physics 00 Mtin with Cnstant Acceleratin Experiment In this lab, we will study the mtin f a glider as it accelerates dwnhill n a tilted air track. The glider is supprted ver the air track by a cushin
More informationPlan o o. I(t) Divide problem into subproblems Modify schematic and coordinate system (if needed) Write general equations
STAPLE Physics 201 Name Final Exam May 14, 2013 This is a clsed bk examinatin but during the exam yu may refer t a 5 x7 nte card with wrds f wisdm yu have written n it. There is extra scratch paper available.
More informationPipetting 101 Developed by BSU CityLab
Discver the Micrbes Within: The Wlbachia Prject Pipetting 101 Develped by BSU CityLab Clr Cmparisns Pipetting Exercise #1 STUDENT OBJECTIVES Students will be able t: Chse the crrect size micrpipette fr
More informationCHM112 Lab Graphing with Excel Grading Rubric
Name CHM112 Lab Graphing with Excel Grading Rubric Criteria Pints pssible Pints earned Graphs crrectly pltted and adhere t all guidelines (including descriptive title, prperly frmatted axes, trendline
More informationThis section is primarily focused on tools to aid us in finding roots/zeros/ intercepts of polynomials. Essentially, our focus turns to solving.
Sectin 3.2: Many f yu WILL need t watch the crrespnding vides fr this sectin n MyOpenMath! This sectin is primarily fcused n tls t aid us in finding rts/zers/ intercepts f plynmials. Essentially, ur fcus
More informationCESAR Science Case The differential rotation of the Sun and its Chromosphere. Introduction. Material that is necessary during the laboratory
Teacher s guide CESAR Science Case The differential rtatin f the Sun and its Chrmsphere Material that is necessary during the labratry CESAR Astrnmical wrd list CESAR Bklet CESAR Frmula sheet CESAR Student
More informationSPH3U1 Lesson 06 Kinematics
PROJECTILE MOTION LEARNING GOALS Students will: Describe the mtin f an bject thrwn at arbitrary angles thrugh the air. Describe the hrizntal and vertical mtins f a prjectile. Slve prjectile mtin prblems.
More informationI. Analytical Potential and Field of a Uniform Rod. V E d. The definition of electric potential difference is
Length L>>a,b,c Phys 232 Lab 4 Ch 17 Electric Ptential Difference Materials: whitebards & pens, cmputers with VPythn, pwer supply & cables, multimeter, crkbard, thumbtacks, individual prbes and jined prbes,
More informationChemistry 20 Lesson 11 Electronegativity, Polarity and Shapes
Chemistry 20 Lessn 11 Electrnegativity, Plarity and Shapes In ur previus wrk we learned why atms frm cvalent bnds and hw t draw the resulting rganizatin f atms. In this lessn we will learn (a) hw the cmbinatin
More information, which yields. where z1. and z2
The Gaussian r Nrmal PDF, Page 1 The Gaussian r Nrmal Prbability Density Functin Authr: Jhn M Cimbala, Penn State University Latest revisin: 11 September 13 The Gaussian r Nrmal Prbability Density Functin
More informationMODULE 1. e x + c. [You can t separate a demominator, but you can divide a single denominator into each numerator term] a + b a(a + b)+1 = a + b
. REVIEW OF SOME BASIC ALGEBRA MODULE () Slving Equatins Yu shuld be able t slve fr x: a + b = c a d + e x + c and get x = e(ba +) b(c a) d(ba +) c Cmmn mistakes and strategies:. a b + c a b + a c, but
More informationLab #3: Pendulum Period and Proportionalities
Physics 144 Chwdary Hw Things Wrk Spring 2006 Name: Partners Name(s): Intrductin Lab #3: Pendulum Perid and Prprtinalities Smetimes, it is useful t knw the dependence f ne quantity n anther, like hw the
More information5 th grade Common Core Standards
5 th grade Cmmn Cre Standards In Grade 5, instructinal time shuld fcus n three critical areas: (1) develping fluency with additin and subtractin f fractins, and develping understanding f the multiplicatin
More informationAP Statistics Notes Unit Two: The Normal Distributions
AP Statistics Ntes Unit Tw: The Nrmal Distributins Syllabus Objectives: 1.5 The student will summarize distributins f data measuring the psitin using quartiles, percentiles, and standardized scres (zscres).
More informationFigure 1a. A planar mechanism.
ME 5  Machine Design I Fall Semester 0 Name f Student Lab Sectin Number EXAM. OPEN BOOK AND CLOSED NOTES. Mnday, September rd, 0 Write n ne side nly f the paper prvided fr yur slutins. Where necessary,
More information20 Faraday s Law and Maxwell s Extension to Ampere s Law
Chapter 20 Faraday s Law and Maxwell s Extensin t Ampere s Law 20 Faraday s Law and Maxwell s Extensin t Ampere s Law Cnsider the case f a charged particle that is ming in the icinity f a ming bar magnet
More informationName Honors Chemistry / /
Name Hnrs Chemistry / / Beynd Lewis Structures Exceptins t the Octet Rule Mdel Hydrgen is an exceptin t the ctet rule because it fills its uter energy level with nly 2 electrns. The secnd rw elements B
More informationHow do scientists measure trees? What is DBH?
Hw d scientists measure trees? What is DBH? Purpse Students develp an understanding f tree size and hw scientists measure trees. Students bserve and measure tree ckies and explre the relatinship between
More informationCHAPTER 3 INEQUALITIES. Copyright The Institute of Chartered Accountants of India
CHAPTER 3 INEQUALITIES Cpyright The Institute f Chartered Accuntants f India INEQUALITIES LEARNING OBJECTIVES One f the widely used decisin making prblems, nwadays, is t decide n the ptimal mix f scarce
More informationhttps://goo.gl/eaqvfo SUMMER REV: HalfLife DUE DATE: JULY 2 nd
NAME: DUE DATE: JULY 2 nd AP Chemistry SUMMER REV: HalfLife Why? Every radiistpe has a characteristic rate f decay measured by its halflife. Halflives can be as shrt as a fractin f a secnd r as lng
More informationActivity Guide Loops and Random Numbers
Unit 3 Lessn 7 Name(s) Perid Date Activity Guide Lps and Randm Numbers CS Cntent Lps are a relatively straightfrward idea in prgramming  yu want a certain chunk f cde t run repeatedly  but it takes a
More informationBuilding to Transformations on Coordinate Axis Grade 5: Geometry Graph points on the coordinate plane to solve realworld and mathematical problems.
Building t Transfrmatins n Crdinate Axis Grade 5: Gemetry Graph pints n the crdinate plane t slve realwrld and mathematical prblems. 5.G.1. Use a pair f perpendicular number lines, called axes, t define
More informationChemistry 1A Fall 2000
Chemistry 1A Fall 2000 Midterm Exam III, versin B Nvember 14, 2000 (Clsed bk, 90 minutes, 155 pints) Name: SID: Sectin Number: T.A. Name: Exam infrmatin, extra directins, and useful hints t maximize yur
More informationFive Whys How To Do It Better
Five Whys Definitin. As explained in the previus article, we define rt cause as simply the uncvering f hw the current prblem came int being. Fr a simple causal chain, it is the entire chain. Fr a cmplex
More informationDAP:I~ Female 0 Male 0
Sectin I. Identifying Infrmatin Name DAP:I~ Female 0 Male 0 DrawaPersn Intellectual Ability Test fr Children, Adlescents, and Adults Administratin/Scring Frm Schl Date f Testing Date f Birth Test Age
More informationName: Period: Date: ATOMIC STRUCTURE NOTES ADVANCED CHEMISTRY
Name: Perid: Date: ATOMIC STRUCTURE NOTES ADVANCED CHEMISTRY Directins: This packet will serve as yur ntes fr this chapter. Fllw alng with the PwerPint presentatin and fill in the missing infrmatin. Imprtant
More information2004 AP CHEMISTRY FREERESPONSE QUESTIONS
2004 AP CHEMISTRY FREERESPONSE QUESTIONS 6. An electrchemical cell is cnstructed with an pen switch, as shwn in the diagram abve. A strip f Sn and a strip f an unknwn metal, X, are used as electrdes.
More informationIt is compulsory to submit the assignment before filling in the exam form.
OMT101 ASSIGNMENT BOOKLET Bachelr's Preparatry Prgramme PREPARATORY COURSE IN GENERAL MATHEMATICS (This assignment is valid nly upt: 1 st December, 01 And Valid fr bth Jan 01 cycle and July 01 cycle)
More informationMODULE FOUR. This module addresses functions. SC Academic Elementary Algebra Standards:
MODULE FOUR This mdule addresses functins SC Academic Standards: EA3.1 Classify a relatinship as being either a functin r nt a functin when given data as a table, set f rdered pairs, r graph. EA3.2 Use
More informationREADING STATECHART DIAGRAMS
READING STATECHART DIAGRAMS Figure 4.48 A Statechart diagram with events The diagram in Figure 4.48 shws all states that the bject plane can be in during the curse f its life. Furthermre, it shws the pssible
More informationInstructional Plan. Representational/Drawing Level
Instructinal Plan Representatinal/Drawing Level Name f Math Skill/Cncept: Divisin Prcess and Divisin with Remainders Prerequisite Skills Needed: 1.) Mastery f dividing cncrete bjects int equal grups. 2.)
More informationCHAPTER 24: INFERENCE IN REGRESSION. Chapter 24: Make inferences about the population from which the sample data came.
MATH 1342 Ch. 24 April 25 and 27, 2013 Page 1 f 5 CHAPTER 24: INFERENCE IN REGRESSION Chapters 4 and 5: Relatinships between tw quantitative variables. Be able t Make a graph (scatterplt) Summarize the
More informationInterference is when two (or more) sets of waves meet and combine to produce a new pattern.
Interference Interference is when tw (r mre) sets f waves meet and cmbine t prduce a new pattern. This pattern can vary depending n the riginal wave directin, wavelength, amplitude, etc. The tw mst extreme
More information37 Maxwell s Equations
37 Maxwell s quatins In this chapter, the plan is t summarize much f what we knw abut electricity and magnetism in a manner similar t the way in which James Clerk Maxwell summarized what was knwn abut
More informationIf (IV) is (increased, decreased, changed), then (DV) will (increase, decrease, change) because (reason based on prior research).
Science Fair Prject Set Up Instructins 1) Hypthesis Statement 2) Materials List 3) Prcedures 4) Safety Instructins 5) Data Table 1) Hw t write a HYPOTHESIS STATEMENT Use the fllwing frmat: If (IV) is (increased,
More informationChapter 2 GAUSS LAW Recommended Problems:
Chapter GAUSS LAW Recmmended Prblems: 1,4,5,6,7,9,11,13,15,18,19,1,7,9,31,35,37,39,41,43,45,47,49,51,55,57,61,6,69. LCTRIC FLUX lectric flux is a measure f the number f electric filed lines penetrating
More informationAP Physics. Summer Assignment 2012 Date. Name. F m = = + What is due the first day of school? a. T. b. = ( )( ) =
P Physics Name Summer ssignment 0 Date I. The P curriculum is extensive!! This means we have t wrk at a fast pace. This summer hmewrk will allw us t start n new Physics subject matter immediately when
More informationWe can see from the graph above that the intersection is, i.e., [ ).
MTH 111 Cllege Algebra Lecture Ntes July 2, 2014 Functin Arithmetic: With nt t much difficulty, we ntice that inputs f functins are numbers, and utputs f functins are numbers. S whatever we can d with
More informationAcids and Bases Lesson 3
Acids and Bases Lessn 3 The ph f a slutin is defined as the negative lgarithm, t the base ten, f the hydrnium in cncentratin. In a neutral slutin at 25 C, the hydrnium in and the hydrxide in cncentratins
More informationGetting Involved O. Responsibilities of a Member. People Are Depending On You. Participation Is Important. Think It Through
f Getting Invlved O Literature Circles can be fun. It is exciting t be part f a grup that shares smething. S get invlved, read, think, and talk abut bks! Respnsibilities f a Member Remember a Literature
More informationIntroduction to Spacetime Geometry
Intrductin t Spacetime Gemetry Let s start with a review f a basic feature f Euclidean gemetry, the Pythagrean therem. In a twdimensinal crdinate system we can relate the length f a line segment t the
More information4 electron domains: 3 bonding and 1 nonbonding. 2 electron domains: 2 bonding and 0 nonbonding. 3 electron domains: 2 bonding and 1 nonbonding
[4.3D VSEPR] pg. 1 f 7 Curriculum The use f VSEPR thery t predict the electrn dmain gemetry and the mlecular gemetry fr species with tw, three and fur electrn dmains. Shapes f species are determined by
More informationPhysics 2B Chapter 23 Notes  Faraday s Law & Inductors Spring 2018
Michael Faraday lived in the Lndn area frm 1791 t 1867. He was 29 years ld when Hand Oersted, in 1820, accidentally discvered that electric current creates magnetic field. Thrugh empirical bservatin and
More informationYou need to be able to define the following terms and answer basic questions about them:
CS440/ECE448 Sectin Q Fall 2017 Midterm Review Yu need t be able t define the fllwing terms and answer basic questins abut them: Intr t AI, agents and envirnments Pssible definitins f AI, prs and cns f
More informationWeathering. Title: Chemical and Mechanical Weathering. Grade Level: Subject/Content: Earth and Space Science
Weathering Title: Chemical and Mechanical Weathering Grade Level: 912 Subject/Cntent: Earth and Space Science Summary f Lessn: Students will test hw chemical and mechanical weathering can affect a rck
More informationANSWER KEY FOR MATH 10 SAMPLE EXAMINATION. Instructions: If asked to label the axes please use real world (contextual) labels
ANSWER KEY FOR MATH 10 SAMPLE EXAMINATION Instructins: If asked t label the axes please use real wrld (cntextual) labels Multiple Chice Answers: 0 questins x 1.5 = 30 Pints ttal Questin Answer Number 1
More informationTEST 3A AP Statistics Name: Directions: Work on these sheets. A standard normal table is attached.
TEST 3A AP Statistics Name: Directins: Wrk n these sheets. A standard nrmal table is attached. Part 1: Multiple Chice. Circle the letter crrespnding t the best answer. 1. In a statistics curse, a linear
More informationUnit Project Descriptio
Unit Prject Descriptin: Using Newtn s Laws f Mtin and the scientific methd, create a catapult r trebuchet that will sht a marshmallw at least eight feet. After building and testing yur machine at hme,
More informationCells though to send feedback signals from the medulla back to the lamina o L: Lamina Monopolar cells
Classificatin Rules (and Exceptins) Name: Cell type fllwed by either a clumn ID (determined by the visual lcatin f the cell) r a numeric identifier t separate ut different examples f a given cell type
More informationName: Period: Date: BONDING NOTES ADVANCED CHEMISTRY
Name: Perid: Date: BONDING NOTES ADVANCED CHEMISTRY Directins: This packet will serve as yur ntes fr this chapter. Fllw alng with the PwerPint presentatin and fill in the missing infrmatin. Imprtant terms
More informationTo get you thinking...
T get yu thinking... 1.) What is an element? Give at least 4 examples f elements. 2.) What is the atmic number f hydrgen? What des a neutral hydrgen atm cnsist f? Describe its "mtin". 3.) Hw des an atm
More informationTutorial 3: Building a spectral library in Skyline
SRM Curse 2013 Tutrial 3 Spectral Library Tutrial 3: Building a spectral library in Skyline Spectral libraries fr SRM methd design and fr data analysis can be either directly added t a Skyline dcument
More informationThree charges, all with a charge of 10 C are situated as shown (each grid line is separated by 1 meter).
Three charges, all with a charge f 0 are situated as shwn (each grid line is separated by meter). ) What is the net wrk needed t assemble this charge distributin? a) +0.5 J b) +0.8 J c) 0 J d) 0.8 J e)
More informationPlate Tectonics and the Fossil Record
Plate Tectnics and the Fssil Recrd Accrding t the thery f plate tectnics, the earth's surface is dynamic. The current cnfiguratin f its land and cean masses is the result f mtins that have ccurred ver
More informationChapter 6 Fingerprints
Chapter 6 Fingerprints Vcabulary: Arch: a fingerprint pattern in which the ridge pattern riginates frm ne side f the print and leaves frm the ther side Cre: Delta: a triangular ridge pattern with ridges
More informationPlease Stop Laughing at Me and Pay it Forward Final Writing Assignment
Kirk Please Stp Laughing at Me and Pay it Frward Final Writing Assignment Our fcus fr the past few mnths has been n bullying and hw we treat ther peple. We ve played sme games, read sme articles, read
More informationA Quick Overview of the. Framework for K 12 Science Education
A Quick Overview f the NGSS EQuIP MODULE 1 Framewrk fr K 12 Science Educatin Mdule 1: A Quick Overview f the Framewrk fr K 12 Science Educatin This mdule prvides a brief backgrund n the Framewrk fr K12
More informationMedium Scale Integrated (MSI) devices [Sections 2.9 and 2.10]
EECS 270, Winter 2017, Lecture 3 Page 1 f 6 Medium Scale Integrated (MSI) devices [Sectins 2.9 and 2.10] As we ve seen, it s smetimes nt reasnable t d all the design wrk at the gatelevel smetimes we just
More informationBASD HIGH SCHOOL FORMAL LAB REPORT
BASD HIGH SCHOOL FORMAL LAB REPORT *WARNING: After an explanatin f what t include in each sectin, there is an example f hw the sectin might lk using a sample experiment Keep in mind, the sample lab used
More informationNUMBERS, MATHEMATICS AND EQUATIONS
AUSTRALIAN CURRICULUM PHYSICS GETTING STARTED WITH PHYSICS NUMBERS, MATHEMATICS AND EQUATIONS An integral part t the understanding f ur physical wrld is the use f mathematical mdels which can be used t
More informationGroup Color: Subgroup Number: How Science Works. Grade 5. Module 2. Class Question: Scientist (Your Name): Teacher s Name: SciTrek Volunteer s Name:
Grup Clr: Subgrup Number: Hw Science Wrks Grade 5 Mdule 2 Class Questin: Scientist (Yur Name): Teacher s Name: SciTrek Vlunteer s Name: VOCABULARY Science: The study f the material wrld using human reasn.
More informationM thematics. National 5 Practice Paper D. Paper 1. Duration 1 hour. Total marks 40
N5 M thematics Natinal 5 Practice Paper D Paper 1 Duratin 1 hur Ttal marks 40 Yu may NOT use a calculatr Attempt all the questins. Use blue r black ink. Full credit will nly be given t slutins which cntain
More informationFIZIKA ANGOL NYELVEN JAVÍTÁSIÉRTÉKELÉSI ÚTMUTATÓ
Fizika angl nyelven emelt szint 0804 ÉRETTSÉGI VIZSGA 010. május 18. FIZIKA ANGOL NYELVEN EMELT SZINTŰ ÍRÁSBELI ÉRETTSÉGI VIZSGA JAVÍTÁSIÉRTÉKELÉSI ÚTMUTATÓ OKTATÁSI ÉS KULTURÁLIS MINISZTÉRIUM In marking
More informationFall 2013 Physics 172 Recitation 3 Momentum and Springs
Fall 03 Physics 7 Recitatin 3 Mmentum and Springs Purpse: The purpse f this recitatin is t give yu experience wrking with mmentum and the mmentum update frmula. Readings: Chapter.3.5 Learning Objectives:.3.
More informationSubject description processes
Subject representatin 6.1.2. Subject descriptin prcesses Overview Fur majr prcesses r areas f practice fr representing subjects are classificatin, subject catalging, indexing, and abstracting. The prcesses
More informationEinstein's special relativity the essentials
VCE Physics Unit 3: Detailed study Einstein's special relativity the essentials Key knwledge and skills (frm Study Design) describe the predictin frm Maxwell equatins that the speed f light depends nly
More informationPrecalculus A. Semester Exam Review
Precalculus A 015016 MCPS 015 016 1 The semester A eaminatin fr Precalculus cnsists f tw parts. Part 1 is selected respnse n which a calculatr will NOT be allwed. Part is shrt answer n which a calculatr
More informationLDS emarket. Section 11  Catalog Load Process
LDS emarket Sectin 11  Catalg Lad Prcess Catalg Lad Prcess There are three types f catalgs in LDS emarket: Supplier Direct Web Site An nline catalg f items hsted by the supplier using HTML cding PRG A
More information[COLLEGE ALGEBRA EXAM I REVIEW TOPICS] ( u s e t h i s t o m a k e s u r e y o u a r e r e a d y )
(Abut the final) [COLLEGE ALGEBRA EXAM I REVIEW TOPICS] ( u s e t h i s t m a k e s u r e y u a r e r e a d y ) The department writes the final exam s I dn't really knw what's n it and I can't very well
More informationChem 115 POGIL Worksheet  Week 12 Molecular Shapes
Chem 115 POGIL Wrksheet  Week 12 Mlecular Shapes Why? Cntrary t the impressin that Lewis structures may give, many mlecules have threedimensinal gemetries. These mlecular shapes are very imprtant t understanding
More informationPhysics 101 Math Review. Solutions
Physics 0 Math eview Slutins . The fllwing are rdinary physics prblems. Place the answer in scientific ntatin when apprpriate and simplify the units (Scientific ntatin is used when it takes less time t
More informationAssociated Students Flacks Internship
Assciated Students Flacks Internship 20162017 Applicatin Persnal Infrmatin: Name: Address: Phne #: Years at UCSB: Cumulative GPA: Email: Majr(s)/Minr(s): Units Cmpleted: Tw persnal references (Different
More information3. Classify the following Numbers (Counting (natural), Whole, Integers, Rational, Irrational)
After yu cmplete each cncept give yurself a rating 1. 15 5 2 (5 3) 2. 2 48 (2 5) 3. Classify the fllwing Numbers (Cunting (natural), Whle, Integers, Ratinal, Irratinal) a. 7 b. 2 3 c. 2 4. Are negative
More informationGAUSS' LAW E. A. surface
Prf. Dr. I. M. A. Nasser GAUSS' LAW 08.11.017 GAUSS' LAW Intrductin: The electric field f a given charge distributin can in principle be calculated using Culmb's law. The examples discussed in electric
More informationChem 163 Section: Team Number: ALE 24. Voltaic Cells and Standard Cell Potentials. (Reference: 21.2 and 21.3 Silberberg 5 th edition)
Name Chem 163 Sectin: Team Number: ALE 24. Vltaic Cells and Standard Cell Ptentials (Reference: 21.2 and 21.3 Silberberg 5 th editin) What des a vltmeter reading tell us? The Mdel: Standard Reductin and
More informationTrigonometric Ratios Unit 5 Tentative TEST date
1 U n i t 5 11U Date: Name: Trignmetric Ratis Unit 5 Tentative TEST date Big idea/learning Gals In this unit yu will extend yur knwledge f SOH CAH TOA t wrk with btuse and reflex angles. This extensin
More informationCambridge Assessment International Education Cambridge International General Certificate of Secondary Education
Cambridge Assessment Internatinal Educatin Cambridge Internatinal General Certificate f Secndary Educatin ADDITIONAL MATHEMATICS 0606/1 Paper 1 MARK SCHEME Maximum Mark: 80 Published This mark scheme is
More informationSAMPLE TEST PAPER A TALENT SEARCH EXAM 2019
SAMPLE TEST PAPER A TALENT SEARCH EXAM 019 Time : 0 Minutes Class : 9 th _ STAGE  1 Max. Marks : 100 Name : Rll N.: [A] General : 1. Attempt ALL the questins. Answer have t be darkened n the OMR sheet..
More informationEnd of Course Algebra I ~ Practice Test #2
End f Curse Algebra I ~ Practice Test #2 Name: Perid: Date: 1: Order the fllwing frm greatest t least., 3, 8.9, 8,, 9.3 A. 8, 8.9,, 9.3, 3 B., 3, 8, 8.9,, 9.3 C. 9.3, 3,,, 8.9, 8 D. 3, 9.3,,, 8.9, 8 2:
More information**DO NOT ONLY RELY ON THIS STUDY GUIDE!!!**
Tpics lists: UVVis Absrbance Spectrscpy Lab & ChemActivity 36 (nly thrugh 4) I. UVVis Absrbance Spectrscpy Lab Beer s law Relates cncentratin f a chemical species in a slutin and the absrbance f that
More informationGEOMETRY Transformation Project
GEOMETRY Transfrmatin Prject T bring tgether the unit f transfrmatins, yu will be making a Gemetry Transfrmatins Prject based n yur interest. This prject is meant t give yu an pprtunity t explre hw transfrmatins
More informationEditorial Calendar User Guide
Editrial Calendar User Guide Table f Cntents Intrductin... 1 Permissins... 1 Navigatin & Views... 1 Navigatin Menu... 2 Mini Calendar... 2 Calendars in View... 3 Cntent Filtering... 4 Mnthly Calendar...
More informationAdministrativia. Assignment 1 due thursday 9/23/2004 BEFORE midnight. Midterm exam 10/07/2003 in class. CS 460, Sessions 89 1
Administrativia Assignment 1 due thursday 9/23/2004 BEFORE midnight Midterm eam 10/07/2003 in class CS 460, Sessins 89 1 Last time: search strategies Uninfrmed: Use nly infrmatin available in the prblem
More informationSections 15.1 to 15.12, 16.1 and 16.2 of the textbook (RobbinsMiller) cover the materials required for this topic.
Tpic : AC Fundamentals, Sinusidal Wavefrm, and Phasrs Sectins 5. t 5., 6. and 6. f the textbk (RbbinsMiller) cver the materials required fr this tpic.. Wavefrms in electrical systems are current r vltage
More information